KEGG   Meriones unguiculatus (Mongolian gerbil): 110556252
Entry
110556252         CDS       T05884                                 
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mun  Meriones unguiculatus (Mongolian gerbil)
Pathway
mun00562  Inositol phosphate metabolism
mun01100  Metabolic pathways
mun01521  EGFR tyrosine kinase inhibitor resistance
mun01522  Endocrine resistance
mun01524  Platinum drug resistance
mun04012  ErbB signaling pathway
mun04014  Ras signaling pathway
mun04015  Rap1 signaling pathway
mun04024  cAMP signaling pathway
mun04062  Chemokine signaling pathway
mun04066  HIF-1 signaling pathway
mun04068  FoxO signaling pathway
mun04070  Phosphatidylinositol signaling system
mun04071  Sphingolipid signaling pathway
mun04072  Phospholipase D signaling pathway
mun04081  Hormone signaling
mun04140  Autophagy - animal
mun04150  mTOR signaling pathway
mun04151  PI3K-Akt signaling pathway
mun04152  AMPK signaling pathway
mun04210  Apoptosis
mun04211  Longevity regulating pathway
mun04213  Longevity regulating pathway - multiple species
mun04218  Cellular senescence
mun04360  Axon guidance
mun04370  VEGF signaling pathway
mun04380  Osteoclast differentiation
mun04510  Focal adhesion
mun04550  Signaling pathways regulating pluripotency of stem cells
mun04611  Platelet activation
mun04613  Neutrophil extracellular trap formation
mun04620  Toll-like receptor signaling pathway
mun04625  C-type lectin receptor signaling pathway
mun04630  JAK-STAT signaling pathway
mun04650  Natural killer cell mediated cytotoxicity
mun04660  T cell receptor signaling pathway
mun04662  B cell receptor signaling pathway
mun04664  Fc epsilon RI signaling pathway
mun04666  Fc gamma R-mediated phagocytosis
mun04668  TNF signaling pathway
mun04670  Leukocyte transendothelial migration
mun04722  Neurotrophin signaling pathway
mun04725  Cholinergic synapse
mun04750  Inflammatory mediator regulation of TRP channels
mun04810  Regulation of actin cytoskeleton
mun04910  Insulin signaling pathway
mun04914  Progesterone-mediated oocyte maturation
mun04915  Estrogen signaling pathway
mun04917  Prolactin signaling pathway
mun04919  Thyroid hormone signaling pathway
mun04923  Regulation of lipolysis in adipocytes
mun04926  Relaxin signaling pathway
mun04929  GnRH secretion
mun04930  Type II diabetes mellitus
mun04931  Insulin resistance
mun04932  Non-alcoholic fatty liver disease
mun04933  AGE-RAGE signaling pathway in diabetic complications
mun04935  Growth hormone synthesis, secretion and action
mun04960  Aldosterone-regulated sodium reabsorption
mun04973  Carbohydrate digestion and absorption
mun05010  Alzheimer disease
mun05017  Spinocerebellar ataxia
mun05020  Prion disease
mun05100  Bacterial invasion of epithelial cells
mun05132  Salmonella infection
mun05135  Yersinia infection
mun05142  Chagas disease
mun05146  Amoebiasis
mun05160  Hepatitis C
mun05161  Hepatitis B
mun05162  Measles
mun05163  Human cytomegalovirus infection
mun05164  Influenza A
mun05165  Human papillomavirus infection
mun05166  Human T-cell leukemia virus 1 infection
mun05167  Kaposi sarcoma-associated herpesvirus infection
mun05168  Herpes simplex virus 1 infection
mun05169  Epstein-Barr virus infection
mun05170  Human immunodeficiency virus 1 infection
mun05171  Coronavirus disease - COVID-19
mun05200  Pathways in cancer
mun05203  Viral carcinogenesis
mun05205  Proteoglycans in cancer
mun05206  MicroRNAs in cancer
mun05207  Chemical carcinogenesis - receptor activation
mun05208  Chemical carcinogenesis - reactive oxygen species
mun05210  Colorectal cancer
