Mycobacterium tuberculosis H37Rv: Rv1603
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Entry
Rv1603 CDS
T00015
Symbol
hisA
Name
(RefSeq) 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase
KO
K24017
phosphoribosyl isomerase A [EC:
5.3.1.16
5.3.1.24
]
Organism
mtu
Mycobacterium tuberculosis H37Rv
Pathway
mtu00340
Histidine metabolism
mtu00400
Phenylalanine, tyrosine and tryptophan biosynthesis
mtu01100
Metabolic pathways
mtu01110
Biosynthesis of secondary metabolites
mtu01230
Biosynthesis of amino acids
Module
mtu_M00026
Histidine biosynthesis, PRPP => histidine
Brite
KEGG Orthology (KO) [BR:
mtu00001
]
09100 Metabolism
09105 Amino acid metabolism
00340 Histidine metabolism
Rv1603 (hisA)
00400 Phenylalanine, tyrosine and tryptophan biosynthesis
Rv1603 (hisA)
Enzymes [BR:
mtu01000
]
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.1 Interconverting aldoses and ketoses, and related compounds
5.3.1.16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
Rv1603 (hisA)
5.3.1.24 phosphoribosylanthranilate isomerase
Rv1603 (hisA)
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Gene cluster
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Motif
Pfam:
His_biosynth
NMO
Dus
Motif
Other DBs
NCBI-GeneID:
885873
NCBI-ProteinID:
NP_216119
TubercuList:
Rv1603
UniProt:
P9WMM5
Structure
PDB
PDBj
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All DBs
Position
1803294..1804031
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AA seq
245 aa
AA seq
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MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGR
GSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGE
HGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGG
PNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQAL
AAVRD
NT seq
738 nt
NT seq
+upstream
nt +downstream
nt
gtgatgccgctgatacttttgcccgccgtcgacgtggtcgagggtcgtgccgtgcgcctc
gttcaagggaaggccggcagccaaaccgagtacggctcagcggtggatgccgcgttgggc
tggcaacgcgatggcgccgagtggatccatttggtggacctggatgctgcgttcggccgc
ggttccaaccacgaactgcttgccgaggttgtcggcaagctcgacgtacaggttgagcta
tccggcggtattcgagacgacgagtcgctggccgcggcgctggccaccggatgcgctcgg
gtcaatgtgggcactgctgccctggaaaacccgcagtggtgtgcccgggtgattggcgag
cacggcgaccaggtcgccgtcggcttggacgtccagatcatcgacggcgagcatcggttg
cgcggacgcggctgggaaaccgacggcggcgacctgtgggacgtgctagaacgcctagac
agtgaaggatgttcgcggttcgtcgtgaccgatatcaccaaggacggcaccctgggcggc
cccaatctggacctgctggccggtgttgccgaccgcaccgacgccccggtgatcgcgtcc
ggaggtgtgtccagcctcgatgacctgcgcgccattgcgactctcacgcaccgcggcgtc
gagggggccatcgtcggcaaggccctctacgcccgtcggttcaccttgccgcaagcgttg
gccgcggttcgggactag
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