KEGG   Macaca thibetana thibetana (Pere David's macaque): 126954697
Entry
126954697         CDS       T08579                                 
Name
(RefSeq) mitogen-activated protein kinase 10 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
mthb  Macaca thibetana thibetana (Pere David's macaque)
Pathway
mthb01522  Endocrine resistance
mthb04010  MAPK signaling pathway
mthb04012  ErbB signaling pathway
mthb04014  Ras signaling pathway
mthb04024  cAMP signaling pathway
mthb04068  FoxO signaling pathway
mthb04071  Sphingolipid signaling pathway
mthb04137  Mitophagy - animal
mthb04140  Autophagy - animal
mthb04141  Protein processing in endoplasmic reticulum
mthb04210  Apoptosis
mthb04215  Apoptosis - multiple species
mthb04217  Necroptosis
mthb04310  Wnt signaling pathway
mthb04380  Osteoclast differentiation
mthb04510  Focal adhesion
mthb04530  Tight junction
mthb04620  Toll-like receptor signaling pathway
mthb04621  NOD-like receptor signaling pathway
mthb04622  RIG-I-like receptor signaling pathway
mthb04625  C-type lectin receptor signaling pathway
mthb04657  IL-17 signaling pathway
mthb04658  Th1 and Th2 cell differentiation
mthb04659  Th17 cell differentiation
mthb04660  T cell receptor signaling pathway
mthb04664  Fc epsilon RI signaling pathway
mthb04668  TNF signaling pathway
mthb04722  Neurotrophin signaling pathway
mthb04723  Retrograde endocannabinoid signaling
mthb04728  Dopaminergic synapse
mthb04750  Inflammatory mediator regulation of TRP channels
mthb04910  Insulin signaling pathway
mthb04912  GnRH signaling pathway
mthb04914  Progesterone-mediated oocyte maturation
mthb04917  Prolactin signaling pathway
mthb04920  Adipocytokine signaling pathway
mthb04926  Relaxin signaling pathway
mthb04930  Type II diabetes mellitus
mthb04931  Insulin resistance
mthb04932  Non-alcoholic fatty liver disease
mthb04933  AGE-RAGE signaling pathway in diabetic complications
mthb04935  Growth hormone synthesis, secretion and action
mthb04936  Alcoholic liver disease
mthb05010  Alzheimer disease
mthb05012  Parkinson disease
mthb05016  Huntington disease
mthb05017  Spinocerebellar ataxia
mthb05020  Prion disease
mthb05022  Pathways of neurodegeneration - multiple diseases
mthb05132  Salmonella infection
mthb05133  Pertussis
mthb05135  Yersinia infection
mthb05142  Chagas disease
mthb05145  Toxoplasmosis
mthb05152  Tuberculosis
mthb05161  Hepatitis B
mthb05162  Measles
mthb05166  Human T-cell leukemia virus 1 infection
mthb05167  Kaposi sarcoma-associated herpesvirus infection
mthb05169  Epstein-Barr virus infection
mthb05170  Human immunodeficiency virus 1 infection
mthb05171  Coronavirus disease - COVID-19
mthb05200  Pathways in cancer
mthb05208  Chemical carcinogenesis - reactive oxygen species
mthb05210  Colorectal cancer
mthb05212  Pancreatic cancer
mthb05231  Choline metabolism in cancer
mthb05415  Diabetic cardiomyopathy
mthb05417  Lipid and atherosclerosis
mthb05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mthb00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    126954697
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    126954697
   04012 ErbB signaling pathway
    126954697
   04014 Ras signaling pathway
    126954697
   04310 Wnt signaling pathway
    126954697
   04668 TNF signaling pathway
    126954697
   04068 FoxO signaling pathway
    126954697
   04071 Sphingolipid signaling pathway
    126954697
   04024 cAMP signaling pathway
    126954697
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    126954697
   04137 Mitophagy - animal
    126954697
  09143 Cell growth and death
   04210 Apoptosis
    126954697
   04215 Apoptosis - multiple species
    126954697
   04217 Necroptosis
    126954697
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    126954697
   04530 Tight junction
    126954697
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    126954697
   04621 NOD-like receptor signaling pathway
    126954697
   04622 RIG-I-like receptor signaling pathway
    126954697
   04625 C-type lectin receptor signaling pathway
    126954697
   04660 T cell receptor signaling pathway
    126954697
   04658 Th1 and Th2 cell differentiation
    126954697
   04659 Th17 cell differentiation
    126954697
   04657 IL-17 signaling pathway
    126954697
   04664 Fc epsilon RI signaling pathway
    126954697
  09152 Endocrine system
   04910 Insulin signaling pathway
    126954697
   04920 Adipocytokine signaling pathway
