Muntiacus reevesi (Reeves' muntjac): 136159722 Help Entry 136159722         CDS       T10466                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism mree  Muntiacus reevesi (Reeves' muntjac) Pathway mree04020   Calcium signaling pathway mree04024   cAMP signaling pathway mree04260   Cardiac muscle contraction mree04261   Adrenergic signaling in cardiomyocytes mree04371   Apelin signaling pathway mree04713   Circadian entrainment mree04911   Insulin secretion mree04921   Oxytocin signaling pathway mree04972   Pancreatic secretion mree05020   Prion disease mree05022   Pathways of neurodegeneration - multiple diseases mree05410   Hypertrophic cardiomyopathy mree05412   Arrhythmogenic right ventricular cardiomyopathy mree05414   Dilated cardiomyopathy mree05415   Diabetic cardiomyopathy Brite Ion channels [BR:mree04040]  Voltage-gated cation channels   Ryanodine receptor    136159722 (RYR2) Domain-containing proteins not elsewhere classified [BR:mree04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    136159722 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  136159722 NCBI-ProteinID:  XP_065778312 LinkDB All DBs Position 2:complement(83633462..84447292) Genome browser AA seq 4978 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGKVDVEKWKFMMKTAQGGGHRTLLYGHAVL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHISTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERSYTRDLLGPTVSLTQAAFTPIPVDTTQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARADMCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTAAG GIPGTGLFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRGDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGR NNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CVEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFP DESKKHGLPGIGLSTSLRPRMQFSSPSFVSINTEGYQYSPEFPLDILKAKTIQMLTEAVR EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHVLQLIEPSVFKEAASPEEE TEVVEKEPCVEDSKLEGAPDEENKGAKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDRSLDGNNDLTIRGRLLSLVEKVTYLK KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPTTGSSKTPDTDEEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHAHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI YSIYNTKSSRERSALNLPTNVEDVCPNIPSLEKLMEEIVDLAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPGRAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNQEAEDLFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLIMDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTED TSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYNLGSTVEHPQRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEG AKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVT GSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGG NSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKV LQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFY WYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLH VFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNN VEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSC AETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYF QPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELF VNFCEDTIFEMQLAAQISESDLNERSVNKEESEKEKPEEQGPRMGFFSIVTVKSALFALR