Myotis davidii (David's myotis): 102765493 Help Entry 102765493         CDS       T02992                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism myd  Myotis davidii (David's myotis) Pathway myd04020   Calcium signaling pathway myd04024   cAMP signaling pathway myd04260   Cardiac muscle contraction myd04261   Adrenergic signaling in cardiomyocytes myd04371   Apelin signaling pathway myd04713   Circadian entrainment myd04911   Insulin secretion myd04921   Oxytocin signaling pathway myd04972   Pancreatic secretion myd05020   Prion disease myd05022   Pathways of neurodegeneration - multiple diseases myd05410   Hypertrophic cardiomyopathy myd05412   Arrhythmogenic right ventricular cardiomyopathy myd05414   Dilated cardiomyopathy myd05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:myd00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102765493 (RYR2)    04020 Calcium signaling pathway     102765493 (RYR2)    04024 cAMP signaling pathway     102765493 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     102765493 (RYR2)    04921 Oxytocin signaling pathway     102765493 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     102765493 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     102765493 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     102765493 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     102765493 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     102765493 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     102765493 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     102765493 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     102765493 (RYR2)    05414 Dilated cardiomyopathy     102765493 (RYR2)    05415 Diabetic cardiomyopathy     102765493 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:myd04040]     102765493 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:myd04990]     102765493 (RYR2) Ion channels [BR:myd04040]  Voltage-gated cation channels   Ryanodine receptor    102765493 (RYR2) Domain-containing proteins not elsewhere classified [BR:myd04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    102765493 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  102765493 NCBI-ProteinID:  XP_015417817 LinkDB All DBs Position Un AA seq 5046 aa AA seqDB search MEVIYGHEEIQDDEVVLQCTAAAHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSIC TFVLEQSLSVRALQEMLANTMEKSEGKFMMKTAQGGGHRTLLYGHAILLRHSNSGMYLCC LSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGSGSGSLHVDAAFQLTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSG EHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLME DKNLLLMDKEKADVKSTAFTFRSSKEKLDAGVRKEVDGMGTSEIKYGDSVCYIQHVNTGL WLTYQAVDVKSVRMGAIQRKAIMHHEGHMDDGINLSRSQHEESRTARVIRSTVFLFNRFI RGLDALGRKAKAPPVDLPIESVSLSLRDLISYLHPPAEHLEHEDRQNRLRALKNRQNLFQ EEGMISLVLQCVDRLHVYSSAAHFAEVAGREAGESWKSILNSLYELLAALIRGNRKNCAQ FSGSLDWLVSRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKV LDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQY KKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGL HLWAGCIASTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFP VVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDL LGPTVALTQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDD NKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEERVKKMKLPKNY QLTSGYKPAPMDLSFIKLTPSQEAMVDRLAENAHNVWARDRIRQGWTYGIQQDVKNRRNP RLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYSLEAPDQDHAARAEVCSSPGERFRIFRA EKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGCDEHAFAFDGFKAQRWHQGNE HYGRSWQAGDVMGCMVDMTERTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVA QVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEV TRIDGTADSSPCLKVTQKSFSSQNSSTDIMFYRLSMPIECAEVFSRTAAGGLPGAGLFGP KSDLEDYDVDSDFEVLMKTAHGHLVPDRGDKDKEATKPEFNNHKDYAQEKPSRLKQRFLL RKTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPASVWVGWVTADF HQYDTCFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQVRNNNGLEIGCV VDAASGLLTFTANSKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGL FKSEHRNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRVSERQGWLVQCVDPLQFMSL HIPEENRSVDILELTEQEELLRFHSHTLRLYSAVCALGNHRVAHALCSHVDEAQLLYAIE SKYMPGLLRAGYYDLLIDIHLSAYATARLMMNNEFIVPMTEETKSITLFPDKHKEHGLPG IGLSTSLRPRMRFSSPSFVCLNHDCYQYSPEFPLDTLKAKTMQMLTEVVQEGGLRARDPV GGTTEFLFVPLIKLFYTLLTMGVFQGEDLKHILQLIEPRVFKEASLEEEHQAPLKEPHTE DARPEGIRGDAAEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVARLQD NQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNECPCPEEIRDQLLD FHEDLMAHCGIELDDDGSLDGSSDLTIRGRLLSLVEKVTSLKKKQADKPAESASDKSSTL QQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVQALPKTYTISAVSVEDTIN LLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNV LGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGST PLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPMLVAKGYPDIGWNPVEGERY LDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPS RDGPSPTSGSSKTPDTAEEDNTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRI RSILRSLIPLGDLVGVISITFQMPAIAKGEVPLSGEGLSEPNVTSSSRLICFCFPGMIHD SDTAEEDNTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDL VGVISITFQMPAIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGF LPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTV YRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRFVFDVPLLNEHAKMPLKLLTN HYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAV AGALPPDYMESNHVGMMEKQSSMDSEGNFNPQPVETSNITIPEKLEYFINRYAEHSHDRW SMDKLANGWIYGETYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERT REGDSMALYHRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIW AKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLEL DAPTIEKRFAYSFLQQLIRYVDEAHQYILEFDGGCRGKGQRFPYEQEIKFFAKVVLPLID QYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDAASIVNC LHILGQTLDARTVMKTGLESVKGALSAFLDSAAEDLDRTLENLKEGQFTHTRSQPRGVTQ IINYATVALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQR SAVGECLAAFAGAFPVAFLETHLNKHNSCSIYNTSSSRERAALNLPANVEDVCPNIPSLE KLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWEQGPESNPERAGLCCTALNSEH MNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAV VVAEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPSPEA EDLFRMVAEVFIYWSKSHNFKREEQNFVVQNGDPGLMYSWMAAVSDQERKKMRRKGDRYS VQTSLIVAALRRLLPIGLNICAPGDQELIALAKNRLSMKDTEDEVRDIIRSNIHLQGKLE DPAIRWQMALYKDLPNRPEDSADPEKTVERVLDIASVLFHLEQVEHPQRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGADPP EEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEDDDDSEEEVK SFEEKEMEKQKLLYQQARLHERGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNST VQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQD DEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYY SGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFA HMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEM ILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTPSETEFLLSCAET DENETLDYEEFVKRFHEPAKDISFNVAVLLTNLSEHMPNDSRLQTFLELAESVLRYFQPF LGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNF CEDTIFEMQLAAQISESDLSERSASKEESEKEKPEEQSPRTGFFSLLTVRSALLALRHNL LTLLRLLSLKSLKKQMKKVKKMTVRDMVTALFSSYWEALASLLHVVASVLRGFSRIVGSL LLGGSLVEGAKKIRVAELLADMPDPTQDEVRDDGEEGERKPLEAALPSEDLTDLKELTEE SDLLSDIFGLDLKREGGQYRLIPHNPNAGLSDLMSNPDPVPEAPEKVQEQETKEEEKEEK EENRSEPEKAEYVWFPCWLVLSLQGTEWGQAQRQDLVLGHQRPGSQKSSEPFRVYVAVRH AFPFFHLQNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPPRSASESARV SSPDDGGDDAPGVLAVHYVLEESSGYMEPTLRILAVLHTVISFFCIIGYYCLKVPLVIFK REKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFY GRDRISELLGMDKAALDFSDAREKKKPKKDSSLAAVLNSIDVKYQMWKLGVVFTDNSFLY LAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY TVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEI YRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTV PHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQ YEDQLN NT seq 15141 nt NT seq  +upstreamnt  +downstreamnt atggaggtcatttatggccatgaagaaatacaggacgacgaggtggtgctgcagtgcacg gcggccgcccacaaggagcagcagaaactgtgcctggcggcggaaggatttggcaacagg ctctgtttcctggagtccacctccaattccaagaatgtccccccagacctctccatctgc acctttgtgctggaacagtccctctctgtccgggccctacaggagatgctggcgaacacg atggagaagtcagaagggaaattcatgatgaagactgctcaagggggtggtcaccggaca ctcctctacggacacgccatcctgctgcgccactccaacagcggcatgtacctgtgctgc ctgtccacctcccggtcttcaactgacaagctggcctttgatgttggcttgcaagaggac acaacaggcgaggcttgctggtggaccatacaccccgcctccaagcagcggtccgaggga gagaaggtgcgagttggcgatgacctcatcttagtgagtgtgtcctccgaaaggtacctg cacctgtcctatggcagcggcagcggcagcctgcacgtggacgccgctttccagctgacg ctctggagcgtggcccccatcagctcaggaagtgaagcggcccaagggtacctgattggc ggcgacgtcctgaggttgctgcacggacacatggacgagtgcctcaccgtcccctctggg gagcatggggaggagcagcggagaactgtccattatgaaggtggtgccgtgtctgtccac gcccggtccctgtggagactggagacgctgagagttgcgtggagtgggagccacatacgg tggggccagcctttccgactgcggcacgtcaccacgggaaagtacctgagtctcatggaa