    126954697
   04912 GnRH signaling pathway
    126954697
   04914 Progesterone-mediated oocyte maturation
    126954697
   04917 Prolactin signaling pathway
    126954697
   04926 Relaxin signaling pathway
    126954697
   04935 Growth hormone synthesis, secretion and action
    126954697
  09156 Nervous system
   04728 Dopaminergic synapse
    126954697
   04723 Retrograde endocannabinoid signaling
    126954697
   04722 Neurotrophin signaling pathway
    126954697
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    126954697
  09158 Development and regeneration
   04380 Osteoclast differentiation
    126954697
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126954697
   05208 Chemical carcinogenesis - reactive oxygen species
    126954697
   05231 Choline metabolism in cancer
    126954697
  09162 Cancer: specific types
   05210 Colorectal cancer
    126954697
   05212 Pancreatic cancer
    126954697
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    126954697
   05170 Human immunodeficiency virus 1 infection
    126954697
   05161 Hepatitis B
    126954697
   05171 Coronavirus disease - COVID-19
    126954697
   05162 Measles
    126954697
   05167 Kaposi sarcoma-associated herpesvirus infection
    126954697
   05169 Epstein-Barr virus infection
    126954697
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    126954697
   05135 Yersinia infection
    126954697
   05133 Pertussis
    126954697
   05152 Tuberculosis
    126954697
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    126954697
   05142 Chagas disease
    126954697
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    126954697
   05012 Parkinson disease
    126954697
   05016 Huntington disease
    126954697
   05017 Spinocerebellar ataxia
    126954697
   05020 Prion disease
    126954697
   05022 Pathways of neurodegeneration - multiple diseases
    126954697
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    126954697
   05418 Fluid shear stress and atherosclerosis
    126954697
   05415 Diabetic cardiomyopathy
    126954697
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    126954697
   04936 Alcoholic liver disease
    126954697
   04932 Non-alcoholic fatty liver disease
    126954697
   04931 Insulin resistance
    126954697
   04933 AGE-RAGE signaling pathway in diabetic complications
    126954697
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    126954697
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mthb01001]
    126954697
Enzymes [BR:mthb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     126954697
Protein kinases [BR:mthb01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   126954697
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like APH FTA2
Other DBs
NCBI-GeneID: 126954697
NCBI-ProteinID: XP_050646431
LinkDB
Position
5:102474498..102920380
AA seq 464 aa
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
NT seq 1395 nt   +upstreamnt  +downstreamnt
atgagcctccatttcttatactactgcagtgaaccaacattggatgtgaaaattgccttt
tgtcagggattcgataaacaagtggatgtgtcatatattgccaaacattacaacatgagc
aaaagcaaagttgacaaccaattctacagtgtggaagtgggagactcaaccttcacagtt
ctcaagcgctaccagaatctaaagcctattggctctggggctcagggcatagtttgtgcc
gcgtatgatgctgtccttgacagaaatgtggccattaagaagctcagcagaccctttcag
aaccaaacccatgccaagagagcgtaccgggagctggtcctcatgaagtgtgtgaaccat
aaaaacattattagtttattaaatgtcttcacaccccagaaaacgctggaggagttccaa
gatgtttacttagtaatggaactgatggatgccaacttatgtcaagtgattcagatggaa
ttagaccacgagcgaatgtcttacctgctgtaccaaatgctgtgtggcattaagcacctc
cactctgctggaattattcacagggatttaaaaccaagtaacattgtagtcaagtctgat
tgcacattgaaaatcctggactttggactggccaggacagcaggcacaagcttcatgatg
actccatatgtggtgacacgttattacagagccccggaggtcatcctggggatgggctac
aaggagaacgtggatatatggtctgtgggatgcattatgggagaaatggttcgccacaaa
atcctctttccaggaagggactatattgaccagtggaataaggtaattgaacaactagga
acaccatgtccagaattcatgaagaaattgcaacccacagtaagaaactatgtggagaat
cggcccaagtatgcgggactcaccttccccaagctcttcccagattccctcttcccagcg
gactccgagcacaataaactcaaagccagccaagccagggacttgttgtcaaagatgcta
gtgattgacccagcaaaaagaatatcagtggacgacgccttacagcatccctacatcaac
gtctggtatgacccagctgaagtggaggcgcctccacctcagatatatgacaagcagttg
gatgaaagagaacacacaattgaagaatggaaagaacttatctacaaggaagtaatgaac
tcagaagagaagactaaaaatggcgtagtaaaaggacagccttctccttcaggtgcagca
gtgaacagcagtgagagtctccctccatcctcgtctgtcaatgacatctcctccatgtcc
accgaccagaccctggcatctgacactgacagcagcctggaagcttcggcaggacccctg
ggttgttgcaggtga

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