KEGG   Macaca thibetana thibetana (Pere David's macaque): 126964414
Entry
126964414         CDS       T08579                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mthb  Macaca thibetana thibetana (Pere David's macaque)
Pathway
mthb00562  Inositol phosphate metabolism
mthb01100  Metabolic pathways
mthb04015  Rap1 signaling pathway
mthb04020  Calcium signaling pathway
mthb04022  cGMP-PKG signaling pathway
mthb04062  Chemokine signaling pathway
mthb04070  Phosphatidylinositol signaling system
mthb04071  Sphingolipid signaling pathway
mthb04072  Phospholipase D signaling pathway
mthb04081  Hormone signaling
mthb04082  Neuroactive ligand signaling
mthb04261  Adrenergic signaling in cardiomyocytes
mthb04270  Vascular smooth muscle contraction
mthb04310  Wnt signaling pathway
mthb04371  Apelin signaling pathway
mthb04540  Gap junction
mthb04611  Platelet activation
mthb04613  Neutrophil extracellular trap formation
mthb04621  NOD-like receptor signaling pathway
mthb04713  Circadian entrainment
mthb04720  Long-term potentiation
mthb04723  Retrograde endocannabinoid signaling
mthb04724  Glutamatergic synapse
mthb04725  Cholinergic synapse
mthb04726  Serotonergic synapse
mthb04728  Dopaminergic synapse
mthb04730  Long-term depression
mthb04742  Taste transduction
mthb04750  Inflammatory mediator regulation of TRP channels
mthb04911  Insulin secretion
mthb04912  GnRH signaling pathway
mthb04915  Estrogen signaling pathway
mthb04916  Melanogenesis
mthb04918  Thyroid hormone synthesis
mthb04919  Thyroid hormone signaling pathway
mthb04921  Oxytocin signaling pathway
mthb04922  Glucagon signaling pathway
mthb04924  Renin secretion
mthb04925  Aldosterone synthesis and secretion
mthb04926  Relaxin signaling pathway
mthb04927  Cortisol synthesis and secretion
mthb04928  Parathyroid hormone synthesis, secretion and action
mthb04929  GnRH secretion
mthb04933  AGE-RAGE signaling pathway in diabetic complications
mthb04934  Cushing syndrome
mthb04935  Growth hormone synthesis, secretion and action
mthb04961  Endocrine and other factor-regulated calcium reabsorption
mthb04970  Salivary secretion
mthb04971  Gastric acid secretion
mthb04972  Pancreatic secretion
mthb04973  Carbohydrate digestion and absorption
mthb05010  Alzheimer disease
mthb05016  Huntington disease
mthb05017  Spinocerebellar ataxia
mthb05022  Pathways of neurodegeneration - multiple diseases
mthb05142  Chagas disease
mthb05143  African trypanosomiasis
mthb05146  Amoebiasis
mthb05163  Human cytomegalovirus infection
mthb05200  Pathways in cancer
mthb05415  Diabetic cardiomyopathy
mthb05417  Lipid and atherosclerosis
Module
mthb_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mthb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    126964414
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    126964414
   04310 Wnt signaling pathway
    126964414
   04070 Phosphatidylinositol signaling system
    126964414
   04072 Phospholipase D signaling pathway
    126964414
   04071 Sphingolipid signaling pathway
    126964414
   04022 cGMP-PKG signaling pathway
    126964414
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    126964414
   04081 Hormone signaling
    126964414
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    126964414
   04613 Neutrophil extracellular trap formation
    126964414
   04062 Chemokine signaling pathway
    126964414
  09152 Endocrine system
   04911 Insulin secretion
    126964414
   04922 Glucagon signaling pathway
    126964414
   04929 GnRH secretion
    126964414
   04915 Estrogen signaling pathway
    126964414
   04921 Oxytocin signaling pathway
    126964414
   04926 Relaxin signaling pathway
    126964414
   04935 Growth hormone synthesis, secretion and action
    126964414
   04918 Thyroid hormone synthesis
    126964414
   04919 Thyroid hormone signaling pathway
    126964414
   04928 Parathyroid hormone synthesis, secretion and action
    126964414
   04924 Renin secretion
    126964414
   04925 Aldosterone synthesis and secretion
    126964414
   04927 Cortisol synthesis and secretion
    126964414
  09154 Digestive system
   04970 Salivary secretion
    126964414
   04971 Gastric acid secretion
    126964414
   04972 Pancreatic secretion
    126964414
   04973 Carbohydrate digestion and absorption
    126964414
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    126964414
  09156 Nervous system
   04724 Glutamatergic synapse
    126964414
   04725 Cholinergic synapse
    126964414
   04728 Dopaminergic synapse
    126964414
   04726 Serotonergic synapse
    126964414
   04720 Long-term potentiation
    126964414
   04730 Long-term depression
    126964414
   04723 Retrograde endocannabinoid signaling
    126964414
  09157 Sensory system
   04742 Taste transduction
    126964414
   04750 Inflammatory mediator regulation of TRP channels
    126964414
  09159 Environmental adaptation
   04713 Circadian entrainment
    126964414
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126964414
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    126964414
