Maylandia zebra (zebra mbuna): 101476662 Help Entry 101476662         CDS       T02814                                  Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism mze  Maylandia zebra (zebra mbuna) Pathway mze04020   Calcium signaling pathway mze04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:mze00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101476662    04020 Calcium signaling pathway     101476662  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mze04040]     101476662 Ion channels [BR:mze04040]  Voltage-gated cation channels   Ryanodine receptor    101476662 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  101476662 NCBI-ProteinID:  XP_024662013 LinkDB All DBs Position LG19:complement(24908114..25016297) Genome browser AA seq 4888 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIQKENRKFCLAAEGLGNRLCYLEPTSEAKYVPP DLCICTFVLEQSLSVRALQEMLAKSGQNSEGRLIRKAAQSGGHKTLLYGHAILLRHSFSS MYLACLKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVS SERYLHLSISSGNIQVDASFMQTLWNVHPICSGSNIEEGYLLGGHVMRLFHGHDEVVTIP GSDQSEEQQRIVNYETGKAGAKARSLWRLEPLRISWSGSHIRWGQPFRLRHLTTGHYLAL TEDRGLVLQDRERSDTVATAFCFRASKEKLEQSPKRDIEGMGVAEIKYGDSICFIMHVAA GLWLSYQAPDVKSARLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTLLFKR FIRDLDCLGVKNRALVALPVEEVLQTLNDLITYFQLPDAELEHEERQIKLRSLKNRQNLF KQEGMLTLVSNCIDRLNVYNSAAHFGECAGSEAGAAWKDILNLLYELLAALIRGNRNNCT QFSNNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQKGHIKSIISLLYKHGRNHK ILDVLCSLCVCNGVAVRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLGVSEGSAQ YKKWYYELMIDQVDHFVTSEPSHLRIGWANTKGYAPYPGGGEGWGGNGVGDDLYSYGFDG LHLWSGRIPRAVASMNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFF PVVSFSAGVKVRFLLGGRHGDFKFLPPSSYAPCYEALLPKEKMKVEPVKEYKRDVDGVRD LLGTTQFMSQASFIPTPVETSQIVMPPHLEKVRDKLAENIHELWGMNKIELGWSYGKIRD DNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCRIVHMNPNAEDSLKKIKLPKN YMMSNGYKPSPLDLSDIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSKRN PRLVPYALLDERTKKSNRDSLREAIRTLIGYGYNIEPSDQEGGQVSERLSIDKIRFFRVE RTYAVKTGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYRGHCLNMGSRL FGRCWHAGDVVGCMINMEDKSMIFTLNGEILITTKGSELCFTDFETEDGFIPVCSLGLSQ VGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKDHNHIAVT RIDGTIDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSVFKISPVVDMNGVHEEETL KVKHRYPLRSVRHSDESRRVDYSSITTYYHSVRVFAGQDPACVWVGWVTPDYHYYSNNFN LSKNRTVTVTLGDERGRVHESVKRSNCYMVWGGDVTSTSHTSGRSNVDLEIGCLIDLATG LLTFTVNGKDISTSYQVEPNTKLFPAVFVRPTSPSLFQFELAKIKNAMPLSSAIFKSEHK NPVPQCPPRLDVQTINAVLWSRMPNSFLKVETARVNERHGWVVQCVEPLQMLAVHIPEEN RCVDVMELSEQEDMKKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSG TLREGFYNVLISTHLETAKEARLMMKDEFVIPVTAETRSIRLFSDASKKHLPPGVGLSTS LKPRLNFTPPCFISTKREHLYSPQIPLDALKEKAISMLTEAVQSGGHHIRDPVGGCVEHQ FVPILKLISTLLTMGVLGSEDVRKILLLIDPNVFKEAREEGATGATDKEGLTGAEEKAVE AGEEEAIKEAQQPMEGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSFVSKL QYNQKFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSMGEDCPCPADIQEELY DFHNQLQLHCGIPMEEDEDEQDTSIKGRLLMLVNRIKGQAHKAEEPTRMEQAAPSNLKEL ISQTMVSWSQECHIQDPELVRKMFSLLRRQYDSVGELLRAMRKTYTISAASVQDTINLLA SLGQIRSLLSVRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRILGMHETVMEVMVNVLGG DKSQEIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLD VAASSVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSF LRFAVFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISETPALDL PGSVQGVSSDVSGDGDDEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIR AILRSLVPTEDLVGIISIPLKMPITNKDGSVTEPDMSASFCPDHKAPMVLFLDRVYGVEA QSFLLHLLEVGFLPDLRAATSLDTEGLCTTETALAMNRYIGSAMLPLLTRCAPLFAGTEH YATLIDSTLHTIYRLSKGRSLTKAQRDAIEECLLSVCKHLRPSMLQQLLRRLVFDVPLLT DYCKMPLRLLTNHYEQNWKYYCLPSGWGSFGTASEDELLLTKKIFWGVFDSLSQRKYDPE LFKMAMPCLSAIAGALPPDYVDASISTTVEKPVSVDAQGNFDPKPINTANIALPEKLEHF ANKYAEHTHEKWSAEKVLLGWKYGDCVDEKAKTHPQLRTYKGLTEKEKDIYRWPIRESLK SMLAMGWSIDRTKDGESMSQQRETEKMRKISQASQANGFNPSPIDTSNVVLSRELQGMVE VVAENYHNIWAKKKKSDLGSRGGGTHPLLVPYDTLTAKEKARDREKAQDLFRFLLINGYS ITRGLKDLEQDSSSMEKRFAYKFLKKLLKYVDSAQEFITHLEAMAVSGKTDRSPHEQEIK FFAKVLLPLIDQYFKNHSLYFLSSPNKNLSSSGYASNKEKEMVTSLFCKLAALVRHRISL FGSDSTTMVSCLHILAHTLDTRTVMKSGSEQVRVGLRTFFENGAEDLEKTFENLKLGKFT HSRSQMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTSLYALG TGKNIYVERQLPALGQCLATLAGALPVAFLEPQLNPYNPCSVFNTKSARERATLGIQDSV EEMCPGMPRLDRLMKDINDMAESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENQPASG GSICCTTVTSEHLSLILGNILKILNNNLGIDEASWMKRIAVYVQPIISKARADLLKSHFL PTLEKLKKKTVKVVAEEELLKADCKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNN RSRWLKEPDSDSNDLFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDNKTKMS KSFKEKSGGQDQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTR YLMKDTDDEVKDHIRQNLHLREKSDDPAVRWQLNLYKDIVMRTEGLSDPEKVVDRIQRIS AAVFNLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHKNNNYFLNSYRHI WLEIMHENADRDSLLSMLTKIQPKVEEEEEEEVRKQPDPLHQLILHFSHNALTECSSLEE DPLYIAYADMMAKSCAEGEEEEGKEKTFEEKEMEKQKMLYQQARLHDRGAAEMVLQMISA SKGRLGATVTVTLKLGISILNGGNILVQQKMLDYLKEKRDVGFFKSLSGLMMSCSVLDLN AFERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRT QTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVIDEAGQRNFSRALAVAKQVFNSL TEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQKDMVV MMLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSFKEYDPESK GVISKKDFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEQFVERFHEPAKDIGFNVAV LLTNLSEHMPHDARLSTFLDLAESVLSYFEPYLGRIEIMGGAKRIERVYFEISQSSRTQW EKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDPVERPEEEED DIQTMMENQEEEDEESAMMESSSAFTIACISMKKSLCHFRQLLTLKSMRRQFRKFRKMSV KEMVRGFFSFFWMIITGLFHFVYSLIWGFFHILWTTMFGGGLVEGAKNMKVTDILGNMPD PTQFGIHGDVLETEKMEASEASALAELGQMAQGEAAEADLMAELLNIQPKKEGKHGAEPG LGDVSEVVVGDAPSIASAVKQKKAQMAAKTRAVNGDYRSDTEKGDSEDGEKKDHDKTRDE APPELSVEEKKAPKKRLGLKKEAPEAFMASFFAGLEVYQTKMLNYLARNFYNLRFLALFV AFAINFILLFYKVTGDYSDDEDPWKGRGRAGEEEDEGALEYFVLQESTGYMAPTLRCLAI LHTIISFLCVVGYYYLKVPLVVFKREKEIARKLEFAGLYITEQPSDDDIKGQWDRLVINT PSFPNNYWDKFVKRKVIKKYGDLYGAERIAELLGLDKSALDFNPTEETVAKEASLVSWLS SIDTKYHVWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSS VTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYV GVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQ VKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESY VWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14667 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggagaaggagaggatgagatccagttcctcagaactgatgatgaagtg gtgctccagtgtgtggcttgcatccagaaggagaatcgcaagttctgcttggctgccgag gggctcggcaatcgactgtgttacctggagcccacatctgaggcaaagtatgttccccca gacctttgcatctgcacctttgtgctggaacagtccctgtcagtgcgagccctgcaggag atgctggctaagagcggacagaacagcgaagggaggctcataaggaaggcagcgcagagt ggcggacacaagactctgctgtacggacacgccatcctcctgcggcattccttcagctct atgtacctggcctgtttgaagacatcaaggtcacagacagataagctttcctttgatgtc ggcctgcaggaggattcaacaggtgaggcttgctggtggacaatccatccagcctccaag cagagatcagagggagagaaagtacgcatcggcgatgacctcatcctcgtcagcgtgtcc tcagagcgataccttcatttatccatctcaagtggcaacatccaggtggacgcttccttc atgcagactctgtggaacgtccatcccatctgctctggtagcaacatagaagaaggctac ctgttaggtggtcacgtgatgcggctgttccacggacatgacgaggttgttacaatcccg ggatcagaccagagtgaagagcagcagaggatagtcaactatgagacgggtaaagctggt gccaaggcgaggtccttgtggaggctggagccactccgaatcagctggagcgggagccac atccgctggggtcagcccttccggctacggcacctgaccaccggtcactacctggctcta acggaggacagggggctggtgcttcaggatcgggagaggtctgacaccgttgcaacggcc ttctgcttcagagcctctaaggagaagctggagcagagccccaagcgcgacatcgaggga atgggagtggctgagattaaatacggggactcgatctgcttcatcatgcacgtggccgcg ggtctctggctctcgtaccaggcgcccgatgtcaaatctgctcgtctgggtccgctcaag agaagagcatgcctgcattctgaaggtcacatggatgacggattgaccctccagcgctgt cagcacgaggagtcccgcgccgcgcgcatcatccgcaacaccacgcttctctttaagcga ttcatcagagacctggattgtctgggtgttaagaacagggcactggtcgctctgcccgtg gaggaggtgctccaaacccttaatgacctcatcacttatttccagctccccgatgccgag ctggagcacgaagaaaggcagatcaagctgcgctcgctcaaaaacagacagaacctcttc aagcaggaaggcatgctgactctggtgtccaactgtattgaccgactgaacgtctataac agcgccgcacattttggggagtgcgcgggctcggaggctggagcggcctggaaagacatt ctcaacctgctgtatgagctgctggctgcgttaatccgaggaaaccgcaacaactgcaca cagttctccaacaacctggactggctggtgagcaagctggagagactggagtcctcttca