Mycobacterium tuberculosis H37Ra: MRA_1424
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Entry
MRA_1424 CDS
T00540
Symbol
ribA2
Name
(GenBank) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
KO
K14652
3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:
4.1.99.12
3.5.4.25
]
Organism
mra
Mycobacterium tuberculosis H37Ra
Pathway
mra00740
Riboflavin metabolism
mra00790
Folate biosynthesis
mra01100
Metabolic pathways
mra01110
Biosynthesis of secondary metabolites
mra01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
mra00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00740 Riboflavin metabolism
MRA_1424 (ribA2)
00790 Folate biosynthesis
MRA_1424 (ribA2)
Enzymes [BR:
mra01000
]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.25 GTP cyclohydrolase II
MRA_1424 (ribA2)
4. Lyases
4.1 Carbon-carbon lyases
4.1.99 Other carbon-carbon lyases
4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase
MRA_1424 (ribA2)
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Gene cluster
GFIT
Motif
Pfam:
DHBP_synthase
GTP_cyclohydro2
fn3
Motif
Other DBs
NCBI-ProteinID:
ABQ73167
UniProt:
A5U2B7
Structure
PDB
PDBj
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All DBs
Position
1591707..1592984
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AA seq
425 aa
AA seq
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MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVP
LDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGIGTGISASDRATTMRLLADPTSVAD
DFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDE
LRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVA
LVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAREGRGVVLYMR
GHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLT
NNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDKLGHDLAGLDDFHESVHLPGE
FGGAL
NT seq
1278 nt
NT seq
+upstream
nt +downstream
nt
atgacgaggttggactccgtcgagcgggcggttgccgacattgcggcgggtaaggccgtc
atcgtcatcgacgacgaagaccgggagaacgagggtgacctgatcttcgccgccgagaag
gcaacgccggagatggtggccttcatggtccgctacacctccggatacctgtgcgttccg
ctggacggtgccatctgcgaccggctgggcctgttgcccatgtacgcggtgaaccaggac
aagcacgggacggcatacaccgtcacagtcgatgcacggaatggcattggaactggcatt
tcggcgtccgatcgggctaccaccatgcggttgctggccgatccgaccagtgtggccgac
gatttcacccgccccggtcacgtggtccccttgcgggccaaggatggtggggttctgcgc
cggcccggccacaccgaggccgccgtggacctggcccggatggccgggctgcaacccgcg
ggggcgatttgcgagatcgtcagccaaaaagatgagggctcgatggcgcacaccgatgaa
ttgcgggtgttcgccgatgagcacggtctggcgctgatcaccattgctgacttgatcgaa
tggcggcgcaagcacgagaagcacattgagcgggtcgccgaggcgcggattccgactcgt
catggggagtttcgcgccatcggctacaccagcatctacgaggacgtggaacatgtcgcg
ctggtccgcggcgagatcgccgggcccaacgccgacggtgacgacgtgctggtccgggtg
cattcggagtgcttgaccggcgatgtgtttgggtcacgccgctgcgattgcgggcctcag
ctggacgccgcgctggcgatggtcgcccgtgaggggcgcggcgtggtgctgtacatgcgt
ggccacgagggccgcggcatcggcctgatgcacaaactgcaggcctaccaactgcaggac
gccggtgccgacaccgttgacgccaatctcaagcttggactacctgccgacgcaagggat
tacgggatcggcgcacagatcctggtcgatcttggggtacgttcgatgaggctgctgacc
aacaacccggccaagcgggtgggactggatggatacggattgcacatcatcgagcgcgtg
ccgctgccggtgcgggccaacgcggagaacatccgttacctgatgaccaagcgtgacaaa
ttggggcacgacttggctgggttggacgattttcacgaatccgtgcatctgcccggagaa
ttcggcggtgccttgtga
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