YNILILMRMLSLKSLKKQMKKVKKMTVKDMITAFFTSYWGILMSLLHFVASVFRGFSRII GSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKTLEGALPSEDLTDLKEL TEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKFQEQKAKEEEK EEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQ KLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSGSARVSSLDS SSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARK LEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISEL LGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMS ILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFF RKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDIT FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHT LQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14937 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggatgagatccagttcctgcgaactgatgatgaagtg gttctacagtgtaccgcaaccatccacaaagaacaacagaaactatgtttggcagcagaa ggatttggcaacagactttgcttcttggagtccacttcgaattccaagaatgtccctcca gacctctccatctgcaccttcgtgctggagcagtccctgtctgtccgggccttgcaggag atgctggctaacactgtggaaaagtctgaagggaaggttgatgtggaaaaatggaaattc atgatgaagactgctcagggtggcggccaccgaacgctcctctatggccatgcagtactg ctgcggcactcctacagcggcatgtatctgtgctgcctgtccacctctcggtcttcaact gataagctggcttttgatgttggcttgcaagaggatacaacaggtgaagcttgttggtgg accatccatcctgcctctaagcagcgctcagaaggggaaaaggtgcgggttggagatgac ctcatcttagtgagcgtgtcctctgaaaggtacctgcacttgtcttacggtaacggcagc ttgcacgtggatgctgctttccagcagaccctctggagcgtggcccccatcagctcagga agtgaagcagcccaagggtatctgattggtggtgacgtcctcaggttgcttcatggacac atggatgaatgcctcacggtcccttcaggagaacacggtgaagagcagcggagaactgtt cattacgaaggtggtgctgtatcggttcacgcacgttccctgtggcgactagagacacta agagttgcgtggagtggaagccacataagatggggacaaccttttcgactacgccatgtc acaacaggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaaagag aaagctgatgtcaaatcaactgcatttaccttccgatcttccaaggaaaaattggatgta ggagtgagaaaagaagtcgatggcatgggaacctctgaaattaaatatggagactcagtg tgttatatacagcacatcagtacaggcttgtggctgacttaccagtctgtggatgtgaaa tcagtgagaatgggatccatacaacgcaaggctattatgcatcatgaaggacacatggat gatggcctaaatttatccagatctcagcatgaagaatcacgaacagcacgtgtcatccgg agcacagtctttctttttaatagatttattaggggccttgatgctctcagcaaaaaggtg aaggcttccacagtagacttacctatagagtctgtaagtctgagtctgcaggaccttatt ggctacttccacccaccagatgagcatttagagcatgaagataagcagaacagattacga gctctgaagaacaggcagaatctcttccaggaagagggaatgatcaacctcgtactcgag tgtatagacagactgcatgtgtatagcagtgctgctcacttcgctgatgttgctgggaga gaagcaggggaatcttggaaatcgattctgaattctttgtatgagttgttggcggcacta attagaggaaatcgtaaaaactgtgctcaattttctggatcccttgactggttaatcagc cgactggaaagactggaagcttcttctggtattcttgaagttttacactgcgtgctagta gaaagtccagaagctctcaatattattaaagaaggccatataaaatccattatctcactt ttagacaagcatggaagaaatcacaaggttctggatgtcttatgctcgctctgtgtttgc catggagtagcagtccgttctaaccagcatctcatctgtgacaatcttctgccaggaaga gacctgttgttgcagacacgccttgtgaaccatgtgagcagcatgagacccaatattttt ctgggtgtcagtgaaggctctgcacagtataagaagtggtactatgagttgatggtggac cacacggagcctttcgtgactgctgaagccactcacctgcgcgtgggctgggcttccaca gagggctactcaccctaccccggcgggggcgaggaatggggtggaaacggcgtcggagac gacctcttctcctacggattcgatggccttcacctctggtcaggttgtattgcccggact gtcagctcaccaaaccagcatctcttgagaactgatgatgtcatcagttgctgtttagat ctaagtgccccgagcatctccttccgaattaatggacaacctgttcaaggcatgtttgag