KEGG   Mustela putorius furo (domestic ferret): 101687768
Entry
101687768         CDS       T07239                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mpuf  Mustela putorius furo (domestic ferret)
Pathway
mpuf00562  Inositol phosphate metabolism
mpuf01100  Metabolic pathways
mpuf04015  Rap1 signaling pathway
mpuf04020  Calcium signaling pathway
mpuf04022  cGMP-PKG signaling pathway
mpuf04062  Chemokine signaling pathway
mpuf04070  Phosphatidylinositol signaling system
mpuf04071  Sphingolipid signaling pathway
mpuf04072  Phospholipase D signaling pathway
mpuf04081  Hormone signaling
mpuf04082  Neuroactive ligand signaling
mpuf04261  Adrenergic signaling in cardiomyocytes
mpuf04270  Vascular smooth muscle contraction
mpuf04310  Wnt signaling pathway
mpuf04371  Apelin signaling pathway
mpuf04540  Gap junction
mpuf04611  Platelet activation
mpuf04613  Neutrophil extracellular trap formation
mpuf04621  NOD-like receptor signaling pathway
mpuf04713  Circadian entrainment
mpuf04720  Long-term potentiation
mpuf04723  Retrograde endocannabinoid signaling
mpuf04724  Glutamatergic synapse
mpuf04725  Cholinergic synapse
mpuf04726  Serotonergic synapse
mpuf04728  Dopaminergic synapse
mpuf04730  Long-term depression
mpuf04742  Taste transduction
mpuf04750  Inflammatory mediator regulation of TRP channels
mpuf04911  Insulin secretion
mpuf04912  GnRH signaling pathway
mpuf04915  Estrogen signaling pathway
mpuf04916  Melanogenesis
mpuf04918  Thyroid hormone synthesis
mpuf04919  Thyroid hormone signaling pathway
mpuf04921  Oxytocin signaling pathway
mpuf04922  Glucagon signaling pathway
mpuf04924  Renin secretion
mpuf04925  Aldosterone synthesis and secretion
mpuf04926  Relaxin signaling pathway
mpuf04927  Cortisol synthesis and secretion
mpuf04928  Parathyroid hormone synthesis, secretion and action
mpuf04929  GnRH secretion
mpuf04933  AGE-RAGE signaling pathway in diabetic complications
mpuf04934  Cushing syndrome
mpuf04935  Growth hormone synthesis, secretion and action
mpuf04961  Endocrine and other factor-regulated calcium reabsorption
mpuf04970  Salivary secretion
mpuf04971  Gastric acid secretion
mpuf04972  Pancreatic secretion
mpuf04973  Carbohydrate digestion and absorption
mpuf05010  Alzheimer disease
mpuf05016  Huntington disease
mpuf05017  Spinocerebellar ataxia
mpuf05022  Pathways of neurodegeneration - multiple diseases
mpuf05142  Chagas disease
mpuf05143  African trypanosomiasis
mpuf05146  Amoebiasis
mpuf05163  Human cytomegalovirus infection
mpuf05200  Pathways in cancer
mpuf05415  Diabetic cardiomyopathy
mpuf05417  Lipid and atherosclerosis
Module
mpuf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mpuf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101687768 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101687768 (PLCB3)
   04310 Wnt signaling pathway
    101687768 (PLCB3)
   04371 Apelin signaling pathway
    101687768 (PLCB3)
   04020 Calcium signaling pathway
    101687768 (PLCB3)
   04070 Phosphatidylinositol signaling system
    101687768 (PLCB3)
   04072 Phospholipase D signaling pathway
    101687768 (PLCB3)
   04071 Sphingolipid signaling pathway
    101687768 (PLCB3)
   04022 cGMP-PKG signaling pathway
    101687768 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    101687768 (PLCB3)
   04081 Hormone signaling
    101687768 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101687768 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101687768 (PLCB3)
   04613 Neutrophil extracellular trap formation
    101687768 (PLCB3)
   04621 NOD-like receptor signaling pathway
    101687768 (PLCB3)
   04062 Chemokine signaling pathway
    101687768 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    101687768 (PLCB3)
   04922 Glucagon signaling pathway
    101687768 (PLCB3)
   04929 GnRH secretion
    101687768 (PLCB3)
