KEGG   Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise): 112393112
Entry
112393112         CDS       T08872                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
nasi  Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Pathway
nasi01521  EGFR tyrosine kinase inhibitor resistance
nasi01522  Endocrine resistance
nasi04010  MAPK signaling pathway
nasi04012  ErbB signaling pathway
nasi04014  Ras signaling pathway
nasi04015  Rap1 signaling pathway
nasi04022  cGMP-PKG signaling pathway
nasi04024  cAMP signaling pathway
nasi04062  Chemokine signaling pathway
nasi04066  HIF-1 signaling pathway
nasi04068  FoxO signaling pathway
nasi04071  Sphingolipid signaling pathway
nasi04072  Phospholipase D signaling pathway
nasi04114  Oocyte meiosis
nasi04140  Autophagy - animal
nasi04148  Efferocytosis
nasi04150  mTOR signaling pathway
nasi04151  PI3K-Akt signaling pathway
nasi04210  Apoptosis
nasi04218  Cellular senescence
nasi04270  Vascular smooth muscle contraction
nasi04370  VEGF signaling pathway
nasi04371  Apelin signaling pathway
nasi04380  Osteoclast differentiation
nasi04510  Focal adhesion
nasi04540  Gap junction
nasi04550  Signaling pathways regulating pluripotency of stem cells
nasi04613  Neutrophil extracellular trap formation
nasi04620  Toll-like receptor signaling pathway
nasi04650  Natural killer cell mediated cytotoxicity
nasi04660  T cell receptor signaling pathway
nasi04662  B cell receptor signaling pathway
nasi04664  Fc epsilon RI signaling pathway
nasi04666  Fc gamma R-mediated phagocytosis
nasi04668  TNF signaling pathway
nasi04720  Long-term potentiation
nasi04722  Neurotrophin signaling pathway
nasi04725  Cholinergic synapse
nasi04726  Serotonergic synapse
nasi04730  Long-term depression
nasi04810  Regulation of actin cytoskeleton
nasi04910  Insulin signaling pathway
nasi04912  GnRH signaling pathway
nasi04914  Progesterone-mediated oocyte maturation
nasi04915  Estrogen signaling pathway
nasi04916  Melanogenesis
nasi04917  Prolactin signaling pathway
nasi04919  Thyroid hormone signaling pathway
nasi04921  Oxytocin signaling pathway
nasi04926  Relaxin signaling pathway
nasi04928  Parathyroid hormone synthesis, secretion and action
nasi04929  GnRH secretion
nasi04934  Cushing syndrome
nasi04935  Growth hormone synthesis, secretion and action
nasi05010  Alzheimer disease
nasi05022  Pathways of neurodegeneration - multiple diseases
nasi05034  Alcoholism
nasi05132  Salmonella infection
nasi05135  Yersinia infection
nasi05160  Hepatitis C
nasi05161  Hepatitis B
nasi05163  Human cytomegalovirus infection
nasi05164  Influenza A
nasi05165  Human papillomavirus infection
nasi05166  Human T-cell leukemia virus 1 infection
nasi05167  Kaposi sarcoma-associated herpesvirus infection
nasi05170  Human immunodeficiency virus 1 infection
nasi05200  Pathways in cancer
nasi05205  Proteoglycans in cancer
nasi05206  MicroRNAs in cancer
nasi05207  Chemical carcinogenesis - receptor activation
nasi05208  Chemical carcinogenesis - reactive oxygen species
nasi05210  Colorectal cancer
nasi05211  Renal cell carcinoma
nasi05212  Pancreatic cancer
nasi05213  Endometrial cancer
nasi05214  Glioma
nasi05215  Prostate cancer
nasi05216  Thyroid cancer
nasi05218  Melanoma
nasi05219  Bladder cancer
nasi05220  Chronic myeloid leukemia
nasi05221  Acute myeloid leukemia
nasi05223  Non-small cell lung cancer
nasi05224  Breast cancer
nasi05225  Hepatocellular carcinoma
nasi05226  Gastric cancer
nasi05230  Central carbon metabolism in cancer
nasi05231  Choline metabolism in cancer
nasi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:nasi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112393112 (MAP2K1)
   04012 ErbB signaling pathway
    112393112 (MAP2K1)
   04014 Ras signaling pathway
    112393112 (MAP2K1)
   04015 Rap1 signaling pathway
    112393112 (MAP2K1)
   04370 VEGF signaling pathway
    112393112 (MAP2K1)
   04371 Apelin signaling pathway
    112393112 (MAP2K1)
   04668 TNF signaling pathway
    112393112 (MAP2K1)
   04066 HIF-1 signaling pathway
    112393112 (MAP2K1)
   04068 FoxO signaling pathway
    112393112 (MAP2K1)
   04072 Phospholipase D signaling pathway
    112393112 (MAP2K1)
   04071 Sphingolipid signaling pathway
    112393112 (MAP2K1)
   04024 cAMP signaling pathway
    112393112 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    112393112 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    112393112 (MAP2K1)
   04150 mTOR signaling pathway
    112393112 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112393112 (MAP2K1)
   04148 Efferocytosis
    112393112 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    112393112 (MAP2K1)
   04210 Apoptosis
    112393112 (MAP2K1)
   04218 Cellular senescence
    112393112 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112393112 (MAP2K1)
   04540 Gap junction
    112393112 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    112393112 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112393112 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    112393112 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    112393112 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    112393112 (MAP2K1)
