KEGG   Myotis davidii (David's myotis): 102758951
Entry
102758951         CDS       T02992                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
myd  Myotis davidii (David's myotis)
Pathway
myd00562  Inositol phosphate metabolism
myd01100  Metabolic pathways
myd01521  EGFR tyrosine kinase inhibitor resistance
myd01522  Endocrine resistance
myd01524  Platinum drug resistance
myd04012  ErbB signaling pathway
myd04014  Ras signaling pathway
myd04015  Rap1 signaling pathway
myd04024  cAMP signaling pathway
myd04062  Chemokine signaling pathway
myd04066  HIF-1 signaling pathway
myd04068  FoxO signaling pathway
myd04070  Phosphatidylinositol signaling system
myd04071  Sphingolipid signaling pathway
myd04072  Phospholipase D signaling pathway
myd04081  Hormone signaling
myd04140  Autophagy - animal
myd04150  mTOR signaling pathway
myd04151  PI3K-Akt signaling pathway
myd04152  AMPK signaling pathway
myd04210  Apoptosis
myd04211  Longevity regulating pathway
myd04213  Longevity regulating pathway - multiple species
myd04218  Cellular senescence
myd04360  Axon guidance
myd04370  VEGF signaling pathway
myd04380  Osteoclast differentiation
myd04510  Focal adhesion
myd04550  Signaling pathways regulating pluripotency of stem cells
myd04611  Platelet activation
myd04613  Neutrophil extracellular trap formation
myd04620  Toll-like receptor signaling pathway
myd04625  C-type lectin receptor signaling pathway
myd04630  JAK-STAT signaling pathway
myd04650  Natural killer cell mediated cytotoxicity
myd04660  T cell receptor signaling pathway
myd04662  B cell receptor signaling pathway
myd04664  Fc epsilon RI signaling pathway
myd04666  Fc gamma R-mediated phagocytosis
myd04668  TNF signaling pathway
myd04670  Leukocyte transendothelial migration
myd04722  Neurotrophin signaling pathway
myd04725  Cholinergic synapse
myd04750  Inflammatory mediator regulation of TRP channels
myd04810  Regulation of actin cytoskeleton
myd04910  Insulin signaling pathway
myd04914  Progesterone-mediated oocyte maturation
myd04915  Estrogen signaling pathway
myd04917  Prolactin signaling pathway
myd04919  Thyroid hormone signaling pathway
myd04923  Regulation of lipolysis in adipocytes
myd04926  Relaxin signaling pathway
myd04929  GnRH secretion
myd04930  Type II diabetes mellitus
myd04931  Insulin resistance
myd04932  Non-alcoholic fatty liver disease
myd04933  AGE-RAGE signaling pathway in diabetic complications
myd04935  Growth hormone synthesis, secretion and action
myd04960  Aldosterone-regulated sodium reabsorption
myd04973  Carbohydrate digestion and absorption
myd05010  Alzheimer disease
myd05017  Spinocerebellar ataxia
myd05020  Prion disease
myd05100  Bacterial invasion of epithelial cells
myd05132  Salmonella infection
myd05135  Yersinia infection
myd05142  Chagas disease
myd05146  Amoebiasis
myd05160  Hepatitis C
myd05161  Hepatitis B
myd05162  Measles
myd05163  Human cytomegalovirus infection
myd05164  Influenza A
myd05165  Human papillomavirus infection
myd05166  Human T-cell leukemia virus 1 infection
myd05167  Kaposi sarcoma-associated herpesvirus infection
myd05168  Herpes simplex virus 1 infection
myd05169  Epstein-Barr virus infection
myd05170  Human immunodeficiency virus 1 infection
myd05171  Coronavirus disease - COVID-19
myd05200  Pathways in cancer
myd05203  Viral carcinogenesis
myd05205  Proteoglycans in cancer
myd05206  MicroRNAs in cancer
myd05207  Chemical carcinogenesis - receptor activation
myd05208  Chemical carcinogenesis - reactive oxygen species
myd05210  Colorectal cancer
myd05211  Renal cell carcinoma
myd05212  Pancreatic cancer
myd05213  Endometrial cancer
myd05214  Glioma
myd05215  Prostate cancer
myd05218  Melanoma
myd05220  Chronic myeloid leukemia
myd05221  Acute myeloid leukemia
myd05222  Small cell lung cancer
myd05223  Non-small cell lung cancer
myd05224  Breast cancer
myd05225  Hepatocellular carcinoma
myd05226  Gastric cancer
myd05230  Central carbon metabolism in cancer
myd05231  Choline metabolism in cancer
myd05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
myd05415  Diabetic cardiomyopathy
myd05417  Lipid and atherosclerosis
myd05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:myd00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102758951 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102758951 (PIK3CA)
   04014 Ras signaling pathway
    102758951 (PIK3CA)
   04015 Rap1 signaling pathway
    102758951 (PIK3CA)
   04370 VEGF signaling pathway
    102758951 (PIK3CA)
   04630 JAK-STAT signaling pathway
    102758951 (PIK3CA)
   04668 TNF signaling pathway
    102758951 (PIK3CA)
   04066 HIF-1 signaling pathway
    102758951 (PIK3CA)
   04068 FoxO signaling pathway
    102758951 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    102758951 (PIK3CA)
   04072 Phospholipase D signaling pathway
