Mustela putorius furo (domestic ferret): 101684592
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Entry
101684592 CDS
T07239
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
mpuf
Mustela putorius furo (domestic ferret)
Pathway
mpuf05012
Parkinson disease
mpuf05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
mpuf00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
101684592 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
101684592 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mpuf01001
]
101684592 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mpuf04131
]
101684592 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
mpuf04147
]
101684592 (LRRK2)
Enzymes [BR:
mpuf01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
101684592 (LRRK2)
Protein kinases [BR:
mpuf01001
]
Serine/threonine kinases: TKL group
LRRK family
101684592 (LRRK2)
Membrane trafficking [BR:
mpuf04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
101684592 (LRRK2)
Exosome [BR:
mpuf04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
101684592 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR
Ras
LRR_14
LRR_9
LRR_NXF1-5
Arf
LRR_13
Beta-prop_RSE1_2nd
Beta-prop_EML_2
AAA_22
T2SSE
nSTAND3
Ank_2
PduV-EutP
Kdo
ABC_tran
MMR_HSR1
GTP_EFTU
SRPRB
LRR_6
TniB
AAA_7
AAA_16
G-alpha
TsaE
cobW
MobB
Septin
AAA_29
NACHT
TrwB_AAD_bind
WD40_WDHD1_1st
SRP54
Motif
Other DBs
NCBI-GeneID:
101684592
NCBI-ProteinID:
XP_004771900
Ensembl:
ENSMPUG00000000236
UniProt:
M3XMD3
LinkDB
All DBs
Position
Unknown
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKK
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGHDWEVLGVHQLIL
KMLTVHNANVNLLTVGLKALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEVQKL
GCKALHVLFERVSEEQLTEFVENKDYIILLNALKNFKDEEEIVLHVLHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKTFPVNEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
QRYSENATLQIAALSCLALLTETIFLNQDLEEKNENQENDDEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQSSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTTLDTM
AAVAPKIITVMKSHETSLSVQLEALRAVLHFIVPGMPEESGEDTEYQHKLNMVKRQCFKN
DIHKLVLAALNKFIGNPGIQKCGLKVISSIAHSPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCIGTGHLLAKILVSSLQRFKDMAEVQIKGFQTILAILELSV
SFSNLLVHHSFDSVIFHQMSSSIMEQKDQQFLNLCCKCFAKLVMDDELKSVLLERACDQN
NSIMVECLLLLGADANGTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALAISIG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIEPSWLGPLFPDKTSNLRKETNIGSTLA
RMVLRYQMKSSLEEGAASGSNGNFPEGVLDKFDEWTFIPDSYVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYRDRALQRCSPNLQRHSNSLGPIFDHEDLLKQKRKMLSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKSGISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLHSNKFTSFPYYLLKMNCIANLDVSRNDISPSVVLDPAV
KCPTLKHFNLSYNQLSSFPENLGDVVEKLEQLILEGNKIPEICSPLSLKELKILNLSKNH
ITSLSEDFLEACPKVESFSARMNYLAAMPLLPSSLTSLKLSQNRFTCVPEVILNLPHLRS
LDMSSNEIEYLPSPAHWKSLNLRELLFSFNQISILDLSEKAYVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKTKKSDLGVQSATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKGSLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAGIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRHISIPKNFSVECMVATNH
NSKNASIWLGCGHRDKGQLLFLDLNTEKQTSEEVIDSRILCLALVPLPAEKESWIVCGTQ
SGMLLVINTEDGDKRHTLGKMTDSVTCLYCNPFPKQSKQKNFLLVGTADGNLAIFEDKTV
KCKGAAPLKILNIGNVSTPLMCLSESMNSAEKNIVWGGCGTKLFSFSDDFTIQKLIETKT
HQLFSYAAFSDSNIIAVVVDTALYVAKKNSPFVEVRDKKTEKLCELIDCVHFLKEEMVKV
NAESKHKLSYTGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIQNFCDSVRVMMT
AQLGSLKNVMLVLGYIRKSTESSQHQKEIQSCLSVWDINLPHEVQNLEKHIEVRKELAEK
MRRVSVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaattctg
gaggatatgctggtgttcacgtacgccgaccacgcctccaagttatttcaaggcaaaaaa
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagtgtgcagcag
gtgggttggtcacttctttgcaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggacctcaggatattggacatgattgggaagtacttggggttcaccaacttattctt
aaaatgctaacagttcataatgccaacgtaaacctattaactgttgggctgaaggcctta
gatctccttctaacttcaggcaaaatcactttgctgatattggacgaagaaagtgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgatgaagtccagaaactt
ggatgcaaagctttacatgtgctgtttgaaagagtttctgaggagcagctgactgaattt
gttgagaataaagattatattatcttgctcaatgcattaaaaaattttaaagatgaagag
gaaattgtgcttcacgtcctgcactgtttacattccctagcaattccttgcaataatgtt
gaagtcctcatgagtggcaatgtcaggtgttataatattgtggtagaagccatgaaaaca
ttccctgtcaatgaaaagattcaagaagtgagttgttgcttgctccatagacttacatta
ggtaatttttttaatattctggtgttaaacgaggtacatgagtttgtggtgaaagccgtg
cagcgatattcagagaacgccacgttacagattgcagcactcagctgtttagcgctcctc
actgagaccatcttcttaaatcaagacttagaggaaaagaatgagaatcaggagaatgat
gatgaggaagaggataaattgttctggttggaagcctgttacaaagcattgacatggcat
agaaagaacaagcatgtgcaggaggctgcatgctgggcccttaacaatctccttatgtac
cagagcagtttacatgagaagattggagatgaagatggccagttcccagctcatagggaa
gtgatgctttccatgctgatgcattcttcatcaaaagaagtcttccaggcatctgcaaat
gcattgtcgactctgttagaacaaaacgttaatttcagaaagatcctgttgtccaaagga
atatacctcaatgtactggagttaatgcagaagcatatacattctccagaagttgctgaa
agtggctgtaaaatgctaaatcatctctttgaaggaagcaacacgaccctggatacaatg
gcagcagtggcccccaaaataataacagttatgaaaagtcatgagacatccttatcagtg
cagctggaagcactcagagctgttttacattttatagttccagggatgccagaagaatct
ggagaagatactgaatatcaacataagctaaatatggttaaaagacagtgtttcaagaat
gatattcataaactagtcctagcagctttgaacaagttcattggaaatcctgggattcag
aaatgtgggttgaaagtgatttcttctatagcacattctcctgatgcgctagaagtattg
tccttggaaggtgctattgattctgtgcttcacacgctgcagatgtatcccgatgaccaa
gaaattcaatgtctgggattaagtctgataggatgcttgattacaaagaagaatttatgc
ataggaactgggcatctgctggcaaaaattctggtttccagtttacaacgatttaaggat
atggccgaagtacagattaaaggatttcagacaatcttggcaatactggaattgtcagtg
tctttttccaacctgctggtgcatcattcctttgattctgtgatattccatcagatgtct
tctagtatcatggaacaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattagttatggatgacgagttaaaaagtgtgctgctagagagagcatgcgatcagaat
aacagtatcatggttgaatgcttgcttctgttgggagcggacgccaatggaacaaaggag
gccacgtctttaatttgtcaggtatgtgagaaagccagcagtcccaaattggtggaactg
ctactgaatggtggttcccgcgaacaagatgttcggaaggcgctggcgataagcattggg
aaaggtgacagccagatcattagcttactcttaagaagacttgctctggatctggccaat
aatagcatttgccttggaggattttgcataggaaaaattgaaccttcatggcttggtcct
ttatttccagataagacatctaatttaagaaaagaaacaaacataggatccaccctagca
agaatggtgctcagatatcagatgaaaagttctttggaggaaggggcagcctcaggcagc
aatgggaactttcctgaaggagtacttgataaatttgatgaatggaccttcattccagac
tcctatgtggacagtgtttttggtcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaagaaaatctaattcaattagtgtaggagaattttaccgagatcgt
gccttgcagcgttgctcaccaaatttgcaaaggcattccaactcattgggacctattttc
gatcatgaagatttactgaagcaaaaaagaaaaatgttgtcttcagatgactcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttccctggcttcggag
agagaatatatcacatcattagacctttcagcaaatgaactaagagatattgatgccttg
agccagaaaagcggtatcagtggtcatttggagcatcttgaaaagctggagcttcatcag
aatgcactcacgagctttccacaacaactctgtgaaaccctgaagtgtttgacacatttg
gatttgcacagtaataaatttacatcatttccctattacttgttgaaaatgaattgtatt
gccaacctcgatgtctctcgaaacgacatcagcccttcagtagttttggatcctgcagtg
aagtgcccaaccttgaaacattttaacttgtcatataatcagctgtcttcttttcctgag
aaccttggtgatgtggtagagaaattggaacagctcattttagaaggaaataaaatacca
gaaatatgttccccattaagcctgaaggaactgaagattttaaatcttagtaaaaaccac
attacatctctatcagaagacttccttgaggcatgtcctaaagtggagagtttcagtgcc
agaatgaattatctcgctgctatgcctcttttgccttcttccctgacaagcctaaaacta
tctcaaaacagatttacatgtgttccagaagtaattttaaatcttccacacttgcgatct
ttagatatgagcagcaatgaaattgagtatctgccgagtcctgcacactggaaatctttg
aacttaagggaactcttgttcagttttaatcagatcagcatcttggacttgagcgaaaaa
gcatatgtgtggtcaagagtagagaaactacatctttctcataataaactgaaagagatt
cctcctgagattggctgtctcgaaaacctgacctcccttgatgtcagttacaatttggag
