KEGG   Meriones unguiculatus (Mongolian gerbil): 110559000
Entry
110559000         CDS       T05884                                 
Symbol
Map2k1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mun  Meriones unguiculatus (Mongolian gerbil)
Pathway
mun01521  EGFR tyrosine kinase inhibitor resistance
mun01522  Endocrine resistance
mun04010  MAPK signaling pathway
mun04012  ErbB signaling pathway
mun04014  Ras signaling pathway
mun04015  Rap1 signaling pathway
mun04022  cGMP-PKG signaling pathway
mun04024  cAMP signaling pathway
mun04062  Chemokine signaling pathway
mun04066  HIF-1 signaling pathway
mun04068  FoxO signaling pathway
mun04071  Sphingolipid signaling pathway
mun04072  Phospholipase D signaling pathway
mun04114  Oocyte meiosis
mun04140  Autophagy - animal
mun04148  Efferocytosis
mun04150  mTOR signaling pathway
mun04151  PI3K-Akt signaling pathway
mun04210  Apoptosis
mun04218  Cellular senescence
mun04270  Vascular smooth muscle contraction
mun04370  VEGF signaling pathway
mun04371  Apelin signaling pathway
mun04380  Osteoclast differentiation
mun04510  Focal adhesion
mun04540  Gap junction
mun04550  Signaling pathways regulating pluripotency of stem cells
mun04613  Neutrophil extracellular trap formation
mun04620  Toll-like receptor signaling pathway
mun04650  Natural killer cell mediated cytotoxicity
mun04660  T cell receptor signaling pathway
mun04662  B cell receptor signaling pathway
mun04664  Fc epsilon RI signaling pathway
mun04666  Fc gamma R-mediated phagocytosis
mun04668  TNF signaling pathway
mun04720  Long-term potentiation
mun04722  Neurotrophin signaling pathway
mun04725  Cholinergic synapse
mun04726  Serotonergic synapse
mun04730  Long-term depression
mun04810  Regulation of actin cytoskeleton
mun04910  Insulin signaling pathway
mun04912  GnRH signaling pathway
mun04914  Progesterone-mediated oocyte maturation
mun04915  Estrogen signaling pathway
mun04916  Melanogenesis
mun04917  Prolactin signaling pathway
mun04919  Thyroid hormone signaling pathway
mun04921  Oxytocin signaling pathway
mun04926  Relaxin signaling pathway
mun04928  Parathyroid hormone synthesis, secretion and action
mun04929  GnRH secretion
mun04934  Cushing syndrome
mun04935  Growth hormone synthesis, secretion and action
mun05010  Alzheimer disease
mun05022  Pathways of neurodegeneration - multiple diseases
mun05034  Alcoholism
mun05132  Salmonella infection
mun05135  Yersinia infection
mun05160  Hepatitis C
mun05161  Hepatitis B
mun05163  Human cytomegalovirus infection
mun05164  Influenza A
mun05165  Human papillomavirus infection
mun05166  Human T-cell leukemia virus 1 infection
mun05167  Kaposi sarcoma-associated herpesvirus infection
mun05170  Human immunodeficiency virus 1 infection
mun05200  Pathways in cancer
mun05205  Proteoglycans in cancer
mun05206  MicroRNAs in cancer
mun05207  Chemical carcinogenesis - receptor activation
mun05208  Chemical carcinogenesis - reactive oxygen species
mun05210  Colorectal cancer
mun05211  Renal cell carcinoma
mun05212  Pancreatic cancer
mun05213  Endometrial cancer
mun05214  Glioma
mun05215  Prostate cancer
mun05216  Thyroid cancer
mun05218  Melanoma
mun05219  Bladder cancer
mun05220  Chronic myeloid leukemia
mun05221  Acute myeloid leukemia
mun05223  Non-small cell lung cancer
mun05224  Breast cancer
mun05225  Hepatocellular carcinoma
mun05226  Gastric cancer
mun05230  Central carbon metabolism in cancer
mun05231  Choline metabolism in cancer
mun05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mun00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    110559000 (Map2k1)
