KEGG   Myotis brandtii (Brandt's bat): 102260487
Entry
102260487         CDS       T02920                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
myb  Myotis brandtii (Brandt's bat)
Pathway
myb00562  Inositol phosphate metabolism
myb01100  Metabolic pathways
myb01521  EGFR tyrosine kinase inhibitor resistance
myb01522  Endocrine resistance
myb01524  Platinum drug resistance
myb04012  ErbB signaling pathway
myb04014  Ras signaling pathway
myb04015  Rap1 signaling pathway
myb04024  cAMP signaling pathway
myb04062  Chemokine signaling pathway
myb04066  HIF-1 signaling pathway
myb04068  FoxO signaling pathway
myb04070  Phosphatidylinositol signaling system
myb04071  Sphingolipid signaling pathway
myb04072  Phospholipase D signaling pathway
myb04081  Hormone signaling
myb04140  Autophagy - animal
myb04150  mTOR signaling pathway
myb04151  PI3K-Akt signaling pathway
myb04152  AMPK signaling pathway
myb04210  Apoptosis
myb04211  Longevity regulating pathway
myb04213  Longevity regulating pathway - multiple species
myb04218  Cellular senescence
myb04360  Axon guidance
myb04370  VEGF signaling pathway
myb04380  Osteoclast differentiation
myb04510  Focal adhesion
myb04550  Signaling pathways regulating pluripotency of stem cells
myb04611  Platelet activation
myb04613  Neutrophil extracellular trap formation
myb04620  Toll-like receptor signaling pathway
myb04625  C-type lectin receptor signaling pathway
myb04630  JAK-STAT signaling pathway
myb04650  Natural killer cell mediated cytotoxicity
myb04660  T cell receptor signaling pathway
myb04662  B cell receptor signaling pathway
myb04664  Fc epsilon RI signaling pathway
myb04666  Fc gamma R-mediated phagocytosis
myb04668  TNF signaling pathway
myb04670  Leukocyte transendothelial migration
myb04722  Neurotrophin signaling pathway
myb04725  Cholinergic synapse
myb04750  Inflammatory mediator regulation of TRP channels
myb04810  Regulation of actin cytoskeleton
myb04910  Insulin signaling pathway
myb04914  Progesterone-mediated oocyte maturation
myb04915  Estrogen signaling pathway
myb04917  Prolactin signaling pathway
myb04919  Thyroid hormone signaling pathway
myb04923  Regulation of lipolysis in adipocytes
myb04926  Relaxin signaling pathway
myb04929  GnRH secretion
myb04930  Type II diabetes mellitus
myb04931  Insulin resistance
myb04932  Non-alcoholic fatty liver disease
myb04933  AGE-RAGE signaling pathway in diabetic complications
myb04935  Growth hormone synthesis, secretion and action
myb04960  Aldosterone-regulated sodium reabsorption
myb04973  Carbohydrate digestion and absorption
myb05010  Alzheimer disease
myb05017  Spinocerebellar ataxia
myb05020  Prion disease
myb05100  Bacterial invasion of epithelial cells
myb05132  Salmonella infection
myb05135  Yersinia infection
myb05142  Chagas disease
myb05146  Amoebiasis
myb05160  Hepatitis C
myb05161  Hepatitis B
myb05162  Measles
myb05163  Human cytomegalovirus infection
myb05164  Influenza A
myb05165  Human papillomavirus infection
myb05166  Human T-cell leukemia virus 1 infection
myb05167  Kaposi sarcoma-associated herpesvirus infection
myb05168  Herpes simplex virus 1 infection
myb05169  Epstein-Barr virus infection
myb05170  Human immunodeficiency virus 1 infection
myb05171  Coronavirus disease - COVID-19
myb05200  Pathways in cancer
myb05203  Viral carcinogenesis
myb05205  Proteoglycans in cancer
myb05206  MicroRNAs in cancer
myb05207  Chemical carcinogenesis - receptor activation
myb05208  Chemical carcinogenesis - reactive oxygen species
myb05210  Colorectal cancer
myb05211  Renal cell carcinoma
myb05212  Pancreatic cancer
myb05213  Endometrial cancer
myb05214  Glioma
myb05215  Prostate cancer
myb05218  Melanoma
myb05220  Chronic myeloid leukemia
myb05221  Acute myeloid leukemia
myb05222  Small cell lung cancer
myb05223  Non-small cell lung cancer
myb05224  Breast cancer
myb05225  Hepatocellular carcinoma
myb05226  Gastric cancer
myb05230  Central carbon metabolism in cancer
myb05231  Choline metabolism in cancer
myb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
myb05415  Diabetic cardiomyopathy
myb05417  Lipid and atherosclerosis
myb05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:myb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102260487 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102260487 (PIK3CB)
   04014 Ras signaling pathway
    102260487 (PIK3CB)
   04015 Rap1 signaling pathway
    102260487 (PIK3CB)
   04370 VEGF signaling pathway
    102260487 (PIK3CB)
   04630 JAK-STAT signaling pathway
    102260487 (PIK3CB)
   04668 TNF signaling pathway
    102260487 (PIK3CB)
   04066 HIF-1 signaling pathway
    102260487 (PIK3CB)
   04068 FoxO signaling pathway
    102260487 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    102260487 (PIK3CB)
   04072 Phospholipase D signaling pathway
    102260487 (PIK3CB)
   04071 Sphingolipid signaling pathway
    102260487 (PIK3CB)
   04024 cAMP signaling pathway
    102260487 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    102260487 (PIK3CB)
   04152 AMPK signaling pathway
    102260487 (PIK3CB)
   04150 mTOR signaling pathway
