KEGG   Myotis davidii (David's myotis): 102755690
Entry
102755690         CDS       T02992                                 
Symbol
ARAF
Name
(RefSeq) A-Raf proto-oncogene, serine/threonine kinase
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
myd  Myotis davidii (David's myotis)
Pathway
myd01521  EGFR tyrosine kinase inhibitor resistance
myd01522  Endocrine resistance
myd04010  MAPK signaling pathway
myd04012  ErbB signaling pathway
myd04068  FoxO signaling pathway
myd04270  Vascular smooth muscle contraction
myd04650  Natural killer cell mediated cytotoxicity
myd04720  Long-term potentiation
myd04726  Serotonergic synapse
myd04730  Long-term depression
myd04810  Regulation of actin cytoskeleton
myd04910  Insulin signaling pathway
myd04914  Progesterone-mediated oocyte maturation
myd04928  Parathyroid hormone synthesis, secretion and action
myd05010  Alzheimer disease
myd05022  Pathways of neurodegeneration - multiple diseases
myd05034  Alcoholism
myd05160  Hepatitis C
myd05161  Hepatitis B
myd05200  Pathways in cancer
myd05205  Proteoglycans in cancer
myd05208  Chemical carcinogenesis - reactive oxygen species
myd05210  Colorectal cancer
myd05211  Renal cell carcinoma
myd05212  Pancreatic cancer
myd05213  Endometrial cancer
myd05214  Glioma
myd05215  Prostate cancer
myd05218  Melanoma
myd05219  Bladder cancer
myd05220  Chronic myeloid leukemia
myd05221  Acute myeloid leukemia
myd05223  Non-small cell lung cancer
myd05224  Breast cancer
myd05225  Hepatocellular carcinoma
myd05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:myd00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102755690 (ARAF)
   04012 ErbB signaling pathway
    102755690 (ARAF)
   04068 FoxO signaling pathway
    102755690 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102755690 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    102755690 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102755690 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    102755690 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    102755690 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102755690 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    102755690 (ARAF)
   04720 Long-term potentiation
    102755690 (ARAF)
   04730 Long-term depression
    102755690 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102755690 (ARAF)
   05205 Proteoglycans in cancer
    102755690 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    102755690 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102755690 (ARAF)
   05212 Pancreatic cancer
    102755690 (ARAF)
   05225 Hepatocellular carcinoma
    102755690 (ARAF)
   05226 Gastric cancer
    102755690 (ARAF)
   05214 Glioma
    102755690 (ARAF)
   05221 Acute myeloid leukemia
    102755690 (ARAF)
   05220 Chronic myeloid leukemia
    102755690 (ARAF)
   05218 Melanoma
    102755690 (ARAF)
   05211 Renal cell carcinoma
    102755690 (ARAF)
   05219 Bladder cancer
    102755690 (ARAF)
   05215 Prostate cancer
    102755690 (ARAF)
   05213 Endometrial cancer
    102755690 (ARAF)
   05224 Breast cancer
    102755690 (ARAF)
   05223 Non-small cell lung cancer
    102755690 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    102755690 (ARAF)
   05160 Hepatitis C
    102755690 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102755690 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    102755690 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    102755690 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102755690 (ARAF)
   01522 Endocrine resistance
    102755690 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:myd01001]
    102755690 (ARAF)
Enzymes [BR:myd01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     102755690 (ARAF)
Protein kinases [BR:myd01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   102755690 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like Pkinase_fungal TUG-UBL1
Other DBs
NCBI-GeneID: 102755690
NCBI-ProteinID: XP_006772195
LinkDB
Position
Un
AA seq 616 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLVFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQYYHSIQDLSGGYRQHEAPSNRPLNEPL
TPQGSSSSSQHRDPEHFPFPATANAPLQRIRSTSTPNVHMVSTTTPLDSSLIQLAAQSFN
AEAAGSRGGSDGVPRGSPSPASVSSGRKSPHSKSPSEQRERKSVADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDQF
ATHFHPHSYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSV
LWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPD
LSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQ
ADELPACLLSAARLVP
NT seq 1851 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcacc
gtcaaagtgtacctgcccaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggctctcaaggtgcggggtctcaatcaggattgttgcgtg
gtctaccggctcatcaaagggagaaagacagtcactgcctgggacacagccattgccccc
ctggatggcgaggagctcattgttgaggtccttgaagatgtcccactgactatgcacaat
tttgtacggaaaacattcttcagcctggtgttctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctctaaggtc
cccacagtctgtgttgacatgagtaccaactgccgacagtactaccacagtatccaggat
ttgtctggaggctacagacagcatgaggctccctccaaccgtcctctgaatgagccacta
acccctcagggttccagctccagctcccagcaccgagaccctgaacacttcccctttcct
gccacggccaacgcccccctgcagcgcatccgctccacatctactcccaacgtccatatg
gtcagcaccacaacccccctggactccagtctcatccagctcgctgcccagagtttcaac
gctgaagctgctggtagtagaggtggcagtgatggagtgccccgggggagccccagcccg
gctagtgtgtcctcggggaggaagtccccacattccaagtccccctcagaacagcgagag
aggaagtccgtggctgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgcgggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgtcatgtcaacatcttgctgttcatgggcttcatgacccggccggggttcgccatc
atcacacagtggtgcgagggctccagcctctaccaccacctgcatgtggctgacacacgc
ttcgacatggtccagctcattgatgtggcccggcagactgcccagggcatggaccaattt
gccacccacttccacccccacagctacctccatgccaagaacatcatccaccgggatctc
aagtctaacaacatcttcctacatgaggggctcacagtgaagatcggcgacttcggcctg
gccacggtgaagacaagatggagcggggctcagcccttggagcagccctcaggctctgtg
ctgtggatggcggctgaggtgattcgtatgcaggacccgaacccctacagcttccagtcg
gatgtctacgcctatggggttgtgctctacgagctcatgaccggctccttgccttatagc
cacattggcagccgtgaccagattatctttatggtgggccgtggctatctgtccccggac
ctcagcaaaatctccagcaactgccccaaggccatgcggcgcctgctgtctgattgcctc
aagtttcagcgagaggagcggcccctcttcccccagatcctggccaccattgagctgctg
cagcggtcactccccaagattgagcggagtgcctccgaaccctccttgcatcgcacccag
gctgatgagttgcccgcctgcctactcagcgcagcccgccttgtgccttag

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