Micropterus salmoides (largemouth bass): 119916007 Help Entry 119916007         CDS       T07309                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism msam  Micropterus salmoides (largemouth bass) Pathway msam04020   Calcium signaling pathway msam04260   Cardiac muscle contraction msam04261   Adrenergic signaling in cardiomyocytes msam04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:msam00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     119916007 (ryr2a)    04020 Calcium signaling pathway     119916007 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     119916007 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     119916007 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:msam04040]     119916007 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:msam04990]     119916007 (ryr2a) Ion channels [BR:msam04040]  Voltage-gated cation channels   Ryanodine receptor    119916007 (ryr2a) Domain-containing proteins not elsewhere classified [BR:msam04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    119916007 (ryr2a) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  119916007 NCBI-ProteinID:  XP_038591762 LinkDB All DBs Position Unknown AA seq 4969 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATFHKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGTAQGGGHRTLLYGHAVLLRHSYSGMYLCC LSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGYLIGGDVLRLLHGHMDECLTVPSGEH GDEQRRTVHYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKYLSLIEDK SLLLMDKEKADVKSTAFCFRSSKEKLDPGVKKEVDGMGVPDIKYGDSVCYIQHVDTCLWL TYQAVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNLFIRG LDTLREKGKSSTLDLPIDSVSLSLQDLIGYFQPPGDHLEHEDKQNRLRALKNRQNLFQEE GMISLVLECIDRLHVYSSAAHFAEAIGREAGEAWSSILNSLYQLLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLINHVSSMRPNIFLGVSDGSAQYRK WYYELIVDQALPFVTAEATHLRVGWANTSGYAPYPSGGEGWGGNGVGDDLYSYGFDGLHL WSGCIARTVSSPNQHLLRAEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSDGLFFPVA SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEHSQDQTAAKDLLGPTVT MSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRDDNKRQHP CLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVEKFKSMKLSSTYELSSGY KPAPLDLSHIKLTSTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYT LLDERTKKSNKDSLREAVRTLLGYGYNLEASDQDHAAQSDPSNMSAERFRIFRAEKTYCV NAGKWYFELEVITAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGNEHFGRAW QTGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEVVEGFIPVCSLGVCQVGRMN FGKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPPNHQHIEVTRIDGT VESCPCLRVTQRSFGSQNSYTDITFYRLSMPIECADSFSRSSPSDSLFSPKRELEDFETV SDFEVLMKSSHSHSGPNGPERDEFNNHKDYNQEKPSKLKQRFMLKRNKPDNSCPSSARLS GEGMADDRDEYEFLMQASTHYYSVRIFPGQEPSCVWVGWVTSDFHQHDPGFELHKVRTVT