   04012 ErbB signaling pathway
    110559000 (Map2k1)
   04014 Ras signaling pathway
    110559000 (Map2k1)
   04015 Rap1 signaling pathway
    110559000 (Map2k1)
   04370 VEGF signaling pathway
    110559000 (Map2k1)
   04371 Apelin signaling pathway
    110559000 (Map2k1)
   04668 TNF signaling pathway
    110559000 (Map2k1)
   04066 HIF-1 signaling pathway
    110559000 (Map2k1)
   04068 FoxO signaling pathway
    110559000 (Map2k1)
   04072 Phospholipase D signaling pathway
    110559000 (Map2k1)
   04071 Sphingolipid signaling pathway
    110559000 (Map2k1)
   04024 cAMP signaling pathway
    110559000 (Map2k1)
   04022 cGMP-PKG signaling pathway
    110559000 (Map2k1)
   04151 PI3K-Akt signaling pathway
    110559000 (Map2k1)
   04150 mTOR signaling pathway
    110559000 (Map2k1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110559000 (Map2k1)
   04148 Efferocytosis
    110559000 (Map2k1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    110559000 (Map2k1)
   04210 Apoptosis
    110559000 (Map2k1)
   04218 Cellular senescence
    110559000 (Map2k1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110559000 (Map2k1)
   04540 Gap junction
    110559000 (Map2k1)
   04550 Signaling pathways regulating pluripotency of stem cells
    110559000 (Map2k1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110559000 (Map2k1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    110559000 (Map2k1)
   04620 Toll-like receptor signaling pathway
    110559000 (Map2k1)
   04650 Natural killer cell mediated cytotoxicity
    110559000 (Map2k1)
   04660 T cell receptor signaling pathway
    110559000 (Map2k1)
   04662 B cell receptor signaling pathway
    110559000 (Map2k1)
   04664 Fc epsilon RI signaling pathway
    110559000 (Map2k1)
   04666 Fc gamma R-mediated phagocytosis
    110559000 (Map2k1)
   04062 Chemokine signaling pathway
    110559000 (Map2k1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110559000 (Map2k1)
   04929 GnRH secretion
    110559000 (Map2k1)
   04912 GnRH signaling pathway
    110559000 (Map2k1)
   04915 Estrogen signaling pathway
    110559000 (Map2k1)
   04914 Progesterone-mediated oocyte maturation
    110559000 (Map2k1)
   04917 Prolactin signaling pathway
    110559000 (Map2k1)
   04921 Oxytocin signaling pathway
    110559000 (Map2k1)
   04926 Relaxin signaling pathway
    110559000 (Map2k1)
   04935 Growth hormone synthesis, secretion and action
    110559000 (Map2k1)
   04919 Thyroid hormone signaling pathway
    110559000 (Map2k1)
   04928 Parathyroid hormone synthesis, secretion and action
    110559000 (Map2k1)
   04916 Melanogenesis
    110559000 (Map2k1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    110559000 (Map2k1)
  09156 Nervous system
   04725 Cholinergic synapse
    110559000 (Map2k1)
   04726 Serotonergic synapse
    110559000 (Map2k1)
   04720 Long-term potentiation
    110559000 (Map2k1)
   04730 Long-term depression
    110559000 (Map2k1)
   04722 Neurotrophin signaling pathway
    110559000 (Map2k1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    110559000 (Map2k1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110559000 (Map2k1)
   05206 MicroRNAs in cancer
    110559000 (Map2k1)
   05205 Proteoglycans in cancer
    110559000 (Map2k1)
   05207 Chemical carcinogenesis - receptor activation
    110559000 (Map2k1)
   05208 Chemical carcinogenesis - reactive oxygen species
    110559000 (Map2k1)
   05230 Central carbon metabolism in cancer
    110559000 (Map2k1)
   05231 Choline metabolism in cancer