   04912 GnRH signaling pathway
    101687768 (PLCB3)
   04915 Estrogen signaling pathway
    101687768 (PLCB3)
   04921 Oxytocin signaling pathway
    101687768 (PLCB3)
   04926 Relaxin signaling pathway
    101687768 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    101687768 (PLCB3)
   04918 Thyroid hormone synthesis
    101687768 (PLCB3)
   04919 Thyroid hormone signaling pathway
    101687768 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    101687768 (PLCB3)
   04916 Melanogenesis
    101687768 (PLCB3)
   04924 Renin secretion
    101687768 (PLCB3)
   04925 Aldosterone synthesis and secretion
    101687768 (PLCB3)
   04927 Cortisol synthesis and secretion
    101687768 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101687768 (PLCB3)
   04270 Vascular smooth muscle contraction
    101687768 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    101687768 (PLCB3)
   04971 Gastric acid secretion
    101687768 (PLCB3)
   04972 Pancreatic secretion
    101687768 (PLCB3)
   04973 Carbohydrate digestion and absorption
    101687768 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101687768 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    101687768 (PLCB3)
   04725 Cholinergic synapse
    101687768 (PLCB3)
   04728 Dopaminergic synapse
    101687768 (PLCB3)
   04726 Serotonergic synapse
    101687768 (PLCB3)
   04720 Long-term potentiation
    101687768 (PLCB3)
   04730 Long-term depression
    101687768 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    101687768 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    101687768 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    101687768 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101687768 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101687768 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    101687768 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101687768 (PLCB3)
   05142 Chagas disease
    101687768 (PLCB3)
   05143 African trypanosomiasis
    101687768 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101687768 (PLCB3)
   05016 Huntington disease
    101687768 (PLCB3)
   05017 Spinocerebellar ataxia
    101687768 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    101687768 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101687768 (PLCB3)
   05415 Diabetic cardiomyopathy
    101687768 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101687768 (PLCB3)
   04934 Cushing syndrome
    101687768 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mpuf04131]
    101687768 (PLCB3)
Enzymes [BR:mpuf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101687768 (PLCB3)
Membrane trafficking [BR:mpuf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101687768 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101687768 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 101687768
NCBI-ProteinID: XP_004770227
Ensembl: ENSMPUG00000012959
LinkDB
Position
Unknown
AA seq 1236 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHQPSTGVPNS
SVRKRPLEQSNSALSESSAATTEPSSPQLGSPSSDSCPGLSNGEEVALEKPSLEPRKSLG
EDGLQRGTDALGSADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEP
VKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNY
MPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVI
VDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEE
PFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALL
IYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASPETCQETPSQQ
LGSQLTPNPTPSPLDTSPRQPPLRCGAGLCGRGVGRSRGARQPPPSPPVLCCSEVAPASL
DELRGHKVLVKLRGRQERELRELHKKHQRKAVALTRRLLSGLAQARTEGRCRPRPGVPGG
ENEEEEEEEAKQYQEFQKRQVQSLLELREAQADTEAERRLEHLRQAQLRLREIVLEAHTT
QIKRLKEVNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRR
LEEAQKQRHERLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGETPEG
LGDGHLVACASNGHAPGSSGHLSGADSESQEENTKL
NT seq 3711 nt   +upstreamnt  +downstreamnt
atggccggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtagag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtaaccctgcgtgtggactccaatggcttctttctgtattggaccggacccaacatggag
gtggacacactggacatcagttccatcagggacacgcggacgggtcgctacgcccgcctg
cccaaggaccccaagatccgggaggtgctgggctttgggggccctgatgcccggctggag
gagaagttgatgacggtggtagctgggccagacccggtgaatacgacgttcttgaacttc
atggccgtgcaggatgacacagccaaggtctggaccgaggagctgtttaagctggctatg
aacatcctggctcagaacgcctcccggaacacgttcctgcgaaaagcatacacaaagctg
aagctgcaggtgaaccaggacggacggattccggtgaagaatatcctgaagatgttttca
gcagataagaagcgggtagagactgcactggaatcctgtggcctcaatttcaaccggagt
gagtccatccggcccgacgagttttccttggagatcttcgagcggttcctgaataagttg
tgtctgcggccagacattgacaagatcctgctggagataggcgccaagggcaagccttac
ctgacgctggagcagctcatggacttcatcaaccaaaagcaacgggacccgaggctcaac
gaggtgctgtacccacccctgcggccgtcccaggcccggctgctcatcgagaagtatgag
cccaaccagcagttcctagagcgagaccagatgtccatggagggcttcagccgctacctg
ggcggtgaggagaacggcatcctgcccctggaggccctggatctcagtgcggacatgacc
cagccgctgagcgcctacttcatcaactcctcacacaacacctatctcacagcggggcag
ctggccgggacctcgtcggtggagatgtaccggcaggcgctgttgtggggctgccgctgc
gtggagctggacgtgtggaaaggccggccgcccgaggaggagcccttcatcacccatggc
ttcaccatgaccacggaggtgccgctgcgggacgtgctcgaggccatcgcggagactgcc
ttcaagacctcgccttaccctgtcatcctctcttttgagaaccacgtggactcggcaaag
caacaggccaagatggccgagtactgccggtccatctttggggacgcactgctcattgac
ccactggacaagtacccgctggccccaggcgtccccctgcccagcccgcaggacctgatg
ggccgcatcctggtgaagaacaagaagcgacaccagcccagcaccggtgtccccaacagc
tctgtgcgcaagcggcccctggaacagagcaactcggccctgagcgagagctcggccgcc
accactgagccctcctcccctcagctcgggtcccccagctctgacagctgcccaggcctg
agcaacggggaagaagtggccctggagaagcccagcctggagcctcgcaagtctctgggc
gaggacgggctacagcggggcactgatgctcttggatctgcagaccgtgaggatgaggag
gaggatgaggaagaagaggaacagacagatcctaaaaagccaaccacagatgagggcact
gccagcagtgaggtcaatgccaccgaggaaatgtccacactcgtcaactacatcgagcct
gtcaagttcaagtcctttgaggctgctcgaaaaaggaacaaatgcttcgagatgtcatcc
ttcgtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatac
aacaagcagcagctcagccgcatctaccccaagggcacccgcgtggactcatccaactat
atgccccagctcttctggaatgtcggctgccagcttgtcgcgctcaacttccaaaccctg
gacgtggcgatgcagctaaacgcaggcgtgttcgagtacaacgggcgcagcggctacctg
ctcaagcccgagttcatgcggcggccggacaagtccttcgatcccttcaccgaagtcatc
gtggacggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctgtca
gacaggaaggtgggcatctatgtggaagtggacatgttcggcctccccgtggatacgcgg
cgcaaataccgcactcggacttctcaggggaattccttcaatcccgtatgggacgaggag
ccctttgacttccccaaggtggtgctgcccacgctggcttccctgcgcatcgcggccttt
gaggagggcggcaagtttgtggggcatcgaatcctgcccgtctcggccatccgctcaggg
taccactacatctgtctgcggaacgaggccaaccagccgctctgcctgccggccctgctc
atttacactgaagcctctgactacattcctgacgaccaccaggactacgcggaggccctt
atcaaccccatcaagcatgtcagcctgatggaccagagggccaagcagctggctgccctc
attggggagagcgaggctcaggccagcccagagacctgccaagagactccgtctcagcag
ctggggtcccagctgaccccaaaccccacacccagcccactggacacttccccncgccag
cctcctctcaggtgcggggcaggcctgtgcgggaggggagtggggcgctcccggggggcc
cgccagcccccgcccagcccacccgtgctctgttgctcagaggtggccccggcctcgctg
gacgagctccgaggccacaaggtgctggtgaagctccggggccggcaggagcgagagctt
cgagagctgcacaagaagcaccagcgcaaggccgttgccctcacgcgccggctgctcagc
ggcctggcccaggcccggacggagggcaggtgccgcccacggccgggtgtcccaggtggg
gagaacgaggaggaggaggaggaagaggcgaagcagtatcaggaattccagaagagacag
gtgcagagtctcctggagctgagggaggcccaggccgatactgaggctgagcggcggctg
gagcacctgagacaggctcagctgcggctcagggagattgtcctggaggctcacacaact
cagatcaagaggctgaaggaggtgaacgagagggagaagaaggaactgcagaagattctg
gacaggaagcgtcataacagtatctcagaggccaagacaagggagaaacataagaaggag
gcggaactgacagagattaaccgccggcacatcaccgagtcggtcaactctatccgtcgg
ctggaggaggcccagaagcagcggcacgagcgccttgtggctgggcagcagcaggtccta
cagcagctggcagaggaggagcccaagctgctagcccagttggcccaggagtgccaggaa
cagcgggcaaggctgccccaggagatccgccggagcctgctgggcgagacgccggagggg
ctgggggacgggcatctggtggcctgtgccagtaacggtcacgcacctggaagcagtggg
cacctgtccggcgctgactcggagagccaagaggagaatacgaagctctga

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