    102758951 (PIK3CA)
   04071 Sphingolipid signaling pathway
    102758951 (PIK3CA)
   04024 cAMP signaling pathway
    102758951 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    102758951 (PIK3CA)
   04152 AMPK signaling pathway
    102758951 (PIK3CA)
   04150 mTOR signaling pathway
    102758951 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102758951 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102758951 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    102758951 (PIK3CA)
   04218 Cellular senescence
    102758951 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102758951 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    102758951 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102758951 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102758951 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    102758951 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    102758951 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    102758951 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    102758951 (PIK3CA)
   04660 T cell receptor signaling pathway
    102758951 (PIK3CA)
   04662 B cell receptor signaling pathway
    102758951 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    102758951 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    102758951 (PIK3CA)
   04670 Leukocyte transendothelial migration
    102758951 (PIK3CA)
   04062 Chemokine signaling pathway
    102758951 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102758951 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    102758951 (PIK3CA)
   04929 GnRH secretion
    102758951 (PIK3CA)
   04915 Estrogen signaling pathway
    102758951 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    102758951 (PIK3CA)
   04917 Prolactin signaling pathway
    102758951 (PIK3CA)
   04926 Relaxin signaling pathway
    102758951 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    102758951 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    102758951 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102758951 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102758951 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    102758951 (PIK3CA)
   04722 Neurotrophin signaling pathway
    102758951 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102758951 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    102758951 (PIK3CA)
   04380 Osteoclast differentiation
    102758951 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    102758951 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    102758951 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102758951 (PIK3CA)
   05206 MicroRNAs in cancer
    102758951 (PIK3CA)
   05205 Proteoglycans in cancer
    102758951 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    102758951 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    102758951 (PIK3CA)
   05203 Viral carcinogenesis
    102758951 (PIK3CA)
   05230 Central carbon metabolism in cancer
    102758951 (PIK3CA)
   05231 Choline metabolism in cancer
    102758951 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102758951 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102758951 (PIK3CA)
   05212 Pancreatic cancer
    102758951 (PIK3CA)
   05225 Hepatocellular carcinoma
    102758951 (PIK3CA)
   05226 Gastric cancer
    102758951 (PIK3CA)
   05214 Glioma
    102758951 (PIK3CA)
   05221 Acute myeloid leukemia
    102758951 (PIK3CA)
   05220 Chronic myeloid leukemia
    102758951 (PIK3CA)
   05218 Melanoma
    102758951 (PIK3CA)
   05211 Renal cell carcinoma
    102758951 (PIK3CA)
   05215 Prostate cancer
    102758951 (PIK3CA)
   05213 Endometrial cancer
    102758951 (PIK3CA)
   05224 Breast cancer
    102758951 (PIK3CA)
   05222 Small cell lung cancer
    102758951 (PIK3CA)
   05223 Non-small cell lung cancer
    102758951 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102758951 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    102758951 (PIK3CA)
   05161 Hepatitis B
    102758951 (PIK3CA)
   05160 Hepatitis C
    102758951 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    102758951 (PIK3CA)
   05164 Influenza A
    102758951 (PIK3CA)
   05162 Measles
    102758951 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    102758951 (PIK3CA)
   05163 Human cytomegalovirus infection
    102758951 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102758951 (PIK3CA)
   05169 Epstein-Barr virus infection
    102758951 (PIK3CA)
   05165 Human papillomavirus infection
    102758951 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102758951 (PIK3CA)
   05135 Yersinia infection
    102758951 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    102758951 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102758951 (PIK3CA)