VTLGDEKGKVHESIKRSNCYMVWAGESSSPGQGRTNNGLEIGCLVDTTNGLLTFTANGKE LSTYYQVEPSTKLFPAVFAKATSPNVVQFELGRIKNVMPLSAGLFKSERKNPVPQCPPRL HVQFLTPVLWSRVPNHFLKVSASRVNDRHGWLVQCNEPLQFMSLHIPEENWSVDILELSE QRDLLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLQAIENKYMPGLLRAGYYDLL IDIHLSSYATARLMMNNEYIVPMTGETKSITLFPDEKKKHGLPGIGLSTSLRPRMHFSSP SFVCGTGPSYRNNGNNGSGSGDCFQYSPEFPLDILKIKTIEMLTEAVQEGSMHVRDPIGG STEFLFVPLIKLFYTMLIMGVFQNGDLKNILRLIEPSVFCERREGQEEIHMDPEVVKEVE PEGRGEDGGRKMPKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVACL QDNQRFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQECPCPEYIREQL LDFHEDLMRHCGIELDEESGIEGDSDFTIRGRLISLVEKVAYLKRKMSNLPKEKKDRKPS TLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINSVSIEDT INLLAALGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMV NVLSGGDSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRG STPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLVRKGYPDIGWNPVEGE RYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEEAIKISQD LSRDGPSPTSESSKTLSDMLEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKG EAIRIRAILRSLIPIEDLVGVISIPFSMPNLAKDGLVVEPDMSAGFCPDHKAAMVLFLDR VYGIEDQNFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLPLLTKCAPL FAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHLLRRLVF DVPLLNEHTKMPLKLLTNHYERCWKYYCLAGGWGNFGAASDEELHLSRKLFWGIFDALSR KRYDQELFKLGLPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADTANVTVP EKLDYFITRYAEHNHEKWCIEKFSNGWSYGDQMCEISKSHPLLKPYKGLSEKDKEAYYWP VRESLKTMLSWGWSIDRIREGDPASLHNKSRRISQASQLSFEGGPAFSPRPIDMSNVTLS RDMQSMAELLAENYHNIWARKKKMELEAKGGGNHPLLVPYDTLTAKEKSKDREKAQDILK FLQINGYTVSRGVKSQELDTPAIEKRFAYTFLQQLITYVDQAHQHMMEFDLGTRPKGEKI PHEQQIKFFGKVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTSLFCKLGVL VRHRISLFGNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRSYFDSAAEDLEKTQEN LKLGQFTHSREQPRGVTQIINYTTFALLPVLSSLFEHIGQNMFGEDLVFDDVQVSCYRIL NSLYFLGTNKSIYVERQRPALGKCLAAFSAAFPVAFLEPHINKFNSFSIYNSKGAKDRAA LGLPGQVGEVCPLIPNLEKALEEIMELAESGMRYTQMPHVMEVVLPMLCSYMSHWWEHGP ESNPEKADSCCTSVTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKAQL LKTHFLPLMEKLKKKAAVVLMDEEHSKAEGRGEMSETELLIMDQFTILVRDLYAFYPLLI RFVDYNRARWLKESNPEAEEVFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLITD TKCKMSKGIVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPVGLNMCAPGEQELIALAKN RFTQKDTEDEVREIIRNNLHLQGKLEDPAIRWQMALYRDLPNHYEDTSDPEKTVDRVLDI AHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEK SWIEAEEHYFEDKLIEDLAKPGEQEPCEEEEGVKHIDPLHQLIQLFSRTALTEKCKLDED NLYMAYADIMAESCHDEEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISA SKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLN AFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRT QTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTL TEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVV MLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGK GVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAV LLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQW EKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAVKEESE REKPDEDNPEMGFFSVTTVRMALLALQYNVMLLIKVLSMKSLKKQVKRIKNMTVKDMVTA LVSFYLSVLLGLLHVAFSVARGFCRIFYNTFMGGNLVEGAKTIKVSELLANMPDPTQDEV RGEGEDREKRPSERSSPKEDLADLAVNTSETELLSDIFGLDLRREGGQYKITPHNPNATL TELLNSPVPSPAPSSAPTAPLPELRRRHPSKSSSSEEKEATADTDCEPEKTEDGHVEKQL KNEKMKPKVRRHHTSKSDEPDLQESAFLKKIIAYQRKLLNYFARNFYNMRMLALFVAFAI NFILLFYKVSTSSSVMEEREVVYTSSQPDNSVQWDPLGGEAMETKEGVMDEAPLKPVTVR FVLEESTGYMEPMLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYIT EQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALD FSDAHKKRKPRRDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFF FAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKGED GELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVIL LAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANY LFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14910 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggaggagaaggcgaggatgagatccagttcctgcgaactgatgatgaggtg gtcctacagtgctcagccacattccacaaggagcaacagaaactctgtctggctgctgaa ggcttcggaaacagactctgcttccttgaatccatctccaactccaagaatgtgccccca gatctgtccatctgcacttttgtgttggagcagtcgctgtcggtacgggcccttcaggag atgctggccaacacagaggagaaggctgaggggacggcccaggggggcggtcatcgcacc ttactgtacggtcacgctgtcctgctgcgacactcctacagtggaatgtacctgtgctgt ctgtccacctcccgctcatccacagacaaactggcttttgatgttggactacaggaagat accacaggcgaggcatgctggtggaccatccatccagcatcgaagcagcgttcagaggga gagaaggttagagtcggagacgatctcatcctggtcagcgtctcctctgaaagatatctg catctgtcctatggaaatggcagtctccatgtagatgcagcgttccagcagacactgtgg agtgtggctcccatctgttctggcagtgaagtagcacaaggttacctgataggaggggac gtcctgcgcctccttcacggtcacatggacgagtgtctaactgttccatctggggagcat ggggatgagcagaggaggacagtgcactatgaggggggagcagtgtccagtcatgccagg tccctgtggagacttgagacacttcgggtcgtgtggagtgggagtcatattcgctggggt cagccgttccgactgagacatgtgacgacagggaagtatcttagtctcatagaagacaaa tcactgctgctgatggacaaagagaaagctgatgtcaagtctacagccttctgcttcagg tcttccaaggaaaagttggaccccggtgtgaagaaggaggtggatgggatgggtgttcct gacattaagtatggtgactctgtgtgttacatccaacatgttgacacctgcctgtggctt acataccaggctgtcgatgctaagtgtgcacgcatgggtggagtgcagagaaaggccatc atgcaccatgagggtcacatggatgatgggctgacactgtctcggtcacaacatgaggag agtcgcactgccagagtcatccgcagtacggtctttctgttcaacctcttcatcaggggt ctggacacactaagggaaaaggggaagagttccactctagatctgccaatcgattcggtc agtctgagtctgcaggatctgattggctactttcaaccacccggcgatcacctggagcat gaagacaagcagaaccgactgagagctctgaagaaccggcagaacctctttcaggaagag gggatgatcagcctggtgctggagtgtatcgatcgtcttcacgtctacagcagtgcagct cattttgctgaggcaataggaagggaggcaggagaggcctggagctccatactcaactcc