KEGG   Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise): 112391181
Entry
112391181         CDS       T08872                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
nasi  Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Pathway
nasi00562  Inositol phosphate metabolism
nasi01100  Metabolic pathways
nasi04015  Rap1 signaling pathway
nasi04020  Calcium signaling pathway
nasi04022  cGMP-PKG signaling pathway
nasi04062  Chemokine signaling pathway
nasi04070  Phosphatidylinositol signaling system
nasi04071  Sphingolipid signaling pathway
nasi04072  Phospholipase D signaling pathway
nasi04081  Hormone signaling
nasi04082  Neuroactive ligand signaling
nasi04261  Adrenergic signaling in cardiomyocytes
nasi04270  Vascular smooth muscle contraction
nasi04310  Wnt signaling pathway
nasi04371  Apelin signaling pathway
nasi04540  Gap junction
nasi04611  Platelet activation
nasi04613  Neutrophil extracellular trap formation
nasi04621  NOD-like receptor signaling pathway
nasi04713  Circadian entrainment
nasi04720  Long-term potentiation
nasi04723  Retrograde endocannabinoid signaling
nasi04724  Glutamatergic synapse
nasi04725  Cholinergic synapse
nasi04726  Serotonergic synapse
nasi04728  Dopaminergic synapse
nasi04730  Long-term depression
nasi04742  Taste transduction
nasi04750  Inflammatory mediator regulation of TRP channels
nasi04911  Insulin secretion
nasi04912  GnRH signaling pathway
nasi04915  Estrogen signaling pathway
nasi04916  Melanogenesis
nasi04918  Thyroid hormone synthesis
nasi04919  Thyroid hormone signaling pathway
nasi04921  Oxytocin signaling pathway
nasi04922  Glucagon signaling pathway
nasi04924  Renin secretion
nasi04925  Aldosterone synthesis and secretion
nasi04926  Relaxin signaling pathway
nasi04927  Cortisol synthesis and secretion
nasi04928  Parathyroid hormone synthesis, secretion and action
nasi04929  GnRH secretion
nasi04933  AGE-RAGE signaling pathway in diabetic complications
nasi04934  Cushing syndrome
nasi04935  Growth hormone synthesis, secretion and action
nasi04961  Endocrine and other factor-regulated calcium reabsorption
nasi04970  Salivary secretion
nasi04971  Gastric acid secretion
nasi04972  Pancreatic secretion
nasi04973  Carbohydrate digestion and absorption
nasi05010  Alzheimer disease
nasi05016  Huntington disease
nasi05017  Spinocerebellar ataxia
nasi05022  Pathways of neurodegeneration - multiple diseases
nasi05142  Chagas disease
nasi05143  African trypanosomiasis
nasi05146  Amoebiasis
nasi05163  Human cytomegalovirus infection
nasi05200  Pathways in cancer
nasi05415  Diabetic cardiomyopathy
nasi05417  Lipid and atherosclerosis
Module
nasi_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:nasi00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    112391181 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    112391181 (PLCB2)
   04310 Wnt signaling pathway
    112391181 (PLCB2)
   04371 Apelin signaling pathway
    112391181 (PLCB2)
   04020 Calcium signaling pathway
    112391181 (PLCB2)
   04070 Phosphatidylinositol signaling system
    112391181 (PLCB2)
   04072 Phospholipase D signaling pathway
    112391181 (PLCB2)
   04071 Sphingolipid signaling pathway
    112391181 (PLCB2)
   04022 cGMP-PKG signaling pathway
    112391181 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    112391181 (PLCB2)
   04081 Hormone signaling
    112391181 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    112391181 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112391181 (PLCB2)
