Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise): 112402589
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Entry
112402589 CDS
T08872
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
nasi
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Pathway
nasi01521
EGFR tyrosine kinase inhibitor resistance
nasi01522
Endocrine resistance
nasi04010
MAPK signaling pathway
nasi04012
ErbB signaling pathway
nasi04068
FoxO signaling pathway
nasi04270
Vascular smooth muscle contraction
nasi04650
Natural killer cell mediated cytotoxicity
nasi04720
Long-term potentiation
nasi04726
Serotonergic synapse
nasi04730
Long-term depression
nasi04810
Regulation of actin cytoskeleton
nasi04910
Insulin signaling pathway
nasi04914
Progesterone-mediated oocyte maturation
nasi04928
Parathyroid hormone synthesis, secretion and action
nasi05010
Alzheimer disease
nasi05022
Pathways of neurodegeneration - multiple diseases
nasi05034
Alcoholism
nasi05160
Hepatitis C
nasi05161
Hepatitis B
nasi05200
Pathways in cancer
nasi05205
Proteoglycans in cancer
nasi05208
Chemical carcinogenesis - reactive oxygen species
nasi05210
Colorectal cancer
nasi05211
Renal cell carcinoma
nasi05212
Pancreatic cancer
nasi05213
Endometrial cancer
nasi05214
Glioma
nasi05215
Prostate cancer
nasi05218
Melanoma
nasi05219
Bladder cancer
nasi05220
Chronic myeloid leukemia
nasi05221
Acute myeloid leukemia
nasi05223
Non-small cell lung cancer
nasi05224
Breast cancer
nasi05225
Hepatocellular carcinoma
nasi05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
nasi00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
112402589 (ARAF)
04012 ErbB signaling pathway
112402589 (ARAF)
04068 FoxO signaling pathway
112402589 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
112402589 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
112402589 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
112402589 (ARAF)
04914 Progesterone-mediated oocyte maturation
112402589 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
112402589 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
112402589 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
112402589 (ARAF)
04720 Long-term potentiation
112402589 (ARAF)
04730 Long-term depression
112402589 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
112402589 (ARAF)
05205 Proteoglycans in cancer
112402589 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
112402589 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
112402589 (ARAF)
05212 Pancreatic cancer
112402589 (ARAF)
05225 Hepatocellular carcinoma
112402589 (ARAF)
05226 Gastric cancer
112402589 (ARAF)
05214 Glioma
112402589 (ARAF)
05221 Acute myeloid leukemia
112402589 (ARAF)
05220 Chronic myeloid leukemia
112402589 (ARAF)
05218 Melanoma
112402589 (ARAF)
05211 Renal cell carcinoma
112402589 (ARAF)
05219 Bladder cancer
112402589 (ARAF)
05215 Prostate cancer
112402589 (ARAF)
05213 Endometrial cancer
112402589 (ARAF)
05224 Breast cancer
112402589 (ARAF)
05223 Non-small cell lung cancer
112402589 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
112402589 (ARAF)
05160 Hepatitis C
112402589 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
112402589 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
112402589 (ARAF)
09165 Substance dependence
05034 Alcoholism
112402589 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
112402589 (ARAF)
01522 Endocrine resistance
112402589 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
nasi01001
]
112402589 (ARAF)
Enzymes [BR:
nasi01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
112402589 (ARAF)
Protein kinases [BR:
nasi01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
112402589 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
TUG-UBL1
Motif
Other DBs
NCBI-GeneID:
112402589
NCBI-ProteinID:
XP_024605367
UniProt:
A0A341BUL1
LinkDB
All DBs
Position
Unknown
AA seq
625 aa
AA seq
DB search
MPPARNRRSGLTRGAPWHLPSPTLARLDKVLGSMEPPRGPPANGAEPSRAVGTVKVYLPN
KQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELI
VEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDM
STNRRQFYHSVQDLCGGSRQHEAPSNRPLNEPLTPQGPSLSPASSCTQHRDPKHFPFPAP
ANAPLQRIRSTSTPNVHMVSTTAPMDSGLIQLPAQSFNTDAAGNRGGGDGTPRGSPSPAS
MSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFG
TVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFFWGW
GDEVAPRQSDTCLYPNSYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQ
PLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFM
VGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSA
SEPSLHRTQADELPACLLSAARLVP
NT seq
1878 nt
NT seq
+upstream
nt +downstream
nt
atgccccccgcccggaaccggaggagtggtttgacccggggagccccatggcacctgccc
agccccaccttagcccgtcttgacaaagtcctaggctccatggagccaccacggggcccc
cctgccaacggggccgaaccatcccgggcggtgggcaccgtcaaagtgtacctgcccaac
aagcaacgcacggtggtgactgtccgggatggcatgagtgtctacgactctttagacaag
gccctcaaggtgcggggactcaatcaggattgctgtgtggtctaccggctcatcaagggt
cgaaagacagtcaccgcctgggacacagccattgcacccctggatggcgaggagctcatt
gtggaggtcctcgaagacgtccccctgaccatgcacaattttgtacggaagacgttcttc
agcctggccttttgtgacttctgccttaagtttctgttccatggcttccgctgccaaacc
tgtggatacaagttccaccagcattgttcctccaaggtccccacagtctgtgttgacatg
agtaccaaccgccgacagttctaccacagtgtccaggatttgtgcggaggctccagacag
catgaggctccctcgaaccgccccctgaatgagccactcacccctcagggtcccagcctt
tcccctgccagctcctgcacccagcaccgcgatcccaagcacttccccttccctgccccg
gccaacgcccccctccagcgcatccgctccacatccacccccaacgtccacatggtcagc
accacggcccccatggactccggcctcatccagctccctgcccagagtttcaacactgac
gctgccgggaatagaggtggtggcgatggaaccccccgggggagccccagcccagccagc
atgtcctcggggaggaagtccccacattccaagtccccatcagagcagcgggagcggaag
tccttggccgatgacaagaagaaagtgaagaatctggggtaccgggactcgggctattac
tgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacgggctcgtttggg
accgtgtttcgtgggcggtggcacggcgatgtggccgtgaaggtgctcaaggtggcccaa
cccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaagacacgt
cacgtcaacatcttgctgttcatgggcttcatgacccggccgggatttttctgggggtgg
ggagatgaggtagcccccagacagtctgacacctgcttgtaccccaacagctacctccat
gccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacacgaggggctc
acggtgaagatcggggacttcggcctggccacagtgaagacgcggtggagtggggcccag
cctttggaacagccctcgggctctgtgctatggatggcagctgaggtgatccgtatgcag
gacccgaacccctacagcttccagtcggatgtctacgcctatggggttgtgctctacgag
ctcatgaccggctcgctgccttacagccacattggcagccgtgaccagattatctttatg
gtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaaggcc
atgaggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctcttcccc
cagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagtgcc
tccgaaccctccttgcaccgtacccaggctgatgagttgcctgcctgcctactcagcgca
gcccgccttgtgccttag
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