Mycobacterium ulcerans: MUL_4300
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Entry
MUL_4300 CDS
T00435
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase LeuA
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
mul
Mycobacterium ulcerans
Pathway
mul00290
Valine, leucine and isoleucine biosynthesis
mul00620
Pyruvate metabolism
mul01100
Metabolic pathways
mul01110
Biosynthesis of secondary metabolites
mul01210
2-Oxocarboxylic acid metabolism
mul01230
Biosynthesis of amino acids
Module
mul_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
mul00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
MUL_4300 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
MUL_4300 (leuA)
Enzymes [BR:
mul01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
MUL_4300 (leuA)
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Motif
Pfam:
HMGL-like
IPMS_D2
LeuA_dimer
Motif
Other DBs
NCBI-ProteinID:
ABL06315
Pasteur:
MUL_4300
UniProt:
A0PVE6
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Position
4776991..4778691
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AA seq
566 aa
AA seq
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MPVNRYRPFAEEVEHIRVTDRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD
LLVRMGYKEIEVGFPSASQTDFDFVREIITEGAIPDDVTIQVLTQCRPELIERTFEACAG
ASKVIVHFYNSTSILQRRVVFRADRAAVEAIATDGARRCVEEAAKYPDTQWRFEYSPESY
TGTELEYAKQVCDAVAEVIQPTPENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESV
ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLATLGLNLFSRGVDPQI
DFSNIDEIRRTVEYCNQLPVPERHPYGGDLVYTAFSGSHQDAINKGLDAMEFDADAADSD
MDDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSRA
IQEIAEGSAGEGGEVSPKEMWDAFAEEYLAPVRPLERIKQRVIAAEEDGGTTSIDATVKI
DGKEAEISGSGNGPLAAFVHALGTVGFDVAVLDYSEHAMSAGDDAQAAAYVEASVAGKTV
WGVGIAPSITTASLRAVVSAINRASR
NT seq
1701 nt
NT seq
+upstream
nt +downstream
nt
atgccggtcaaccgttaccggccgttcgccgaggaagtcgaacacatccgggttaccgac
cgcacctggcccgaccgcgtcatcgaccgcgcccccctgtggtgcgcggtggacctgcgt
gacggcaaccaggcactgatcgatccgatgagcccggcccgcaagcggcgcatgttcgac
ctgctagttcggatgggttacaaggagatcgaggtcggctttccctcggccagccagacc
gacttcgacttcgtccgcgagatcatcaccgaaggcgccattcccgacgacgtcaccatc
caggtgctgactcagtgccgccccgagctgatcgagcgcacgttcgaggcgtgcgctggg
gcgtcgaaggtgatcgtgcacttctacaactcaacgtcgatcctgcagcgccgcgtggtg
ttccgcgccgaccgggccgcggtagaagcgatcgcgaccgacggcgcccgcagatgcgtc
gaggaagcggccaaataccccgacacccagtggcgcttcgagtactcaccggagtcctac
acgggcaccgagctggaatacgccaaacaggtgtgcgacgcggtggccgaagtcatccag
cccaccccggaaaacccgatcatcttcaatctgcccgccactgtggagatggccaccccg
aacgtctacgccgactcgatcgagtggatgagccgcaacctggccaaccgggagtcggtc
attctgagcctgcatccccacaacgatcgcggaaccgccgtcgccgcagccgaattgggc
ttcgccgcaggcgccgaccggatcgagggctgcctgttcggcaacggcgagcgcaccggc
aacgtgtgtctggcgaccctggggctgaacctgttctcccgcggcgtggacccgcagatc
gatttctccaacatcgacgagatccggcgcaccgtggagtactgcaaccagctgccggtg
cccgaacgtcacccctacggcggggacctggtctacaccgcgttctccggcagccaccag
gacgccatcaacaagggcctggacgcgatggagttcgatgccgacgctgccgattccgac
atggacgacatgctgtggcaggtgccctacctgcccatcgaccccaaggacgtcggacgc
acctacgaagcggtgatccgagtcaactcgcagtccggcaagggtggggtggcctacatc
atgaaggccgaccacggcctggccctgccacgacggctgcagatcgagttctcgcgcgcg
atccaagagatcgccgagggcagcgcgggcgaagggggcgaggtctcgcccaaagagatg
tgggacgcgttcgccgaggagtacctggcgccggtgcgcccgctggagcggatcaaacag
cgcgtcattgccgccgaggaagatggcggcaccaccagcatcgacgccaccgtcaagatc
gacgggaaagaggccgagatcagtggctcgggcaacggtccgctggccgcgttcgttcac
gcgctgggcaccgtcgggttcgacgtggccgtgttggactactccgagcacgcgatgagc
gccggcgacgacgctcaggcggcggcgtacgtggaggcctccgtggccggcaagacggtg
tggggcgtgggcatcgcgccgtcgatcaccaccgcgtcactgcgggccgtcgtgtcggcg
atcaaccgggcgtcgcgctag
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