gggattctggaagttctgcactgcattttaatcgagagccccgaggcgctcaatatcatc cagaaaggacacattaaatccatcatatcgctgctgtacaagcatggacgcaaccacaag atactagatgtgctctgttcactgtgtgtgtgtaatggcgtagctgtgcgaaccaatcag aacctcatctgcgatcacttgctgcccaagagagatctgctgttgcaaacccagctggtc aatgatgtccagagcatgagaccgaacatcttcctgggcgtgagtgaaggctcggctcag tacaagaagtggtactatgaactcatgatcgaccaggtggaccactttgtgaccagcgag ccctcccacctcagaatcggctgggcgaacacaaaaggctatgcaccctacccgggagga ggagagggctggggaggtaatggagttggtgatgatctctactcgtacggctttgatgga ctccacctctggtcaggtcgtatcccgcgggcggttgcgtctatgaaccagcacattctg acctcagaggacgtggtgagctgctgcctggaccttggagcccccagcatatccttcagg atcaacggacagcccgtccagggcatgtttgaaaatttcaacacagacggactcttcttc cctgttgtcagtttctctgcaggtgtcaaggttcgtttcctgttgggcggacggcacggt gacttcaagttcctgcctccatcaagctacgcaccgtgttatgaggctctgctgccaaaa gagaagatgaaggtggagccggtgaaagagtataagagagatgtggacggagttcgagat ctgctgggcaccacccagttcatgtcgcaggcctccttcatccccacacctgtggaaacc agccagattgtcatgccgcctcatttggagaaggttcgggacaagctggctgaaaatatc catgagctctggggcatgaataagattgagcttggctggtcttatggcaagataagggat gataataagcggcagcatccgtgcctggtggatttctccaagctgccggaaacggaaaaa aactacaatctgcagatgtcaacggagactctgaagactctgctggccttaggctgtcgt atagttcacatgaatccaaatgctgaggactctctcaaaaagataaagctccctaagaac tacatgatgtccaatggttataagccgtcccctctggacctgtccgatatcaaactgact ccagggcaggagctgctggtggacaaactggcagagaacgctcacaatgtgtgggccaag gaccggatcaaacagggatggacatacgggattcagcaggatcttaaaagtaagcgtaac cctcgcctggttccttatgctctgctggatgaacgcaccaagaagtcgaacagggacagc ctgcgggaagctatccgcactctgattggctacgggtacaacatcgagccctcggaccag gaaggcggacaagtctcggagcgcctcagcattgataagatccgcttctttagggtagag agaacgtacgcagtgaagaccgggaagtggtacttcgaatttgaggccgttaccggtgga gacatgagagtgggctgggccagacctgggtgtaagccagatgtggagcttggcacagat gagcttgcgtttgtctttgatggatacaggggccactgcctgaacatgggcagccggctg tttgggcgctgttggcatgctggggacgtggtgggctgcatgatcaacatggaggacaag tccatgatcttcactctgaacggggagatcctgatcaccaccaagggctctgaactctgc ttcacggactttgaaactgaggatgggtttattccagtgtgtagcctcggtctgtcgcag gtgggtcgtatgaacctcgggaaggatgctagcacctttaagtactacaccatgtgcggc ttgcaggagggattcgagccatttgccgtcaacatgaatcgagaggtcacaatgtggttc agcaagcgtctgcctacttttgtcaacgtgccgaaggaccacaaccacattgcggtaacc aggatcgacggcaccatcgacagccctccttgtctcaaagtcacccacaagacgtttggg acacagaacagtaacgcagacatggtgttttgtcgtctgagcatgcctgtggagttccac tccgtcttcaagatcagccctgtggtggacatgaacggtgttcatgaggaagaaaccctt aaagtcaaacacagatatccactgagatctgtgaggcacagcgatgaaagtagacgagtg gactacagcagcatcactacgtactaccattcagtgagggtcttcgcaggtcaggaccct gcctgtgtgtgggttggatgggttactcctgactaccattactatagcaacaacttcaac ctcagcaagaatcgtacagtgactgtaaccctgggcgatgaacgtgggcgagtccacgag agcgtgaagaggagtaactgctacatggtgtggggtggtgatgtcaccagcacttcccac acctccggtcgcagcaatgtggatctggagatcggctgtctaatagatttggccactggc