Numenius arquata (Eurasian curlew): 141474727 Help Entry 141474727         CDS       T11436                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism narq  Numenius arquata (Eurasian curlew) Pathway narq04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:narq00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     141474727 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:narq03036]     141474727 (SYNE1) Chromosome and associated proteins [BR:narq03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     141474727 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH Spectrin_SYNE1_2 SYNE3 Motif Other DBs NCBI-GeneID:  141474727 NCBI-ProteinID:  XP_074018890 LinkDB All DBs Position 2:11582041..11838003 Genome browser AA seq 8713 aa AA seqDB search MARYKGAGGRNVTSLNLLPGFFQYRQDEQESVQKRTFTKWINTHLAKRNPPILVNDLFED IKDGVMLIALLEVLSGQKLPCEQGRHLKRIHWVANIGTALKFLEGRRSIYRGSPIKLVNI NSTDIADGRPSIVLGLVWTIILYFQIEELTSNLPQLQSMSSSASSVESVVSSETASPPSK RKVVTKVQGSARKALLKWIQYTAAKQVGIEIKDFGQSWRSGVAFHSIIHAIRPNLVDMDK VRGRSNRENLEEAFTIAEAELGIPRLLDPEDVDVDKPDEKSVMTYVAQFLKYYPDPHHTV TDVQENDKEDRLMLRDLKVWAEQFERDIARAQVAETSLQEKYQSFKHFRVQYDVKRKQIE LVTQSLRKDGKLSLDQAMVKQAWDRVTSRLVDWHRHLDKSLPAPLGTIGAWLYRAEAALR EEVTVQQVHEETANTIHRKLEQHKDLLKNIDGHKKAFHEIHGARSVNGVPVPPDQLEDMA ERFNFVVSSSELHLLKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVELLLQNYISV IENSKFFEQYEVTYQILKRAAEMYAKANGSVEEVENVMKFMNETSAQWRNLSVEVRSVRS MLEEVIANWDRYSSTVAGLQAWLEDAEKMLNQPEHSKKDFFRHLPHWIQQHTAMNDAGNF LIETCDETISRDLKQQLLLLNGRWRELFMQVKQYARADELDKMKKEYLDGVAHLTAFIDG SNRKFLVPVEVSFLDVKMFVQDLENIKQKLPAMEAQYKMVTRTAQLVTKEVSEEEVKEIL GTLTRIKEQLSKVKEYSCALLYECQRLLSPLEELEKQITHFYESLEKVNEIISILDPEAQ PTSVLKQKAQDLVAYQENCKKDLSLIERNSQSILQCVASSEVLQHFHQSTFQKKVTQVQL TFQNMVRKAGDWRKNIEANSRLMKKFEESRAELENVIQIANCCLKEKGNPEELLRKHSEF FNQLDQRVLNAFLKACDELTDILPEQEQHNLQEAVRKLHRQWKDLQTEAPYHLIHLKIEI QKSRFLVTVEECKAELARQNKVLSREGNERMIEEHKLFFGDKGPYQLCEKRLQRIEELCQ KLPVSDPVRATLESSQRILKDLKSQINSTYIKLTEHSDTWKGYKNRFSELANWISSTETE LKKIKESVHDTAKFKQCKASVGEIRKRINKQGENHSWLKSRLAVLTTVCPDLEAKKTEDE LCKLSSDFKGLLDLLAEVEKTLGTVGDCVQYKEEVKSAIEELINNSKEAQAEAEKILDTE SLLQAQQLLLHHQQRTRRLRAKRQDVQQQISQAKQLQTEGGLPSTMQEDLQKLEGTLENM QQTMEKREEQLQVTINKWEQFERDKETVVKYLNQASSALERILNFSSLESLSSELDQTKE LSKQAEAMAVQAENLVKNSSEIQLGSKNKQSLQQQAKSIQEQLKKVEVTLEEDIKSMEMV KSKWDHFGNNFEALSIWIAEQEKELETLETSSSPLDIQISQIKVINKEIDGKITGISKLE EEAESFSQFVTSGEYAHIKAKLTQVKRYWEELRDHAQRLEGTITGNALAQQKHEENLKQV QQAVSEFEAKLAEPLTSCSSAAATYTALQDCTDLCHTVEKLSNTLASLSACARKLANKEK AAQEVTSLQQKYEKVLENAKEKQTLLETLLAQWQKQEKELSAFLTWLEECEATAKPSEQY VSADRVKLEAELQSLQDLRADIESRASVYESLLQLNESLFPTASKQCVKAIKEKLEELDE RWKALPQTVDKRINFLQSLVAEHGQFDELLLRFSDWIKQFLAELQATSEINTADQQLAAS HNKNHSMEIESRKKQLQSLKEHVDKLCSFCCPEDQQTLQGKTEDCFQIFQEASQITSQRQ EALDQLRVFLELHSVASGVLHQLRQTVEKTGNMDKAKSELLEKKLNDVIQDLNKLESVAI SLDGSLTKAQYHLKHSISEQRTSCRAVVDNLCLELEAVQNLLGTKQSEAEALGALRRSFT ERKEQLLKRIEDTEEKADKEGMKEATLQALQQRLRIFNQLDEELNSHQHELQWLMDKAKQ IAQKDITLAPEIDKEINRLESLWEDTKKVIHEKKEQSCILIDLMKEYQSLKSTVMKVIDS ADSASVIKSIWKDHEDVRRALSKHEAAKNDLSDKQKDLDTFTNKGKHLLAELKRVHNCDS TAVKKDLDCTVDKWLDVSERIEGNIDQLGVSVSLWDDILKTGDEMDGWCTKCISQLNEGI SNLSNSQRMEGFLKDFQSEVKDNELKLEQLSSKISDLKELTHSQEPPADLQFIESDLRQK LDHVKEMSETAKETLKDFSAQKMQLQKSIDQMTDWLMEVEETLLSCARELDPEALSKVKE TQKDLQLQQSSIDSIRENLNSLCRKYHSVELETLGGTVTSLIKKYEGVNLLCSRTQASMQ ESLEKHFLHSMQEFQEWFSGVKAAVKESSDRSGDSKAIEAKLHDLQSVLDSVSDGRNKLD AACKEGENLYACLPKPVVSHIQEQIAKSNQNFQEFLNQCLNDKKALEACASHLGSFEDQH KKLGLWIHDMEERISTEALGECKQLIPEKKKEVQKVEKFLEELLNSRESFDKLSQMAQAL NEEGHGAGREVRLASQHLTSYQNMVKTVKEKLRTCQLALQEHLTLEEALQSMWSWVKEVQ NKLASSESTVGSKATLERRLAQIQEILLLKGDGDVKLNMAIGKGEQALRSSNEEGQKVIQ TELQTLKDVWNDIISTSVNWQSCLETVISQWNEYLERKNQLEQWLEKLDHKVEQPLEPQI GLKEKFAQLDHFQAIVSEIEDHSGDLQQLTEKAAELYEKTEDDSFGKAAQEELKTQFNDI TTVAKEKMRKVEDIVKDHLLYLDAVHEFTDWLHSAKEELHRWSDTSGDTSTIQKKLAKIN ELVESRQIGAGRLGRVETLAPAAERGTAAGGCQLLAAEMRALQSDWRQWEESAFRSQSSL RDVLSQMALSEQEFAAQVAQLEEAAQRFGGLLAAWAQSLVPPDSRLTDAEVVESWRKEKE TLDALVKSEHMTDEIKTQLNDLCRFSRDLSTHSSKVSGLIKEYNSLCLQASKGCQSKEQL LQQRFRTAFRDFQQWLVNAKVTTAKCFDVPQNISEVSASLQKIQEFLSESENGQQKLNLV ASKGELLCSVLPKDKAKVIRDKCASAKEDWKSFITTLHRKESALENLKIQMKDFEATAEP LQEWLTTTERIVQGSSSRLHDLPSKRREQQKLQSVLEEISCHEHQLNRLKEKAQQLWEEQ AVSKSFMRRVSQLSSQYLTLSNLTKEKVSRMDRLVAEHQQFSHSVKDLQDWVADAVHMLD SYCHPTADKSVLDSRMLKLEALLAVKQEKEIQMKMVLTRGESVLQNTSLEGLPVIERQLQ TLKDNWASLLSACIQCKSQLEGALSKWTSYQEDVRQFSGWMDKVEASMNASERQYPELRE KTSALSKAKLLSEEVLSHSSLLETIEVKGSGMAEHYVTQLELQDLQERYKFLKDRTREAV TKAEGLLNLHQEYQRNLKTFEIWLEKEQEKLDCLSHLDGDTQKQEATLRDLQELQVHCAE GQALLNAAVHAREEVIPWGIPQIEDRALESLRQDWQVYQHRLSEARSQLNATVSRLRLME KKFQKVNDWLTDLEEKVAIRTGRQSGRATKEVQLQQMKKWHEEITIYKDDVEEVGVLAQQ ILEESLTASTMGSQATQLTSRYQTILLHVLEQIKFLEEEIRCMEESELAFSAYTNWYGAT NKNFRNVITKFDVVDKTAMEKKVQKLELLLSDMDIGHSLLKSAREKGERAIKYMEENEVD QLRKEIGDHVEQLEELAGSIRKEHMTSEKCLQLAKEFSDKYKAQTQWVVEHQAMLHAPAE PKIELYEKKAQLSKYKSIQQTVLSHEPSIKSVTEKGEALFDLVNDVTLKNNIQDLQSSYQ ELCSAAKAYVETLEVRVKEHEDYNSDLQEGEKWLLHMSSRLVSPDLMESNSLEIITQQLA NHKAIMEEIAGFEDRLNNLKSKGDYLINQCTEHLQAKFKQNIQSHLQGTKDSYSAICSTA QRVYQSLEHELQKHVNHQDTLQQCQTWLSTVQSELKPTTWPPFSLADAVKQVKHFRALQE QANTYLDLLCSMCDLSDATVKSTATDIQHTKQTIEQQIMHSQYLAQGWEEIKQMKAELWI YFQDADQQLQNLKRRRAELELNIAQNMVFQVKEFSQKLQSKQSALTSVTEKMNKLTQGQE SPEHKEIGDLSNQWLDLCLQAHSLLIQREEDLQRTGDYHDRMNVVEGFLEKLTKEWDNLA RSDAESTNVHLEALQKLALALQERRFALEDLKDQKQKMIEHLNLDDKELVKEQFGHFEQR WAQLEDLVKRKIQVSVSTLEELSLVHCKFQELMEWAEEQQPSISEALKQSPPPDLAQSLL MDHLTICSELEAKQLVLKMLVKDADRVMTNLGLNERQELQKALCDAQHHVDCLSDLVGQR RKHLNKALSEKTQFLMAVFQATNQIHQHEKKVTFPEHICLLPEDVNKQIRSCKNTQANLK AYQNEVTGLWAQGRDLMKEATEQEKNEVLGKLQELQNVYDTVLQKCNQRLVELEKNIVSR KYFKEDLDKACHWLKQTDIVTFPEVNVMNSNSELYTQLAKYQQILEQSPEYENLLLALQR DGQEILPSLNEVDHSYLDEKLNSLPQQFNTVTALAKEKLYKVQEAICARKEYASLIELTS KTLTELEDQFINMDKAPAAVLAKEAVSLQQAYRDLLGEVVSLGGAVDELNQKKEAFRSTG QPWQPDEMLKLVTLYHKLKRQIEQKINLLEDTIEACQEHEKMCMQFEAQLEAVKKEQTKV NEETLPIDEKLKIYHSLVGSLQDSGSLLKRITEHLETLSPQLDSSAYETANHQVQSWQEK LKSLHAAIGDTVMECENRLVQSIDFQTEIRRSLDWLRWVKTELNGTLSLDLKLQSIQEEI RKVQIHQEEVQSSLRVMNALSNKEKERYMKAKELIPADLENTLAELTELDGEVQEAIHVR QATLNKLYGLCQRYYQVMQVANDWLEDAQEFLHLARNGLDVENSEENLRNHIEFFSTESQ FSNHLKELQGLVSEIQPYIQATAREQLMQSVAALEEKANGTKQEAKTQQEQLQRCASEWQ EYQTARQKVIEVMNEAEKKLSEFSVAKAASSHEAEEKLLTHKTLVSVVNSFHEKITALEQ KASQLEKVSNDASRATISRSMTTVWQRWTRLRNVAQEQEKILEDAVQEWKGFNDKIEKAT IAIDQLQGRLPESSVEKASKTELLELLDYHSSFLLEVEHQLSSLGLLKQHAVSMLQDVEI KPLSQEELPVMQEIKAMQDRCHNMQQKVKKGVKMVKQELKEREEVEADINIVQTWIQETK EYLLSPDVEVDTQLQELQSLLGEVTTHRQAVEKMAEQQQNKYLGLYTILPSELSLHLAEV GLALVNVQDQIQTKERETQQIKTLNQEFGQKIQGIANELNAILSKLKKKTTDIAQAKLEQ KILGEELDSCNIKLLELDASVQDFAEQNAPLAKQLANRIGKLTALHQQTIQQAEYRAAKL SQAASHLEEYNEMLEFILKWIEKANILVHGSITWNSSSQLRDQFKAYQTMLDESGEIHSD LEAMTERTEYLASVYCTEEMSQQVLELGRRTEELQQVIKVRLPNLQDAAKDMKKFEVELR ALQAALEQAQATLTSPELGHLSLKEQLSHRQHLLSEMESLKPKVHAVQVCQSALRIPEEV VTSLPMCHSALRLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQMIESAHCEIQ DKPIATGNIRELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVE GLSEGMEELDSDLLPAHPAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSP SPVANTDASVNQDIAYYQALSAEQLALSAEQLQTEAAKIQPSTSATQEFYEPGLESAASA KLDDLQRSWETLKNVISEKQRTLYEALERQQRYQDTLQSISTKMETIEVKLNESLEPAKS PESQMAEHQALMDEILMLQEEITELQTSLAQELVSERLDAEAADQLALQSTLMVLAERMA TIRMKASGKRQLLEEKLNEQLEEQRQEQALQRYRCEADELDHWLLNTRATLDTTLVTAEE PMDMEAQLVDCQNMLVEIEQKVVALSELSVHNENLLMEGKAHTKDEAEQLAVKLRTLKGS LLELQRVLHDKQINIRQGSLQEKEESDLDFVSSQSPSVQEWLVQARTTRSQQQQSTLQQQ KELEQELEEQKKLLRSVASLGEEILTQHVAPEGLCLSEKPDTLSEELGLEGEKPSSEEQM KMKWESLNQDFNTKERLLQKALEQEQLQLYSRPNRLLSGMPLYMEEGQDEDKSSVSPVLV ELNQAFEDVSSEAGQVEESLHLEQKLYDGVAATSLWLDGVEEQVFVDTALLPEEETETYL CKQESLAKEIKEITEEMNKNKNLFAQIFPENGDNRGIMEDTLDCLLRRLTLLESVVNQRC RQMKGRLQQIATFKNDLKLLFTSVADKKYLVVQKLAEAAERPETEQMQVILQAEEGLKEL DIGINELKKHVDKLQIDQPSMQELSKIQDMYDELMMIIGSRRNDLNQNLALKRQYERALQ DLADLLETGQEKMAGDQKMIVASKEEVRSLLDKHKEYFQGLESHMILTETLFRKMSSFAL LKETRSHSDLMTQASAVLKLAHKRGVELEYILETWMHLDEDYQELTRQLESIEGSIPIVG LVEETEDRLTDRITLFQHLRSNLTEYQPKLYQVLDDGKRLLFSVSCSDLESQLNQLGERW LSNSSKVTKELHRLETILKHWTRYQSESSELTHWLQSAKERLEFWSQQSLTVPQELETVR DHLNSFLEFSKEVDAKSSQKSSVLSTGNQLLRLKKVDTAALRAGLSHIDSQWTELLTQIP AVQEKLHQLQMEKIPSRHAITEVMSWISLMENVIQEDEENIKNVVGQKAIQDYVKKYKGF KIDLNCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNRRWQILQGLITEKIQL LESLQESWAEYENNVQGLKTWFETQEKKLRQQQKIGDQASVQNALKDCQELEELIRTKEK EVENVEQSGLSLIQNKKEVVSSAVMKTLQEINHSWANLDHMVSQLKILLQSVLDQWSIYK VAYEELNSYLTEARYSLSRFYLLTGSLEAVKVQVDSLQSLQDELEKQENSLQKFGSVTNQ LLKECHPPVTETLTNTLKEVNMRWNNLLQEIAERLHASKGLLQLWQRYKDCYQQCSSTLR QREDQTNELLKTATSKDIADDEVTTWIRDCNDVLTDLKTAQESLVVLQELGEELKSQVEA SAAASIQSEHLSLNQNLSTLEQALRKQQAVLQAGVLDYQTFAKNLQVLEAWITEAEVVLK GQDPSHSSDLSAIQSRMEELKSQMLKFSSMSPDLDRLNELGYRLPLNDKEIKRMQNLNRH WSLISSQTTERFSKLQSFLLQQQTFLEKCETWMDLLVQTEQKLAAEISGNYQSLLEQQRA HELFQAEMFSRQQILHSIISDGQHLIEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG IIDSQIHQWQRYREMAEKLRKWLVEISCQPVSGLGDAPFPLQQARALLDEVQLKEKVLLR QQGSYILTVEAGKQLLLSADSGAEAALQAELTEIQERWKTASTQLEQQKKQLALLLKDWE KCEKGIGDSLEKLRSFKKNLSQPLPEHHDELHAEQIRCKELENAVEGWTDDLAHLSLLKE TLSIYISADDISILSERIELLHRQWEELCHQVSLRRQQVSERLNEWAVFSEKNKELCEWL TQMESKVSQNGDILIEEMIEKLKKDYQEEIAVAQKNKIQLQQMGERLAKASHESKASEIE YKLGKINDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRSWLAHIESELSKPIVYET CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATEAECDSIQQATRNL DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKISERTAAFPSSSGVLYTVAK EELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSDCSLKQMVHEGNQRWDNLQKRV TSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI SLNNNKIEQIIVQGEQLIEKSEPMDAAVIEEELDELRRYCQEVFGRVERYHKKLIRLPLT DDEHDLSDREVDLDESADLSDIHWHDKSADSVLSPHPSSNLSLPLSQPVRSERSGRDTPA SVDSIPLEWDHDYDLSRDLETAVSRALHSEEEDGGQEKDFYLRGATGIAGEPGALEAHIR QLDKALDTSRFQIQQTENIIRSKTPTGPELDSSYKGYMKLLGECSGSIDSVKRLGYKLKE EEEKLSGLINLNSTETQTAGVIDRWELIQAQALSKELRMKQNLQQWQQFNSDLNSIWAWL GETEEELEKIRRLDLSTDIQTIELRIKKLKDLQKAVDNRKAIILSINLCSSEFTQSDSEE SKKLQERLSQMNVRWDHVCSMIEEWRCSLQDALMQCQDFHEMSHGLLLWLENIDRRKNEI VPINPNLDSETLQDHHRLLMQIRRELLESQLKVASLQDMSRQLLVNAEGKDCLEAKEKVH VIGNRLKVLLKEVTRHIKDLEKILDISSSQLELSSWSSADELDTSGSVSPVSGRSTPSRQ RTVHKKWLRFLPF NT seq 26142 nt NT seq  +upstreamnt  +downstreamnt atggctcgctacaaaggtgctggtggcagaaatgttacgtcgctaaatctgcttcctggg ttctttcagtaccggcaggatgagcaagagtcagtgcagaaaaggactttcacaaaatgg atcaatactcatctggctaagcgcaatcctcccattctggtgaatgatctgtttgaagat atcaaagatggggtaatgctaattgcccttttggaggttctttcagggcagaagctgcct tgtgagcaaggacgtcatctgaagagaatccactgggttgccaacattggcacagctctt aagtttctagaaggaagacggtccatatacagaggatctccgattaagcttgtcaacata aactcaactgatattgctgatggcaggccttctatcgtgcttggcttggtgtggaccata attttatattttcagattgaagagcttaccagcaacctcccacagctgcagtcgatgtct agcagcgcttcttctgtggagagtgttgtcagctcagagactgcgagtcccccaagcaaa cggaaggtggtaaccaaggtccaaggaagtgccaggaaggctttgttaaaatggatacag tacacagcagcaaagcaagttggaattgaaatcaaagattttggacaaagttggaggagt ggcgttgcatttcattccattattcatgctatccgcccaaatttagtggacatggacaaa gtgagaggaagatcaaatagagaaaacctggaagaagccttcacaattgcagaagcagaa ttaggaattccaaggctgcttgatccagaagatgtggatgttgacaagccagatgaaaag tctgtcatgacctatgtagcccagtttttgaagtactatcctgatcctcatcatacagtg accgatgtgcaggagaatgacaaggaagatagactgatgctgagagacctaaaagtgtgg gcagaacaatttgaaagagacatagcccgagcacaggtggcagaaacaagcttacaggag aaatatcagtcatttaagcatttcagagtacaatatgatgtaaaaaggaaacagattgaa cttgtaacccagtcattaaggaaagatggtaaattatcacttgatcaggctatggtgaag caagcatgggacagagttacttccaggctagttgattggcacagacaccttgataaatct cttcctgcacctctgggtaccataggtgcttggctctacagagcagaggctgctctgaga gaagaagtaactgttcagcaagttcatgaggaaacagcaaatacaatacatcggaagctt gaacaacataaggatctgctgaaaaacatagatggtcacaaaaaagcattccatgagatc cacggggccaggtctgttaatggagtgcctgttccacctgatcaattagaggatatggca gaaaggtttaattttgttgtctcttcatctgagctccatctgttgaagatggagtttctg gaactgaagtaccgtctactgtcactcttagtccttgcagaatcaaagttaaaatcatgg attatcaaatatggaaggcgagagtcggtggaactacttcttcaaaattatatctctgtt attgaaaatagtaagttctttgagcagtatgaagttacttaccagatcttgaaaagagca gctgaaatgtatgccaaagcaaatggctcagtggaagaagttgagaacgtgatgaaattc atgaacgaaacatcagcacagtggaggaacctgtcggtagaggtgagaagtgtaagaagc atgttggaagaagtaattgctaattgggacagatatagcagcactgtggcaggtctacaa gcttggctagaagatgctgaaaaaatgctgaatcagcctgaacattctaaaaaggatttc ttccggcacttacctcattggatccaacagcacacagccatgaatgatgctggtaatttt ctgattgaaacatgtgatgagaccatttccagagaccttaaacagcagcttctgttacta