KEGG   Muntiacus reevesi (Reeves' muntjac): 136148934
Entry
136148934         CDS       T10466                                 
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
mree  Muntiacus reevesi (Reeves' muntjac)
Pathway
mree01521  EGFR tyrosine kinase inhibitor resistance
mree01522  Endocrine resistance
mree01524  Platinum drug resistance
mree04010  MAPK signaling pathway
mree04012  ErbB signaling pathway
mree04020  Calcium signaling pathway
mree04066  HIF-1 signaling pathway
mree04151  PI3K-Akt signaling pathway
mree04510  Focal adhesion
mree04520  Adherens junction
mree04530  Tight junction
mree05200  Pathways in cancer
mree05205  Proteoglycans in cancer
mree05206  MicroRNAs in cancer
mree05212  Pancreatic cancer
mree05213  Endometrial cancer
mree05215  Prostate cancer
mree05219  Bladder cancer
mree05223  Non-small cell lung cancer
mree05224  Breast cancer
mree05226  Gastric cancer
mree05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:mree00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    136148934 (ERBB2)
   04012 ErbB signaling pathway
    136148934 (ERBB2)
   04066 HIF-1 signaling pathway
    136148934 (ERBB2)
   04020 Calcium signaling pathway
    136148934 (ERBB2)
   04151 PI3K-Akt signaling pathway
    136148934 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    136148934 (ERBB2)
   04520 Adherens junction
    136148934 (ERBB2)
   04530 Tight junction
    136148934 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    136148934 (ERBB2)
   05206 MicroRNAs in cancer
    136148934 (ERBB2)
   05205 Proteoglycans in cancer
    136148934 (ERBB2)
   05230 Central carbon metabolism in cancer
    136148934 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    136148934 (ERBB2)
   05226 Gastric cancer
    136148934 (ERBB2)
   05219 Bladder cancer
    136148934 (ERBB2)
   05215 Prostate cancer
    136148934 (ERBB2)
   05213 Endometrial cancer
    136148934 (ERBB2)
   05224 Breast cancer
    136148934 (ERBB2)
   05223 Non-small cell lung cancer
    136148934 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    136148934 (ERBB2)
   01524 Platinum drug resistance
    136148934 (ERBB2)
   01522 Endocrine resistance
    136148934 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mree01001]
    136148934 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mree04147]
    136148934 (ERBB2)
   04090 CD molecules [BR:mree04090]
    136148934 (ERBB2)
Enzymes [BR:mree01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     136148934 (ERBB2)
Protein kinases [BR:mree01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   136148934 (ERBB2)
Exosome [BR:mree04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   136148934 (ERBB2)
CD molecules [BR:mree04090]
 Proteins
  136148934 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 ABC1 Haspin_kinase Kinase-like APH CcmD Bestrophin-like
Other DBs
NCBI-GeneID: 136148934
NCBI-ProteinID: XP_065764701
LinkDB
Position
18:complement(22337379..22361806)
AA seq 1255 aa
MELAAWCRWGLLLALLPPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPAHASLSFLQEIQEVQGYVLIAHNRVSQVPLQRLRIVRGTQLFEEHYALAVLDNG
DFLESAAPAAGMAPGGLQELQLRSLTEILKGGVLIQRNPQLCHQDTILWEDIFHKNNQLP
LKQIDTNRSRACAPCSPACKAPKCWGESPEDCQSLTRTVCASGCARCKGPQPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLNNQEVTAEDGTQRCEKCSKPCAPVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFAGDPDSNIPPLQAEQLQVFESLEEITGYLYISAWPDSLP
DLSVFQNLRVIRGRVLHDGAYSLTLQGLGISWLGLRSLRELGSGLALIHRNARLCFVHTV
PWDQLFQNPHQALLHSANRPEDECVGEGLACYPLCAQGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVKDRYCLPCHPECHPQNGSVTCFGSEADQCVACAHYKDPPFCVARC
PSGVKPDLSFMPIWKFPDEEGICQPCPINCTHSCVDLDDRGCPAEQRASPVTSIIAAVVG
VLLAVLVGLVFGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVAEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA
EEYLVPQQGFFCPDPAPGAGGTAHRRHRSTSTRSGGGELTLGLEPSEEEPPRSPLAPSEG
AGSDVFDGDLGMGSAKGLQTLPQHDSSPLQRYSEDPTVPLSPEADGYVAPLTCSPQPEYV
NQPEVRPQPPSPLEGPLPPPRPAGSTLERPKTLSPGKNGVVKDVFAFGAAVENPEYLAPR
