KEGG   Macaca thibetana thibetana (Pere David's macaque): 126959416
Entry
126959416         CDS       T08579                                 
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mthb  Macaca thibetana thibetana (Pere David's macaque)
Pathway
mthb01521  EGFR tyrosine kinase inhibitor resistance
mthb01522  Endocrine resistance
mthb01524  Platinum drug resistance
mthb04010  MAPK signaling pathway
mthb04012  ErbB signaling pathway
mthb04014  Ras signaling pathway
mthb04015  Rap1 signaling pathway
mthb04022  cGMP-PKG signaling pathway
mthb04024  cAMP signaling pathway
mthb04062  Chemokine signaling pathway
mthb04066  HIF-1 signaling pathway
mthb04068  FoxO signaling pathway
mthb04071  Sphingolipid signaling pathway
mthb04072  Phospholipase D signaling pathway
mthb04140  Autophagy - animal
mthb04150  mTOR signaling pathway
mthb04151  PI3K-Akt signaling pathway
mthb04152  AMPK signaling pathway
mthb04210  Apoptosis
mthb04211  Longevity regulating pathway
mthb04213  Longevity regulating pathway - multiple species
mthb04218  Cellular senescence
mthb04261  Adrenergic signaling in cardiomyocytes
mthb04370  VEGF signaling pathway
mthb04371  Apelin signaling pathway
mthb04380  Osteoclast differentiation
mthb04510  Focal adhesion
mthb04550  Signaling pathways regulating pluripotency of stem cells
mthb04611  Platelet activation
mthb04613  Neutrophil extracellular trap formation
mthb04620  Toll-like receptor signaling pathway
mthb04625  C-type lectin receptor signaling pathway
mthb04630  JAK-STAT signaling pathway
mthb04660  T cell receptor signaling pathway
mthb04662  B cell receptor signaling pathway
mthb04664  Fc epsilon RI signaling pathway
mthb04666  Fc gamma R-mediated phagocytosis
mthb04668  TNF signaling pathway
mthb04722  Neurotrophin signaling pathway
mthb04725  Cholinergic synapse
mthb04728  Dopaminergic synapse
mthb04810  Regulation of actin cytoskeleton
mthb04910  Insulin signaling pathway
mthb04914  Progesterone-mediated oocyte maturation
mthb04915  Estrogen signaling pathway
mthb04917  Prolactin signaling pathway
mthb04919  Thyroid hormone signaling pathway
mthb04920  Adipocytokine signaling pathway
mthb04922  Glucagon signaling pathway
mthb04923  Regulation of lipolysis in adipocytes
mthb04926  Relaxin signaling pathway
mthb04929  GnRH secretion
mthb04931  Insulin resistance
mthb04932  Non-alcoholic fatty liver disease
mthb04933  AGE-RAGE signaling pathway in diabetic complications
mthb04935  Growth hormone synthesis, secretion and action
mthb04936  Alcoholic liver disease
mthb04973  Carbohydrate digestion and absorption
mthb05010  Alzheimer disease
mthb05017  Spinocerebellar ataxia
mthb05132  Salmonella infection
mthb05135  Yersinia infection
mthb05142  Chagas disease
mthb05145  Toxoplasmosis
mthb05152  Tuberculosis
mthb05160  Hepatitis C
mthb05161  Hepatitis B
mthb05162  Measles
mthb05163  Human cytomegalovirus infection
mthb05164  Influenza A
mthb05165  Human papillomavirus infection
mthb05166  Human T-cell leukemia virus 1 infection
mthb05167  Kaposi sarcoma-associated herpesvirus infection
mthb05168  Herpes simplex virus 1 infection
mthb05169  Epstein-Barr virus infection
mthb05170  Human immunodeficiency virus 1 infection
mthb05200  Pathways in cancer
mthb05205  Proteoglycans in cancer
mthb05207  Chemical carcinogenesis - receptor activation
mthb05208  Chemical carcinogenesis - reactive oxygen species
mthb05210  Colorectal cancer
mthb05211  Renal cell carcinoma
mthb05212  Pancreatic cancer
mthb05213  Endometrial cancer
mthb05214  Glioma
mthb05215  Prostate cancer
mthb05218  Melanoma
