KEGG   Myotis yumanensis (Yuma myotis): 138994326
Entry
138994326         CDS       T10762                                 
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2 isoform X1
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
myum  Myotis yumanensis (Yuma myotis)
Pathway
myum01521  EGFR tyrosine kinase inhibitor resistance
myum01522  Endocrine resistance
myum01524  Platinum drug resistance
myum04010  MAPK signaling pathway
myum04012  ErbB signaling pathway
myum04020  Calcium signaling pathway
myum04066  HIF-1 signaling pathway
myum04151  PI3K-Akt signaling pathway
myum04510  Focal adhesion
myum04520  Adherens junction
myum04530  Tight junction
myum05200  Pathways in cancer
myum05205  Proteoglycans in cancer
myum05206  MicroRNAs in cancer
myum05212  Pancreatic cancer
myum05213  Endometrial cancer
myum05215  Prostate cancer
myum05219  Bladder cancer
myum05223  Non-small cell lung cancer
myum05224  Breast cancer
myum05226  Gastric cancer
myum05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:myum00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    138994326 (ERBB2)
   04012 ErbB signaling pathway
    138994326 (ERBB2)
   04066 HIF-1 signaling pathway
    138994326 (ERBB2)
   04020 Calcium signaling pathway
    138994326 (ERBB2)
   04151 PI3K-Akt signaling pathway
    138994326 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    138994326 (ERBB2)
   04520 Adherens junction
    138994326 (ERBB2)
   04530 Tight junction
    138994326 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    138994326 (ERBB2)
   05206 MicroRNAs in cancer
    138994326 (ERBB2)
   05205 Proteoglycans in cancer
    138994326 (ERBB2)
   05230 Central carbon metabolism in cancer
    138994326 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    138994326 (ERBB2)
   05226 Gastric cancer
    138994326 (ERBB2)
   05219 Bladder cancer
    138994326 (ERBB2)
   05215 Prostate cancer
    138994326 (ERBB2)
   05213 Endometrial cancer
    138994326 (ERBB2)
   05224 Breast cancer
    138994326 (ERBB2)
   05223 Non-small cell lung cancer
    138994326 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    138994326 (ERBB2)
   01524 Platinum drug resistance
    138994326 (ERBB2)
   01522 Endocrine resistance
    138994326 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:myum01001]
    138994326 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:myum04147]
    138994326 (ERBB2)
   04090 CD molecules [BR:myum04090]
    138994326 (ERBB2)
Enzymes [BR:myum01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     138994326 (ERBB2)
Protein kinases [BR:myum01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   138994326 (ERBB2)
Exosome [BR:myum04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   138994326 (ERBB2)
CD molecules [BR:myum04090]
 Proteins
  138994326 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 ABC1 Haspin_kinase Kinase-like RIFIN Tcell_CD4_C APH
Other DBs
NCBI-GeneID: 138994326
NCBI-ProteinID: XP_070250268
LinkDB
Position
Unknown
AA seq 1257 aa
MELAAWYRWGLLLALLPPGAAGTQVCTGTDMKLQFPASPETHLDMLRHLYQGCQVVQGNL
ELTHLPGNASLSFLQDIQEVQGYVLIAHSQVTQVPLQRLRIIRGTQLFEDNYALAVLDNG
DSATPVAGATPGGLRELQLRSLTEILKGGVLMQRNPQLCHQDTVLWTDIFHKNNRLALLQ
IDTNRSRACKPCSPSCNPSHCWGDSSKDCQILTRTLCASGCARCKGSLPTDCCHEQCAAG
CTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTTCPYNY
LSTDVGSCTLVCPLNNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREARAVTSANIQE
FAGCKKIFGSLAFLPESFKGNSTSDTAPLEPEQLRVFETLEEITGYLYISAWPDSMPDLS
VFQNLQVIRGRVLYDGAYSLTLQGLGIRWLGLRSLRELGSGLALIHRNAHLCFVHTVPWD
QLFRNPHQALLHSANRPEDECVGEGQVCYLLCAHGHCWGPGPTQCVNCSQFLRGQECVEE
CRVLQGLPREYVKDRYCLPCHPECQPQNGSATCLGSEADQCMACAHYKDSPFCVARCPSG
VKTDLSFMPIWKFPDEEGTCQPCPINCTHSCVDLDEKGCPAEQRASPVTSIIAAVVGILL
VMVMGVVFGVLIRRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKV
KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS
RLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVH
RDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQS
DVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDS
ECRPRFRELVTEFSRMARDPQRFVVIQNEDLGPTSPLDSTFYRSLLEDDDMGDLVDAEEY
LVPQQGFFCPDPAPGAGGTAHRRHRSSSTRSGGGELTLGLEPPEEEPPKSPLAPSEGAGS