ctctaccaactactagctgccctgatcagaggaaacagaaagaactgtgctcagttttcc gggtcgttagactggctcattagcagactggagcgactggaggcctcctctggtatacta gaggtgcttcactgtgtgctggtggagagtcctgaggcactgaatataatcaaagaggga cacatcaaatccattatatctctgctggacaagcatggacgcaaccacaaggttctagat gtgttgtgttcgctgtgtgtgtgtcacggcgttgcagtgcgctccaaccagcacctgatc tgtgacaacctgctgccaggaagagatctgttactgcagacccgtctgatcaaccacgta agcagcatgcgtcccaacatcttcctaggagtcagcgacggctccgctcagtacaggaag tggtactatgagctgattgtggatcaggcgctgccattcgtcacagcagaggccactcac ctcagggtgggctgggccaacaccagtggctacgcgccataccccagcgggggagagggg tggggaggcaacggggtgggtgatgacctctactcatacggctttgatggcctccatctc tggtcaggctgcattgcccggactgtcagctcacccaatcagcatcttctgagagcagag gacgtggtgagctgctgcctggacctcagtgttcccagtatctccttcaggatcaatggc cagccggtccagggcatgtttgagaacttcaactctgatggcctgttcttccccgtggcc agtttctctgccggagtcaaggttcgtttcctcctggggggtcgtcatggggagtttaag ttcctccctcctccgggttatgctccttgctatgaggcggtgttgcccagggagaagctg aaactggagcacagtcaggaccagacagcagccaaagacctactgggacccaccgtcacc atgagccaggcagcgttcacccctacacctgtggacaccagccagattgtgctgccacct cacttggagaggatcagggagaagcttgcagaaaacatccatgaactgtgggtgatgaac aagatagaactgggctggacctacggtgcagtgcgagatgataacaagcggcagcacccc tgtctggtggagttctccaagcttcctgaacaagagcgaagctacaacttgcagatgtct ctggagactctcaagactctcctggccttgggttgccatgttggcctagcagatgaacac gcagtagagaaattcaagagcatgaaactgtcatcaacctatgagttgtccagtggttat aaacctgctcctctggacctgagtcacatcaaactgacctccacccaggaagccatggtg gacaaactggctgagaatgcacacaacgtctgggcaagagaccgcatccgccagggctgg acctatggcatccaacaggatgtgaaaaatcgtagaaaccctcgtctggtcccctacact ctgctggatgagagaaccaagaagtccaacaaagacagtttgagagaggctgtcaggaca ctgctgggatatggatacaacctggaagcttctgaccaggaccatgcagctcaatctgac cccagcaacatgtcagctgagaggttccgcatcttcagagcagagaaaacctactgtgtt aatgcagggaagtggtactttgagctggaggtaataacagcaggagagatgagggtaggc tgggccaggccaggatgcctcccagaccaggagctgggatctgacgaccaggcctttgtc tttgatggcttcaaggtccagcgttggcaccagggtaatgagcactttgggcgtgcctgg cagacgggggacgtggtgggctgcatggtggatctgaacgaacacaccatgatgttcaca cttaatggagaagtgcttctggatgactctggatctgagctggccttcaaggactttgaa gttgttgaaggttttattccagtgtgcagtctgggtgtgtgtcaggttggaagaatgaac tttggtaaagacgtcagcactctaaagtacttcaccatctgcggcctgcaggaaggttat gaaccgttcgctgtcaacatgaaccgggatgtcaccatgtggctcagcaagaggctgcct cagtttgtacctgtaccccccaaccaccaacacatagaggtgacaaggatagatgggaca gtggagtcatgtccatgcctaagggtcacccagaggtcatttggctcacaaaacagttac actgacatcaccttctacagactgagcatgcccatagagtgcgcagactccttctccaga tcctcacctagtgacagcctcttttcgcctaagagggagctggaggactttgaaactgtg tcagactttgaggtcctgatgaagtcttctcatagtcacagtggtcccaatggacctgag agagatgaattcaacaaccacaaagattataaccaggagaagccctccaagctcaaacaa cggttcatgttgaagagaaacaagccggacaacagctgtccatcatctgcccgtctgtca ggggaagggatggctgatgacagagatgaatatgaattccttatgcaagcctctactcac tactactcagtgcggatcttccctggtcaggagcccagctgtgtttgggtggggtgggta