KEGG   Myotis davidii (David's myotis): 102763997
Entry
102763997         CDS       T02992                                 
Symbol
MAP2K1
Name
(RefSeq) mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
myd  Myotis davidii (David's myotis)
Pathway
myd01521  EGFR tyrosine kinase inhibitor resistance
myd01522  Endocrine resistance
myd04010  MAPK signaling pathway
myd04012  ErbB signaling pathway
myd04014  Ras signaling pathway
myd04015  Rap1 signaling pathway
myd04022  cGMP-PKG signaling pathway
myd04024  cAMP signaling pathway
myd04062  Chemokine signaling pathway
myd04066  HIF-1 signaling pathway
myd04068  FoxO signaling pathway
myd04071  Sphingolipid signaling pathway
myd04072  Phospholipase D signaling pathway
myd04114  Oocyte meiosis
myd04140  Autophagy - animal
myd04148  Efferocytosis
myd04150  mTOR signaling pathway
myd04151  PI3K-Akt signaling pathway
myd04210  Apoptosis
myd04218  Cellular senescence
myd04270  Vascular smooth muscle contraction
myd04370  VEGF signaling pathway
myd04371  Apelin signaling pathway
myd04380  Osteoclast differentiation
myd04510  Focal adhesion
myd04517  IgSF CAM signaling
myd04519  Cadherin signaling
myd04540  Gap junction
myd04550  Signaling pathways regulating pluripotency of stem cells
myd04613  Neutrophil extracellular trap formation
myd04620  Toll-like receptor signaling pathway
myd04650  Natural killer cell mediated cytotoxicity
myd04660  T cell receptor signaling pathway
myd04662  B cell receptor signaling pathway
myd04664  Fc epsilon RI signaling pathway
myd04666  Fc gamma R-mediated phagosome formation
myd04668  TNF signaling pathway
myd04720  Long-term potentiation
myd04722  Neurotrophin signaling pathway
myd04725  Cholinergic synapse
myd04726  Serotonergic synapse
myd04730  Long-term depression
myd04810  Regulation of actin cytoskeleton
myd04910  Insulin signaling pathway
myd04912  GnRH signaling pathway
myd04914  Progesterone-mediated oocyte maturation
myd04915  Estrogen signaling pathway
myd04916  Melanogenesis
myd04917  Prolactin signaling pathway
myd04919  Thyroid hormone signaling pathway
myd04921  Oxytocin signaling pathway
myd04926  Relaxin signaling pathway
myd04928  Parathyroid hormone synthesis, secretion and action
myd04929  GnRH secretion
myd04934  Cushing syndrome
myd04935  Growth hormone synthesis, secretion and action
myd05010  Alzheimer disease
myd05022  Pathways of neurodegeneration - multiple diseases
myd05034  Alcoholism
myd05132  Salmonella infection
myd05135  Yersinia infection
myd05160  Hepatitis C
myd05161  Hepatitis B
myd05163  Human cytomegalovirus infection
myd05164  Influenza A
myd05165  Human papillomavirus infection
myd05166  Human T-cell leukemia virus 1 infection
myd05167  Kaposi sarcoma-associated herpesvirus infection
myd05170  Human immunodeficiency virus 1 infection
myd05200  Pathways in cancer
myd05205  Proteoglycans in cancer
myd05206  MicroRNAs in cancer
myd05207  Chemical carcinogenesis - receptor activation
myd05208  Chemical carcinogenesis - reactive oxygen species
myd05210  Colorectal cancer
myd05211  Renal cell carcinoma
myd05212  Pancreatic cancer
myd05213  Endometrial cancer
myd05214  Glioma
myd05215  Prostate cancer
myd05216  Thyroid cancer
myd05218  Melanoma
myd05219  Bladder cancer
myd05220  Chronic myeloid leukemia
myd05221  Acute myeloid leukemia
myd05223  Non-small cell lung cancer
myd05224  Breast cancer
myd05225  Hepatocellular carcinoma
myd05226  Gastric cancer
myd05230  Central carbon metabolism in cancer
myd05231  Choline metabolism in cancer
myd05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:myd00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102763997 (MAP2K1)
   04012 ErbB signaling pathway
    102763997 (MAP2K1)
   04014 Ras signaling pathway
    102763997 (MAP2K1)
   04015 Rap1 signaling pathway
    102763997 (MAP2K1)
   04370 VEGF signaling pathway
    102763997 (MAP2K1)
   04371 Apelin signaling pathway
    102763997 (MAP2K1)
   04668 TNF signaling pathway
    102763997 (MAP2K1)
   04066 HIF-1 signaling pathway
    102763997 (MAP2K1)
   04068 FoxO signaling pathway
    102763997 (MAP2K1)
   04072 Phospholipase D signaling pathway
    102763997 (MAP2K1)
   04071 Sphingolipid signaling pathway
    102763997 (MAP2K1)
   04024 cAMP signaling pathway
    102763997 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    102763997 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    102763997 (MAP2K1)
   04150 mTOR signaling pathway
    102763997 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    102763997 (MAP2K1)
   04519 Cadherin signaling
    102763997 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102763997 (MAP2K1)
   04148 Efferocytosis
    102763997 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102763997 (MAP2K1)
   04210 Apoptosis
    102763997 (MAP2K1)
   04218 Cellular senescence
    102763997 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102763997 (MAP2K1)
   04540 Gap junction
    102763997 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102763997 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102763997 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102763997 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    102763997 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    102763997 (MAP2K1)
   04660 T cell receptor signaling pathway
    102763997 (MAP2K1)
   04662 B cell receptor signaling pathway
    102763997 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    102763997 (MAP2K1)