   04660 T cell receptor signaling pathway
    112393112 (MAP2K1)
   04662 B cell receptor signaling pathway
    112393112 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    112393112 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    112393112 (MAP2K1)
   04062 Chemokine signaling pathway
    112393112 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112393112 (MAP2K1)
   04929 GnRH secretion
    112393112 (MAP2K1)
   04912 GnRH signaling pathway
    112393112 (MAP2K1)
   04915 Estrogen signaling pathway
    112393112 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    112393112 (MAP2K1)
   04917 Prolactin signaling pathway
    112393112 (MAP2K1)
   04921 Oxytocin signaling pathway
    112393112 (MAP2K1)
   04926 Relaxin signaling pathway
    112393112 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    112393112 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    112393112 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    112393112 (MAP2K1)
   04916 Melanogenesis
    112393112 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    112393112 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    112393112 (MAP2K1)
   04726 Serotonergic synapse
    112393112 (MAP2K1)
   04720 Long-term potentiation
    112393112 (MAP2K1)
   04730 Long-term depression
    112393112 (MAP2K1)
   04722 Neurotrophin signaling pathway
    112393112 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112393112 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112393112 (MAP2K1)
   05206 MicroRNAs in cancer
    112393112 (MAP2K1)
   05205 Proteoglycans in cancer
    112393112 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    112393112 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    112393112 (MAP2K1)
   05230 Central carbon metabolism in cancer
    112393112 (MAP2K1)
   05231 Choline metabolism in cancer
    112393112 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112393112 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112393112 (MAP2K1)
   05212 Pancreatic cancer
    112393112 (MAP2K1)
   05225 Hepatocellular carcinoma
    112393112 (MAP2K1)
   05226 Gastric cancer
    112393112 (MAP2K1)
   05214 Glioma
    112393112 (MAP2K1)
   05216 Thyroid cancer
    112393112 (MAP2K1)
   05221 Acute myeloid leukemia
    112393112 (MAP2K1)
   05220 Chronic myeloid leukemia
    112393112 (MAP2K1)
   05218 Melanoma
    112393112 (MAP2K1)
   05211 Renal cell carcinoma
    112393112 (MAP2K1)
   05219 Bladder cancer
    112393112 (MAP2K1)
   05215 Prostate cancer
    112393112 (MAP2K1)
   05213 Endometrial cancer
    112393112 (MAP2K1)
   05224 Breast cancer
    112393112 (MAP2K1)
   05223 Non-small cell lung cancer
    112393112 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112393112 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    112393112 (MAP2K1)
   05161 Hepatitis B
    112393112 (MAP2K1)
   05160 Hepatitis C
    112393112 (MAP2K1)
   05164 Influenza A
    112393112 (MAP2K1)
   05163 Human cytomegalovirus infection
    112393112 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112393112 (MAP2K1)
   05165 Human papillomavirus infection
    112393112 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112393112 (MAP2K1)
   05135 Yersinia infection
    112393112 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112393112 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    112393112 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    112393112 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    112393112 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112393112 (MAP2K1)
   01522 Endocrine resistance
    112393112 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nasi01001]
    112393112 (MAP2K1)
Enzymes [BR:nasi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     112393112 (MAP2K1)
Protein kinases [BR:nasi01001]
 Serine/threonine kinases: STE group
  STE7 family
   112393112 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 112393112
NCBI-ProteinID: XP_024590930
UniProt: A0A341AJX6
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELVFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHVAGI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcaaaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgccttgaggccttccttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggtgctggcaatggaggt
gtggtgttcaaggtctcccacaagccatccggtctggttatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcatacgggagctgcaggttctacatgag
tgcaactccccttacattgtgggcttctacggtgcattctacagtgatggcgagatcagt
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaatattaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactcc
cgtggggagatcaagctctgcgactttggggtcagcgggcagctcatcgactccatggct
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggtcgggagg
tatcccatccctcctccagatgccaaggagctggagctggtgtttgggtgccaggtggag
ggagatgcggctgagacaccgccccggccaaggactcccggaaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaattgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccacgtggctggtatctaa

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