KEGG   Macaca thibetana thibetana (Pere David's macaque): 126935739
Entry
126935739         CDS       T08579                                 
Name
(RefSeq) tyrosine-protein kinase JAK1 isoform X1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
mthb  Macaca thibetana thibetana (Pere David's macaque)
Pathway
mthb01521  EGFR tyrosine kinase inhibitor resistance
mthb04151  PI3K-Akt signaling pathway
mthb04217  Necroptosis
mthb04380  Osteoclast differentiation
mthb04550  Signaling pathways regulating pluripotency of stem cells
mthb04620  Toll-like receptor signaling pathway
mthb04621  NOD-like receptor signaling pathway
mthb04630  JAK-STAT signaling pathway
mthb04658  Th1 and Th2 cell differentiation
mthb04659  Th17 cell differentiation
mthb05140  Leishmaniasis
mthb05145  Toxoplasmosis
mthb05152  Tuberculosis
mthb05160  Hepatitis C
mthb05161  Hepatitis B
mthb05162  Measles
mthb05163  Human cytomegalovirus infection
mthb05164  Influenza A
mthb05165  Human papillomavirus infection
mthb05166  Human T-cell leukemia virus 1 infection
mthb05167  Kaposi sarcoma-associated herpesvirus infection
mthb05168  Herpes simplex virus 1 infection
mthb05169  Epstein-Barr virus infection
mthb05171  Coronavirus disease - COVID-19
mthb05200  Pathways in cancer
mthb05203  Viral carcinogenesis
mthb05212  Pancreatic cancer
mthb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mthb00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    126935739
   04151 PI3K-Akt signaling pathway
    126935739
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    126935739
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    126935739
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    126935739
   04621 NOD-like receptor signaling pathway
    126935739
   04658 Th1 and Th2 cell differentiation
    126935739
   04659 Th17 cell differentiation
    126935739
  09158 Development and regeneration
   04380 Osteoclast differentiation
    126935739
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126935739
   05203 Viral carcinogenesis
    126935739
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    126935739
  09162 Cancer: specific types
   05212 Pancreatic cancer
    126935739
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    126935739
   05161 Hepatitis B
    126935739
   05160 Hepatitis C
    126935739
   05171 Coronavirus disease - COVID-19
    126935739
   05164 Influenza A
    126935739
   05162 Measles
    126935739
   05168 Herpes simplex virus 1 infection
    126935739
   05163 Human cytomegalovirus infection
    126935739
   05167 Kaposi sarcoma-associated herpesvirus infection
    126935739
   05169 Epstein-Barr virus infection
    126935739
   05165 Human papillomavirus infection
    126935739
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    126935739
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    126935739
   05140 Leishmaniasis
    126935739
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    126935739
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mthb01001]
    126935739
Enzymes [BR:mthb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     126935739
Protein kinases [BR:mthb01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   126935739
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 FERM_C_FAK1
Other DBs
NCBI-GeneID: 126935739
NCBI-ProteinID: XP_050613540
LinkDB
Position
1:complement(64060435..64190948)
AA seq 1216 aa
MNQNSLFSEEALESREENPVCFLGNTGQLNKCSHIVVLPVLFSESSSTGHCQLDFFLFQT
MSHLYLNIKEDCNAMAFCAKMRSSKKTEVNLEVPEPGVEVIFYMSDREPLRLGSGEYTAE
ELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHG
TNDNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKT
EQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRM
RINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENE
MNWFHSNDSGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNK
IREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTAD
AHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMT
VTCFEKSEQGQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISF
MLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRIFKKDLVQGEHLGRGTRTHIY
SGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCV
RDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTK
NLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWS
FGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFF
RAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEG
DNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEF
LPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVK
IGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYC
DSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSN
RTSFQNLIEGFEALLK
NT seq 3651 nt   +upstreamnt  +downstreamnt
atgaaccagaactctctcttctctgaagaagctttggaaagtagagaagaaaatccagtc
tgcttcttggggaacactggacagctgaataaatgcagccacatagtagtcctgcctgtt
ttgtttagtgagtcctcttctactggacattgtcagttggattttttcctatttcaaaca
atgtcacatctttatctaaatataaaagaggactgcaatgccatggctttctgtgctaaa
atgaggagctccaagaagactgaggtgaacctggaggtccctgagccaggggtggaagtg
atcttctatatgtcggacagggagcccctccggctgggcagtggagagtatacagcagag
gaactgtgcatcagggctgcacaggcatgccgtatctctcctctttgtcacaacctcttt
gccctgtatgatgagaacaccaagctctggtatgctccaaatcgcaccatcaccgttgat
gacaagatgtccctccgactccactaccggatgaggttctatttcaccaattggcacgga
accaacgacaatgagcagtcagtgtggcgtcattctccaaagaagcagaaaaatggctac
gagaaaaaaaaggttccagatgcaacccctctccttgatgccagctcactggagtatctg
tttgctcagggacagtatgatttggtgaaatgcctggctcccattcgagaccccaagacc
gagcaggatgggcatgatattgaaaacgagtgtctggggatggctgtcctggccatctca
cactatgccatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaag
cgatatattccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatg
cggataaataatgttttcaaggatttcctaaaggaatttaacaacaagaccatttgtgac
agcagcgtgtccacgcatgacctgaaggtgaaatacttggctactttggaaactttgaca
aaacattatggcgctgaaatatttgagacttccatgttgctgatttcatcagaaaatgag
atgaattggtttcattcgaatgacagtggaaacgttctgtactatgaagtgatggtgact
gggaatcttggaatccagtggaggcataaaccaaatgttgtttctgttgaaaaggaaaaa
aataaactgaagcggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaag
atccgggaagagtggaataatttttcttacttccctgaaatcactcacattgtaataaag
gagtctgtggtcagcattaacaagcaggacaacaagaaaatggaactgaagctctcttcc
catgaggaggccttgtcctttgtgtcactggtagatggctacttccggctcaccgcagac
gcccatcattacctctgcaccgacgtggcccccccgttgatcgtccacaacatacagaat
ggctgtcatggtccaatctgtacagaatatgccatcaataaattgcggcaagaaggaagc
gaggaggggatgtacgtgctgaggtggagctgcaccgactttgacaacatcctcatgacc
gtcacctgctttgagaagtctgagcaggggcagggtgcccagaagcagttcaagaacttt
cagatcgaggtgcagaagggccgctacagcctgcatggttcagaccgcagcttccccagc
ttgggagacctcatgagccacctcaagaagcagatcctgcgcacggataacatcagcttc
atgttgaaacgctgctgccagcccaagccccgagaaatctccaacctgctggtggctact
aagaaagcccaggagtggcagcccgtctaccccatgagccagctgagttttgatcggatc
ttcaagaaggatctggtgcagggcgagcaccttgggagaggcacgagaacacacatctac
tctgggaccctgatggattacaaggatgacgaaggaacttctgaagagaagaagataaaa
gtgatcctcaaagtcttagaccccagccacagggatatttccctggccttcttcgaggcg
gccagcatgatgagacaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtc
cgcgacgtggagaatatcatggtggaagagtttgtggaagggggtcctctggatctcttc
atgcaccggaaaagcgatgtccttactacaccctggaaattcaaagttgccaaacagctg
gccagtgccctgagctacttggaagataaagacctggtccatggaaatgtgtgtactaaa
aacctcctcctggcccgtgagggcatcgacagcgagtgtggtccgttcatcaagctcagt
gaccctggcatccccattacggtgctgtctaggcaagagtgcattgaacgaatcccatgg
attgctcctgagtgtgttgaggactccaagaacctgagtgtggctgctgacaagtggagc
tttggaactacgctctgggaaatctgctacaatggcgagatccccttgaaagacaagaca
ctgattgagaaagagagattctatgaaagccggtgcaggccagtgacaccatcatgtaag
gagctggctgacctcatgacccgctgcatgaactacgaccccaatcagaggcccttcttc
cgagccatcatgagagacattaataagcttgaagagcagaatccagatattgtttcagaa
aaaaagccagcaactgaagtggaccccacgcattttgagaagcgcttcctaaagaggatc
cgtgacttgggagagggccactttgggaaggttgagctctgcaggtatgaccccgaaggg
gacaatacaggggagcaggtggctgtcaaatctctgaagcctgagagtggaggtaaccac
atagctgatctgaaaaaggaaatcgagatcttaaggaacctctatcatgagaacattgtg
aagtacaaaggaatctgcacggaagacggaggaaatggtattaagctcatcatggaattt
ctgccttcgggaagccttaaggagtatcttccaaagaataagaacaaaattaacctcaaa
cagcagctaaaatatgccgttcagatttgtaaggggatggactatttgggttctcggcaa
tatgttcaccgtgacttggcagcaagaaatgtccttgttgagagtgaacaccaagtgaaa
attggagacttcggtttaaccaaagcaattgaaaccgataaggagtattacaccgtcaag
gatgaccgggacagccctgtgttttggtatgctccagaatgtttaatgcaatctaaattt
tatatcgcctctgacgtctggtcttttggagtcactctgcatgagctgctgacttactgt
gattcagattctagtcccatggctttgttcctgaaaatgataggcccaacccatggccag
atgacagtcacaagacttgtgaatacattaaaagaaggaaaacgcctgccgtgcccgcct
aactgtccagatgaggtttatcaacttatgaggaaatgctgggaattccaaccatccaat
cggacaagctttcagaaccttattgaaggatttgaagcacttttaaaataa

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