mthb05220  Chronic myeloid leukemia
mthb05221  Acute myeloid leukemia
mthb05222  Small cell lung cancer
mthb05223  Non-small cell lung cancer
mthb05224  Breast cancer
mthb05225  Hepatocellular carcinoma
mthb05226  Gastric cancer
mthb05230  Central carbon metabolism in cancer
mthb05231  Choline metabolism in cancer
mthb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mthb05415  Diabetic cardiomyopathy
mthb05417  Lipid and atherosclerosis
mthb05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mthb00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    126959416
   04015 Rap1 signaling pathway
    126959416
   04630 JAK-STAT signaling pathway
    126959416
   04668 TNF signaling pathway
    126959416
   04066 HIF-1 signaling pathway
    126959416
   04068 FoxO signaling pathway
    126959416
   04072 Phospholipase D signaling pathway
    126959416
   04071 Sphingolipid signaling pathway
    126959416
   04024 cAMP signaling pathway
    126959416
   04022 cGMP-PKG signaling pathway
    126959416
   04151 PI3K-Akt signaling pathway
    126959416
   04152 AMPK signaling pathway
    126959416
   04150 mTOR signaling pathway
    126959416
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    126959416
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    126959416
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    126959416
   04613 Neutrophil extracellular trap formation
    126959416
   04620 Toll-like receptor signaling pathway
    126959416
   04660 T cell receptor signaling pathway
    126959416
   04662 B cell receptor signaling pathway
    126959416
   04664 Fc epsilon RI signaling pathway
    126959416
   04666 Fc gamma R-mediated phagocytosis
    126959416
   04062 Chemokine signaling pathway
    126959416
  09152 Endocrine system
   04922 Glucagon signaling pathway
    126959416
   04923 Regulation of lipolysis in adipocytes
    126959416
   04929 GnRH secretion
    126959416
   04915 Estrogen signaling pathway
    126959416
   04917 Prolactin signaling pathway
    126959416
   04926 Relaxin signaling pathway
    126959416
   04935 Growth hormone synthesis, secretion and action
    126959416
   04919 Thyroid hormone signaling pathway
    126959416
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    126959416
  09156 Nervous system
   04725 Cholinergic synapse
    126959416
   04728 Dopaminergic synapse
    126959416
   04722 Neurotrophin signaling pathway
    126959416
  09158 Development and regeneration
   04380 Osteoclast differentiation
    126959416
  09149 Aging
   04211 Longevity regulating pathway
    126959416
   04213 Longevity regulating pathway - multiple species
    126959416
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126959416
   05205 Proteoglycans in cancer
    126959416
   05207 Chemical carcinogenesis - receptor activation
    126959416
   05208 Chemical carcinogenesis - reactive oxygen species
    126959416
   05230 Central carbon metabolism in cancer
    126959416
   05231 Choline metabolism in cancer
    126959416
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    126959416
  09162 Cancer: specific types
   05210 Colorectal cancer
    126959416
   05212 Pancreatic cancer
    126959416
   05225 Hepatocellular carcinoma
    126959416
   05226 Gastric cancer
    126959416
   05214 Glioma
    126959416
   05221 Acute myeloid leukemia
    126959416
   05220 Chronic myeloid leukemia
    126959416
   05218 Melanoma
    126959416
   05211 Renal cell carcinoma
    126959416
   05215 Prostate cancer
    126959416
   05213 Endometrial cancer
    126959416
   05224 Breast cancer
