Entry |
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
|
KO |
|
Organism |
mthb Macaca thibetana thibetana (Pere David's macaque)
|
Pathway |
mthb04070 | Phosphatidylinositol signaling system |
mthb04261 | Adrenergic signaling in cardiomyocytes |
mthb04613 | Neutrophil extracellular trap formation |
mthb04621 | NOD-like receptor signaling pathway |
mthb04723 | Retrograde endocannabinoid signaling |
mthb04750 | Inflammatory mediator regulation of TRP channels |
mthb04925 | Aldosterone synthesis and secretion |
mthb04928 | Parathyroid hormone synthesis, secretion and action |
mthb04933 | AGE-RAGE signaling pathway in diabetic complications |
mthb04935 | Growth hormone synthesis, secretion and action |
mthb04961 | Endocrine and other factor-regulated calcium reabsorption |
mthb04973 | Carbohydrate digestion and absorption |
mthb05022 | Pathways of neurodegeneration - multiple diseases |
|
Module |
mthb_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:mthb00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
126964415
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
126964415
04310 Wnt signaling pathway
126964415
04371 Apelin signaling pathway
126964415
04020 Calcium signaling pathway
126964415
04070 Phosphatidylinositol signaling system
126964415
04072 Phospholipase D signaling pathway
126964415
04071 Sphingolipid signaling pathway
126964415
04022 cGMP-PKG signaling pathway
126964415
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
126964415
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
126964415
04613 Neutrophil extracellular trap formation
126964415
04621 NOD-like receptor signaling pathway
126964415
04062 Chemokine signaling pathway
126964415
09152 Endocrine system
04911 Insulin secretion
126964415
04922 Glucagon signaling pathway
126964415
04929 GnRH secretion
126964415
04912 GnRH signaling pathway
126964415
04915 Estrogen signaling pathway
126964415
04921 Oxytocin signaling pathway
126964415
04926 Relaxin signaling pathway
126964415
04935 Growth hormone synthesis, secretion and action
126964415
04918 Thyroid hormone synthesis
126964415
04919 Thyroid hormone signaling pathway
126964415
04928 Parathyroid hormone synthesis, secretion and action
126964415
04916 Melanogenesis
126964415
04924 Renin secretion
126964415
04925 Aldosterone synthesis and secretion
126964415
04927 Cortisol synthesis and secretion
126964415
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
126964415
04270 Vascular smooth muscle contraction
126964415
09154 Digestive system
04970 Salivary secretion
126964415
04971 Gastric acid secretion
126964415
04972 Pancreatic secretion
126964415
04973 Carbohydrate digestion and absorption
126964415
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
126964415
09156 Nervous system
04724 Glutamatergic synapse
126964415
04725 Cholinergic synapse
126964415
04728 Dopaminergic synapse
126964415
04726 Serotonergic synapse
126964415
04720 Long-term potentiation
126964415
04730 Long-term depression
126964415
04723 Retrograde endocannabinoid signaling
126964415
09157 Sensory system
04742 Taste transduction
126964415
04750 Inflammatory mediator regulation of TRP channels
126964415
09159 Environmental adaptation
04713 Circadian entrainment
126964415
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
126964415
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
126964415
09174 Infectious disease: parasitic
05146 Amoebiasis
126964415
05142 Chagas disease
126964415
05143 African trypanosomiasis
126964415
09164 Neurodegenerative disease
05010 Alzheimer disease
126964415
05016 Huntington disease
126964415
05017 Spinocerebellar ataxia
126964415
05022 Pathways of neurodegeneration - multiple diseases
126964415
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
126964415
05415 Diabetic cardiomyopathy
126964415
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
126964415
04934 Cushing syndrome
126964415
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mthb04131]
126964415
Enzymes [BR:mthb01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
126964415
Membrane trafficking [BR:mthb04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
126964415
Endocytosis
Macropinocytosis
Phospholipase C
126964415
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
10:77744185..78155945
|
AA seq |
1210 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPMAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEGNTT
ERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGC
QMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCS
VQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVIL
PDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYV
PDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTTKAN
VTPQSSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKK
KHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQT
LTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLISAHEQQTQQ
LKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKR
LAMKQSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQSQGEGDAADGEIGSRDGPQTS
NSSMKLQNAN |
NT seq |
3633 nt +upstreamnt +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaaggtcggatagtttgtgtc
tgcagtggcacagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacgtgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cccatggcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aacgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttacctgactggcagacagttcggcgggaag
tcttcggtagagatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggagatctcctgttgaaacaagcgcttgaatcacat
ccacttgaaccaggcagacctttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagaggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaatctgcctccccagcaaacatcttagaggatgataatgaagaggag
atcgaaagtgctgaccaagaggaggaagctcaccccgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcctcagat
gaccttgaacatgaaaacaacaaaaagggcctggtaactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtccacaatg
atcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaaggtaacaccaca
gaacgcaatattcattataacatgtcttcttttaatgaatcagtcggtcttggctacttg
aagacacatgcaattgaatttgtcaattataacaaacggcaaatgagtcgcatttacccc
aagggaggccgagtcgattccagtaattacatgcctcagattttctggaacgctggctgc
cagatggtttccctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaa
tttgagtataatggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgat
cgaacatttgaccccttctctgaaactcctgttgatggcgttattgcagccacttgctca
gtgcaggttatatcaggtcaattcttatcagataagaaaattggcacctatgtagaagtg
gatatgtatgggttgcccactgacactatacgtaaggaattccgaactcgtatggttatg
aataatggactaaatccagtttacaatgaagagtctttcgtatttcggaaggtgatcctg
ccagacctggctgtcttgagaatagcagtgtatgatgataacaacaagctgattggccag
aggatcctcccgcttgatggcctccaagcaggataccgacacatttcccttcgaaatgag
ggaaataaaccattatcactgccaacaattttctgcaatattgttcttaaaacatacgtg
cctgatggatttggagatattgtggatgctttatcagatccaaagaaatttctctcaatt
acagaaaagagagcagaccaaatgagagctatgggcattgaaactagtgacatagctgat
gtgcccagtgacacttccaaaaatgacaagaaaggaaaggccaataccaccaaagcaaac
gtgacccctcagagtagctctgagctcagaccaaccaccacagctgccctggcctctggt
gtggaagccaaaaaaggtattgaacttatccctcaagtaaggatagaagatttaaagcag
atgaaggcttacttgaagcatttaaagaaacagcagaaagagctaaattctttaaagaag
aaacatgcaaaggagcacagtaccatgcagaagttacactgcacgcaagttgacaaaatt
gtggcacagtatgacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaag
aagaaggggggaagtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacg
ctgacatcagatcacaaatctaaggtcaaagagattgtagcacagcacacaaaggaatgg
tcagaaatgatcaatacccacagtgctgaggagcaagaaatccgagacctgcacctcagc
cagcagtgtgagctgctgaaaaagctactcatcagtgcccacgagcagcaaacccagcag
ctgaaactgtcccatgacagggaaagcaaggaaatgcgagcacaccaggctaagatttct
atggaaaatagcaaagccatcagccaagataaatctatcaagaataaggcagaacgggaa
aggcgagtcagggagttaaacagcagcaacactaaaaagtttctggaagaaagaaagaga
ctcgcaatgaagcagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatcta
gaattcctagagaaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaatcg
caaggcgaaggagatgcagcagatggtgaaattggaagccgagatggaccgcagaccagc
aacagtagtatgaaactccaaaatgcaaactga |