   04666 Fc gamma R-mediated phagosome formation
    102763997 (MAP2K1)
   04062 Chemokine signaling pathway
    102763997 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102763997 (MAP2K1)
   04929 GnRH secretion
    102763997 (MAP2K1)
   04912 GnRH signaling pathway
    102763997 (MAP2K1)
   04915 Estrogen signaling pathway
    102763997 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    102763997 (MAP2K1)
   04917 Prolactin signaling pathway
    102763997 (MAP2K1)
   04921 Oxytocin signaling pathway
    102763997 (MAP2K1)
   04926 Relaxin signaling pathway
    102763997 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    102763997 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    102763997 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    102763997 (MAP2K1)
   04916 Melanogenesis
    102763997 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102763997 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    102763997 (MAP2K1)
   04726 Serotonergic synapse
    102763997 (MAP2K1)
   04720 Long-term potentiation
    102763997 (MAP2K1)
   04730 Long-term depression
    102763997 (MAP2K1)
   04722 Neurotrophin signaling pathway
    102763997 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102763997 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102763997 (MAP2K1)
   05206 MicroRNAs in cancer
    102763997 (MAP2K1)
   05205 Proteoglycans in cancer
    102763997 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    102763997 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102763997 (MAP2K1)
   05230 Central carbon metabolism in cancer
    102763997 (MAP2K1)
   05231 Choline metabolism in cancer
    102763997 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102763997 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102763997 (MAP2K1)
   05212 Pancreatic cancer
    102763997 (MAP2K1)
   05225 Hepatocellular carcinoma
    102763997 (MAP2K1)
   05226 Gastric cancer
    102763997 (MAP2K1)
   05214 Glioma
    102763997 (MAP2K1)
   05216 Thyroid cancer
    102763997 (MAP2K1)
   05221 Acute myeloid leukemia
    102763997 (MAP2K1)
   05220 Chronic myeloid leukemia
    102763997 (MAP2K1)
   05218 Melanoma
    102763997 (MAP2K1)
   05211 Renal cell carcinoma
    102763997 (MAP2K1)
   05219 Bladder cancer
    102763997 (MAP2K1)
   05215 Prostate cancer
    102763997 (MAP2K1)
   05213 Endometrial cancer
    102763997 (MAP2K1)
   05224 Breast cancer
    102763997 (MAP2K1)
   05223 Non-small cell lung cancer
    102763997 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102763997 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    102763997 (MAP2K1)
   05161 Hepatitis B
    102763997 (MAP2K1)
   05160 Hepatitis C
    102763997 (MAP2K1)
   05164 Influenza A
    102763997 (MAP2K1)
   05163 Human cytomegalovirus infection
    102763997 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102763997 (MAP2K1)
   05165 Human papillomavirus infection
    102763997 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102763997 (MAP2K1)
   05135 Yersinia infection
    102763997 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102763997 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    102763997 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    102763997 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102763997 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102763997 (MAP2K1)
   01522 Endocrine resistance
    102763997 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:myd01001]
    102763997 (MAP2K1)
Enzymes [BR:myd01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102763997 (MAP2K1)
Protein kinases [BR:myd01001]
 Serine/threonine kinases: STE group
  STE7 family
   102763997 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 NAD_binding_6
Other DBs
NCBI-GeneID: 102763997
NCBI-ProteinID: XP_015423963
LinkDB
Position
Un
AA seq 371 aa
MKLERTNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV
FKVSHQPSGLVMARKLFHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC
MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG
EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP
IPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPP
PKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN
QPSTPTHAAGV
NT seq 1116 nt   +upstreamnt  +downstreamnt
atgaagctggagaggaccaacctggaggctttgcagaagaagctggaggagctggagctc
gatgagcagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtgggggaa
ctgaaggatgatgactttgagaagatcagtgagctgggtgctggcaatggtggtgtggtg
ttcaaggtctcccaccagccgtccggcctggttatggccagaaagctatttcacctggag
atcaaacctgcgatccggaaccagataataagggagctgcaggttctacatgagtgtaac
tccccatacattgtgggcttctatggtgcattctacagcgatggagagatcagcatctgc
atggagcatatggatgggggttccttggatcaagtcctgaagaaagctggaagaattcct
gaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctgagggag
aaacacaagattatgcatagagatgtcaagccttctaacatcctagtgaactcccgtggg
gagatcaagctctgtgactttggagtcagcgggcagctcatcgactccatggccaactcc
ttcgtgggcacaaggtcctacatgtcgccagagagactccaggggactcattactccgtg
cagtcggacatctggagcatggggctctctctggttgagatggcggttgggaggtatccc
atccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggagggagat
gcggctgagacaccaccccggccaaggacccctgggaggccccttagctcttatggaatg
gacagccgaccgcccatggcaatttttgagttattggattacatagtcaacgagcctcct
ccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaatgctta
ataaaaaaccctgcagagagagcagatttgaagcaactcatggttcatgcttttatcaag
agatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggccttaac
cagcccagcacaccaacccatgcggctggtgtctaa

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