    102260487 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102260487 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102260487 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    102260487 (PIK3CB)
   04218 Cellular senescence
    102260487 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102260487 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    102260487 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102260487 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102260487 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    102260487 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    102260487 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    102260487 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    102260487 (PIK3CB)
   04660 T cell receptor signaling pathway
    102260487 (PIK3CB)
   04662 B cell receptor signaling pathway
    102260487 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    102260487 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    102260487 (PIK3CB)
   04670 Leukocyte transendothelial migration
    102260487 (PIK3CB)
   04062 Chemokine signaling pathway
    102260487 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102260487 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    102260487 (PIK3CB)
   04929 GnRH secretion
    102260487 (PIK3CB)
   04915 Estrogen signaling pathway
    102260487 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    102260487 (PIK3CB)
   04917 Prolactin signaling pathway
    102260487 (PIK3CB)
   04926 Relaxin signaling pathway
    102260487 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    102260487 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    102260487 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102260487 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102260487 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    102260487 (PIK3CB)
   04722 Neurotrophin signaling pathway
    102260487 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102260487 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    102260487 (PIK3CB)
   04380 Osteoclast differentiation
    102260487 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    102260487 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    102260487 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102260487 (PIK3CB)
   05206 MicroRNAs in cancer
    102260487 (PIK3CB)
   05205 Proteoglycans in cancer
    102260487 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    102260487 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    102260487 (PIK3CB)
   05203 Viral carcinogenesis
    102260487 (PIK3CB)
   05230 Central carbon metabolism in cancer
    102260487 (PIK3CB)
   05231 Choline metabolism in cancer
    102260487 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102260487 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102260487 (PIK3CB)
   05212 Pancreatic cancer
    102260487 (PIK3CB)
   05225 Hepatocellular carcinoma
    102260487 (PIK3CB)
   05226 Gastric cancer
    102260487 (PIK3CB)
   05214 Glioma
    102260487 (PIK3CB)
   05221 Acute myeloid leukemia
    102260487 (PIK3CB)
   05220 Chronic myeloid leukemia
    102260487 (PIK3CB)
   05218 Melanoma
    102260487 (PIK3CB)
   05211 Renal cell carcinoma
    102260487 (PIK3CB)
   05215 Prostate cancer
    102260487 (PIK3CB)
   05213 Endometrial cancer
    102260487 (PIK3CB)
   05224 Breast cancer
    102260487 (PIK3CB)
   05222 Small cell lung cancer
    102260487 (PIK3CB)
   05223 Non-small cell lung cancer
    102260487 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102260487 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    102260487 (PIK3CB)
   05161 Hepatitis B
    102260487 (PIK3CB)
   05160 Hepatitis C
    102260487 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    102260487 (PIK3CB)
   05164 Influenza A
    102260487 (PIK3CB)
   05162 Measles
    102260487 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    102260487 (PIK3CB)
   05163 Human cytomegalovirus infection
    102260487 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102260487 (PIK3CB)
   05169 Epstein-Barr virus infection
    102260487 (PIK3CB)
   05165 Human papillomavirus infection
    102260487 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102260487 (PIK3CB)
   05135 Yersinia infection
    102260487 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    102260487 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102260487 (PIK3CB)
   05142 Chagas disease
    102260487 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102260487 (PIK3CB)
   05017 Spinocerebellar ataxia
    102260487 (PIK3CB)
   05020 Prion disease
    102260487 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102260487 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    102260487 (PIK3CB)
   05415 Diabetic cardiomyopathy
    102260487 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102260487 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    102260487 (PIK3CB)
   04931 Insulin resistance