aatggaagatggagagaattgtttatgcaagttaagcagtatgctcgagcagatgaactg gacaaaatgaagaaggaatacttggatggtgttgcccatttgacagcttttattgatgga agcaacaggaaatttttggtccctgtagaagtgtccttccttgatgtcaaaatgtttgta caagatttagaaaatattaagcaaaaattgcctgcaatggaagctcagtacaaaatggtt acaagaacagcccaacttgttacaaaagaagtttccgaagaggaagtgaaggaaatcctt ggaactttgacaaggatcaaagagcagctgagcaaggttaaggagtattcctgtgccctg ctctatgaatgccagcgtctactgtctccactggaagaactggagaaacaaatcacacat ttttatgaatctcttgaaaaagtcaatgaaataatttctatcctggatcctgaagcacaa cccacatctgttcttaaacaaaaagcccaagatttggtagcttatcaagaaaactgcaag aaagatttgtccctgattgagaggaatagtcagagtatcctgcagtgcgtggcttcgagc gaagtgttacagcatttccatcagtcaacatttcagaagaaagttacacaagttcagctt acttttcagaatatggtcaggaaagctggtgactggagaaaaaacatagaagcaaatagc cgtttgatgaagaaatttgaggagtctagagcagaactggagaatgtaatacagattgcc aattgttgcttaaaagaaaaaggaaatcctgaagaacttctcaggaaacatagcgaattc tttaaccagttggatcagagagtcctaaatgcctttctgaaagcttgtgatgaacttact gacatcctcccagaacaagagcaacacaacctgcaggaagctgtcagaaaactccatagg cagtggaaggatcttcaaacagaggcaccatatcatttgatccacttgaagatagaaata cagaaaagcaggttcctggtcacagtggaggagtgcaaagctgaactagctcgacagaac aaggtgttgtcaagagaaggcaatgaaaggatgattgaggagcacaagttattcttcggt gacaagggaccttaccagctgtgtgagaaaaggctacaaaggattgaagaactgtgccaa aaactgccagtttctgatccagtgagggctacattggaaagcagccaacgaatcttgaag gatctcaaatcccagataaacagcacatacataaagctaacagagcactcggacacctgg aagggctataagaacagattttctgaattggcaaattggatttcatcaacagaaacagag ctaaagaagataaaggaaagtgtccatgatactgctaaattcaagcagtgtaaagcatct gtgggggaaattaggaagcgtattaacaagcaaggagaaaatcacagctggctgaaatct aggcttgctgttttaaccacagtatgtcctgatttggaggccaaaaagacagaggatgag ctttgtaaactttccagtgacttcaagggactcctagatttgctggctgaggttgaaaag acattaggcactgttggagactgtgtccagtacaaagaagaagttaaaagtgcaattgaa gagttaatcaacaactctaaagaagcccaagcagaggctgaaaagatcctggatacagaa agtttactacaagctcagcaactactacttcatcatcagcaaaggacaaggagactccgt gcaaaaaggcaagatgtgcaacagcagatttcccaagctaagcagttgcagactgaaggt ggactgcccagcacaatgcaagaggatttgcaaaagttggaaggaacattggagaacatg cagcagactatggagaaacgtgaagagcaactgcaggtcacaataaataaatgggagcag tttgaaagggacaaagaaacagtagtaaaatacctcaatcaagcaagttctgcacttgaa cgtatcttaaactttagcagtttagagagcctctcctcagaactggaccagacaaaggaa ctctctaaacaggctgaagcaatggctgtgcaggctgagaatttggtgaagaattcttct gagatacagcttggttcaaagaacaagcagtctcttcaacagcaggcaaaatcaatccaa gaacaactgaaaaaagtggaagttactcttgaagaagatattaaaagcatggaaatggtg aaaagcaagtgggatcattttggcaataattttgaagctctgtccatctggatagctgaa caagagaaagaactggaaactttggaaacatcatcatctcctttggacatacagatcagc caaatcaaggttattaataaagaaatagatggtaaaataactggaatctcaaaactagaa gaggaagccgagtctttttcccagtttgttacctctggagaatatgcacatattaaagcc aaactgactcaggtcaaaaggtattgggaagagctaagagatcacgcacagagactggaa 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gtcaccagcctgcccatgtgccacagtgccctgcggctgcaggaggaggccagccgcctg cagcacactgccattcagcagtgcaacatcatgcaggaagcagtggtgcagtatgaacaa tatgagcaagaaatgaaacatttgcagcagatgatagagagcgcccattgtgagatccaa gacaagccaatagcaaccggcaacatccgggaactccaggcccagatttcgcgtcatgag gagctggctcagaagatcaagggataccaggagcaaattgcttctttgaattcgaagtgc