aatttcaacattgatggcctcttctttccagttgtcagtttctctgcaggaatcaaagta cgctttctgcttggggggagacatggagaatttaaattccttcctccgcctgggtatgct ccttgttacgaagctgttctgccaaaagaaaagttgaaggtggagcacagccgggagtac aagcaggaaaggagttacacgcgggacctcctgggccccacggtttccctgacacaagct gccttcacgccgatcccagtggacaccacccagattgtgttgcctccccacctggagagg atacgagaaaaactggcagagaatatccatgagctctgggtgatgaataaaattgaactt ggctggcagtatggtccggttagagacgacaataagagacagcacccatgtctggtggag ttctccaagctgcctgaacaggaacgcaattacaatttacagatgtcgcttgagaccctg aagacgttgttggctttaggatgtcatgtgggtatatcagatgaacatgctgaagaaaag gtgaaaaaaatgaagctgccaaagaattaccaactgacaagtggatacaaacctgcccca atggacctgagctttatcaaactcaccccatctcaagaggctatggtggacaagctggcg gaaaatgctcataacgtgtgggctcgggatcggattcgacagggctggacctacggcatc caacaggatgtaaagaacagaagaaaccctcggcttgttccctatgcccttctagatgac agaactaagaaatccaataaggatagcctccgtgaggctgtacgcacactcctgggatat ggctacaacctggaggcaccggatcaagatcatgctgccagagcagacatgtgcagcggc acgggagagaggttccggatcttccgtgctgagaagacgtacgctgtgaaggctggaagg tggtattttgaattcgaggcggtcactgctggagacatgcgagttggctggagcaggcca ggctgtcaacctgatcaggagcttggctcagatgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggcaatgagcactatgggcgctcttggcaagctggcgat gttgtggggtgtatggttgacatgacagagcacaccatgatgttcacactgaatggtgaa atcctccttgatgattcaggttcagaactggctttcaaggactttgatgttggtgatgga ttcatacctgtgtgtagccttggagtggctcaagtgggcaggatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgagccatttgcc gttaacacaaatagggatattaccatgtggctgagcaagaggcttcctcaatttctccaa gttccatcaaaccatgaacatattgaggtaaccagaatagatggcaccatcgacagttcc ccatgtttaaaggtcactcagaagtcctttggttctcagaacagcagcacggatatcatg ttttatcgtctgagcatgcccatagagtgtgcagaggtcttctccaagactgcagctgga gggatccctggcaccggcctctttgggcccaagaatgatctggaggattatgatgtggat tcggactttgaggttctcatgaagacagctcacggccatctggtgccagatcgaggagac aaagacaaagaggctacaaaaccagagtttaataaccacaaagattatgctcaggaaaaa ccctctcgtctgaaacagaggtttttgcttcgaagaacaaagccagattatagcaccagc cattctgcaagactcactgaagatgtccttgcagatgagagggatgactacgattacttg atgcaaacgtccacgtactattactcagtgagaatctttcctggacaagaacctgccaat gtctgggtgggctggatcacatctgatttccatcagtacgatacaggctttgacttggac agagttcgtacagtgaccgtgactctgggagatgaaaaaggaaaggtgcacgaaagcatc aaacgcagcaattgctatatggtgtgtgcgggtgagagcctgagcccagggcaaggacgc aacaacaacggcctggagattggctgcgtggtggatgccgccagtgggctgctcaccttc acggccaacggcaaggaactgagcacctattatcaggtggagccaagcacaaagttattc cctgcagtttttgcgcaagctacaagtcccaatgtttttcagtttgagttgggaagaata aagaatgtgatgcctctctcagcgggattattcaagagtgagcacaaaaatcctgtgcca cagtgtcccccacgtctccatgtgcaatttctctcacatgtcctgtggagcagaatgccc aaccagttcttgaaggtagatgtctctcgaataagtgaacgccagggctggctggtgcag tgcgtggagcctctgcagttcatgtcacttcatatcccagaggagaacagatctgtggac attctggaactgacggagcaggaggagctgctgaagttccactaccacactctccggctc tactcggctgtctgcgcgctcgggaaccaccgcgtggcccacgccctgtgcagccacgtg gacgagccgcagctgctctacgccatcgagaacaagtacatgcccggcttgctgcgcgcc ggctactacgacctgctcattgacatccacctcagttcctacgccaccgccaggctcatg atgaacaacgagttcatcgtccccatgaccgaggagacgaagagcatcaccctcttcccg gatgagagcaaaaagcacgggctcccgggcatcggcctcagcacctccctccggccgcgg atgcagttttcctccccgagctttgtcagcattaataccgagggttaccagtacagcccg gagttcccgctggacatcctgaaggccaagaccattcagatgctgacggaagccgtgaga gagggcagccttcatgcgcgagaccccgttgggggcaccactgagttcctcttcgtccct ctcatcaagctgttctataccctgctcatcatgggtgtcttccacaacgaggacttgaag