ctattgacattcaccgtcaatggcaaagatatctctacctcctaccaggtggaaccaaac accaagcttttccccgctgtgtttgtgcgacccaccagccccagcctctttcagtttgaa ctggctaaaataaagaacgccatgcctctgtcatcagccatcttcaagagtgagcataag aacccggttccacagtgtccgccccgactggatgtccagaccataaacgccgtgctgtgg agccgcatgcccaacagtttcctcaaagtggaaacggccagggttaatgagaggcatgga tgggtggttcagtgcgtggagcccctgcagatgttggcagtgcacatacctgaagagaac aggtgcgttgacgtcatggagctctcggagcaggaggacatgaagaagttccactatcac accttgaaactgtactgtgccctctgcgctctgggaaacactcgtgtggcccacgccctt tgcagccacctggaccaatcacagctcttgtacaccatcgacaatcagtacctgtctggc acgttacgcgagggcttctacaatgttctgattagcacccacctggagacagccaaagag gcacgactcatgatgaaagatgagttcgtcattcctgtcacggccgagacacgctccatt cgtctcttttctgatgcttctaaaaagcacctcccgcctggggtggggcttagcacctcc ctgaaaccacgcctaaactttaccccaccgtgcttcatcagcaccaaacgggagcatctg tacagtccccaaatcccactggatgcactgaaggagaaagcgatttcgatgttgacagag gctgttcaaagcggagggcaccacatccgagatcctgtcggaggatgcgtggagcaccag tttgttccaatcctgaagctcattagcaccttgctgacgatgggtgtgttaggaagcgag gacgttcgtaagattttactgctcattgacccgaacgtcttcaaagaggcaagagaggag ggagccacgggggccacagacaaagagggactaacaggggcagaggaaaaggcggtggaa gctggagaagaagaggcaatcaaagaggctcaacagccaatggaaggactgctggagaag aggctgccagagccggttaaacgacagatgtgcgagctgcttcactatttctgtgactgc gaactgaagcaccgtatcgaggccattgtgtccttttctgacagcttcgtgtccaagctg cagtacaaccagaagttccgctacaatgagctgatgctggccctcaatatgtctgctgct gttacagcgaagaagaccaaagagttcagatcaccgcctcaagaacagatcaacatgctg ctgaacttcagtatgggagaggactgcccgtgccctgcagacatccaggaggaactctat gattttcataatcagctgcagctccactgtggaatccctatggaggaagatgaagacgag caggatacatcgattaaaggtcgcctccttatgctggtgaacaggatcaaaggccaggcg cacaaagcagaggagcccacgaggatggagcaagctgcaccctccaatctgaaagagctt atctctcagaccatggtcagctggtcccaggagtgtcacatccaggaccctgaacttgtt cgcaaaatgttcagcctgctgaggaggcagtacgacagcgttggagagctcctccgagcc atgaggaagacgtacaccatcagcgctgcctcggtccaggacaccatcaacctcttggcc tccctgggccagatcaggtctctgctgtcagttcgaatgggaaaggaggaggaaaagctc atgattgatggactgggtgacattatgaacaacaaggtcttctaccagcacccgaacctg atgagaatactgggcatgcacgagactgtcatggaggtcatggtcaatgtcctcggagga gacaagtcccaggaaattgcctttcccaagatggtggccagctgttgtcgcttcctgtgc tacttctgccggatcagccgtcagaatcagaaggccatgtttgaccacctcagttaccta ctggagaacagcagcgtgggcctagcttcgccagctatgaggggctccactccgctagat gtggctgcttcctcagtgatggacaataacgggctggctctggcacttgaagaacctgac ctggacaaggtggtcacctacttggctggctgtggtcttcagagttgtccaatgcttctg gctaaaggttatccagacattggctggaaccccattgagggagagcgctatctgtccttc ttgcggtttgctgtctttgtgaacggcgagagtgtggaggagaactcgagcgttgtggtg aagctgctgatccgtcgtccggagtgtttcggacctgctctgagaggagagggagggaac ggtctcctggctgccatgaaggaagctattaagatctctgagacgcccgctttggacctc ccaggctccgtccagggagttagctctgatgtgtctggtgatggtgacgatgaagaggag