gacaagaaccttctccttatggacaaagagaaagccgacgtgaagtctacggccttcacc ttccgctcctccaaggaaaaattggatgcaggggtgagaaaggaagttgatggcatggga acctctgagatcaagtatggagactcggtctgctacatacagcatgtgaacacaggcctg tggctgacttaccaggctgtggacgtgaagtctgtgaggatgggagccatacagcgcaag gccatcatgcatcacgaaggccacatggacgacggcataaacttgtccaggtcgcagcac gaagagtcgcggacagcgcgggtcatccggagcaccgtcttccttttcaacaggtttata aggggcctggatgctctgggcaggaaggcgaaggcgcccccagtggacttgcccatcgag tcggtcagcctgagcctgcgggacctgatcagctacctgcacccgccggccgagcacctg gagcacgaggacaggcagaaccggctgcgggccctgaagaaccggcagaacctcttccag gaggaggggatgatcagcctcgtgctccagtgcgtggaccggctgcacgtctacagcagc gccgcccactttgccgaggtcgctggcagagaggcgggggagtcctggaagtccattctg aattccctgtatgagttgctggcggctctaattagaggaaatcgtaaaaactgtgcccag ttttctggctccctcgactggctggtcagccgactggaaagactggaagcttcttctggt attcttgaagttttgcactgtgtgttagtagaaagtccagaagctctaaatattatcaaa gaagggcatattaaatccattatttcacttttagacaagcatggaagaaatcacaaggtt ctggacgtcttgtgctctctctgcgtttgccacggggtggcagtccgttccaaccagcat ctcatctgtgacaatctcctgcctggaagggacctgttactgcagacacgcctggtgaac catgtcagcagcatgaggcccaacattttcctgggcgtcagcgaaggctctgcacagtat aagaagtggtactatgaactgatggtggaccacacagagcccttcgtgacggccgaagcc acccacctgcgcgtgggctgggcgtccacggaagggtactctccctaccccggagggggc gaggagtggggcgggaacggcgttggagacgacctcttttcctatggatttgatggcctg cacctctgggcaggctgtatcgccagcaccgtgagctcgccaaaccagcacctgctgagg acggatgacgtcatcagctgctgtttagatctgagtgccccaagcatctcattccgaatt aatggacagcctgttcaggggatgtttgagaacttcaacatcgatggcctcttctttccc gttgttagtttctctgcgggaatcaaggtacgctttctgcttggggggagacacggagaa tttaaattccttcccccaccgggctatgctccttgttacgaagctgtgctgccaaaagaa aagctgaaagtggaacacagccgcgagtacaagcaggagagaacttacacccgggacctg ctgggccccacagttgccctgacccaagccgccttcacgccggtccccgtggacaccagc cagatcgtgttgcccccccacctggagaggataagagaaaagctggcggagaacatccat gagctctgggttatgaataaaattgaacttggctggcagtatggcccggtcagagatgac aacaagaggcagcacccgtgtctggtggagttctccaagctgccggagcaagaacgcaac tacaacctgcagatgtcgctcgagaccctgaagaccttgttggcattaggatgccacgtg ggtatatcggatgaacatgctgaggaaagggtgaaaaagatgaagctccccaagaattac cagctgacaagtggctacaagccggcaccgatggacctgagctttatcaaactcaccccg tcccaggaagcaatggtggacagactggcagaaaatgctcacaacgtgtgggcccgggac cggatccggcagggctggacctacggcatccagcaggacgtcaagaacagaagaaaccca cgccttgtgccctacacccttctcgatgacagaaccaagaagtccaacaaggacagcctc cgggaggcggtgcgcacgctgctggggtacgggtacagcctggaggcgcccgaccaagac cacgctgcccgagcagaagtgtgcagcagccccggggaacggttccggatcttccgggct gagaaaacctacgccgtgaaggcgggaaggtggtactttgagttcgaggctgtcactgct ggggacatgcgcgttggctggagcaggccaggctgccagcctgatcaggagctgggctgc gatgaacacgccttcgcctttgatggcttcaaggcccagcggtggcaccagggcaatgag cactatggtcgctcctggcaagcaggcgatgtcatggggtgcatggtggacatgacagag cgcaccatgatgttcacactgaatggcgaaatcctccttgatgactcagggtcagaactg gcttttaaggactttgatgttggtgacgggttcatacctgtgtgcagccttggggtggct caggtgggaaggatgaactttggaaaggacgtgagcaccttgaagtatttcaccatctgt ggcttacaggagggctacgagccattcgccgttaatacaaatagggatattaccatgtgg ctaagcaagcgacttcctcagtttctccaggttccatcaaaccatgaacacattgaggtg