   04613 Neutrophil extracellular trap formation
    112391181 (PLCB2)
   04621 NOD-like receptor signaling pathway
    112391181 (PLCB2)
   04062 Chemokine signaling pathway
    112391181 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    112391181 (PLCB2)
   04922 Glucagon signaling pathway
    112391181 (PLCB2)
   04929 GnRH secretion
    112391181 (PLCB2)
   04912 GnRH signaling pathway
    112391181 (PLCB2)
   04915 Estrogen signaling pathway
    112391181 (PLCB2)
   04921 Oxytocin signaling pathway
    112391181 (PLCB2)
   04926 Relaxin signaling pathway
    112391181 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    112391181 (PLCB2)
   04918 Thyroid hormone synthesis
    112391181 (PLCB2)
   04919 Thyroid hormone signaling pathway
    112391181 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    112391181 (PLCB2)
   04916 Melanogenesis
    112391181 (PLCB2)
   04924 Renin secretion
    112391181 (PLCB2)
   04925 Aldosterone synthesis and secretion
    112391181 (PLCB2)
   04927 Cortisol synthesis and secretion
    112391181 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    112391181 (PLCB2)
   04270 Vascular smooth muscle contraction
    112391181 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    112391181 (PLCB2)
   04971 Gastric acid secretion
    112391181 (PLCB2)
   04972 Pancreatic secretion
    112391181 (PLCB2)
   04973 Carbohydrate digestion and absorption
    112391181 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    112391181 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    112391181 (PLCB2)
   04725 Cholinergic synapse
    112391181 (PLCB2)
   04728 Dopaminergic synapse
    112391181 (PLCB2)
   04726 Serotonergic synapse
    112391181 (PLCB2)
   04720 Long-term potentiation
    112391181 (PLCB2)
   04730 Long-term depression
    112391181 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    112391181 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    112391181 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    112391181 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    112391181 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112391181 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    112391181 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112391181 (PLCB2)
   05142 Chagas disease
    112391181 (PLCB2)
   05143 African trypanosomiasis
    112391181 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112391181 (PLCB2)
   05016 Huntington disease
    112391181 (PLCB2)
   05017 Spinocerebellar ataxia
    112391181 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    112391181 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112391181 (PLCB2)
   05415 Diabetic cardiomyopathy
    112391181 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    112391181 (PLCB2)
   04934 Cushing syndrome
    112391181 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nasi04131]
    112391181 (PLCB2)
Enzymes [BR:nasi01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     112391181 (PLCB2)
Membrane trafficking [BR:nasi04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    112391181 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    112391181 (PLCB2)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh C2 EF-hand_like
Other DBs
NCBI-GeneID: 112391181
NCBI-ProteinID: XP_024588192
UniProt: A0A341AGD5
LinkDB
Position
Unknown
AA seq 890 aa
MSLLNPVLQPPGVKAYLSQGERFIRWDDETTIASPVILRVDPKGYYLYWTYQNKEMEFLD
ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLALAKHPLMANASRSTFLDKSLVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LAKFINQKQRDSRLNSLLFPLARPDQVQGLIDKYEPRGINVQRGQLSPEGMVWLLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDICFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTIFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPPAPSQEPGGE
AEGSGPPNVPVGEDTVWAGEEGAELEEEEVEEEEEESGSLDEEGMKKMQSDEGTAGLEVT
AYKEMSSLVNYVQPTKFISFESSARELACSGEKNRSYVISSFTELKAYDLLSKFSVQFVD
YNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGY
LLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDP
KRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEDGNKFLGHRIIPVNALN
SGYHHLCLHSESNMPLTMPALFVFLEMKDYVPDTWADLTVALTNPIKFFSAHDKSVKLKE
AMGGLPENPFPLGSPVARQVNGASALTSNGSAAGAKAREEATREAAGKAC
NT seq 2673 nt   +upstreamnt  +downstreamnt
atgtctctgcttaaccctgtcctgcaaccccccggggtgaaggcctatctgagccaaggg
gagcgcttcatcagatgggatgatgaaacaacaatagcctccccagttatcctccgtgtg
gatcccaagggctactacttgtactggacatatcagaataaggagatggagtttctggat
atcaccagcatccgggacacccgctttgggaagtttgccaagatgcccaagagccagaag
ctccgggatgtcttcaacatggactttcctgacaacaacttcctgctgaagacgctcacc
gtggtgtctggccccgacatggtggacctcaccttccataacttcgtctcctacaaagag
aacgtgggcaaggactgggctgaagatgtcctggctctggccaagcacccgctgatggcc
aacgcctcccgcagcaccttcctggacaagagcctggtgaaactcaagatgcagctcaac
cctgaaggaaagattcctgtgaagaattttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgcccttagcgcctgccacctcccaaaaggcaagaatgatgccatcaatccc
gaggacttcccagaatccgtctacaagagtttcctcatgagcctttgtcctcggccagaa
atagatgagatcttcacttcctaccacgccaaggccaaaccctacatgactaaggagcac
ctggccaaattcatcaaccagaaacagcgcgactccaggctcaactccctgctgttcccg
ctcgcgcggcctgaccaggtgcagggcctcatcgacaagtacgagcccagaggcatcaac
gtgcagaggggccagctgtcccccgagggcatggtatggttactctgtgggccagagaac
agcgtgctggcccaggacaagctgctgctgcaccacgacatgacgcagccgctcaaccat
tacttcatcaactcctcccacaacacctacctgacagccggccagttctcaggcctttcc
tctgccgagatgtaccgccaggtactgctggcgggctgccgctgcgtggagctggactgc
tggaaggggaagccccctgacgaggagcccattatcacccacggcttcaccatgaccaca
gacatctgtttcaaggaagcaattgaagctattgcagaaagtgcctttaagacctcccct
tatccggtcatcctgtcgtttgaaaaccacgtggactcaccccgccaacaggctaagatg
gccgagtactgccgaacgatatttggggatatgctgctcacagagccactggaaaagttc
ccactgaaaccaggcatccccctgcccagccctgaggatctccgaggcaagatcctcatc
aaaaacaagaagaaccagttttctggtcccccagcccccagccaggagccgggtggggag
gctgaggggagcggcccacccaatgtccctgtgggtgaggacacagtgtgggctggtgag
gaaggggctgagctggaggaggaggaggtggaagaggaagaggaggagtcgggaagcctg
gatgaagaagggatgaagaagatgcagtcagatgagggcacagcgggcctggaggtgacg
gcttacaaggagatgtccagcttagtcaattacgtccaacccaccaagttcatctccttc
gagtcctctgcccgtgagttagcatgcagtggtgagaagaatcgaagttatgtcatttcc
tccttcacggagctcaaggcttacgacctgctctccaagttctcagtgcagtttgtggac
tacaacaagcgccagatgagccgcatctaccccaagggcacccgcatggactcctccaac
tacatgccccagatgttctggaatgctggttgccagatggttgccctcaacttccagacg
atggacctgcccatgcagcagaacatggcgctctttgagttcaacgggcagagtggctac
ctcctcaagcatgagttcatgcgccggttggacaagcagttcaaccccttttcggtggac
cgcatcgacgtggtggtagccaccaccctttccattacggtgatctctgggcagttcctg
tcagaacgcagtgtgcgcacctatgtggaagtggagctgtttggccttcctggggacccc
aagaggcgctatcgcaccaagctgtcacccagtaccaattccatcaatcctgtctggaag
gaggagccctttgtctttgaaaagatcttgatgcctgagctggcctccctcagggtggct
gtgatggaggacggcaacaagtttcttggacaccgcatcatccccgtcaacgccctgaat
tctggataccaccatctgtgcctgcacagcgagagcaacatgccactcaccatgcctgca
ctcttcgtcttcctggagatgaaggactatgtacctgacacctgggcagatctcacggtg
gccctcactaatcccatcaagttcttcagtgctcatgataagtctgtgaagctcaaggaa
gccatgggaggcctgcctgagaatcccttccctctcgggagtccagttgcccgccaggtc
aatggggcatcagctttaacgagcaacgggtcagcagccggggccaaggccagggaggag
gccacgagagaagctgcgggtaaggcctgctga

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