mun05211  Renal cell carcinoma
mun05212  Pancreatic cancer
mun05213  Endometrial cancer
mun05214  Glioma
mun05215  Prostate cancer
mun05218  Melanoma
mun05220  Chronic myeloid leukemia
mun05221  Acute myeloid leukemia
mun05222  Small cell lung cancer
mun05223  Non-small cell lung cancer
mun05224  Breast cancer
mun05225  Hepatocellular carcinoma
mun05226  Gastric cancer
mun05230  Central carbon metabolism in cancer
mun05231  Choline metabolism in cancer
mun05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mun05415  Diabetic cardiomyopathy
mun05417  Lipid and atherosclerosis
mun05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mun00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    110556252 (Pik3ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    110556252 (Pik3ca)
   04014 Ras signaling pathway
    110556252 (Pik3ca)
   04015 Rap1 signaling pathway
    110556252 (Pik3ca)
   04370 VEGF signaling pathway
    110556252 (Pik3ca)
   04630 JAK-STAT signaling pathway
    110556252 (Pik3ca)
   04668 TNF signaling pathway
    110556252 (Pik3ca)
   04066 HIF-1 signaling pathway
    110556252 (Pik3ca)
   04068 FoxO signaling pathway
    110556252 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    110556252 (Pik3ca)
   04072 Phospholipase D signaling pathway
    110556252 (Pik3ca)
   04071 Sphingolipid signaling pathway
    110556252 (Pik3ca)
   04024 cAMP signaling pathway
    110556252 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    110556252 (Pik3ca)
   04152 AMPK signaling pathway
    110556252 (Pik3ca)
   04150 mTOR signaling pathway
    110556252 (Pik3ca)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    110556252 (Pik3ca)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110556252 (Pik3ca)
  09143 Cell growth and death
   04210 Apoptosis
    110556252 (Pik3ca)
   04218 Cellular senescence
    110556252 (Pik3ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110556252 (Pik3ca)
   04550 Signaling pathways regulating pluripotency of stem cells
    110556252 (Pik3ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110556252 (Pik3ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110556252 (Pik3ca)
   04613 Neutrophil extracellular trap formation
    110556252 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    110556252 (Pik3ca)
   04625 C-type lectin receptor signaling pathway
    110556252 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    110556252 (Pik3ca)
   04660 T cell receptor signaling pathway
    110556252 (Pik3ca)
   04662 B cell receptor signaling pathway
    110556252 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    110556252 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    110556252 (Pik3ca)
   04670 Leukocyte transendothelial migration
    110556252 (Pik3ca)
   04062 Chemokine signaling pathway
    110556252 (Pik3ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110556252 (Pik3ca)
   04923 Regulation of lipolysis in adipocytes
    110556252 (Pik3ca)
   04929 GnRH secretion
    110556252 (Pik3ca)
   04915 Estrogen signaling pathway
    110556252 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    110556252 (Pik3ca)
   04917 Prolactin signaling pathway
    110556252 (Pik3ca)
   04926 Relaxin signaling pathway
    110556252 (Pik3ca)
   04935 Growth hormone synthesis, secretion and action
    110556252 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    110556252 (Pik3ca)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    110556252 (Pik3ca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110556252 (Pik3ca)
  09156 Nervous system