accagaatagacggcaccgcggacagctctccgtgtttaaaggtcactcagaagtccttc agttcccagaacagcagcacggacatcatgttctaccggctgagcatgcccatcgagtgc gcagaggtcttctccaggacggccgccggggggctcccgggtgccggcctcttcgggccc aagagtgatctggaggattacgacgtggattctgattttgaggttctgatgaagacagct catggccatctggtgcccgatcgaggggacaaagacaaagaagctacgaaaccagagttt aataaccacaaagattacgcgcaggaaaagccctctcgtctgaaacaaagatttttgctt agaaaaacaaagccggattacagcacgagccattccgcgaggctcactgaggacgtcctt gcggatgatcgagatgactacgactacctgatgcagacatccacgtactattactcggtg aggatcttccctggacaggagccggccagcgtctgggtgggctgggtcacggccgacttc caccagtacgacacgtgcttcgacttggacagagttcgcaccgtcaccgtgactctggga gatgaaaaagggaaagtgcacgagagcatcaaacgcagcaactgctacatggtgtgtgcg ggcgagagcatgagccccgggcaggtccgcaacaacaacgggctggagatcggctgcgtg gtggacgccgccagcgggctgctcaccttcacggccaacagcaaggagctgagcacctac taccaggtggagccaagcaccaaattatttcctgcagtttttgcacaagctacaagtccc aatgttttccagtttgagttgggaagaataaagaatgtgatgcctctctcggcgggactc ttcaagagcgagcacagaaaccccgtgcctcagtgtcccccgcgcctccacgtgcagttc ctgtcccacgtcctgtggagcagaatgcccaaccagtttctgaaggtggacgtgtcacgg gtcagcgagcgccagggctggctggtgcagtgcgtggaccccctgcagttcatgtccctg cacatccccgaggagaacaggtccgtggacatcctggagctgacggagcaggaggagctg ctgcgcttccactcgcacaccctgcggctgtactcggccgtgtgtgccctgggcaaccac cgcgtggcacacgcgctctgcagccacgtggacgaggcacagctgctgtacgccatcgag agcaagtacatgcccggcctgctgcgcgcgggctactacgacctgctcatcgacatccac ctgagcgcctacgccaccgcgcggctcatgatgaacaacgagttcatcgtgcccatgacc gaggagaccaagagcatcacgcttttccccgacaagcacaaggagcacgggctgccgggc atcggcctcagcacctcgctgcggccgcgcatgcgcttctcctcgcctagctttgtgtgc ctcaatcacgactgctaccagtacagccccgagttcccactggacacgctcaaggccaag accatgcagatgctgaccgaggtggtgcaggagggcggactgcgcgcgagggaccccgta gggggcaccactgagttcctcttcgtgccccttatcaagctcttctacacgctgctcaca atgggtgtcttccaaggggaggacctgaagcacatcctgcaactgattgagccccgggtg ttcaaggaggcctccctggaggaggagcaccaggcaccactcaaggagccccacaccgaa gatgccaggcccgagggcatacgaggggatgcggcagaggggctgctgcagatgaaactg cctgagcctgtgaagctccagatgtgcctgctcctgcagtacctctgcgactgccaggtc cgacaccgcatagaagccattgtggccttttcagacgactttgtcgctaggctccaggac aaccagcgcttccgctataacgaagtcatgcaagccctgaacatgtcggccgcactcaca gcccggaagactaaggagttcaggtcgcccccacaagaacagatcaatatgcttctcaat tttaaggatgacaaaaacgagtgtccatgtccagaggaaattcgagaccaactcttagat tttcatgaagatctgatggcacattgtggaattgagctggatgacgatgggtctctggac ggaagcagtgacctaacaattagagggcgcctgctgtccctggtggagaaggtgacgtcc ctgaagaagaagcaagctgacaagccagcggagagtgcctccgacaagtcctccactctt cagcagctgatctctgagacgatggtgcggtgggctcaggagtctgtcatcgaggacccc gagctggtgagggccatgttcgtgctgcttcaccggcagtacgacggcatcgggggcctg gtccaggccctgcccaagacctacaccatcagcgctgtctccgtggaggacaccatcaac ctgctggcctccctgggccagatccgctctctgctgagtgtgaggatgggcagagaagag gagaagctcatgattcggggactaggggacattatgaataataaagtgttttaccagcac cctaacctcatgagggcactggggatgcacgagacagtgatggaggtcatggtgaacgtc cttggcggtggggagtccaaggagatcacttttcccaagatggtagccaactgttgtcgt ttcctctgttacttctgtcggataagccggcagaaccaaaaagctatgtttgaccatctc agttacttattggaaaacagcagtgttggtctagcttcgccagcgatgagagggtcgacg