acctctgacttccatcagcacgacccaggctttgagctgcacaaggtccgaactgtcact gttaccctgggagatgagaagggtaaagttcatgagagtatcaagcgtagtaactgttac atggtgtgggccggagagagcagcagtcctggtcaggggaggaccaacaatggcttagag atcggctgtttggttgacacaacaaacggactgctgaccttcacagccaacggcaaagaa ctcagcacatactaccaggtggagcccagtactaagctgttcccagcagtctttgccaag gccaccagccctaatgttgtccagtttgaactggggcgtattaagaatgtgatgcctttg tcagctggtctgtttaaaagtgagaggaagaatccagttcctcagtgtcctccacggctg cacgtccagtttctcactcctgtattatggagtcgtgttcccaaccacttccttaaggtg tcagcatccagagtaaatgacagacacggctggctggtccagtgtaacgaacctctgcag tttatgtctctgcacatacctgaggagaactggtcggtggatatcctggagctgtcagag cagagggacttattaaagtttcactaccataccctcagactgtactctgccatttgtgct ctgggaaataaccgagtggcacatgccctttgctcacacgtagacgaggcacagctcctg caggctatagagaataaatacatgccaggtttgcttcgtgcgggctactacgacctcctc atagacatccacctgagcagctacgctacagctcgcctcatgatgaacaatgaatacatt gttcccatgacaggcgaaaccaagagcatcaccctgtttccagatgagaagaagaaacat ggccttccaggcattggcctcagcacttccctgagacccagaatgcacttctcatcccca agttttgtctgtgggaccggaccgtcgtatcgtaataatggcaacaacggatcaggatca ggagactgtttccagtacagccctgaattccccctagatatactgaaaattaaaaccatc gagatgctaacagaggcagtacaggagggaagcatgcacgtacgggatccaataggaggc agcactgagtttctcttcgtccctctcatcaagctgttctacaccatgctcatcatggga gttttccaaaatggagatctgaaaaacatcctcagactgattgaaccgtctgtgttctgt gaaagacgggaagggcaggaggaaatccacatggacccggaggtggtgaaggaggtggag cctgaaggacgaggagaagatggagggaggaagatgcctaaagaaggactgttacagatg aagctaccagagcctgtaaaactccagatgtgccatgtgcttcagtacctgtgtgactgc caggtgcgtcaccgtatcgaggctgtggtggccttctctgatgactttgtggcctgtctc caagacaaccagcggttccgctacaatgaggtgatgttggcactcaacatgtctgccgcc ctcactgccaaaaagaccaaagagttcagatctcctccacaggaacagatcaacatgctg ctgaactttaaggatgagaagcaggagtgtccctgtcctgaatacatccgagaacagctg ctcgacttccatgaggacctgatgagacactgtggtattgagttggatgaggagagcggg atagagggtgacagtgacttcaccatccgaggtcgactcatttcattggtggagaaagta gcttacttgaaaaggaagatgtccaacctgccaaaggagaaaaaagacaggaaacccagt acgttgcagcagttgatttcagatacgatggtccgctgggcacaggagtcagttattgag gatccagagctggtcagagccatgttcgtcctgctgcaccgccagtatgatggcattgga ggacaggtgcgggctcttcctaagacctacactataaactctgtgtcgatcgaggacacc atcaacctgttggctgctctgggccagatcagatctctgctgagtgtccgcatgggaaga gaggaggagaaactgatgatcagagggctaggtgatatcatgaacaacaaggtgttctac caacatcctaacctgatgagagctctggggatgcatgagaccgtcatggaggtcatggtc aatgtactcagtggtggagactccaaggaaatcacctttcctaaaatggtggccaactgc tgtcgatttctctgctacttctgtcgaatcagccgtcagaaccagaaagccatgtttgac catcttagctacctgctggagaacagcagtgtcggcctcgcttctccgtccatgcgagga tctactcctctggatgtggctgcagcatcagttatggataataatgaattggccctggct ttaagagagccagacctggaaaaggtggtgcagtacctggccggctgtgggctgcagagc tgtgtgatgctggtgcgtaaaggatacccagacatcggctggaaccctgtggagggtgaa cgctacctcgacttcctgcgctttgctgtcttctgcaacggtgaaagcgtggaggagaat