KEGG   Macaca thibetana thibetana (Pere David's macaque): 126943961
Entry
126943961         CDS       T08579                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
mthb  Macaca thibetana thibetana (Pere David's macaque)
Pathway
mthb00562  Inositol phosphate metabolism
mthb01100  Metabolic pathways
mthb01521  EGFR tyrosine kinase inhibitor resistance
mthb04012  ErbB signaling pathway
mthb04014  Ras signaling pathway
mthb04020  Calcium signaling pathway
mthb04062  Chemokine signaling pathway
mthb04064  NF-kappa B signaling pathway
mthb04066  HIF-1 signaling pathway
mthb04070  Phosphatidylinositol signaling system
mthb04072  Phospholipase D signaling pathway
mthb04360  Axon guidance
mthb04370  VEGF signaling pathway
mthb04380  Osteoclast differentiation
mthb04611  Platelet activation
mthb04613  Neutrophil extracellular trap formation
mthb04625  C-type lectin receptor signaling pathway
mthb04650  Natural killer cell mediated cytotoxicity
mthb04662  B cell receptor signaling pathway
mthb04664  Fc epsilon RI signaling pathway
mthb04666  Fc gamma R-mediated phagocytosis
mthb04670  Leukocyte transendothelial migration
mthb04722  Neurotrophin signaling pathway
mthb04750  Inflammatory mediator regulation of TRP channels
mthb04919  Thyroid hormone signaling pathway
mthb04933  AGE-RAGE signaling pathway in diabetic complications
mthb04935  Growth hormone synthesis, secretion and action
mthb05167  Kaposi sarcoma-associated herpesvirus infection
mthb05169  Epstein-Barr virus infection
mthb05170  Human immunodeficiency virus 1 infection
mthb05171  Coronavirus disease - COVID-19
mthb05200  Pathways in cancer
mthb05205  Proteoglycans in cancer
mthb05206  MicroRNAs in cancer
mthb05214  Glioma
mthb05223  Non-small cell lung cancer
mthb05225  Hepatocellular carcinoma
Module
mthb_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mthb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    126943961
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    126943961
   04014 Ras signaling pathway
    126943961
   04370 VEGF signaling pathway
    126943961
   04064 NF-kappa B signaling pathway
    126943961
   04066 HIF-1 signaling pathway
    126943961
   04020 Calcium signaling pathway
    126943961
   04070 Phosphatidylinositol signaling system
    126943961
   04072 Phospholipase D signaling pathway
    126943961
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    126943961
   04613 Neutrophil extracellular trap formation
    126943961
   04625 C-type lectin receptor signaling pathway
    126943961
   04650 Natural killer cell mediated cytotoxicity
    126943961
   04662 B cell receptor signaling pathway
    126943961
   04664 Fc epsilon RI signaling pathway
    126943961
   04666 Fc gamma R-mediated phagocytosis
    126943961
   04670 Leukocyte transendothelial migration
    126943961
   04062 Chemokine signaling pathway
    126943961
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    126943961
   04919 Thyroid hormone signaling pathway
    126943961
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    126943961
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    126943961
  09158 Development and regeneration
   04360 Axon guidance
    126943961
   04380 Osteoclast differentiation
    126943961
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126943961
   05206 MicroRNAs in cancer
    126943961
   05205 Proteoglycans in cancer
    126943961
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    126943961
   05214 Glioma
    126943961
   05223 Non-small cell lung cancer
    126943961
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    126943961
   05171 Coronavirus disease - COVID-19
    126943961
   05167 Kaposi sarcoma-associated herpesvirus infection
    126943961
   05169 Epstein-Barr virus infection
    126943961
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    126943961
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    126943961
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mthb04131]
    126943961
Enzymes [BR:mthb01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     126943961
Membrane trafficking [BR:mthb04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    126943961
 Endocytosis
  Macropinocytosis
   Phospholipase C
    126943961
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 SH3_1 C2 SH3_9 PH PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 EF-hand_like
Other DBs
NCBI-GeneID: 126943961
NCBI-ProteinID: XP_050629150
LinkDB
Position
20:24788082..24978393
AA seq 1265 aa
MSTMVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAL
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHRDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLVHEQQEHWAQDLSKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKEHAFVTSSFPVILSIEEHCSVEQQRHMAKT
FKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTTEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYESLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGCLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSITRQKPVDLLRYNQKGLTRIYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKF
MQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGADYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq 3798 nt   +upstreamnt  +downstreamnt
atgtccaccatggtcaatgtggattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacagtgatgactgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgaacgtgcaaaagcggttcgccagaaagaagattgctgcttcaccatcctgtat
ggcactcagttcgtcctcagcacactcagcttggcagctgactctaaagaagatgcactt
aattggctctccggcttgaaaatcttacaccaagaagcgatgaatgcgtccacacccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacagagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgttcgagcagcaaaaatcgattctcgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacacagacaggccggatgcctccgct
gtttacctgcatgacttccagaggtttctcgtacatgaacagcaggagcattgggctcag
gatctgagcaaagtccgtgagcggatgacaaagttcatcgatgacaccatgcgcgaaact
gctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagc
atctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtcccataacacgtacctcacaggtgaccagctgcggagcgagtca
tccccagaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccgatcatctaccacggctggacgcggaccaccaagatc
aagtttgacgacgtcgtacaggccatcaaagagcacgcctttgttacctcaagcttccca
gtgatcctgtccatcgaggagcactgcagcgtggagcagcagcgtcacatggccaagacc
ttcaaggaagtgtttggtgacctgctgctgatgaagcccacggaggccagcgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggtccc
cgaggcgacgtggatgtcaacgtggaggacaagaaggatgagcacaagcaacagggagag
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgcgccattgctgac
gccaagctgtccttcagtgatgacattgaacagactacggaggaggaagtgccccaggat
ataccccctacagagctacattttggggagaaatggttccacaagaaggtggagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggacggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtgcagcactgccggatccgttccaccatggaaggtggaaccctaaagtactac
ctgactgacaacctcaccttcagcagcatctacgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgagagcctgagccgcggagaggcagaggacatgctg
atgaggatcccccgggacggagccttcctgatccggaagcgagagggaagcgactcctac
gccatcaccttcagggctaggggcaaggtgaagcattgtcgaatcaaccgggatggccgg
cactttgtgctggggacctccgcctattttgagagcctggtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaacatggaaagagatataaactccctctacgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggtgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatctcaacggcagatgtcgaggagctggaaaagcagattatt
gaagacaatcccttagggtgtctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagccccacagggaaaaaaccagaagccctttgtctttatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctcttcgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccgacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcatcaccagacagaagcccgtcgacctcctgaggtacaatcaaaag
ggcctgacccgcatctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacagcagataagttc
atgcagatgaatcacgcgttgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgagggcagagaaatatgacccaatgccacccgagtcccagaggaagatcctg
atgacgctgacggtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccctttgtagaggtggagatctgtggagccgactatgacaacaacaagttcaag
acgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acatttgaaatttatgacccaaacctggcatttctgcgctttgtggtttacgaagaagat
atgttcagtgatcccaactttcttgctcatgccacttaccccattaaagcaatcaaatca
ggattcaggtctgttcctctgaagaacgggtacagcgaggacatagagctggcttccctc
ctggttttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgt
cgccagctaaggaggcggcaagaagaactgaacaaccaactctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctggttaaagagttcaatgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttactcatag

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