cccctggacgtggcggcagcctcggtgatggacaacaatgagctggccttagctctgcgc gagccggacctggagaaggtcgtccggtatttggccggctgtggactgcagagctgccca atgctggtggccaagggctacccagatatcggctggaacccagtcgaaggggaaagatat ctcgactttctcagatttgctgttttctgtaacggggagagtgtggaggagaacgcgaac gtggtggtgcggctgctcatccgcaggcccgagtgcttcggccccgccctgcgcggcgag ggtgggaacgggctcctcgcagccatggaggaggccatcaaaatcgccgaggacccttct cgagatggcccctcaccaaccagcgggtccagcaaaactcctgacacagcggaggaggac aacaccatccacatggggaatgccatcatgaccttctatgcggctttgatcgacctgtta ggacgttgtgctcctgaaatgcatctgattcacgccgggaagggggaagccatcaggatc agatccattttgaggtccctgattccactgggagatttggtgggcgtgatcagcatcacc ttccagatgcctgcgatagccaaaggtgaggtccctctgagtggcgaaggcctgtctgaa ccaaatgtcacttcctcctcccgtttgatttgtttctgtttccctggaatgatccatgac agtgacacagcggaggaggacaacaccatccacatggggaatgccatcatgaccttctat gcggctttgatcgacctgttaggacgttgtgctcctgaaatgcatctgattcacgccggg aagggggaagccatcaggatcagatccattttgaggtccctgattccactgggagatttg gtgggcgtgatcagcatcaccttccagatgcctgcgatagccaaagatgggaatgtggtg gagcctgacatgtctgcggggttctgcccagatcacaaggcagccatggttttgttcctt gacagggtctatggcattgaggttcaggatttcctcctccacctcctggaggttggcttt ctgccagatctccgggctgctgcttccttagacacggctgctttgagtgctacggacatg gccttggccctcaatcggtacctctgcacggccgtgttgcctttgttaacaagatgtgct cctctttttgctggcacagagcaccacgcttccctcatcgactcgttgcttcataccgtg tacagactttctaagggctgctcactgaccaaagctcagagggattccatagaagtttgt ttgctctctatctgtggccaactgagaccttctatgatgcagcacttactcaggagattc gtgtttgatgtcccgctgttaaatgagcatgcaaagatgcccctcaagctgctgaccaac cactatgaaaggtgctggaagtactactgtctgccgggcgggtgggggaacttcggagct gcctcagaggaagaacttcatttatcaagaaaattgttctggggcatttttgatgccctg tctcaaaagaaatatgaacaagagcttttcaaactggctctgccgtgcctgagtgcggtg gcgggcgcactgcccccggactacatggagtcaaaccatgtgggcatgatggagaagcag tcatccatggattcggaggggaacttcaacccccagcctgtcgaaacctcaaatattacg attcctgagaagctggaatacttcattaacagatacgctgagcactcccacgacaggtgg tccatggacaagttggccaatggatggatttatggagaaacttattcagactcatctaaa gttcaaccattaatgaagccatataaactattatctgaaaaggaaaaagaaatctatcgc tggccaatcaaagaatctttgaaaacgatgctggcttggggctggagaattgagcgcacg cgggagggggacagcatggccctctaccaccggacccggcgcatctctcagaccagccag gtttctgtggatgctgctcatgggtacagcccccgggccattgacatgagcaatgtcaca ctgtccagggacctgcatgctatggcagaaatgatggctgaaaactaccataatatatgg gcaaagaagaagaaaatggaactggagtccaaaggaggcgggaaccaccccctgctggtg ccttacgatacgctgaccgccaaagagaaagccaaggaccgggagaaagcacaggacatc ctcaagttcttgcagatcaatggctacgctgtgtccagagggttcaaagacctggagttg gacgcgcctacgattgagaagcgatttgcctacagcttccttcagcagctcatccgctac gtggacgaagcccatcagtatatcttggagtttgatggcggctgcagaggaaaaggacag cgtttcccttacgagcaagagatcaagttctttgctaaagttgtcctgcctctaattgat cagtatttcaaaaaccatcgtttatacttcctgtctgcagcgagcagaccgctgtgttct ggaggacatgcgtcaaacaaggagaaggaaatggtgacaagcctgttctgcaaactcgga gttcttgtcaggcataggatctcactgtttggaaacgatgcagcatccattgtcaactgt cttcacattttgggtcagaccctggatgcaaggaccgtcatgaagaccggcctggagagt gtgaagggcgcactcagtgcatttctggacagtgcagcggaggacctggacaggaccctg