Mycobacterium tuberculosis H37Rv: Rv2245
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Entry
Rv2245 CDS
T00015
Symbol
kasA
Name
(RefSeq) 3-oxoacyl-ACP synthase 1
KO
K11609
meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase I [EC:
2.3.1.293
]
Organism
mtu
Mycobacterium tuberculosis H37Rv
Pathway
mtu00074
Mycolic acid biosynthesis
mtu01100
Metabolic pathways
mtu01110
Biosynthesis of secondary metabolites
Module
mtu_M00885
Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)
mtu_M00886
Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)
Brite
KEGG Orthology (KO) [BR:
mtu00001
]
09100 Metabolism
09103 Lipid metabolism
00074 Mycolic acid biosynthesis
Rv2245 (kasA)
09180 Brite Hierarchies
09181 Protein families: metabolism
01004 Lipid biosynthesis proteins [BR:
mtu01004
]
Rv2245 (kasA)
Enzymes [BR:
mtu01000
]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.293 meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I
Rv2245 (kasA)
Lipid biosynthesis proteins [BR:
mtu01004
]
Fatty acid synthase
Component type
Rv2245 (kasA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ketoacyl-synt
Ketoacyl-synt_C
Thiolase_N
DUF2749
Motif
Other DBs
NCBI-GeneID:
887269
NCBI-ProteinID:
NP_216761
TubercuList:
Rv2245
UniProt:
P9WQD9
Structure
PDB
PDBj
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Position
2518115..2519365
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AA seq
416 aa
AA seq
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MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKI
GGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAE
RIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGARAGVMTPVSACSSGSEAIAH
AWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGL
SPADIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVL
TLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNSFGFGGHNVALAFGRY
NT seq
1251 nt
NT seq
+upstream
nt +downstream
nt
gtgagtcagccttccaccgctaatggcggtttccccagcgttgtggtgaccgccgtcaca
gcgacgacgtcgatctcgccggacatcgagagcacgtggaagggtctgttggccggcgag
agcggcatccacgcactcgaagacgagttcgtcaccaagtgggatctagcggtcaagatc
ggcggtcacctcaaggatccggtcgacagccacatgggccgactcgacatgcgacgcatg
tcgtacgtccagcggatgggcaagttgctgggcggacagctatgggagtccgccggcagc
ccggaggtcgatccagaccggttcgccgttgttgtcggcaccggtctaggtggagccgag
aggattgtcgagagctacgacctgatgaatgcgggcggcccccggaaggtgtccccgctg
gccgttcagatgatcatgcccaacggtgccgcggcggtgatcggtctgcagcttggggcc
cgcgccggggtgatgaccccggtgtcggcctgttcgtcgggctcggaagcgatcgcccac
gcgtggcgtcagatcgtgatgggcgacgccgacgtcgccgtctgcggcggtgtcgaagga
cccatcgaggcgctgcccatcgcggcgttctccatgatgcgggccatgtcgacccgcaac
gacgagcctgagcgggcctcccggccgttcgacaaggaccgcgacggctttgtgttcggc
gaggccggtgcgctgatgctcatcgagacggaggagcacgccaaagcccgtggcgccaag
ccgttggcccgattgctgggtgccggtatcacctcggacgcctttcatatggtggcgccc
gcggccgatggtgttcgtgccggtagggcgatgactcgctcgctggagctggccgggttg
tcgccggcggacatcgaccacgtcaacgcgcacggcacggcgacgcctatcggcgacgcc
gcggaggccaacgccatccgcgtcgccggttgtgatcaggccgcggtgtacgcgccgaag
tctgcgctgggccactcgatcggcgcggtcggtgcgctcgagtcggtgctcacggtgctg
acgctgcgcgacggcgtcatcccgccgaccctgaactacgagacacccgatcccgagatc
gaccttgacgtcgtcgccggcgaaccgcgctatggcgattaccgctacgcagtcaacaac
tcgttcgggttcggcggccacaatgtggcgcttgccttcgggcgttactga
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