    126959416
   05222 Small cell lung cancer
    126959416
   05223 Non-small cell lung cancer
    126959416
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    126959416
   05170 Human immunodeficiency virus 1 infection
    126959416
   05161 Hepatitis B
    126959416
   05160 Hepatitis C
    126959416
   05164 Influenza A
    126959416
   05162 Measles
    126959416
   05163 Human cytomegalovirus infection
    126959416
   05167 Kaposi sarcoma-associated herpesvirus infection
    126959416
   05169 Epstein-Barr virus infection
    126959416
   05165 Human papillomavirus infection
    126959416
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    126959416
   05152 Tuberculosis
    126959416
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    126959416
   05142 Chagas disease
    126959416
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    126959416
   05017 Spinocerebellar ataxia
    126959416
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    126959416
   05418 Fluid shear stress and atherosclerosis
    126959416
   05415 Diabetic cardiomyopathy
    126959416
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    126959416
   04932 Non-alcoholic fatty liver disease
    126959416
   04931 Insulin resistance
    126959416
   04933 AGE-RAGE signaling pathway in diabetic complications
    126959416
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    126959416
   01524 Platinum drug resistance
    126959416
   01522 Endocrine resistance
    126959416
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mthb01001]
    126959416
Enzymes [BR:mthb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     126959416
Protein kinases [BR:mthb01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   126959416
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_11 PH_20 Seadorna_VP7
Other DBs
NCBI-GeneID: 126959416
NCBI-ProteinID: XP_050654374
LinkDB
Position
7:2651098..2679179
AA seq 480 aa
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKHEEEMMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgagcgacgtggctattgtgaaggagggctggctgcacaaacgaggggagtacatcaag
acctggcgaccacgctacttcctcctcaagaatgatggcactttcattggctataaggag
cggccgcaggacgtggaccaacgtgaggcccccctcaacaacttctctgtggcacagtgc
cagctgatgaagacggagcggccccggcccaacaccttcatcatccgctgcctgcagtgg
accactgtcatcgaacgcaccttccacgtggagactcccgaggagcgggaggagtggaca
accgccatccagacagtggccgatggcctcaagaagcacgaggaggagatgatggacttc
cggtcgggctcacccagcgacaactcaggggctgaagagatggaggtgtccctggccaaa
cccaagcaccgtgtgaccatgaacgagtttgagtacctgaagctgctgggcaagggcact
ttcgggaaggtgatcctggtgaaggagaaggcaacgggccgctactatgccatgaagatc
ctcaagaaggaggtcatcgtggccaaggacgaggtggcccacacactcaccgagaaccgt
gttctgcagaactccaggcaccccttcctcacggccctgaagtactccttccagacccac
gaccgcctctgcttcgtcatggagtacgccaatgggggcgagctcttcttccacctgtcc
cgggagcgtgtgttctctgaggaccgggcccgcttctatggcgccgagatcgtgtcagcc
ctggactacctgcactcggagaagaatgtggtgtaccgggacctcaagctggagaacctc
atgctggacaaggacgggcacattaagatcacagacttcgggctgtgcaaggaggggatc
aaggacggcgccaccatgaagaccttctgcggcacacctgagtacctggcccccgaggtg
ctggaggacaatgactacggccgtgcggtggactggtgggggctgggcgtggtcatgtat
gagatgatgtgcggccgcctgcccttctacaaccaggaccacgagaagctttttgagctc
atcctcatggaggagatccgcttcccgcgcacgcttggtcctgaagccaagtccttgctc
tcagggctgctcaagaaggaccccaagcagaggcttggcgggggctctgaggacgccaag
gagatcatgcagcatcgcttctttgccggcatcgtgtggcagcacgtgtatgagaagaag
ctcagcccacccttcaagccccaggtcacatcggagaccgacaccaggtattttgatgag
gagttcacggcccagatgatcaccatcacaccacctgaccaagacgacagcatggagtgc
gtggacagcgagcgcaggccccacttcccccagttctcctactcggccagcggcacggcc
tga

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