   04725 Cholinergic synapse
    110556252 (Pik3ca)
   04722 Neurotrophin signaling pathway
    110556252 (Pik3ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110556252 (Pik3ca)
  09158 Development and regeneration
   04360 Axon guidance
    110556252 (Pik3ca)
   04380 Osteoclast differentiation
    110556252 (Pik3ca)
  09149 Aging
   04211 Longevity regulating pathway
    110556252 (Pik3ca)
   04213 Longevity regulating pathway - multiple species
    110556252 (Pik3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110556252 (Pik3ca)
   05206 MicroRNAs in cancer
    110556252 (Pik3ca)
   05205 Proteoglycans in cancer
    110556252 (Pik3ca)
   05207 Chemical carcinogenesis - receptor activation
    110556252 (Pik3ca)
   05208 Chemical carcinogenesis - reactive oxygen species
    110556252 (Pik3ca)
   05203 Viral carcinogenesis
    110556252 (Pik3ca)
   05230 Central carbon metabolism in cancer
    110556252 (Pik3ca)
   05231 Choline metabolism in cancer
    110556252 (Pik3ca)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110556252 (Pik3ca)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110556252 (Pik3ca)
   05212 Pancreatic cancer
    110556252 (Pik3ca)
   05225 Hepatocellular carcinoma
    110556252 (Pik3ca)
   05226 Gastric cancer
    110556252 (Pik3ca)
   05214 Glioma
    110556252 (Pik3ca)
   05221 Acute myeloid leukemia
    110556252 (Pik3ca)
   05220 Chronic myeloid leukemia
    110556252 (Pik3ca)
   05218 Melanoma
    110556252 (Pik3ca)
   05211 Renal cell carcinoma
    110556252 (Pik3ca)
   05215 Prostate cancer
    110556252 (Pik3ca)
   05213 Endometrial cancer
    110556252 (Pik3ca)
   05224 Breast cancer
    110556252 (Pik3ca)
   05222 Small cell lung cancer
    110556252 (Pik3ca)
   05223 Non-small cell lung cancer
    110556252 (Pik3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110556252 (Pik3ca)
   05170 Human immunodeficiency virus 1 infection
    110556252 (Pik3ca)
   05161 Hepatitis B
    110556252 (Pik3ca)
   05160 Hepatitis C
    110556252 (Pik3ca)
   05171 Coronavirus disease - COVID-19
    110556252 (Pik3ca)
   05164 Influenza A
    110556252 (Pik3ca)
   05162 Measles
    110556252 (Pik3ca)
   05168 Herpes simplex virus 1 infection
    110556252 (Pik3ca)
   05163 Human cytomegalovirus infection
    110556252 (Pik3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110556252 (Pik3ca)
   05169 Epstein-Barr virus infection
    110556252 (Pik3ca)
   05165 Human papillomavirus infection
    110556252 (Pik3ca)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110556252 (Pik3ca)
   05135 Yersinia infection
    110556252 (Pik3ca)
   05100 Bacterial invasion of epithelial cells
    110556252 (Pik3ca)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110556252 (Pik3ca)
   05142 Chagas disease
    110556252 (Pik3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110556252 (Pik3ca)
   05017 Spinocerebellar ataxia
    110556252 (Pik3ca)
   05020 Prion disease
    110556252 (Pik3ca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110556252 (Pik3ca)
   05418 Fluid shear stress and atherosclerosis
    110556252 (Pik3ca)
   05415 Diabetic cardiomyopathy
    110556252 (Pik3ca)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110556252 (Pik3ca)
   04932 Non-alcoholic fatty liver disease
    110556252 (Pik3ca)
   04931 Insulin resistance
    110556252 (Pik3ca)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110556252 (Pik3ca)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110556252 (Pik3ca)
   01524 Platinum drug resistance
    110556252 (Pik3ca)
   01522 Endocrine resistance