DVFESDLGMGAAKGLQSLSPHDPSPLQRYSEDPTVPLPPETDGYVAPATCGPQPEYVNQP
EVRPKPPSPLEGPLPPPRSASATLEKPKTLSPKTLSPGKNGVVKDVFAFGGAVENPEYLA
PRGRAAPQPHPPPAFSPAFDNLYYWDQDPSERGSLPSTFEGTPTAENPEYLGLDAPV
NT seq 3774 nt   +upstreamnt  +downstreamnt
atggagctggcggcctggtaccgctgggggctcctcctcgccctcctgccccccggagcc
gcgggcacccaagtatgcaccggcacagacatgaagctgcagttcccagccagtcccgag
acccacctggacatgctgcgccacctctaccagggctgtcaggtggtgcagggtaacctg
gagctcacccacctgcctggcaatgccagcctctccttcctacaggatatccaggaggtg
cagggctacgtgctcatcgctcacagccaagtgacacaggtcccgctgcagaggctgcga
atcatccgaggcacccagctctttgaggacaactatgccctggccgtgctggacaacgga
gacagcgccacccctgtcgccggggccaccccaggagggctgcgggagctgcagcttcga
agcctcacagagatcctgaagggaggggtgttgatgcagcggaacccacagctctgccac
caggacacggtcctgtggacggacatcttccacaagaacaaccggctggccctcctgcag
atagacaccaaccgctcgcgggcctgcaaaccctgttctccatcctgcaacccttcccac
tgctggggagacagttccaaggactgtcagatcttgactcgaactctgtgtgccagtggc
tgtgcccgctgcaagggctcactgcccaccgactgctgccacgagcagtgtgctgccggc
tgcacgggccccaagcactctgactgcctggcctgcctccacttcaaccacagtggcatc
tgtgagctgcactgcccagccctggtcacctacaacacggacacctttgagtccatgccc
aaccccgagggccgctacacctttggtgccagctgtgtgaccacctgtccctacaactac
ctgtcaacggacgtgggatcctgcaccctggtctgtcccctgaacaaccaagaggtgaca
gctgaggacggaacacagcggtgtgagaagtgcagcaagccctgtgcccgagtgtgctat
gggctgggcatggaacacctgcgggaggcgagggcagtcaccagtgccaatatccaggag
tttgccggctgcaagaagatctttgggagcctggcgtttctgccagagagctttaagggg
aactccacctccgacactgcccccctagagcctgagcagctcagagtgttcgagaccttg
gaggagatcacaggttacctgtacatctcggcgtggccagacagcatgcctgacctcagt
gtcttccagaacctgcaagtgatccggggacgcgttctatatgacggcgcctactcgctg
accctgcaaggactgggcatccgatggctggggctgcgctcgctgcgggaactgggcagt
gggctggccctcatccaccgcaacgcccacctctgctttgtccacacggtgccctgggac
cagctcttccggaaccctcaccaggccctgctccacagtgccaaccggccagaggatgag
tgtgtgggtgagggccaggtctgctacctgctgtgcgcccacgggcactgctggggtccg
gggcccacccagtgcgtcaactgcagccagttccttcggggccaggagtgcgtggaggag
tgccgagtactgcaggggctccccagggagtacgtgaaggacaggtactgcctgccttgc
caccccgagtgccagccccagaatggctcagcgacctgcttaggatcggaggccgaccag
tgtatggcctgcgcccactacaaggactctcccttctgtgtggcccggtgccccagtggc
gtgaagactgacctctccttcatgcccatctggaagttccccgacgaggagggcacgtgc
cagccatgcccgatcaactgcacccactcctgcgtggacctggatgagaagggctgcccc
gccgagcagagagccagccctgtgacgtccatcattgctgctgtggtgggcattctgctg
gtcatggtcatgggggtagtcttcggcgtcctaatcaggagaaggcggcagaagatccgg
aagtacacgatgcggaggctgctgcaggaaacggagctggtggagccgctgacgcctagc
ggggcgatgcccaaccaggctcagatgcggatcctcaaagagaccgagctgaggaaggtg
aaggtgctcggatccggagcttttggcaccgtctacaagggcatctggatccccgatggg
gagaacgtgaagatcccagtggccatcaaagtgttgagggaaaacacatctcccaaagcc
aacaaagaaatcttggatgaagcatatgtgatggccggtgtgggctccccgtatgtgtcg
cgcctcctgggcatctgcctgacctccacggtgcagctggtgacacagctcatgccctat
ggctgcctcctggaccacgtccgcgaacaccgtgggcgcctgggctcccaggacctgctg
aactggtgtgtgcagattgccaagggaatgagctacttggaggatgtgcggcttgtgcac
agggacctggctgcccggaacgtactggtcaagagtcccaaccacgtcaagatcacagac
tttgggctggctcggctgctggacatcgacgagacggagtaccatgcagatgggggcaag
gtgcccatcaagtggatggcgctggagtccattctccgccgacggttcacccaccagagt
gatgtgtggagctacggcgtgactgtgtgggagctgatgacttttggggccaaaccttac
gatgggatcccagcccgggagatccctgacctgctggagaagggggaacggctgccccag
ccccccatctgcaccatcgatgtctacatgatcatggtcaaatgttggatgattgactct
gaatgccggccccggttccgggagttggtgaccgaattctcccgcatggccagggacccc
cagcgcttcgtggttatccagaacgaggacttgggccccaccagccccttggacagcacc
ttctaccgctcgctgctggaggatgacgacatgggggacctggtggatgccgaggagtac
ctggtgccccagcaaggcttcttctgcccagaccctgccccgggggcggggggcacggcc
caccgcaggcatcgcagctcatccaccaggagtggcggtggtgaactgacactggggctg
gagccccctgaggaggagcccccgaaatctccactggcgccctccgagggggcgggctct
gatgtgtttgagagcgacttgggaatgggggcggccaaggggctgcagagcctctcccca
catgaccccagccctctacagcggtacagtgaggaccccacagtgcccctgccccctgag
actgatggctatgttgcccctgcgacctgcggtccccagccagaatacgtgaaccagcca
gaggtccgcccgaagcccccctcacccctagagggccccctgccgcctcctcgatctgcc
agtgccactctggaaaagcccaagactctctcccccaagactctgtcccctgggaagaac
ggggttgtcaaagacgtttttgcctttgggggtgccgtggagaaccctgagtacttggca
ccccgcggcagggctgcccctcagccccaccctcctccagccttcagtccagcctttgac
aacctctattactgggaccaggacccatccgagcgtggctctctgcccagcacctttgaa
gggacccctacggcagagaaccccgagtacctgggcctggatgcgccagtgtga

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