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    126964414
   05142 Chagas disease
    126964414
   05143 African trypanosomiasis
    126964414
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    126964414
   05016 Huntington disease
    126964414
   05017 Spinocerebellar ataxia
    126964414
   05022 Pathways of neurodegeneration - multiple diseases
    126964414
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    126964414
   05415 Diabetic cardiomyopathy
    126964414
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    126964414
   04934 Cushing syndrome
    126964414
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mthb04131]
    126964414
Enzymes [BR:mthb01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     126964414
Membrane trafficking [BR:mthb04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    126964414
 Endocytosis
  Macropinocytosis
   Phospholipase C
    126964414
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 126964414
NCBI-ProteinID: XP_050663457
LinkDB
Position
10:76828456..77569996
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGIKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSFAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMELMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTCSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSETPSEVRTTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSS
EELGGDIPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcatcaaattcgtcaagtgggatgatgactcaactattgttactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctactggatctcagccttgtcaaagatgccagatgtgggagacacgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacatcgggcgcctggagcag
cgcatgatcacggtggtgtatgggcctgacctcgtgaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgtattcctctcaaaaacatatatcgcttgttttcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctcaacaacctttgc
cctcgacctgaaattgataacatcttttcagaatttggtgccaaaagcaaaccatatctt
accgttgaccagatgatggattttatcaaccttaagcagcgagatcctcggcttaatgaa
atactttatccacctctaaaacaagagcaagtccaagtattgattgagaagtatgaaccc
aacagcagcttcgccaaaaaaggacaaatatcagtggatgggttcatgcgctatctgagt
ggagaagaaaacggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcag
cccctttctcactatttcattaattcctcgcacaacacctacctcacagctggccaactg
gctggaaactcctctgttgagatgtatcgccaagtgcttctgtctggttgtcgctgtgtg
gagctggactgctggaagggacgaactgcagaagaggaacctgtcatcacccatggcttc
accatgacaactgaaatatctttcaaggaagtaatagaagcaattgcggagtgtgcattt
aagacttcaccttttccaattctcctttcatttgagaaccatgtggattccccaaagcag
caagccaagatggcggagtactgccgactgatctttggggatgcccttctcatggagccc
ctggaaaaatatccactggaatctggagttcctcttccaagccctatggagttaatgtat
aaaattttggtgaaaaataagaagaaatcacacaagtcatcagaaggaagcggcaaaaag
aagctctcagaacaagcctccaacacctgcagcgactcctccagcatgttcgagccctca
tccccaggagccggagaagctgatacggaaagtgacgacgatgatgatgatgatgactgt
aaaaaatcttcaatggatgaggggaccgctggaagtgaggctatggccacagaggaaatg
tctaacctggtgaactacattcagccggtcaagtttgagtcatttgaaatttcaaaaaaa
agaaataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacaactcacc
aagtctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
ggaacacgtgtggattcatccaactatatgcctcagctcttctggaatgcgggttgtcag
atggtggcacttaatttccagacaatggacctggctatgcaaataaatatggggatgtat
gaatacaacggaaagagtggctatcgattgaagccagagttcatgaggaggcctgacaag
cattttgatccatttactgaaggcatcgtagatgggatagtggcaaacactttgtctgtt
aagattatatcaggtcagtttctttctgataagaaagtcgggacttacgtggaagtggat
atgtttggtttgcctgtggatacaaggaggaaggcatttaagaccaagacatcccaagga
aatgctgtgaatcctgtctgggaagaagaacctattgtgttcaaaaaggtggttcttcct
actctggcctgtttgagaatagcagtttatgaagaaggaggtaaattcattggccaccgt
atcttgccagtgcaagccattcggccaggctatcactatatatgtctaaggaatgaaagg
aaccagcctctgatgctgcctgctgtctttgtctacatagaagtgaaagactatgtgcca
gacacatatgcagatgtcattgaagctttatcaaacccaatccggtatgtgaacctgatg
gagcagagagctaagcaattggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggagaaacaccatcagagactccaagtgaagtgagaacaactccagca
gaaaacggggtgaatcacactacatccctgacacccaagccaccctcccaggctctccac
agccagccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gtcttaacagaagtggaagcacagaccatcgaagagctaaagcaacagaaatcgtttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggttaagagacaccacaagaaa
accactgaccttatcaaagaacacactaccaagtataatgaaattcagaatgactacttg
agaaggagagcagctttggaaaagtccgccaaaaaggacagtaagaaaaaatcagaaccc
agcagccctgatcatggttcatcaacgattgagcaagacctcgctgccctggatgctgaa
atgacccaaaaattgatagacttgaaggacaaacaacagcagcagctgcttaatcttcgg
caagaacagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaa
aagttgacggatgtcgcagaagagtgtcagaacaatcagttaaagaagctcaaagaaatc
tgtgagaaagaaaagaaagaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagctaaatctaaagacaaaagtcagatggaagaggagaagacagagatgatccgg
tcatatatccaggaagtggtgcagtacatcaagaggctagaagaggcgcaaagtaaacgg
caagaaaaactcgtagagaaacacaaggaaatacgtcagcagatcctggatgaaaagccc
aagctgcaggtggagctggagcaagaataccaagacaaattcaaaagactgcccctcgag
attttggaattcgtgcaggaagccatgaaaggaaagatcagtgaagacagcaatcacggt
tctgcccctctctccctgtcctcagaccctggaaaagtgaaccacaagactccctccagt
gaggagctgggaggagacatcccaggaaaagaatttgatactcctctgtga

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