aagatgctgacaatgaaagcaaaacatgccaccatgctgctgacagtgacagaagtggag gggctttcagagggaatggaggagctggattcagacctgcttccagcacaccccgctcat ccctcggtggttatgatgactgctggtcgctgtcacacgctgctctcccctgtcactgag gagtctggggaggagggaaccaacagtgagatttcttctccacctgcctgtcgctctccc tcacctgtggctaatacagatgcttctgttaaccaggacattgcttattaccaagcctta tctgctgaacagttggccttatctgctgaacagttgcagacagaagctgctaaaattcaa cccagcacttcagccacccaggagttttatgaaccaggcttagaatcagctgctagcgcc aaattggatgacttgcagcgttcttgggaaacactgaaaaatgtgatcagtgaaaagcag cgtaccctttatgaagctcttgagcgtcaacagagatatcaggacacactccagtctata tccacaaaaatggagaccattgaggtcaaactaaatgagagcctggaaccagccaaaagc ccagagagccagatggctgaacatcaggctttgatggatgagattttaatgttacaagaa gaaatcactgagcttcagacatcattagcccaggagctggtttcagaacgactggatgca gaagctgctgatcagctggcattgcagtccactctcatggtcttggcagaacgaatggcc acaattcgaatgaaggcatcaggaaaacgacaactattagaggaaaaactgaatgagcag ctggaagaacagaggcaggagcaggctcttcaaaggtaccgttgtgaagctgatgagctt gaccactggttactcaatacccgagcaacactggacaccactctggttacagctgaggaa cctatggacatggaagcacagctggtagactgtcagaacatgctggttgaaatagagcag aaggtggtagccctgtcagagttatctgtgcacaacgagaacttgcttatggaagggaag gctcacaccaaggacgaggcagagcagctggctgtgaagctcaggacactgaagggcagc cttctggagctgcagagagtgctccacgacaaacagatcaacattcggcagggatcgttg caagaaaaggaggagagtgatctggactttgtttcgtcacaaagccccagtgtccaagaa tggctggtgcaagcaagaaccactcgctcacagcagcagcagagcaccctgcagcaacag aaagagctggaacaagagctagaagaacagaagaaactgcttcggtcagtagcatccctt ggagaagaaatcctaacacagcacgttgctccagaaggcctatgcctaagtgagaagcct gatacactctcagaggaattaggcttggaaggtgagaaaccatcatctgaagaacagatg aagatgaaatgggaaagtctgaaccaggatttcaataccaaggagagactgctccagaaa gctttggaacaagaacagctgcagctgtatagcagaccaaacagactgctatctggaatg cctttgtatatggaggaaggacaggatgaggataaatcctcagtgtcaccagtattggtt gaattgaatcaggcctttgaagatgtgtcatctgaggctggacaggtggaggagagcctg catcttgaacagaaactgtatgatggtgttgcagccacctccctgtggctggatggtgtg gaagagcaggtctttgttgatacagctctgttgccagaggaagaaacagaaacatacctc tgcaagcaagagtctcttgccaaagaaatcaaagagataacagaagaaatgaataagaac aagaatttatttgctcagatatttcctgagaatggtgataataggggtattatggaagac actttggattgtctcctgagaagactgaccttgctggagtcagtagtaaaccagagatgc cgtcagatgaaaggaaggctccagcaaatagcgactttcaagaatgacctgaagcttctg tttacatcggtggctgataagaaatatttagttgtacagaaactagcagaggcagctgag agaccagaaacagaacaaatgcaggtcatactgcaggcagaagaaggtttgaaggaacta gatattggaatcaatgaattaaagaagcatgtagacaagttacaaattgaccaaccttcc atgcaagagctgtctaagatccaggatatgtatgatgagctgatgatgatcattggatcc agacggaatgacctgaatcagaatctggctcttaagaggcagtatgaacgggctttacag gacctggctgacctgttagaaacaggccaagaaaagatggctggtgaccagaaaatgatt gttgcttctaaggaagaggttcgatcactacttgacaaacataaggaatattttcagggg ttggagtctcacatgatcctgacggaaacgctctttagaaagatgagtagctttgccctc ttgaaggaaactcggtcacattcagacctaatgacacaagcttctgctgtattaaagctg gctcataaacgaggtgtggagctggaatacattctagagacctggatgcatctggatgaa gattaccaggaacttaccagacagctggaatctattgaaggtagcatccccatagtcggt ttggtggaagagacggaggacaggcttacagaccggattacactttttcagcatctgaga tctaacctgactgaataccaacctaaattataccaagtgctagatgatgggaaaaggctc cttttttctgttagctgctcagatctcgaaagtcaactgaaccaactaggagaacgctgg