gagaacctgaaggagggccagttcacgcacacccgcagccagccgcggggcgtcacgcag atcatcaactacgcgacggtggcgctgctgcctgtgctgtcctccctgttcgagcacatc ggccagcaccagttcggggaggacctgatcctggaagatgtacaggtgtcctgttataga attctgacgagcttatatgctctgggaacgagcaagagtatttatgtggaaaggcagcga tctgcagtgggcgagtgtctggcggcttttgcgggtgccttcccggtggcgtttctggaa actcatctcaacaaacacaacagctgctccatctacaatactagctcctcacgggagaga gcagctctcaatctgccagccaacgtggaagatgtttgtccgaatatcccatctttggag aaactgatggaagagattgtggagctggctgagtccgggatccgctacacgcagatgcca cacgtgatggaagtgatcctgcccatgctctgcagctacatgtcccggtggtgggagcag gggcccgagagcaaccccgagagggccgggctgtgctgcacggcactgaactcggagcac atgaacaccctgctgggcaacatcctgaaaatcatctacaacaacctggggatcgacgag ggggcctggatgaagaggctggcagtgttttcccagccgattataaataaagtgaagcct cagctcctgaaaactcatttcttgccattaatggagaaactgaagaaaaaggcagctgtg gtggtcgcggaggaagaccatctgaaagccgaggccaggggggacatgtccgaggccgag ctgctcatcctggacgagttcaccacgctggccagggacctctatgccttctacccactc ctgatccgattcgtggactacaacagggcgaagtggctcaaagaaccgagcccggaagcc gaggacctgttccgcatggtggccgaggtgttcatttactggtccaagtcccacaacttc aaaagagaggagcagaatttcgtggtccagaatggggacccaggactgatgtactcatgg atggccgctgtgtccgaccaggagaggaagaagatgaggcggaaaggagaccgctactcc gtgcagacctccctcatcgtggctgcgctgaggcggctgctgcccattgggctgaatatc tgtgcccccggagaccaggagctcattgctctggccaagaaccggttgagtatgaaagac actgaggatgaagtccgagatataatccgcagtaatattcatttacaaggcaagttggag gatcctgctattagatggcaaatggctctttacaaagacctgccgaacaggcctgaggac agtgccgatcccgagaagacggtggagcgagtcctggacatagcgagcgtgctcttccat ctcgagcaggtggagcaccctcagaggtcgaagaaggccgtgtggcacaagctgctctcg aaacagcggaaacgggcggtcgtggcctgcttccgcatggcccctctctacaacctgcca aggcatcgggccgtcaatctttttcttcaggggtatgagaagtcctggattgagacagaa gagcattactttgaggacaaactgatagaagacttagcgaaacctggagcggaccctcca gaggaagacgaaggcactaagcgagttgatcctctgcatcagctgatccttctgttcagc cgaacggccttaacggagaaatgcaaactggaggaggattttttatacatggcttatgca gatattatggcaaagagttgtcatgatgaagatgacgatgacagtgaagaagaggtgaag agttttgaagaaaaggaaatggagaagcagaagcttctgtaccagcaagcccggctgcat gagcgcggcgccgccgagatggtgctgcagaccatcagcgccagcaaaggtgaaactgga ccgatggtggctgctactttgaaacttggaattgctatcctaaacggtgggaactccaca gtgcagcagaaaatgctcgactacctcaaggagaagaaggacgtgggtttcttccagagc ctcgcgggcctgatgcagtcatgcagcgtcctcgacctgaacgcctttgagcggcagaac aaagctgaagggctggggatggtaaccgaggaaggatcaggcgagaaggttcttcaggac gatgagttcacctgcgacctcttccgcttcctgcagctgctctgcgagggacacaactca gattttcagaattacctgaggactcagactggcaacaacaccaccgtgaacatcatcatc tccaccgtggactacctgctgcgggtgcaggagtccatcagtgatttctactggtactac tcggggaaagacgtgatcgatgagcaagggcagcggaacttctccaaagcaattcaagta gcaaaacaagtgtttaacactctcacagagtatatccagggtccgtgcactgggaaccag caaagtctggcccacagccggctctgggacgcggtcgtgggcttcctccacgtgtttgcc cacatgcagatgaagctgtcccaggattccagtcaaatcgagctcctgaaagagctgatg gacctgcagaaggacatggtggtcatgctgctgtccatgttggaaggtaacgtcgtgaac gggaccatcggcaagcagatggtcgacatgcttgtggaatcgtccaacaacgtggagatg atcctcaaattcttcgacatgttcttaaaactaaaggacctgacctcttccgacacgttt aaggaatacgaccccgacggcaagggcgtcatctccaagagggacttccacaaagcgatg