gccaatgttgtggtgaggcttctgattcgcagaccagaatgttttggccccgcccttcgg ggtgaaggtggggatgggttgttggcagcaatggaggaagccattaagatctctcaggat ctctccagagatggtccctctcctacatctgagagcagcaagacactcagtgacatgctg gaggaggaggaagatgataccatccacatgggcaatgccatcatgaccttctatgctgct ctcattgacctgctgggccgctgtgctccggagatgcatttgatccacgctggtaaaggt gaagcgatacgtatcagagccattctgaggtctctgattccgattgaagacctggtggga gtcatcagcattccattctccatgcccaacctggctaaagatggattggtggtggaacca gacatgtcagctggtttctgtccagaccataaagcagccatggtcctgttcctagacaga gtctacggtatagaggaccaaaatttcctgctacacctgctggaggttgggttcttacct gacctgagggctgccgcctctctagacactgttgctctcagtgccacggacatggcgctc gccctcaacaggtatctgtgtacagccgtgttgcctctcctgactaaatgtgctccactg tttgctgggacggagccgttcgcctcactaatcgactccctgctccacacggtttaccgc ctgtccaaaggctgctgcctcaccaaggcccagagggatgccatagaggagtgtctgctg gctgtttgtggtaagctgaggccttcaatgatgcagcatctgttgaggaggctggtcttt gacgttcctctgcttaatgaacacaccaagatgcctctaaagctgttgaccaatcactat gagcgttgttggaagtactactgcctggctggaggctggggcaactttggagctgcatca gatgaagagcttcacctctccaggaaactgttctggggaatatttgatgccctgtcacgc aagcggtatgaccaagaactgtttaagctggggttaccgtgtctcagtgctgtggctgga gctcttcctccagactacatggagtccaactacatggccatgatggagaaacagtcgtcc atggactcagaaggaaacttcactccacagcctgcagacactgccaatgtgactgtccca gagaaactggactattttataaccagatatgcagagcacaaccatgagaagtggtgtata gaaaagttttctaatggctggtcatatggagatcagatgtgtgaaatctctaaaagccac cctttactgaagccatacaaaggcctctctgagaaggataaggaggcctattactggcca gtcagagagtctctgaagaccatgctgtcgtggggctggagcatcgacaggatcagagag ggtgaccctgccagccttcacaacaagtccaggagaatatcacaggccagccagctgtct tttgaaggagggccagcattcagccccagacccattgatatgagcaatgttacactgtct agagacatgcagtcaatggcagagttgcttgcagagaattatcataatatctgggccaga aaaaagaaaatggagcttgaagccaaaggtggaggaaaccatcctctgctggtcccctat gatacactgactgccaaagagaaatccaaagacagagaaaaagcacaagacatcctcaag ttcctgcagatcaatggttacacagtgtccagaggtgtgaagtcgcaggagctggacact ccagctatagagaaacgatttgcctacaccttcctccagcagctcatcacatatgtagac caggcgcaccaacacatgatggagtttgatctgggaacaagaccaaagggagagaagatt cctcatgaacagcagattaaattctttggaaaggttgtcttgccattggtggatcagtac tttaaaaaccacaggctgtacttcctgtccacagccatccatccaatcagcagtggtggc cacgcctccaacaaggagaaagagatggtgacaagtcttttctgcaaactgggagttctt gtcagacataggatatccttatttggtaacaatgccacatctatagtcaactgtctgcag atactgggacaaagcctggatgccaggacagtgatgaagactggtctggagtcagtaaag gcagcactgcggtcgtacttcgatagtgcggcagaagatctggagaagacacaggagaat ctgaagctcggtcagttcacccacagcagagagcagcctcgaggtgtcactcagatcatc aactacactacgttcgccctgctgcccgtcctctcctctctgtttgaacacatcggacag aacatgtttggagaagaccttgtatttgatgatgtccaggtttcctgctacagaattctc aacagtctctactttttgggaaccaacaaaagcatctatgtagagagacagcgtccagca ttaggaaagtgtttagctgccttctcagcagccttccctgttgctttcctagagcctcac atcaacaagttcaacagcttctccatctacaacagcaaaggagctaaagacagagcggct ctaggtcttccagggcaggttggtgaggtttgtccgctgatcccaaacttagaaaaggct