cacgtcctgcagttgattgagcctagtgtgttcaaagaagccgccagccccgaggaggag accgaggtggtggagaaggagccctgcgtggaagactccaagctggaaggagccccagac gaagaaaacaaaggcgctaagaggcccaaggagggcctgctccaaatgaaactaccagag ccagtaaaattacagatgtgcctgctacttcaatacctctgtgactgccaggtccggcac cgaatagaagccattgtggccttttcagatgactttgtagccaagctccaagacaatcaa cgattccgctataacgaagttatgcaagccttaaacatgtcggctgcactcacagccagg aaaacaaaggaattcagatccccgcctcaagaacagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgagaccaactcttggattttcac gaagatttgatgacacattgtggaattgagctggatgaagataggtctctggatggaaac aatgatttaactattagaggacgcctgctgtccttggtagaaaaggtgacatacctaaag aagaagcaagctgaaaagccagttgagagtgactccaagaagtcatccactcttcagcag ttgatttctgagaccatggtccgatgggctcaagagtctgttattgaagaccctgagttg gtgagggccatgtttgtattgctccatcgacagtatgatggcattgggggtctggtacgg gctctgccaaagacctatactataaatggtgtttctgtggaggataccatcaatctgcta gcatctcttggtcagattcgttctctgctaagtgtgagaatgggcaaagaagaagagaaa cttatgattcgtggattaggggatatcatgaacaataaagtgttttaccagcatcctaat ctcatgagggcacttgggatgcatgagacagtaatggaggtcatggtcaatgtccttgga ggtggagagtccaaggaaatcacttttccaaagatggtggccaactgttgccgtttcctc tgttacttctgtcgtataagtaggcagaatcagaaagccatgtttgatcatctcagttat ttactggaaaacagcagtgttggtcttgcctcaccagctatgagagggtcaacaccattg gatgtggcagcagcctcggtgatggataataatgaactagctttagctttgcgggagcca gatctggaaaaggtggttcgatatttggctggttgtggactgcagagttgccagatgctg gtgtcaaagggttatccagacattgggtggaatccagttgaaggagagagatatcttgac tttctcagatttgctgtcttctgtaatggggagagcgtggaggagaatgcaaatgttgtg gtgagattgctcattcggaggcctgagtgtttcggtcctgccttgaggggggaaggtggg aacggcctgctcgcagccatggaagaagccataaaaatagccgaggatccctctcgagat ggtccctcaccaactaccggatccagcaaaacacctgatacagacgaggaagaggatgac accatccacatgggaaatgccatcatgaccttctatgcagctttgattgacctgttagga cgctgtgctcctgagatgcatttgattcatgctgccaagggagaagccatcagaatcagg tctattttgagatctctgattccactgggagatttggtgggagtgatcagcatcgctttt cagatgcccacaatagccaaagatgggaatgtggtggagcctgacatgtctgcagggttt tgtccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggtt caggatttcctcctccatcttcttgaggttggctttctgccagatctccgcgctgctgct tccttagacacggctgctctgagtgccacagacatggccctggccctcaatcggtacctg tgcacagccgtgctgcccttgttaacaaggtgcgcccctctttttgcgggcaccgagcac cacgcttctctcattgattcgttacttcacactgtgtaccggctttctaagggctgctcg ctcaccaaagctcagcgggattccatagaagtgtgcttactctctatctgtggccaattg agaccttctatgatgcaacacttactcagacgattagtatttgatgtcccattattaaat gaacatgcaaagatgcctcttaagctgctgacaaatcattatgaaagatgctggaaatat tactgcctgcctggagggtggggaaacttcggagctgcctcagaagaagaacttcattta tcaagaaagctgttctggggcatctttgatgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaatccacaacctgttgatacctcaaatattacaattcctgagaagttggaatacttc attaacaaatatgcagaacatgcccatgacaagtggtcaatggataagttggcaaatgga tggatttatggagaaatatattcagactcatctaaagttcaaccattaatgaagccatat aaactgttatctgaaaaggaaaaagaaatttatcgctggccaattaaagaatctttaaaa actatgctggcttggggatggagaattgaaaggacacgggagggagacagcatggccctt tataaccgtacccgtcgtatttctcagacaagtcaggtttctgtagatgccgcccatggg tatagcccacgagccattgacatgagcaatgttacactatccagagatctgcatgctatg gcagaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaactggaactg gaggccaaaggaggtggaaaccatcccctgctggtaccttatgatacactgacagccaaa gagaaagccaaggatagggaaaaagcacaggacatcctcaagttcctgcagatcaacggc