Mycobacterium shigaense: MSG_00731
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Entry
MSG_00731 CDS
T05717
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mshg
Mycobacterium shigaense
Pathway
mshg00860
Porphyrin metabolism
mshg01100
Metabolic pathways
mshg01110
Biosynthesis of secondary metabolites
mshg01120
Microbial metabolism in diverse environments
mshg01240
Biosynthesis of cofactors
Module
mshg_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mshg_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mshg00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MSG_00731 (hemD)
Enzymes [BR:
mshg01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MSG_00731 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MSG_00731 (hemD)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BAX90894
UniProt:
A0A1Z4ED58
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All DBs
Position
752136..753809
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AA seq
557 aa
AA seq
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MTTRGRKPRPGRITFVGSGPGDPGLLTTKAAAVLANAALVFTDPDVPAPVLALIGKDLPP
VSGPAPAEPAPVAVDGTTPDGDQQPASPAVITGGPDIRPALGEPAEVAKTLVAEARTGVD
VVRLVAGDPLTLDAVTTEVNAVARSHLHLEIVPGLAATSAVPTYTGLPLGSSHTVADVRD
PHVDWEALAAAPGPLILQATASHLADAARTLIEHELAETTPCVVTAQGTTCQQRSVETTL
HGLTEPGVLDGGGSPAGPLTGSLVVTIGKTVASRAKLNWWESRELYGWTVLVPRTKDQAG
EMSERLTSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKF
GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPDYDSIFDPV
NRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGFDAVCFTS
SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAIGPLVDALAEHAAR
LRAEGALPPPRKKSRRR
NT seq
1674 nt
NT seq
+upstream
nt +downstream
nt
atgacgacgcgagggcgtaagccgagaccgggccgcatcacgttcgtgggctccggcccg
ggcgatccggggttgttgaccacgaaggccgccgcggtgctggccaacgcggccctggtg
ttcaccgaccccgacgtgcctgcaccggtgctggcgctgatcggcaaggatctgccgccg
gtctccggtcccgcgcccgccgaaccggcaccggtggccgtcgacgggaccacccccgac
ggcgatcagcaaccggcctcgccggcggtgatcacgggcggccccgacatccgcccggcg
ctgggcgaacccgccgaggtcgccaagacgctggtcgccgaggcccgcaccggagtcgac
gtggtccgcctcgtggccggtgacccgctgacgctcgacgcggtcaccaccgaggtgaac
gccgtcgcgcgcagccacctgcacctcgagatcgtgccgggcctagccgccaccagcgcg
gtcccgacctacacggggctgccgctgggctcctcgcacaccgtcgccgacgtgcgcgat
ccacatgtcgattgggaggcgctggccgccgcccccgggccgctgatcctgcaggccacc
gcgtcgcatctggccgatgccgcccgcaccctgatcgagcacgagctggccgagaccacc
ccgtgcgtggtgaccgcgcagggcaccacctgtcagcagcgttcggtggagaccacgctg
cacgggctgaccgagccgggcgtgctcgacggcggcggcagccccgcgggaccgctcacc
ggttcgctggtggtgaccatcggcaaaacggtggccagccgcgcgaagctgaactggtgg
gagagccgcgagctgtacggctggaccgtgctggtgccgcgcaccaaggaccaggccggt
gagatgagcgagcggctcacctcctacggcgcgctgccgatcgaggtgccgaccatcgcg
gtcgagccgccgcgcagccccgcccaaatggagcgtgccgtcaagggtttggtcgacggt
cggttccagtgggtggtgttcacctccaccaacgcggtgcgtgcggtgtgggagaagttc
ggcgagttcggcttggacgcccgtgcgttttccggggtgaagatcgcgtgtgtcggcgag
tcgacggccgaccgggtccgagcgttcgggatcagccccgaattggtgccggccggcgag
cagtcctcgctgggcctgctggacgacttcccggactacgacagcattttcgatccggtg
aaccgcgtcctgctgccgcgcgccgacatcgccaccgagaccctggccgaggggctgcgc
gaacgcggttgggagatcgaggatgtcaccgcctaccggaccgtacgcgccgcgccgccg
ccggcggctacccgcgagatgatcaagacgggcggcttcgacgcggtgtgcttcacgtcg
agctcgaccgtgcgcaacctggtgggaatcgccggtaagccgcacgcgcgcaccatcatt
gcgtgcatcggacccaagacggccgagaccgccgccgagttcggtttgcgggtcgacgtc
cagcccgagacggcggccatcggtccgctggtcgacgcactggccgaacatgccgcgcgg
ctgcgcgccgagggcgcgctgccaccgccgcgtaagaagagccgcaggcgctag
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