ctagaggagatcatggagttggcagagtctggcatgagatacactcagatgccccatgtc atggaggtggtgttgccaatgttgtgcagctacatgtctcactggtgggaacacggacca gagagcaacccagaaaaagctgacagctgctgcacctctgtgacctctgaacacatgaac actctgctgggaaacattctcaagataatctacaataacctgggaatagatgaaggggcc tggatgaaaagactagctgtcttctctcagccaatcatcagcaaggccaaagcccagcta ctcaagacccacttcctgcctctgatggagaaactcaaaaaaaaagcagcagttgtgctg atggatgaggaacacagcaaggcagaggggaggggtgagatgtcagagacggaacttctc atcatggaccagtttaccatactggtcagagacctgtatgccttctaccctctcctcata cgatttgttgactacaacagggccagatggctgaaagaatccaacccagaggctgaggag gtgttccgcatggtggctgaggttttcatcttctgggccaagtctcataactttaagaga gaagagcagaactttgtggtccagaatgaaatcaacaacatgtcattcctcatcactgac actaagtgtaagatgtcaaagggaatagtttcagaccaggagaggaagaagatgaagagg aagggagatcgatactctatgcagacgagtctaattgttgccgctctgaagcgcctgctg cctgttggactcaacatgtgtgcccctggagaacaagagctcatcgcactggctaagaac cgcttcacccaaaaagatacagaggatgaagttcgagagatcattaggaacaatctccat ttgcaaggaaagctggaggacccagctattcgttggcagatggctctatacagagacctc ccaaaccactatgaggacacctccgacccagagaagaccgtggacagagtcctggacatt gctcatgtcctcttccacctagaccaggttgaacatcctcagcgcagtaagaaggctgtg tggcacaaactgctgtccaaacagaggaaaagagcagtggttgcgtgcttcaggatggca ccactctataacttgcccaggcaccgggctgtcaacttgttcctgcagggctatgagaag tcctggattgaggcagaggaacattactttgaagataaactcatagaggaccttgctaaa ccaggtgaacaggagccatgtgaggaagaggagggggtgaaacacattgatccactgcat cagctcattcagctgttcagcagaacagccctcacagaaaagtgtaaactggatgaggat aatctctacatggcttatgctgacatcatggctgagagttgccatgatgaagaggatgag gatggagaggaagtgaagagttttgaagagaaggagatggagaagcagaagctgttgtat cagcaggctcggctgcatgaccgtggagctgctgagatggtgcttcaaaccatcagcgct agcaaaggtgagatgggtcccatggtggcctctactctgaagctgggcatagctattctc aatggaggaaactctactgtacagcagaaaatgttggattatctgaaagacaaaaaggat gtgggcttttttcagagtctggctggtctgatgcagtcatgcagtgttctggatctcaat gcatttgagaggcagaacaaagcagaaggactgggaatggtgacagaggagggatcagtc atcactcatgagcgtggtgagaaggtcatgcaggatgatgagttcacctgtgaccttttc cgcttcctgcagctgctctgtgaaggacacaactcagacttccagaactacttgaggaca caaacagggaacaatacgactgtcaacatcattatctctactgttgactacctcctcaga gtacaggagtctatcagtgatttctactggtattattctgggaaagatgttattgacgag cagggccagaggaatttctccaaggcaataaatgtggccaagcaggttttcaatacactc acagagtacatccagggtccgtgtactggcaaccagcaaagtttggcccatagtcgcctc tgggatgctgtggttggttttctacatgtctttgctcacatgcagatgaaattgtctcag gactccagtcagattgagttactgaaggaactgatggatctgcagaaagatatggtggtc atgctgctgtctatgctggagggtaatgtggtgaatgggaccattgggaagcagatggtg gacatgttggtggagtcctccaacaacgtggagatgatcctcaagttctttgacatgttc ctcaaactgaaagacctgacctcctcagacaccttcaaggagtatgaccctgatggaaaa ggtgtcatctccaagagggacttccacaaggccatggagagccacaaacactacacccag tctgagacggagttcctgctctcctgtgctgagactgatgagaatgagcttctggattac gaagaatttgttgagcgcttccatgagccagccaaggacattggcttcaatgtggcggtt ttactgaccaacctgtcggagcacatgcctcatgacacccggctgcagaccttcctggag