   05142 Chagas disease
    102758951 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102758951 (PIK3CA)
   05017 Spinocerebellar ataxia
    102758951 (PIK3CA)
   05020 Prion disease
    102758951 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102758951 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    102758951 (PIK3CA)
   05415 Diabetic cardiomyopathy
    102758951 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102758951 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    102758951 (PIK3CA)
   04931 Insulin resistance
    102758951 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102758951 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102758951 (PIK3CA)
   01524 Platinum drug resistance
    102758951 (PIK3CA)
   01522 Endocrine resistance
    102758951 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:myd04131]
    102758951 (PIK3CA)
Enzymes [BR:myd01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102758951 (PIK3CA)
Membrane trafficking [BR:myd04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102758951 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 102758951
NCBI-ProteinID: XP_006770089
UniProt: L5LGX6
LinkDB
Position
Un
AA seq 1069 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDYVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWGINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLEMEFDWF
SSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDP
LSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAM
ELLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT
NQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDIL
KQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPL
WLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCL
SIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTR
SCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQD
FLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDI
AYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3210 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactataaagcatgaactatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgatcttcggctctttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
atcggcatgccagtgtgtgaatttgacatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcac
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaattgccaaaacac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgattatgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctttgtgttctagaatatcagggcaaatatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaggaaagtctttactcgcaactgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacctctacaaaatccctttggggtataaatagtgcactcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgacatatacattcctgatcttcctcgtgctgct
cggctttgcctttccatttgttctgttaaaggtcgaaaaggtgctaaagaggaacactgt
ccattggcgtggggaaatataaacttgtttgattatacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaatcctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagatggagtttgactggttc
agtagcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaactggtct
gtgtcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctaga
gacaacgaattaagggaaaatgataaagaacagctccgagcaatttgtacccgagatcct
ctctctgaaatcactgagcaggagaaagattttctttggagccacagacactattgtgta
actatccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaa
gtagctcagatgtactgcttggtaaaagactggcctccaatcaaacctgaacaagctatg
gagcttctggactgcaactacccagaccctatggttcgaagttttgctgttcgatgctta
gaaaaatatttaacagatgacaaactttctcagtatctaattcagctagtacaggtccta
aaatacgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcgttgact
aatcaaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaaca
gttagtcagaggtttggcctgcttttggaatcctactgccgtgcatgtgggatgtatttg
aagcacctgaacaggcaagttgaggctatggaaaagctcatcaacttaactgatattctc
aaacaagagaagaaggatgagactcaaaaggtacagatgaaatttttagttgagcagatg
cggcgaccagatttcatggatgctctacagggctttctatctcctctaaatcctgctcat
caattaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactg
tggttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatc
atctttaaaaatggggatgatttgcggcaagatatgctaacacttcaaattattcgcatt
atggaaaatatctggcaaaatcaaggtcttgatcttcgaatgttgccttatggctgccta
tccattggggactgtgtggggctcattgaggtggtgagaaactctcacaccatcatgcag
atccagtgcaaagggggcctgaaaggagccctgcagttcaacagccacacgctgcaccag
tggctcaaggacaagaacaaaggggaaatatacgatgcagccattgatctgtttacacgt
tcatgtgctggatattgtgtcgctaccttcattttgggaattggagatcgtcacaatagc
aacatcatggttaaagatgatggacaactgttccatatagattttggacactttttggat
cacaagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggat
ttcttaatagtgattagtaaaggagcccaggaatgcaccaagacaagagaatttgagagg
tttcaggagatgtgttacaaagcttatctagctatccggcagcatgccaatctcttcata
aatcttttctcaatgatgcttggctctgggatgccagaactacaatcttttgatgatatt
gcatacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttc
atgaaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttc
cacacaattaagcagcatgctttgaactga

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