tatgctgtgtccagagggttcaaagacctggaactggacacaccttctattgagaaacga tttgcctatagtttccttcagcaactcattcgctatgtggatgaagcccatcagtatatc ctggagtttgatggtggcagcagaagcaaaggagaacatttcccttatgagcaagaaatc aagttctttgctaaagtcgttcttcctttaattgatcagtatttcaaaaaccaccgttta tacttcttatctgcagcaagcagacctctctgttctggaggacatgcatcaaacaaagag aaagaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttgggaatgatgcaacatcaattgtcaactgtcttcatattttgggtcagactttg gatgcaaggactgtgatgaagactggcctggagagtgttaaaagtgcactcagagctttc ctggacaatgccgcagaggatctggagaagacaatggaaaatcttaagcagggccagttc acccacacccgaaaccagcccaaaggtgttactcagattatcaattataccacggtggca ctgttgccaatgctgtcatcattatttgagcatattggccagcatcaattcggagaagat ctaatattggaagatgtacaggtgtcatgttatagaattctgactagcttgtatgctttg ggaaccagcaagagtatttatgtggaaaggcaacgttcggcattgggagaatgtctggct gcttttgctggtgcctttcctgtagcatttttagaaactcacctggacaagcacaatatt tactccatctacaacacgaagtcttcgagagagagatcagctcttaatttgcctactaac gtggaagatgtttgtccaaatataccatctttggagaagctcatggaagaaattgtggac ttggctgagtccggtattcgctacactcagatgccacacgtaatggaagttattctgccc atgctttgtagctacatgtctcgttggtgggagcacggacctgagaataatccgggcagg gctgagatgtgctgtacggctctgaactcagagcacatgaacacacttctgggcaatatc ctgaaaatcatatataacaacttgggtattgatgagggagcctggatgaagaggttagca gtgttttcccagcctattataaataaagtgaaacctcagctcttgaaaactcatttcttg ccattaatggagaagctcaagaaaaaggcagcgatggtggtatcagaagaggaccatctg aaatctgaggccaggggagatatgtctgaagctgaacttctcatcctagatgagttcacc acactggccagagatctctatgccttctatccactcctgattagatttgtggactataac agggcaaagtggctgaaagagcctaaccaagaagcagaagatcttttccgcatggttgct gaggtgtttatctactggtcaaaatcccataatttcaaaagggaggagcagaacttcgtg gtgcagaatgaaatcaacaatatgtctttccttattatggacaccaagtcaaagatgtcc aaggcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggggaccgatattcc atgcagacctctcttattgtggccgctctgaagcggttactgcccattgggttgaacatc tgtgcccctggggaccaggagctcattgctctggccaaaaatcgctttagtctgaaagac actgaggatgaagttcgagatataatccgcagtaatattcacttacaaggcaagttggag gatcctgctattagatggcaaatggctctttacaaagatttacccaacaggaccgaagac acttcagaccctgagaagacagtggaaagggtcttggatatagcaaacgtgctttttcat cttgaacagaaatctacatgtatgcgccggagatattacaatctgggaagtacagttgag catcctcagagatccaaaaaggccgtgtggcacaaactgctctctaagcagaggaaacgt gctgtggttgcttgcttccgaatggctcctttatataatctgccgaggcatcgggctgtc aatctctttcttcagggatatgaaaagtcttggattgagacagaagaacattactttgaa gataaattgatagaagatttagcgaaacctggagcagaacctccagaagaagatgaagga gctaagagggttgatcctcttcatcagctgatccttctgtttagtcgaacagctttaacg gagaaatgcaaactggaggaagattttttatatatggcttatgcagatattatggcaaag agttgtcatgatgaggaagatgacgatggggaagaggaagtgaagagttttgaagtcaca ggatcccaacgcagcaaggaaaaagaaatggaaaagcaaaagcttctataccagcaagcc aggctccacgaccgcggtgctgctgagatggtgctgcagaccatcagtgccagcaaaggt gaaactggacccatggtggctgctactttgaaacttggaattgctatcttaaatggaggg aactcgacagtgcagcagaaaatgcttgactacctcaaggagaaaaaggatgtgggcttc tttcagagcctggctggcctgatgcagtcctgcagtgtcctcgacctaaatgcatttgag cgacaaaacaaagctgaaggacttgggatggtgactgaggaaggatcaggagaaaaggtt ctgcaggatgacgaattcacctgtgacctcttccgcttcttgcaactgctttgtgaggga cacaactcagattttcaaaattatctgagaactcagactggcaataatacaactgtcaat ataatcatctctactgtagactaccttctgagagttcaggaatcaattagtgatttctat tggtattactctgggaaagatgtcattgatgaacaaggacaaaggaatttctccaaagct attcaagtagcaaaacaagtctttaacactcttacagagtatattcagggtccttgcact ggcaaccagcagagtttggctcacagcaggctctgggacgctgtggtgggctttcttcat