GRAAPQSHPSPAFSPAFDNLYYWDQDPSDRSTPPSTFEGTPTAENPEYLGLDMPV
NT seq 3768 nt   +upstreamnt  +downstreamnt
atggagctggcggcctggtgccgctgggggctcctcctcgccctcctgccccccggagcc
gcgggcacccaagtgtgcaccggcacagacatgaagctgcggctgccggccagccccgag
acccacctggacatgctccgccacctctaccaaggctgtcaggtggtgcagggtaacctg
gagctcacctatctgcctgctcatgccagcctctccttcctgcaggagatccaggaagtg
cagggctatgtgctcattgctcacaatcgagtgagtcaggtcccactgcagagactgcga
atcgtgcgaggcacccagctctttgaggaacactacgccctggccgtcctggacaatgga
gactttctggaaagtgctgcccctgctgcaggcatggccccaggagggctgcaggagctg
cagctgcgaagcctcacagagatcctcaagggaggggtcctgatccagcggaacccccag
ctctgccaccaggacacgattttgtgggaggacatcttccacaagaacaaccagctgccc
ctcaagcagatagacaccaaccgctcacgggcctgcgcaccctgttctccagcttgtaaa
gctcccaaatgctggggagaaagtcctgaggactgtcagagcttgacgcggaccgtctgt
gccagcggctgtgcccgctgtaagggcccgcagcccacggactgctgccatgagcagtgt
gctgctggctgtactggccccaagcactccgactgcctggcctgcctccacttcaaccat
agcggcatctgcgagctgcactgcccagctctggtcacctacaacacggacaccttcgag
tccatgcccaaccccgaggggcgctatacctttggtgccagctgtgtgaccgcctgtcct
tacaactacctgtctacggacgtgggatcctgcaccctggtgtgtcccctgaacaaccaa
gaggtcacagctgaggacggaacccagaggtgtgagaaatgcagcaagccctgtgcccca
gtgtgctatggtctgggcatggaacacctgcgggaggtgagggcggtcaccagtgccaac
atccaggagtttgccggctgcaagaagatttttgggagcctggcatttctgccagagagc
tttgcaggggacccagactctaacatccccccactgcaggctgagcagctccaagtattt
gagtctctggaggagatcacaggctacctgtacatctcagcgtggccagacagcttgcct
gacctcagcgtcttccagaacctgcgagtaatccggggaagagttctgcatgatggtgcc
tactcgctgaccctccaaggactgggcatcagctggctggggctgcgctctctgcgggaa
ctgggcagcgggctggccctcatccaccgcaatgcccgcctctgcttcgtacacacggtg
ccctgggaccagctcttccagaatccccaccaggctttgctccacagtgccaacaggcca
gaggatgagtgcgtgggcgagggcctggcctgctacccactgtgcgcccaagggcactgc
tggggtcccgggcccacccagtgcgtcaactgcagccagttccttcggggccaggaatgc
gtggaggaatgccgagtactgcaggggctcccccgggagtatgtgaaggacaggtactgt
ctgccctgccaccccgagtgtcatccccagaacggctcagtgacctgctttggctcggag
gctgaccaatgtgtggcatgtgcccactacaaggatcctcccttctgcgtggctcgctgc
cccagcggtgtgaagcctgacctctccttcatgcccatctggaagtttccagatgaggag
ggcatatgccagccgtgccccatcaactgcacccactcctgtgtggacttggatgacagg
ggctgccccgccgagcagagagccagccctgtgacatccatcattgccgctgtggtgggc
gttctgctggctgtccttgtggggctggtgttcggcatcctcatcaagcgaaggcggcag
aagattcggaagtacacgatgcggcgcctgctgcaggagactgagctggtggagcccctg
acgcccagcggagcgatgcccaatcaggctcagatgcggatcttaaaagagacagagttg
agaaaagtgaaggtgctaggatctggagcttttggcaccgtctacaagggcatctggatc
cccgatggggaaaatgtgaaaatccccgtggccatcaaggtgttgagggaaaacacatct
cccaaagccaacaaggaaatcttggatgaagcatatgtgatggctggtgtaggctcccca
tatgtgtcccgcctcctgggcatctgcctgacttccacagtgcagctggtgacacagctt
atgccctatggctgcctcctagaccacgttcgagaacaccgtgggcgcctgggctcccag
gacctgctcaactggtgtgtgcagattgccaaggggatgagctacttggaggatgtgcgg
cttgtgcacagggacctggctgcccggaatgtactggtcaagagtcccaaccacgtgaag
attacagactttgggctggctcggctgcttgacattgacgagacggagtaccacgcggat
gggggcaaggtgcccatcaagtggatggcattggagtccatcctccgccggcggttcacc
caccagagtgacgtgtggagctatggtgtgactgtgtgggagctgatgacttttggagcc
aagccttatgatgggatcccagcccgggagattcctgacctgctggagaagggagaacgg
ctgccccagccccccatctgcaccattgatgtctacatgatcatggtcaaatgttggatg
attgactctgaatgtcggccgaggttccgggagttagtggccgaattctcccgcatggcc
agggacccccagcgctttgtggtcatccagaatgaagacttgggccctgctagccccctg
gatagcaccttctaccgctcgctgctggaggatgatgacatgggcgacctggtggatgcg
gaggagtacctggtaccccagcagggcttcttctgcccagaccctgccccgggtgctgga
ggcacggcccatcgcaggcaccgcagcacatccaccaggagtggcggtggtgagctgaca
ctggggctggagccctccgaggaggagccccccagatctccgctggcaccttccgaaggg
gcaggctctgatgtgtttgatggcgacttgggaatgggatcggccaaggggctgcagacc
ctcccccaacatgactctagccctctacagcggtacagtgaggaccccacagtacccctt
tctcccgaggctgatggctacgttgcccccttgacctgcagcccccagcccgaatatgtg
aaccagccagaggttcgcccacagcccccgtcacccctagagggtcctctgccgcctcct
cgacctgccggctccactctggaaaggcccaagactctctcccctgggaagaatggggtt
gtcaaagacgtttttgcctttggggctgctgtggagaaccctgagtacttggcaccccgg
ggcagggctgcccctcagtcccacccttctccagccttcagcccagcctttgacaacctc
tattattgggaccaggacccatcagaccggagcactccacccagcacctttgaagggacc
cctacggcagagaaccctgagtacctgggtctggacatgccagtatga

DBGET integrated database retrieval system