    110556252 (Pik3ca)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mun04131]
    110556252 (Pik3ca)
Enzymes [BR:mun01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     110556252 (Pik3ca)
Membrane trafficking [BR:mun04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    110556252 (Pik3ca)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 110556252
NCBI-ProteinID: XP_021505591
LinkDB
Position
2:140829605..140904921
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
SFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcttcaggtgaactgtggggtatccacttgatgcccccaagaatc
ctagtggaatgtttactccctaatggaatgatagtgactttagaatgcctccgtgaggct
acactaatcaccatcaaacatgaattgtttaaagaagccaggaaatacccactccatcag
cttctgcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtccaggacttccga
aggaacattctgaatgtttgcaaagaagccgtggacctgcgggacctcaactcgcctcac
agcagagcaatgtatgtctaccctccaaacgtcgagtcttccccagaactgccaaagcac
atctacaacaagttagataaaggacaaatcatagtggtgatttgggtaatagtctctcca
aacaatgacaagcaaaagtacactctgaagatcaaccatgactgtgtgccagagcaagtc
attgctgaagccatcaggaagaagactcggagcatgctgctgtcttctgagcagctgaaa
ctctgtgtcttagagtaccagggcaagtatattctaaaagtgtgtggctgtgacgagtac
ttcctagaaaaatatcctctgagtcagtacaagtacataagaagctgtataatgctgggg
agaatgcccaacttgatgttgatggccaaggaaagcctgtattctcagctgccgatggat
agcttcacgatgccatcgtattccaggcgcatctccacagctacaccctatatgaatgga
gagacctctacgaagtctctctgggttataaatagtgcgctcagaatcaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgctccaat
cctaggtggaatgaatggctgaattatgacatatacattcctgatcttcctcgcgctgct
cgcctttgcctttccatttgttctgttaaaggccgcaagggtgctaaggaggagcactgt
ccgttggcctggggaaacataaacttgtttgattacacagacaccctagtatctgggaaa
atggctttgaatctctggcctgtgccacatgggttagaagatctgctgaaccccattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattggttc
agcagtgtggttaagtttccagacatgtctgtgattgaagagcatgccaattggtctgtg
tcccgagaagctggattcagttactctcacacaggactgagtaacagactagccagagac
aatgagttaagagaaaatgacaaagaacagctccgagcactttgcacccgggacccactg
tctgaaatcactgaacaggaaaaagacttcctatggagccacagacactactgtgtaact
attcctgaaatcctgccaaaattgcttctgtctgtcaagtggaattccagagatgaagta
gcccagatgtactgcttagtaaaagattggcctccaatcaaaccagagcaggccatggag
ctcctcgactgtaattatccagatcctatggttcggagttttgccgttcggtgcttggaa
aaatacctaacagatgacaaactttctcagtacctcattcagcttgtacaggtcttaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcgttgacaaat
caaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagactgtc
agtcagaggtttggcctgctgttggagtcctactgccgtgcctgtgggatgtatctgaaa
cacctcaacagacaggtagaggccatggagaaactcatcaatctaactgacatcctcaag
caggagaaaaaggatgaaacacaaaaggtacagatgaagtttttggttgaacagatgaga
cagccagacttcatggatgctttgcagggttttctgtcccctctaaatcctgctcaccaa
ctaggaaacctcaggcttgaagagtgtcggattatgtcctctgcaaaaaggccactctgg
ttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatcatc
tttaaaaatggcgatgatttacggcaagatatgttaacccttcagatcattcgaatcatg
gagaacatctggcaaaaccaaggccttgaccttcgcatgctgccttatggctgtctgtcc
attggggactgcgtggggcttattgaggtagtgagaaactctcacaccatcatgcagatc
cagtgcaaaggaggcctgaagggggcgctgcagttcaacagccacacactgcatcagtgg
ctcaaggacaagaacaagggcgagatatacgatgcggccattgatctgttcactcggtcg
tgcgccgggtactgtgtggcgaccttcatcttggggattggagatcggcacaatagcaac
atcatggtgaaggatgatggacagctgtttcatatagattttgggcactttttggatcac
aagaagaaaaaatttggctataaacgggaacgtgtgccatttgttctgacgcaagatttc
ttaatagtgattagtaaaggagcccaagaatacacaaagaccagagagtttgagaggttt
caggagatgtgttacaaggcttacctagcaattcggcagcatgccaatctcttcatcaac
cttttttcaatgatgcttggctctggaatgccagaactgcagtcctttgatgacattgca
tatatccgaaagactctagccctggacaaaactgagcaagaggctttggagtatttcaca
aaacagatgaatgatgcacatcatggcggctggacaacaaagatggactggatcttccac
accatcaagcagcatgcgttgaactga

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