gtggtccacatgggcaatgccatcatgtcgttctactctgctctcatcgacctgttagga cgttgtgcccctgagatgcatctcatcaacaaagggaaaggcgaagctctgcgcattcgt gctatcctgcgctctctggtgcctactgaggacctcgtgggaatcattagcataccgctc aaaatgcccattactaacaaagatgggtcagtgacagagccggacatgtcggcgagcttc tgtccggaccacaaggcccccatggtgctgtttttagacagagtgtatggcgtggaagcc cagagctttctgcttcacctgcttgaagttggcttcctccctgacctgagggctgctact tctctggacacggagggtctgtgtaccaccgagacagccctggctatgaaccgctacatc ggttcagccatgctgcccctcctcacccgctgcgcccctctcttcgctggcaccgagcac tacgccaccctcatagactccaccctgcacaccatctaccgcctgtccaaaggccgatcg ctgaccaaggcgcagagagatgcgatagaggagtgtttgctgtctgtttgcaagcacctt cgtccctccatgctgcagcagctcctgcgccgcctcgtctttgatgtgcccttgttgact gattactgcaagatgcctctaaggctgctaaccaaccactacgagcaaaactggaagtac tactgcctcccttcaggctggggcagctttggaacagcctctgaagatgaactactgctt accaagaagatcttctggggagtgtttgactctttgtctcagaggaagtacgaccccgag ctgttcaagatggccatgccttgtctcagtgccatagctggagctttgccgccagactat gtggatgcctccattagtaccactgtggaaaagcctgtttctgtggatgctcagggcaac tttgaccccaaaccaatcaatacggctaacatcgctcttccagagaaacttgagcatttt gccaacaagtacgccgagcatacccatgagaaatggtctgcagagaaggtgctgctgggg tggaaatatggagactgtgttgatgagaaggcgaagactcatcctcagctgaggacctac aaaggcctgacagagaaggagaaggatatttacagatggcctattagagagtccctgaag agtatgctggcaatggggtggagtatcgataggaccaaagatggagagagcatgtctcaa cagagggagactgagaaaatgagaaagatatctcaggcctcacaggctaacggcttcaat ccgagcccaatagacacaagcaacgtggttctatccagagagctgcaagggatggtggag gtggtggctgaaaattaccataacatctgggccaagaagaagaaaagtgaccttggaagt cgaggagggggaacacatcctctgttggtgccctatgacacgctgacggccaaggagaag gcccgcgatcgagagaaggctcaggacctttttcgcttcctgctaatcaatggatatagc atcacaagaggtctgaaggacttggagcaggattcctcctccatggagaaaaggtttgcc tacaaattcctcaagaagctgctcaaatatgttgactcagcccaggaattcattacccac ttagaagccatggctgtcagcggcaagacagacaggtcacctcatgagcaagaaatcaag ttttttgccaaagtgctcctccctctcattgaccagtactttaagaaccactctctctac ttcctgtcctcccctaataagaatctaagcagcagtggctatgcctccaacaaggagaaa gaaatggtcaccagcctcttttgtaaactggcagctcttgtcagacataggatttcactc tttgggagtgactccaccaccatggtcagctgtctgcatatcctggcacacacactcgat accaggacagtgatgaagtcgggctccgagcaggtgagggtggggctgaggacgttcttc gagaacggcgcagaggatctggagaaaacgttcgagaacctgaagctggggaagttcacc cactcccgctcgcagatgaaaggagtgtcgcagaatatcaactacaccaccgtagctctg cttcccatcctaactgctctgtttgaacacatcactcaacaccactttggagtcgacctg ctcctggatgacgtccaagtgtcctgctatcgaatcctgaccagcctctatgctctgggc actgggaaaaacatctacgtagaaagacagctgccagctctcggtcagtgtctggcaact ctggccggcgccttgcctgttgccttcctagagccgcagctcaacccgtacaacccctgc tcagtttttaatacgaagagcgccagagaacgagccactctaggaatacaagactcagtg gaagaaatgtgtcctggcatgccacggctggaccgcctcatgaaggacatcaatgacatg gcagagtctggagcgcggtacacagagatgccccatgtgattgaggtggtgctgcccatg ctgtgtaactatctgtcctactggtgggaaaggggtcctgaaaaccagccggccagcgga