    102260487 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102260487 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102260487 (PIK3CB)
   01524 Platinum drug resistance
    102260487 (PIK3CB)
   01522 Endocrine resistance
    102260487 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:myb04131]
    102260487 (PIK3CB)
Enzymes [BR:myb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102260487 (PIK3CB)
Membrane trafficking [BR:myb04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102260487 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 Tom37_C
Other DBs
NCBI-GeneID: 102260487
NCBI-ProteinID: XP_005863583
LinkDB
Position
Un
AA seq 1091 aa
MCFNFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISHIKQMLW
AQIHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
ESSILENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKINELAIQKRLTIHWKEDE
VSPYDYVLQISGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGT
ELLCKTIVSSEISGKNDHVWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKTIN
ASKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQT
NPYTENATALHIRFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKEI
LDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKL
PPREALELLDFNYPDQYVREYAVGCLRQMSKRIQSRIGKGKRFMGQSLEETSDEELSQYL
LQLVQVLKYEPFLDCALSRFLLERALANRRIGQFLFWHLRSEVHIPAISIQFGVILEAYC
RGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALSDLQ
SPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVVVMFKNGDDLRQDMLTLQM
LRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEIVSNSETIADIQLNSSNVAAAAAFNKD
ALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKNGQLFHIDFG
HILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNL
FITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNW
MAHTVRKDYRS
NT seq 3276 nt   +upstreamnt  +downstreamnt
atgtgcttcaatttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttctcatattaaacagatgttgtgg
gcacagattcataattacccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagctcgaagatgaaacaagaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgactagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtttgcatgaatttgatgccttg
aaggatcctgaagtgaatgaattccgaataaaaatgcgtaaattcagtgaggaaaagatt
cagtcgcttgtgggattgtcttggatggactggctaaagcaaacatatccaccagagcat
gaatcatccatccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gtgcattttgaaaattgtcaggatgtgtttagctttcaagtatctcctaatatgaatcct
ataaaaataaatgaactagcaatccaaaaacgtttgactattcattggaaagaggatgaa
gttagcccctatgactatgtgctgcaaatcagtgggagagtagaatacgtgtttggtgat
cacccactaatccagttccagtatatccggaactgtgtaatgaacaggaccttgccccat
tttatacttgtggaatgttgcaagatcaaaaagatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaattcatctaaccttccccttcctttaccaccaaagaaacga
attatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaagggaaat
aaacttaacacagaagaaactgtaaaagttcatgtcagggctggcctttttcatggtact
gaactcctgtgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcatgtttgg
aatgaaccactggaatttgatattaatacttgtgacctgccacgaatggctagattatgt
tttgctgtttatgcagttttggataaagtgaaaacgaagaaatcaactaaaacaattaat
gcctctaaatatcagaccatcaggaaatctgggaaagtgcattatcctgtagcatgggta
aatacgatggtttttgactttaaaggacagttgagatctggagacataatattgcacagc
tggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaaaca
aatccatatactgagaatgcaacagctttgcatatcagattcccagagaataaaaaacaa
ccttattattaccctccctttgataagattatcgaaaaggcagctgagattgcaagcagt
gatagtgctaatgtatcaagtcggggtggaaaaaagtttcttgctgtactgaaagaaatc
ttggacagggatcccttgtctcagctgtgtgagaatgaaatggatcttatttggactttg
cgacaagactgcagagagaacttcccacagtcactgccaaagttattactatcgatcaag
tggaataaacttgaggatgttgctcagcttcaggcactacttcagatttggcctaaacta
cctcctcgggaggccctggagcttcttgatttcaactatccagatcagtacgttcgggaa
tatgctgtaggctgcctgcgacagatgagcaaaaggatacaaagcagaattggcaaagga
aaaagattcatggggcaaagtctggaggaaaccagcgatgaagaactctcgcaatatctt
ttacaactggtgcaagttttaaaatatgagccttttcttgattgtgccctctctagattc
ctattagaaagagcacttgctaatcggaggatagggcagtttctattttggcaccttaga
tcagaagtgcacattcctgctatctccatacagtttggtgtcatccttgaagcgtactgc
cggggaagcgtagggcacatgaaagtgctttccaagcaggttgaagcactcaataaatta
aaaactttaaatagtttaatcaaactgaatgcagtgaagctaaacagagccaaaggcaaa
gaggccatgcacacttgtttaaaacagaatgcttaccgggaagccctctctgacctgcag
tcccctctgaacccatgcgtcatcctctcagaactctatgttgaaaagtgtaaatacatg
gattctaaaatgaagcctttgtggctggtatacaacaacaaggtatttggtgaggattca
gtcgtagtgatgtttaaaaatggtgatgatttacgacaggatatgttgacactccaaatg
ctgcgcttgatggatttactctggaaagaagccggtctggatcttcggatgttgccttat
ggctgtttagcgacaggagatcgctcaggcctcattgaaattgtgagcaactctgaaaca
attgctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaataaagat
gcccttctgaactggcttaaagaatacaattctggggatgacttggaccgagccattgag
gagtttaccctgtcctgtgctggctactgtgtagcttcttatgtccttggaattggtgac
agacatagtgacaacatcatggtaaagaaaaatggccagctcttccacattgactttgga
catattcttggaaattttaagtctaaatttggcattaaaagggagcgagtgccttttatt
cttacctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaagttt
ggccggttccgccagtgttgtgaggatgcctatctgattttacgacggcacgggaatctc
ttcatcactctctttgcactgatgctgactgcagggcttcctgagctcacatcagtcaag
gatatacagtatcttaaggactcacttgccttagggaagagtgaagaagaagcactcaag
caatttaagcaaaaatttgatgaggcactcagggaaagctggactactaaggtgaactgg
atggcccacacggttcggaaagactacagatcttaa

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