KEGG   Mustela putorius furo (domestic ferret): 101687799
Entry
101687799         CDS       T07239                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mpuf  Mustela putorius furo (domestic ferret)
Pathway
mpuf01521  EGFR tyrosine kinase inhibitor resistance
mpuf01522  Endocrine resistance
mpuf04010  MAPK signaling pathway
mpuf04012  ErbB signaling pathway
mpuf04068  FoxO signaling pathway
mpuf04270  Vascular smooth muscle contraction
mpuf04650  Natural killer cell mediated cytotoxicity
mpuf04720  Long-term potentiation
mpuf04726  Serotonergic synapse
mpuf04730  Long-term depression
mpuf04810  Regulation of actin cytoskeleton
mpuf04910  Insulin signaling pathway
mpuf04914  Progesterone-mediated oocyte maturation
mpuf04928  Parathyroid hormone synthesis, secretion and action
mpuf05010  Alzheimer disease
mpuf05022  Pathways of neurodegeneration - multiple diseases
mpuf05034  Alcoholism
mpuf05160  Hepatitis C
mpuf05161  Hepatitis B
mpuf05200  Pathways in cancer
mpuf05205  Proteoglycans in cancer
mpuf05208  Chemical carcinogenesis - reactive oxygen species
mpuf05210  Colorectal cancer
mpuf05211  Renal cell carcinoma
mpuf05212  Pancreatic cancer
mpuf05213  Endometrial cancer
mpuf05214  Glioma
mpuf05215  Prostate cancer
mpuf05218  Melanoma
mpuf05219  Bladder cancer
mpuf05220  Chronic myeloid leukemia
mpuf05221  Acute myeloid leukemia
mpuf05223  Non-small cell lung cancer
mpuf05224  Breast cancer
mpuf05225  Hepatocellular carcinoma
mpuf05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mpuf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101687799 (ARAF)
   04012 ErbB signaling pathway
    101687799 (ARAF)
   04068 FoxO signaling pathway
    101687799 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101687799 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101687799 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101687799 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    101687799 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    101687799 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101687799 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    101687799 (ARAF)
   04720 Long-term potentiation
    101687799 (ARAF)
   04730 Long-term depression
    101687799 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101687799 (ARAF)
   05205 Proteoglycans in cancer
    101687799 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    101687799 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101687799 (ARAF)
   05212 Pancreatic cancer
    101687799 (ARAF)
   05225 Hepatocellular carcinoma
    101687799 (ARAF)
   05226 Gastric cancer
    101687799 (ARAF)
   05214 Glioma
    101687799 (ARAF)
   05221 Acute myeloid leukemia
    101687799 (ARAF)
   05220 Chronic myeloid leukemia
    101687799 (ARAF)
   05218 Melanoma
    101687799 (ARAF)
   05211 Renal cell carcinoma
    101687799 (ARAF)
   05219 Bladder cancer
    101687799 (ARAF)
   05215 Prostate cancer
    101687799 (ARAF)
   05213 Endometrial cancer
    101687799 (ARAF)
   05224 Breast cancer
    101687799 (ARAF)
   05223 Non-small cell lung cancer
    101687799 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101687799 (ARAF)
   05160 Hepatitis C
    101687799 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101687799 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    101687799 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    101687799 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101687799 (ARAF)
   01522 Endocrine resistance
    101687799 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mpuf01001]
    101687799 (ARAF)
Enzymes [BR:mpuf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101687799 (ARAF)
Protein kinases [BR:mpuf01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   101687799 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 101687799
NCBI-ProteinID: XP_012913024
Ensembl: ENSMPUG00000013346
UniProt: A0A8U0TEA7
LinkDB
Position
Unknown
AA seq 612 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEVPSNRPLNEPL
TPQGPSLYPPSSSCAPHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAATDSSLIQL
TTQSFGTDAAGSRGGGDGAPRGSPSPASVPSGRKSPHSKSPSEQRERKSLADDKKKVKNL
GYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNE
MQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTA
QGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMA
AEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKI
SSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADEL
PACLLSAARLVP
NT seq 1839 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtatatctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtctcaatcaggattgctgtgtg
gtctaccggctcatcgaggggcgaaagacagtcaccgcctgggacacggccattgccccc
ctggatggagaggaactcattgtagaggtcctcgaagatgttccactgaccatgcacaat
tttgtacggaagacattcttcagcctggcattctgtgacttctgccttaagtttctgttc
cacggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctctaaagtc
cccacagtctgtgttgacatgagcaccaactgccgacagttctaccacagtgtccaggat
ttgtccggaggctccaggcagcacgaagttccctcgaaccgtcccctgaatgagccgcta
acccctcagggtcccagcctttaccccccctccagctcctgcgccccgcaccgagacccc
gagcactttcccttccccgcgccggccaatgccccgctccagcgcatccgctccacatcc
actcctaatgtccacatggtcagcaccacagccgccacggactccagcctcatccagctc
actacccagagtttcggcactgatgctgccggtagtagaggtggtggtgatggagccccc
cgggggagccccagcccagccagcgtgccctcggggaggaagtccccccattccaagtcc
ccgtcggagcagcgggagcggaagtccttggccgatgacaagaagaaagtgaagaatctg
gggtaccgggactcgggctattactgggaggtaccgcccagcgaggtgcagctgctgaag
aggatcgggacaggctcgttcggcaccgtgtttcgcgggcggtggcatggcgatgtggcc
gtgaaggtgctcaaggtggcccaacccacagctgagcaggcccaggccttcaagaacgag
atgcaggtgctcaggaagacccgtcacgtcaacatcttgctgttcatgggcttcatgacc
cggccgggatttgccatcatcacgcagtggtgtgagggctccagcctctaccaccacctg
cacgtggccgacactcgcttcgacatggtccagctcatcgatgtggcccggcagactgcc
cagggcatggactacctccacgccaagaacatcattcatcgagatctcaagtctaacaac
atcttcctacatgaggggctcacagtgaagattggtgactttggcctggccacagtgaag
acacggtggagtggggcccagcccttggagcagccctcgggctccgtgctatggatggcg
gctgaggtgatccgtatgcaggacccgaacccctacagcttccagtcggatgtctacgcc
tatggggttgtgctctatgagctcatgaccggctcgctgccttacagccacattggcagc
cgtgaccagatcatctttatggtgggccgtggctatctgtccccggacctcagcaaaatc
tccagcaactgccccaaggccatgcggcgcctgctgtctgactgcctcaagttccagcgg
gaggaacgtcccctcttcccccagatcctggccacgattgagctgctgcagcggtcactc
cccaagatcgagcggagtgcctctgaaccctccttgcaccgcacccaggctgatgagttg
cctgcctgcctcctcagcgctgcccgtctcgtgccttag

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