KEGG   Mycobacterium tuberculosis H37Ra: MRA_2870
Entry
MRA_2870          CDS       T00540                                 
Symbol
cysG
Name
(GenBank) uroporphyrinogen III methyltransferase
  KO
K02302  uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]
Organism
mra  Mycobacterium tuberculosis H37Ra
Pathway
mra00860  Porphyrin metabolism
mra01100  Metabolic pathways
mra01110  Biosynthesis of secondary metabolites
mra01120  Microbial metabolism in diverse environments
mra01240  Biosynthesis of cofactors
Module
mra_M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
Brite
KEGG Orthology (KO) [BR:mra00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    MRA_2870 (cysG)
Enzymes [BR:mra01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.76  precorrin-2 dehydrogenase
     MRA_2870 (cysG)
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.107  uroporphyrinogen-III C-methyltransferase
     MRA_2870 (cysG)
 4. Lyases
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.4  sirohydrochlorin ferrochelatase
     MRA_2870 (cysG)
SSDB
Motif
Pfam: TP_methylase NAD_binding_7 2-Hacid_dh_C
Other DBs
NCBI-ProteinID: ABQ74649
UniProt: A5U6J9
LinkDB
Position
complement(3166646..3167863)
AA seq 405 aa
MTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS
VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG
LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR
RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV
VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV
SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT
AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS
NT seq 1218 nt   +upstreamnt  +downstreamnt
gtgaccgagaacccctatctggtcgggttacggctggctggcaagaaggtcgtcgtggtt
ggcgggggcacggtcgcccagcgccggttacccctgctgatcgccagtggcgcggacgtg
cacgtgatcgcccccagcgtcacccccgccgtcgaggcgatggaccagatcaccttgtcg
gtgcgtgactaccgcgacggcgaccttgacggcgcctggtatgcgatcgcggccaccgat
gacgcgcgggtgaacgtggctgtcgtcgccgaggcggagcgccgacggatcttttgcgtc
cgggccgatatcgcggtggaggggacggcggtgaccccggcgtcattcagctatgcgggc
ctgtcggtgggggtgctcgccggtggtgagcaccgccgttcggcggcgatccgctcggca
atccgggaggcgttgcagcagggcgtcatcactgcgcagagttccgacgtcctcagcggc
ggagtggcgttggtcggcggcggtcccggcgatcccgaactgatcacggttcgcggtcgc
cggctgcttgcccaggccgatgtcgtggtcgccgaccggctcgccccgcccgaactgctg
gccgagctgccgccgcacgtagaagtcatcgacgcggccaagatcccttacggccgggcc
atggcccaggacgcgatcaacgctgtcctgatcgaacgggccagatccggcaactttgtg
gtccgtctcaaagggggcgaccccttcgtgttcgcccggggctatgaagaagtgctggca
tgtgcccacgccggaatcccggtcaccgtggtgccaggtgtgacgagtgccatagccgtg
cccgctatggcgggcgttccagtcactcaccgggccatgacccacgaattcgtggtggtc
agtggccatcttgcgcccggtcatcccgaatcgttagtgaattgggatgcattggctgca
ttgacgggcaccatcgttttgctgatggcggtcgaacgcatcgagcttttcgttgacgtt
ctgctaaagggtggccgaactgcggatacgccggtactggtggttcaacacggaacgacc
gccgctcaacagacgttgcgggccacccttgccgacacgccggagaaggtccgcgcggcg
gggatccgacctcccgcgatcatcgtgatcggggctgtagtcggcctgagcggcgttcgg
ggtttaaacaattcttaa

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