ttaagtaactccagcaaggttaccaaggagcttcatagattggagacaatactgaagcac tggacaagatatcagagtgaatcaagtgaactgacacattggttacaatctgcaaaggag cgacttgagttttggagccagcagtctttgacagttcctcaggaactggaaacggtccga gaccacctgaactcctttttggagttttcaaaagaggtggatgctaaatcatcacagaaa tcgtctgtcctgagtactgggaaccagcttctcaggctgaagaaggtggatacagcagca ctgcgcgcgggattgtcccacattgacagtcagtggacagagctgctcacgcaaatccca gcagtacaagagaaattgcaccagctccagatggagaaaattccttctcgtcatgctatc actgaagttatgagctggatttccctgatggaaaatgtcattcaggaggatgaagagaat ataaaaaatgtagtaggacagaaagccattcaagattatgtcaagaagtacaagggtttc aagatagatttaaattgcaaacagttgacggtagactttgtgaaccaatcagtgctgcaa attagcagccaggatgttgaaagtaaacgtagcgacaagactgattttgcagaacagctt ggagcaatgaacagacgttggcaaatcctgcaaggcctgataacagaaaagatccagcta ttggaaagtctgcaggaatcctgggcagaatatgaaaataatgtgcagggcctgaaaact tggtttgaaacccaagagaagaagctgagacaacaacagaaaattggagaccaggcttca gtacagaatgctttgaaagactgtcaggaattagaagaattaataagaacaaaggaaaaa gaagtagaaaatgtagaacagagcggtctgtctttgatacagaacaagaaagaagtcgtc tcttctgctgttatgaaaacactgcaagaaattaaccattcctgggccaatttggatcac atggttagccagctgaagatattgttgcaatctgttcttgatcagtggagcatttacaag gtggcttatgaagaactgaatagttacctgacagaagccagatactctttgtcccggttt tatcttcttactggttctttggaagctgtgaaagtccaagttgatagccttcagagccta caagatgaattggaaaagcaagaaaacagcttacagaaatttggttctgtgaccaatcaa ctgttgaaagagtgtcacccaccagtgactgaaacacttaccaacactttgaaagaagtg aatatgaggtggaacaaccttctacaggagattgcagagcggttgcatgccagtaagggc ctcctacagctgtggcagaggtacaaggactgttaccagcagtgctcttccacactccgt cagcgggaagaccagaccaatgaactcctgaagactgccaccagtaaagacattgctgat gatgaagttactacttggattcgggactgtaacgatgtactcacggatttgaagacagca caggagtcactggttgttcttcaagaactgggagaggagctgaaaagccaggtggaggct tcagcagcagcatctatacagtctgaacatctttctctgaaccagaatctgtcaacccta gaacaggctctccgcaagcaacaggctgtacttcaggctggagtgctggactatcaaacc tttgccaagaacctgcaagtccttgaggcctggataacagaagcagaagtagtactgaaa ggacaggatcccagtcactcatctgatctctcagcgatacagagtagaatggaggaactc aagagtcagatgttgaagttcagcagtatgagcccagatttggaccgccttaatgagctg ggttataggcttcctctgaatgataaagaaattaaaaggatgcagaacctgaacagacat tggtctctgatctcatctcagactacggagagattcagtaagctgcagtctttcttactg cagcagcagaccttcttggagaagtgtgagacttggatggatttattagttcagactgag cagaagctggcggcagagatttcaggaaactaccagagccttttagaacaacaaagagca catgagctcttccaggcagagatgttcagccgccagcaaattttgcattcaattatctct gatgggcagcacctcatagaacaaggacaggtggatgacagggatgaatttaatctgaag ctgactcttctaagtaatcaatggcaaggagtaattcgccgggcacagcagaggaggggg atcattgacagccagattcaccagtggcaacgctacagggagatggcagagaagctgcgc aagtggctggtggaaatatcctgtcagccagtgagtgggctgggcgacgctcctttccca ttacagcaagccagagcgctactggatgaagtgcagcttaaagagaaagttctcctgagg cagcaagggagttatatcctcacggtggaagctgggaagcaactgctgctctctgctgac agtggagctgaggcagccctgcaggcagagctcactgaaattcaggagcgctggaagaca gctagcacccaactggagcaacaaaagaaacaacttgctttactactgaaagactgggaa aaatgtgaaaagggcataggagactccctggagaagttaagatcattcaaaaaaaacctt tctcagcctttgccagaacaccatgatgagttgcatgcagagcagattcgctgcaaggag ctagagaatgctgttgaaggatggacagatgaccttgcacacctctctctgctgaaggag accctgtcaatatatatcagcgcagatgatatctcaatcctcagtgagcgcatagagctt