ggaagcatctgctgtaccacagtcacctcggagcacctcagtctgattctcggcaacatc ctcaagatcctcaacaacaacctgggcatcgatgaggcctcgtggatgaagagaattgca gtgtacgtacagcccatcatcagcaaggcccgtgcagacctgctgaagagccacttcctg cccacgctggagaaactaaagaagaagacagtgaaagtggtggctgaggaagagctcctc aaggccgactgtaaaggagacactcaggaggccgagctgctcatcctggacgagtttgct gtactctgcagggacctgtacgcgttttaccctatgctcattcgttatgtggacaacaac aggtcaaggtggctgaaagaaccagattcagactccaacgacctcttcaggatggtcgca gagatatttatcctttggtgcaagtcacataatttcaaaagagaagaacaaaactttgtg gtccagaatgaaatcaacaacctttcattcttgactggagataataaaaccaagatgtcc aagtcctttaaggaaaagtctgggggacaagatcaggagaggaagcacaagaagcggcga ggtgagttctactccatccaaacctcactgattgtagccgccctgaagaagatgctgcct atcggtcttaacatgtgcaccccgggagatcaggagctcatctctctggctaagacacgc tacctcatgaaagatacagatgatgaagttaaagaccacattcggcagaacctgcacctt cgtgaaaagtctgatgaccctgccgtgaggtggcagctcaacctgtacaaggacatagtg atgaggactgaggggctttcagaccctgagaaggtggtggatcgtatccagaggatctct gctgccgtctttaacttggagcaggtggaacaaccactgagatccaaaaaatgtgtatgg cagaagttgctgtccaagcagaggaagcgcgccgttgtcgcctgcttccgaatggctccg ctttacaatctgccgaggcacaaaaataacaattacttcctgaattcctaccggcacatt tggctggagattatgcacgagaacgcagaccgtgacagtctgctctcaatgctgacgaaa atacagcctaaagtggaggaagaggaggaggaggaggtgagaaagcagccagaccctctt caccagctcattctgcatttcagccataacgctctgactgaatgcagttctctggaagag gatcccttgtatattgcctatgcagatatgatggcaaagagttgtgctgaaggcgaagaa gaggaaggaaaagagaaaacatttgaggaaaaggaaatggagaagcaaaagatgctgtat cagcaggccagacttcatgacagaggggctgcggagatggtgcttcaaatgatcagcgcc agcaaaggtcgactgggtgctacggtaactgtcacgctcaagctgggcatctccattctc aatggagggaacatcctggttcaacagaaaatgctggattatctcaaggaaaaaagagat gttggcttctttaaaagcttgtccggactcatgatgtcatgcagcgtcctggacttgaat gcttttgaaaggcaaaacaaagctgaaggtctgggtatggtaactgaagagggatcaatc aacgtgagtgagcggggttccaaggtactgcagaatgatgaattcactaaggatcttttt aggtttctgcagcttctctgcgagggacataacaatgattttcaaaacttcctaaggacg cagacagggaacacaactacagtcaacataatcattagtactgtggactacctactaaga ctgcaggaatctattagtgatttctactggtactactctggcaaggatgtcattgatgag gccggtcagaggaacttctccagagcactagcagtggccaaacaggtgttcaactcttta acagagtatatacagggtccgtgtatagggaatcagcagagtctggctcacagcaggctg tgggacgctgtggtgggcttcttgcatgtttttgccaatatgcagatgaagttatctcag gactccagtcagattgaattactaaaggagctgctggacctgcagaaggacatggtcgtc atgatgctctcgctacttgaaggtaatgttgtgaatggaactatcggcaaacagatggtg gacaccttggtggaatcttccagtaacgtggagatgatcctgaaatttttcgacatgttc ctcaagttgaaggacttgactacttcggacagtttcaaggagtacgaccccgagagcaaa ggcgtcatctcaaagaaggatttccagaagtccatggagaaccagaagcagtattctcag tctgagattgagtttcttctctcctgcgccgaggctgacgagaacgacatgttcaactac gagcagtttgttgagaggtttcacgaaccggcaaaagacatcggctttaacgtcgccgtg ttgctaaccaatctttcagagcacatgcctcacgatgcccgcctctcaactttcctggac