ctggcagagagcgtcctcaactacttccaaccctaccttggccggatcgagatcatgggc agcgccaagcgcattgagagggtctactttgagatcagtgagtccagtcgaacacagtgg gagaaacctcaggtcaaagaatccaagcgtcagttcatctttgatgtggtgaatgaagga ggggagaaggagaagatggagctttttgtcaatttctgcgaggacaccatctttgaaatg cagctggcggctcagatgtctgacgctggtgagcgctcagcagtcaaagaggagagtgag cgggagaagccggatgaggacaaccctgagatgggcttcttctctgtcaccactgtccgc atggctctgttagctctgcagtacaacgtcatgctgctgataaaggtgctgtccatgaag agtttgaagaagcaggtgaagaggataaagaacatgacagtgaaggacatggtcaccgcc ctggtgtctttctacttgtctgtgttgctgggcctcctccacgtggccttcagcgtggcc cgaggattttgtcgaatcttctacaacaccttcatgggaggcaatctagtggagggggcc aagaccataaaggtgtcggagctgctggccaacatgcctgatcccacccaggacgaggtc aggggcgaaggggaggacagagagaagagaccctctgaacgcagctccccaaaggaggac ctggctgacctggctgtcaacaccagtgagaccgagctgctgtcagacatttttggccta gacttaagaagagaagggggccagtataagatcaccccacataaccccaatgccaccctg accgaactgctaaactccccggttccttccccggccccatcaagcgcacccacagcaccc ctaccggagctcagacggaggcatccgtcgaagagctcttcctcagaggagaaggaagca acagccgacacagattgtgaacctgagaaaacagaggatggacatgtagagaaacaactg aagaatgagaagatgaagccaaaagtgagaaggcatcacacttcaaagtctgatgaacca gatctgcaggagtctgccttcttgaagaagatcatagcctaccagaggaagctactgaac tactttgccaggaacttttacaatatgaggatgctggcgctgtttgttgcctttgcaatc aacttcatcctcctgttctataaggtttctacatcctcatctgtgatggaggaaagggaa gtggtatacaccagcagccaaccagacaacagtgttcagtgggatccactgggaggagaa gcaatggagacaaaggagggggtgatggatgaggcgcccctaaagcctgtcacagtccgt tttgtcctggaggagagcaccggatacatggagcctatgttacggatcctggccatcctg cacactgtcatctccttcttctgcatcatcggatactactgtctaaaggtgccactggtg atctttaagcgtgagaaggaggtggccaggaagctggaatttgatggcctttacatcaca gagcaaccgtctgaggatgacatcaaggggcagtgggacagactggtaatcaacacacaa tcttttcccaacaactactgggataagtttgtgaagaggaaggtgatggataaatatgga gagttctacggtcacgaccgcatcagtgagctgctgggaatggacaaggctgctctggac ttcagcgatgctcacaaaaagagaaagcccaggagagacagctcactggctgctgtgctg aactccattgatgtcaagtaccagatctggaagctgggggttgtattcacagacaattcc ttcctgtatctggcctggtatatgaccatgtccatcctgggccactataacaacttcttt tttgctgctcatctgcttgacatcgccatgggcttcaagacactgcggaccattttgtcc tcagtaacacacaatggcaaacagctggtgttgacagttggcctgttagcagtggtggtg tacctctacacagtagtggccttcaacttcttcaggaagttctacaacaagggcgaagat ggagaactgccagacatgaagtgtgacgacatgctgacatgctacatgttccacatgtat gtaggtgtgagagcgggtggagggatcggtgatcagattgaggacccagcgggtgacgag tatgagatctatcgcatcatctttgacatcactttcttcttctttgtcattgtaatcctc ctggccatcatccaggggttgatcatcgatgcttttggagagctgagagaccagcaggaa caagtgaaagaagacatggagaccaaatgctttatctgtggaataggcaacgattacttt gacacagtgccacatggctttgaaacgcacacgctacaggagcacaacttagccaactac ctattctttgtgatgtatctcatcaacaaagatgaaacagagcacacaggccaggagtct tacgtgtggaagatgtaccaggagcgttgctgggagtttttcccagctggtgactgtttc cggaaacagtacgaggatcagctcaactga

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