gtatttgcccacatgcagatgaagctgtctcaggactccagtcaaattgagctactaaaa gaactgatggatcttcagaaggacatggtcgtcatgttgctgtccatgttggaaggcaat gttgttaatggcaccattggcaaacagatggttgatatgctcgtggaatcttctaacaac gtggagatgattctcaagttttttgacatgttcttaaaactcaaggacttgacgtcttct gatactttcaaagagtatgaccctgatggtaagggagttatttccaagagggactttcac aaagccatggagagccataaacactacacccagtccgagactgagtttctcctgtcctgt gcagagacagatgaaaatgaaaccctggactatgaagaatttgtcaaacggttccacgag cctgccaaggacattggcttcaacgtggcagtgcttctgacaaacctctccgagcacatg cccaatgatacccggctgcagacttttctggaactggctgagagcgtgctcaattacttc cagcccttcctgggccgcatcgagatcatgggcagtgccaagcgcatagagagggtgtat tttgaaatcagtgagtccagccgaacccagtgggagaagccccaggtcaaggagtccaaa agacaatttatatttgacgtggtcaatgaagggggggaaaaggagaagatggagctcttt gtgaacttctgtgaggacaccatcttcgagatgcagctggcggctcagatatcagagtca gatctgaacgagaggtcagtgaataaagaggagagtgagaaggagaagccggaggagcag ggtccaaggatgggtttcttttccatcgtgacggtcaagtccgccctgtttgccctcagg tacaatatcttgatccttatgcggatgctcagcctgaaaagcttgaagaagcagatgaag aaggtgaagaagatgacagtgaaggacatgatcacggccttctttacatcctactggggt attttgatgagcctcctgcactttgtagccagcgttttcagaggcttctcgcgcatcatc ggcagcctcctgctgggaggaagcctagtcgaaggtgcgaagaagattaaagtggcagag ctcctggccaacatgccagaccccacacaggatgaggttcgaggagacggggaggagggg gagaggaaaactctggaaggggccctgccctctgaagatctgacggatttaaaggaactg acagaggagagtgacctgctttccgatatctttggcttggacctgaagcgagaaggaggg cagtacaaactgattcctcacaatcccaatgctggcctgagtgacctcatgagcaacccc gtccccatcccagaggtgcaagaaaagttccaggaacagaaggcaaaagaagaagaaaag gaagaaaaagaagaaagtaaatccgaacctgagaaagctgaaggagaagatggagaaaaa gaagaaaaagccaaagaagacaagggtaaacaaaaactgagacagctccacacacacaga tatggagagccagaagttcctgagtcagcattctggaagaaaatcatagcctatcaacag aaacttctaaactattttgctcgcaacttctacaacatgagaatgttagccttatttgtc gcatttgcaatcaatttcatcttgctgttttataaggtctccacttcttctgtggttgaa ggaaaggaactacccactcgcagttcaagtggaagcgccagagtcagcagcttggacagc agctcgcctagaatcatcgcggtgcactacgtgctggaggagagcagtggctacatggag cccacgctgcggatattagccattctgcacacggtcatctctttcttctgcatcatcgga tactactgcttgaaagtcccactggttatttttaagcgagaaaaggaagtagctcgaaaa ttggaatttgatgggctttatattacagaacagccttcagaagatgatattaaaggccag tgggatagactcgtaatcaacacacagtcatttcccaacaactactgggacaaatttgtt aaaagaaaggttatggataaatatggagagttctatggccgagacagaatcagcgagtta cttggcatggacaaagctgccttggacttcagtgatgcccgggaaaagaagaagccgaag aaagacagctccctgtcagctgtactgaactctattgatgtgaagtatcagatgtggaaa ctaggagtcgttttcactgacaactccttcctgtaccttgcctggtatatgaccatgtcc attcttggacactacaataactttttttttgctgctcatcttctggacattgctatggga ttcaagacattaagaaccatcttgtcatcagtaactcacaatggcaaacagcttgtatta actgttggcttattggctgttgttgtatacctatatactgtcgtggcattcaattttttc cgaaaattctacaataaaagtgaagatggcgatacaccagacatgaaatgcgatgacatg ctaacatgctatatgttccacatgtatgttggagtacgtgccggagggggtattggtgat gaaatcgaagatccagctggtgatgaatatgagatatatcgaatcatctttgacatcacc ttcttcttttttgtaattgtcattctcttggccataatacaaggtttaatcatcgatgct tttggggaactaagagaccaacaggaacaggtcaaagaagacatggagaccaagtgcttc atctgtgggataggcaatgattactttgacactgtgccacatggctttgaaactcacact ttacaggaacacaacttggccaattatctgttttttctgatgtatctcataaacaaagat gaaacggagcacacaggacaggaatcttatgtttggaagatgtatcaagaaaggtgctgg gaatttttcccagccggagactgtttccggaaacagtatgaagaccagctaaattaa

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