gagagccacaagcactacacgccgtcggagaccgagttcctgctgtcctgtgcggagacg gacgagaacgagaccctggactacgaggagttcgtgaagcgcttccacgagccggccaag gacatcagcttcaacgtggccgtgctgctgaccaacctctcggagcacatgcccaacgac tcgcggctgcagaccttcctggagctggcggagagcgtgctgcgctacttccagcccttc ctgggccgcatcgagatcatgggcagcgccaagcgcatcgagcgcgtgtacttcgagatc agcgagtccagccgcacgcagtgggagaagccgcaggtcaaggagtccaagcgccagttc atcttcgacgtggtcaacgagggcggcgagaaggagaagatggagctgttcgtgaacttc tgcgaggacaccatcttcgagatgcagctggcggcccagatctccgagtcggacctgagc gagcggtcagccagcaaggaggagagtgagaaggagaagccggaggagcagagcccgcgg acgggcttcttctccctgctgaccgtccgctcggccctgctggcgctcaggcacaacctg ctgacgctcctgcgcctgctcagcctgaagagcctgaagaagcagatgaagaaggtgaag aagatgacggtgagggacatggtcacggcgctcttctcctcctactgggaggcgctggcg agcctgctgcacgtggtggccagcgtgctgcgcggcttctcccgcatcgtgggcagcctg ctcctggggggcagcctggtggagggcgcgaagaagatccgggtggcggagctcctggcc gacatgccggaccccacgcaggacgaggtgcgggacgacggggaggagggcgagcggaag ccgctggaggccgccctgccctcggaggacctcaccgacctgaaggagctgacggaggag agcgacctgctctctgacatcttcggcctggacctgaagcgggaaggggggcagtacaga ctcatccctcacaacccgaacgctggcctcagcgacctcatgagcaaccctgaccccgtt cccgaggcgccagagaaagtgcaggaacaggagacaaaagaggaagaaaaggaagaaaaa gaagaaaacagatcggaacccgagaaagccgagtacgtgtggtttccttgttggcttgtg ctctctctccagggtacagaatggggacaggctcagcgccaggacctcgtgctggggcat cagaggccggggtcccagaagtccagtgagcccttcagggtgtacgttgccgtgagacat gcttttcctttttttcaccttcagaactattttgctcgcaacttttacaacatgagaatg ttggccttatttgtcgcctttgcaatcaacttcatcttgctcttctataaggtctccact tcttctgtggttgaaggcaaggagctcccccctcgcagcgcaagcgaaagcgccagagtc agcagccctgacgacggcggtgacgacgcgcctggcgtcctggcggtgcactatgtgctg gaggagagcagcggctacatggagcccacactgcgcatcctggccgtgctgcacaccgtc atctccttcttctgcatcatcggctactactgcctgaaagtcccgctggttatttttaag cgcgaaaaggaagtagctcggaaattggaatttgacgggctttacattacagagcagcct tcggaagacgatattaaaggccagtgggatcgactcgtaatcaacacacagtcatttccc aacaactactgggacaagtttgtcaaaagaaaggttatggataaatacggcgagttctat ggccgggacagaatcagcgagttgcttggtatggacaaagccgccctggacttcagcgac gcccgggagaaaaagaaacccaagaaagacagctccctggcggcggtactgaactccatc gacgtgaagtatcagatgtggaaactcggagtcgttttcactgacaattccttcctgtac ctggcctggtacatgaccatgtccgtgctgggccactacaacaacttcttctttgctgct catcttctcgacatcgcgatggggttcaagacgctgaggaccatcttgtcgtcagtaacg cacaatggcaagcagctggtgttaaccgtgggcttattagccgttgtcgtctacctgtac acggtggtggcattcaatttcttccgaaaattctacaataaaagtgaagacggagacacg ccagatatgaaatgtgacgacatgctgacgtgctacatgttccacatgtacgtgggtgtg cgagctggaggcggcatcggcgatgagatcgaggacccggcgggcgatgagtatgagatc tatcggatcatcttcgacatcaccttcttcttcttcgtgattgtcatcctcttggcgata atacaaggtttaatcatcgatgcgtttggggaactgagagaccagcaggagcaggtcaag gaggacatggagaccaagtgcttcatctgtgggataggcaacgactacttcgacacggtg ccgcacggcttcgaaacccacaccctgcaggagcacaacctggccaactacctgtttttc ctgatgtatcttatcaacaaggacgagacggagcacacggggcaggaatcttacgtgtgg aagatgtaccaggaaagatgttgggagtttttcccagccggagactgtttccggaaacag tatgaagaccagctgaattaa

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