ctgagatcctttcctaatgaaatggggaagttaagcaaaatatgggatcttcctttggat
gaactacggcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaggctgtgccctataaccgaatgaagcttatgattgtg
ggaaatactgggagtggtaaaaccaccttattgcagcaactgacaaaaaccaagaagtca
gatcttggggtgcagagcgccacagttggtatagatgtgaaagactggcctatccaaatt
agaggcaaagggaagaaggacctcattctgaatgtgtgggattttgcaggtcgtgaggaa
ttctacagtactcatccccacttcatgacccagcgagccctctaccttgctgtctatgac
cttagcaaagggcaggctgaagtggacgccatgaaaccttggctcttcaatataaaggct
cgtgcttcttcttcccctgtgattcttgttggcacacatttggatgtttctgatgaaaag
cagcgcaaagcctgcataagtaaaatcaccaaggaactcttgaacaagcgagggtttcct
gcaataagggattaccactttgtgaatgccactgaggaatcggatgctttggcaaagctt
cggaaaaccatcatcaatgagagtcttaatttcaagatccgagatcagcctgttgttggg
cagctgattccagactgctatgtagaacttgagaaaatcattttatcagagcgtaaaaat
gtgccaattgaatttcctgtaatcgaccggaaacgattattacaactcgtaaaagaaaat
cagctgcagttggatgaaaatgagcttcctcatgcagttcacttcctaaatgaatcaggg
gtccttcttcattttcaagacccagcattgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctatcctaaa
catcctaaaggaatcatttcacgtagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatgtcacagtactttaaacttctagaaaaattccagattgccttg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaatcatcattcgactctatgaaatgccttatttt
ccaatgggattttggtccaggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgtccaaacagaatgtactggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcatcctgag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttctgggccaagtt
gtggaccacattgattctctcatggaagaatggtttcctggactactggagattgatatc
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgatgacttgatgaagaaagcagaagaaggagaccttcta
gtaaatccagatcaaccaaggctcaccattccaatatctcaaattgctcctgacttaatt
ttggctgacctgcctaggaatattatgttgaataatgatgaattggaatttgaacaagct
cctgagtttctcttaggtgatggcagttttggatctgtttatcgggcagcctatgaaggg
gaagaagtggctgtgaagattttcaataaacatacatcactgagactgttaagacaagag
ctggtggtcctttgccacctgcaccatcccagcttaatatctttgctggcggctgggatt
cgccctcgcatgttggtgatggagttggcctccaagggttcgctggaccgcttgcttcag
caggacaaaggaagtcttaccagaaccctgcagcacaggattgcgctacacgtggctgat
ggcctgagatacctccactcggccatgattatataccgtgacttaaagccccacaacgtg
ctgctcttcaccctctatcccaatgctggcatcattgcgaagattgcagactatggaatt
gctcagtactgctgtaggatggggataaagacgtcggagggcacaccagggtttcgtgca
cctgaagttgctagaggaaatgttatttataaccaacaagctgatgtttattcatttggt
ttactactctatgacattttgacaactggaggtagaatagcagagggtttgaagtttcca
aatgagtttgatgaactggcaatacaaggaaaattacctgatccagttaaagaatatggc
tgtgccccatggcccatggttgagaagttaattaaaaagtgtttgaaggaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctg
atgaggcatatatcaatacctaaaaactttagcgttgaatgcatggtcgctacaaatcat
aacagcaagaatgcaagcatctggctgggctgtggacaccgtgacaaaggacaactctta
tttcttgacttaaatacagaaaaacagacttctgaggaagttattgatagtagaatactg
tgcctagctttggtgcctcttcctgcggaaaaggaaagctggatagtttgtgggacacag
tctggcatgctcctggtcatcaataccgaagatggggataagagacatactcttggaaag
atgaccgattctgtgacttgcttgtattgcaatccctttcccaagcaaagcaagcaaaaa
aactttcttctggtgggaactgctgatggcaatttagccatttttgaagataaaactgtt
aagtgtaaaggagccgctcctttgaagatactaaatataggaaatgtcagtactccactg
atgtgtttgagtgaatccatgaattcagctgaaaaaaacatcgtgtggggaggatgtggc
acaaaacttttctcgttttctgatgatttcaccattcagaagctcattgagaccaagaca
catcagctgttttcttatgcagctttcagtgattccaacatcatagcagtggtggtagac
acggctctctacgttgctaagaagaatagcccatttgtggaagtacgggataagaaaact
gaaaaactctgtgaactaatagactgtgtgcactttttaaaagaggaaatggtaaaagta
aatgcagaatcaaaacacaaactgtcttatactgggagggtgaaaaccctgtgcctccag
aagaacactgctctctggataggaactggaggaggccatattttactccttgatctttca
actcgtcgaattatacgtataattcagaatttctgtgactctgtcagagtcatgatgaca
gcacagttaggaagtcttaaaaatgtcatgctggttttggggtatattcggaaaagtact
gaaagttcacaacatcaaaaagaaatacaatcttgtttgtctgtttgggacatcaatctt
ccacatgaagtgcaaaacttagaaaaacatattgaagtgagaaaagaattagctgaaaaa
atgagaagagtatctgttgaataa
DBGET
integrated database retrieval system