ctacacagacagtgggaggagctgtgccaccaggtctccttacgtcgacagcaagttagt gagagattgaatgagtgggctgtcttcagtgagaagaacaaggagctctgtgagtggctg acacaaatggaaagtaaggtttctcaaaatggcgatatcctcatagaagaaatgattgag aaacttaaaaaggattatcaagaggaaattgctgtagcccagaagaacaaaatccagctc cagcaaatgggagagcgactagcgaaagccagccatgagagtaaggcatcagagattgag tacaaacttggcaagatcaatgacaggtggcaacatcttctggatcttattgcagccagg gtaaagaagttgaaggagaccctcgttgcagtgcagcaactggataaaaacatgagtagc ctgagatcttggcttgcccacattgagtcagagctgtccaaacctatcgtctatgaaact tgtaactctgaggagatacaaaggaagctaaatgaacagcaggaacttcagagggacata gagaaacacagcactggagtagcgtctgttctcaatttgtgtgaagtgcttctgcatgac tgtgatgcctgtgccacagaagcagagtgtgactctatccagcaggctacacgcaatctg gacagaaggtggaggaacatttgtgcaatgtccatggaaaggcgacttaaaattgaagag acgtggcggctatggcaaaagtttttggatgactactccagatttgaggactggctaaaa atctctgagaggacagctgctttcccgagctcctctggtgtgctttacacggttgctaag gaagaactgaagaaatttgaggccttccagagacaagtgcatgaaagtctgactcagctg gaactgatcaataagcagtatcgccgcctggcgcgggagaaccgcactgactctgactgc agtctcaagcagatggttcatgaggggaaccagagatgggacaacttacaaaagcgagtt acctccatcctgcgcaggctaaaacattttattggccagcgtgaggagtttgagacagca cgtgatagcatcctggtatggctaacagagatggacctgcagctaaccaacattgagcat ttctcagagtgtgatgtccaagcaaagataaagcaacttaaggctttccagcaagaaatc tcactgaacaacaacaaaattgagcagataatcgtgcagggtgagcaactcattgagaaa agtgagcccatggatgcagctgtcattgaagaagaactagacgagctgcgtcgttactgc caagaggtctttggacgtgtggaacgctatcacaagaaactcatccgccttcccctgaca gatgacgaacatgacctctctgacagagaggtggatctggatgaatcagcagatctctct gacatacactggcatgacaaatctgcggacagcgttctctccccgcacccctcttccaac ctttcgctgcctctttcccagccggtgagaagcgagcgatcagggcgagatacacctgca agcgtggactccattcccctggagtgggatcatgactacgaccttagcagagacctggag acagctgtttcacgggcactgcactctgaggaagaagatggaggacaagagaaggacttc tacctgagaggggcaactggtatagcaggagaacctggtgccctggaagcacatatccga cagctggacaaggccttggacaccagtcgtttccaaatacagcaaacagaaaacatcatc cgcagcaaaacacctacaggaccagagctggattccagttacaaaggatatatgaaacta ttaggtgaatgcagtggaagcatagactcagtaaaaaggcttggatataaattgaaggaa gaagaagaaaaattatctggacttattaacctgaacagtactgaaacacaaacagctggt gtaattgaccgatgggaattaatccaggctcaagctctaagcaaggagctgaggatgaaa cagaaccttcagcaatggcagcagtttaactccgaccttaatagtatttgggcttggttg ggagaaactgaagaggaactggagaagatccgccgccttgatctcagcactgacatacaa actattgaactcagaattaaaaaactgaaagatctgcagaaagcagttgataaccgcaaa gcgatcatcttatccatcaatctgtgcagctcagagttcactcagtctgacagcgaagag agcaagaagcttcaagagcgcctgtctcagatgaacgtgcgctgggaccacgtatgcagt atgatcgaagagtggcgctgctcattgcaggatgcattaatgcagtgccaggatttccat gaaatgagccatggtttactgctttggttagagaatattgacagaagaaaaaatgagatt gtgcccatcaatccaaacctggactcagaaacgctgcaggatcatcacagacttttaatg caaatcagacgtgaactgctggagtctcagttgaaggtggcgtcactgcaagatatgtcc cgccagttgctagtcaatgctgaaggcaaggactgtcttgaagctaaagagaaggtgcat gtcattggtaatagactgaaggtcctcttgaaagaggtcacacgtcatattaaagaccta gagaaaattctagacatttcaagtagtcagctggaattgtcctcatggtcctctgctgat gaattagacacatcgggctcagtgagtcctgtatctggaagaagcactccaagcagacag agaacggtccacaagaagtggctcaggttcctccccttctga

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