ctggccgaaagcgtcctcagctacttcgagccttacttgggccgcattgagatcatgggc ggagccaagcgcatcgagagagtgtacttcgagatcagccagtcgagtcgcacgcaatgg gagaagcctcaggtgaaagagtcgaagcggcagttcatctttgacgtggtcaacgagggc ggagagagcgagaagatggagctgtttgtaaacttctgcgaggacacgatcttcgagatg cagctggcctctcagatttcagagccagaccccgttgagcgcccggaggaagaagaggat gacatccagaccatgatggagaaccaggaagaggaagacgaggagagcgcgatgatggag tcttcctcggcatttacaatcgcatgcatctccatgaaaaagagcttgtgtcacttccgc cagctgcttactcttaaaagcatgcggcggcaattcaggaaattcaggaagatgagtgtg aaggagatggtgcggggcttcttctccttcttttggatgatcatcacaggcctctttcac tttgtttacagcctaatttggggattcttccacatcttgtggaccacgatgtttgggggt ggcctcgttgaaggggctaagaacatgaaggttacagatattttgggaaacatgcctgac cccactcagttcgggatccatggagacgtgttagaaacagaaaagatggaggcaagcgaa gcgtcagcgttggctgagttgggtcagatggctcaaggggaagcagcagaggcagatctg atggctgagctactcaacatacagccgaagaaggagggcaagcacggggccgagccaggt ttgggggatgtgtctgaggtggtggtgggagatgccccgtcaatagccagtgcagtcaag cagaagaaggcacagatggctgcaaagacgagggctgtgaacggagactacagatctgat acagagaagggagattcagaagatggtgagaagaaggaccacgacaagactagagacgaa gctcctccagagctgtcagtggaggagaagaaagccccgaagaaaaggctcggcttgaag aaagaggcaccggaggctttcatggcgagcttcttcgccggcttggaagtctaccagact aagatgctgaactacctggcaagaaatttctacaatctccgcttcttggcactttttgtt gcctttgctatcaactttattcttctcttctacaaagtgaccggtgattactcggatgat gaagacccctggaagggtcgaggcagagctggggaggaggaagacgagggagcgcttgag tatttcgtcttgcaggagagcacaggttacatggcaccaacacttcgctgtctggcaata ctacacaccatcatatctttcctgtgtgtagtgggatactactacctgaaggtgcctttg gtagtgttcaagcgggagaaggagatagcaaggaagttggagtttgcaggcctctacatc accgagcagccgtctgatgacgacattaaaggacagtgggacagactggtcatcaacact ccctcctttcccaacaactactgggataaatttgtcaagcgcaaagtgataaaaaagtat ggagacctttacggagcagagaggatagcagagctgctggggttggacaagagtgccctg gatttcaaccctacagaggagactgttgccaaggaggcttcactggtgtcatggttgagc tcaatcgatacaaagtaccatgtctggaaaatgggggttgtgtttacagataattcattc ttgtatctagtttggtacaccaccatgtccatcctgggtcactacaacaacttcttcttt gccgcccatctgctggacattgccatgggcttcaagactctccgcaccatcctttcatct gtcacgcacaatggcaagcagctggtgctgacagtgggcctgctagctgttgtggtctat ctctacactgtggtggccttcaacttcttcaggaagttttacaacaagagtgaggatgag gatgagccggacatgaagtgcgacgacatgatgacgtgctacctattccacatgtatgtt ggggtaagagcaggaggcgggataggggatgagatcgaggacccagctggtgacccctat gagctctaccgcatcctgttcgacatcacgttcttcttctttgttattgtcatcctcttg gccatcatccagggtttgatcattgatgcctttggagagttaagagaccaacaggagcag gtcaaagaggacatggagaccaaatgtttcatctgtgggatcgggaacgattacttcgac acaaccccccacggctttgagacccacaccttacaagagcacaatttggccaactatctg tttttcctgatgtacctcatcaacaaggatgagacagagcacactggacaggagtcctac gtgtggaagatgtatcaggagcgctgctgggactttttcccagctggagattgcttccgc aaacagtacgaagatcagcttggatag

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