    110559000 (Map2k1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110559000 (Map2k1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110559000 (Map2k1)
   05212 Pancreatic cancer
    110559000 (Map2k1)
   05225 Hepatocellular carcinoma
    110559000 (Map2k1)
   05226 Gastric cancer
    110559000 (Map2k1)
   05214 Glioma
    110559000 (Map2k1)
   05216 Thyroid cancer
    110559000 (Map2k1)
   05221 Acute myeloid leukemia
    110559000 (Map2k1)
   05220 Chronic myeloid leukemia
    110559000 (Map2k1)
   05218 Melanoma
    110559000 (Map2k1)
   05211 Renal cell carcinoma
    110559000 (Map2k1)
   05219 Bladder cancer
    110559000 (Map2k1)
   05215 Prostate cancer
    110559000 (Map2k1)
   05213 Endometrial cancer
    110559000 (Map2k1)
   05224 Breast cancer
    110559000 (Map2k1)
   05223 Non-small cell lung cancer
    110559000 (Map2k1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110559000 (Map2k1)
   05170 Human immunodeficiency virus 1 infection
    110559000 (Map2k1)
   05161 Hepatitis B
    110559000 (Map2k1)
   05160 Hepatitis C
    110559000 (Map2k1)
   05164 Influenza A
    110559000 (Map2k1)
   05163 Human cytomegalovirus infection
    110559000 (Map2k1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110559000 (Map2k1)
   05165 Human papillomavirus infection
    110559000 (Map2k1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110559000 (Map2k1)
   05135 Yersinia infection
    110559000 (Map2k1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110559000 (Map2k1)
   05022 Pathways of neurodegeneration - multiple diseases
    110559000 (Map2k1)
  09165 Substance dependence
   05034 Alcoholism
    110559000 (Map2k1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110559000 (Map2k1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110559000 (Map2k1)
   01522 Endocrine resistance
    110559000 (Map2k1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mun01001]
    110559000 (Map2k1)
Enzymes [BR:mun01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     110559000 (Map2k1)
Protein kinases [BR:mun01001]
 Serine/threonine kinases: STE group
  STE7 family
   110559000 (Map2k1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 110559000
NCBI-ProteinID: XP_021509888
LinkDB
Position
6:24104450..24176324
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFDKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDTKELELLFGCHVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgatggctcggcggtt
aacgggaccagctcggccgagaccaacctggaggccttacagaagaaactggaggagctg
gagctggacgagcagcagcggaagcggctggaggccttcctgacgcagaagcagaaggtg
ggcgagctgaaggatgatgactttgacaagatcagtgagctgggggccggcaacggcgga
gtggtgttcaaggtctcccacaagccatcaggcctggtgatggccaggaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcatccgggagctgcaggtgctgcacgag
tgcaactccccgtacatcgtgggcttctacggggccttctacagcgacggcgagatcagc
atctgcatggagcacatggatggtggatccttggatcaagttctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtgataaaaggcctgacgtatctt
cgggagaagcacaagattatgcacagagatgtcaagccttccaacattctagtgaactca
cgtggggagataaaactctgtgattttggggtcagcgggcagctgattgattccatggcc
aactccttcgtgggcacaaggtcctacatgtcgcctgagagactccaggggactcactat
tccgtgcagtcggacatctggagcatggggctctctctggtggagatggcggttgggagg
taccccatccctcctcctgacaccaaggagctggagctgctgtttggatgccatgtggag
ggagatgcagctgaaacaccacccaggccgaggacccctgggaggcccctcagctcatat
ggaatggatagccgacctcccatggcaatttttgaattgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaggattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatctaaagcagcttatggttcacgccttc
atcaagaggtctgatgcagaggaggtagactttgcaggctggctctgctccactatcggg
cttaaccagcccagcacaccgacccatgccgccagcatctga

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