KEGG   Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise): 112408223
Entry
112408223         CDS       T08872                                 
Symbol
MET
Name
(RefSeq) hepatocyte growth factor receptor isoform X1
  KO
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Organism
nasi  Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Pathway
nasi01521  EGFR tyrosine kinase inhibitor resistance
nasi04010  MAPK signaling pathway
nasi04014  Ras signaling pathway
nasi04015  Rap1 signaling pathway
nasi04020  Calcium signaling pathway
nasi04151  PI3K-Akt signaling pathway
nasi04360  Axon guidance
nasi04510  Focal adhesion
nasi04520  Adherens junction
nasi05100  Bacterial invasion of epithelial cells
nasi05144  Malaria
nasi05200  Pathways in cancer
nasi05202  Transcriptional misregulation in cancer
nasi05205  Proteoglycans in cancer
nasi05206  MicroRNAs in cancer
nasi05208  Chemical carcinogenesis - reactive oxygen species
nasi05211  Renal cell carcinoma
nasi05218  Melanoma
nasi05223  Non-small cell lung cancer
nasi05225  Hepatocellular carcinoma
nasi05226  Gastric cancer
nasi05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:nasi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112408223 (MET)
   04014 Ras signaling pathway
    112408223 (MET)
   04015 Rap1 signaling pathway
    112408223 (MET)
   04020 Calcium signaling pathway
    112408223 (MET)
   04151 PI3K-Akt signaling pathway
    112408223 (MET)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112408223 (MET)
   04520 Adherens junction
    112408223 (MET)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    112408223 (MET)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112408223 (MET)
   05202 Transcriptional misregulation in cancer
    112408223 (MET)
   05206 MicroRNAs in cancer
    112408223 (MET)
   05205 Proteoglycans in cancer
    112408223 (MET)
   05208 Chemical carcinogenesis - reactive oxygen species
    112408223 (MET)
   05230 Central carbon metabolism in cancer
    112408223 (MET)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    112408223 (MET)
   05226 Gastric cancer
    112408223 (MET)
   05218 Melanoma
    112408223 (MET)
   05211 Renal cell carcinoma
    112408223 (MET)
   05223 Non-small cell lung cancer
    112408223 (MET)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    112408223 (MET)
  09174 Infectious disease: parasitic
   05144 Malaria
    112408223 (MET)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112408223 (MET)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nasi01001]
    112408223 (MET)
Enzymes [BR:nasi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     112408223 (MET)
Protein kinases [BR:nasi01001]
 Receptor tyrosine kinases (RTK)
  MET family
   112408223 (MET)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr TIG Pkinase Sema PSI Kinase-like Pkinase_fungal Linker_histone
Other DBs
NCBI-GeneID: 112408223
NCBI-ProteinID: XP_024613563
UniProt: A0A341CGB1
LinkDB
Position
Unknown
AA seq 1382 aa
MKAPAVLAPGILVLLFTLVQKSNGECKEALVKSKMNVNMQYQLPNFTAETPIQNVVSHKH
HIYLGAINYLYVLNDKDLQKVAEYKTGPVLEHPDCFPCQNCSHKANLSGGIWKDNINMAL
LVDTYYDDQLISCGSVHRGTCQRHVLPPDNTANIQSEVHCMYSPQADEEPSQCPDCVVSA
LGTKVLLSEKDRFINFFVGNTINSSYLPDHSLHSISVRRLKETQDGFKFLTDQSYIDVLP
EFRDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECI
LTEKRRKRSTREEVFNILQAAYVSKPGTQLAKQIGANLNDDILYGVFAQSKPDSVEPMNR
SAVCAFPVKYVNEFFNKIVNKNNVRCLQHFYGPNHDHCFNRTLLRNSSGCEVRSDEYRTE
FTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGSLTPHVNF
LLDSHPVSPEAIVEHPLNQNGYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPSFVQCG
WCHDKCVRLEECPGGTWTQETCLPTIYKVFPTSAPLEGGTTLTICGWDFGFKRNNKFDLK
KTKVLLGNESCTLTLSESTINMLKCTVGPAMNEHFNMSIVISNSRGTVHYSTFSYVDPII
KSISPSYGPKTGGTLLTLTGKHLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQSTPTE
FPIKLKIDLANREMNSFIYREDPIVYEIHPTKSFVSGGSTITGVGKNLNSVSILRMVINV
HEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGIHSKYFDLIYVHNP
VFKPFEKPVMISIGSKNVLEIKGNDIDPEAVKGEVLKVGNKSCENIQSHSEAVLCTVPND
LLKLNSELNIEWKHAISSTVLGKVIVQPDQNFTGLIVGVVSISIILLLLLGLFLWLKRRK
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNG
SCRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVH
FNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV
LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK
FVHRDLAARNCMLDERFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQTQK
FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC
WHPKAELRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNVDGEG
DT
NT seq 4149 nt   +upstreamnt  +downstreamnt
atgaaggcccctgctgtgcttgcacctggcatccttgtgcttctgtttaccttggtgcag
aagagcaatggggagtgtaaagaggcactagtaaagtccaagatgaatgtgaacatgcag
tatcagcttcctaacttcacagcagaaacacccattcagaatgtcgtttcccacaagcat
cacatttacctcggtgccattaactacctttacgttttaaatgacaaagaccttcagaag
gttgctgagtacaagactgggcctgtgctagaacacccagattgtttcccatgtcagaat
tgcagccacaaagccaatttatcaggtggtatttggaaagataacatcaacatggctctg
cttgttgacacatactatgatgaccaactcattagctgcggcagtgtccacagagggacc
tgccagcgacacgtccttccacctgacaatactgctaacatacagtcggaggttcattgc
atgtactctccacaggcagatgaagagcccagccaatgtcctgactgtgtggtgagtgcc
ctgggaaccaaagtcctgctgtctgaaaaggatcgattcatcaacttcttcgtgggcaat
accataaattcttcttaccttccagatcattcattgcattcgatatctgtgagaaggcta
aaggaaacacaagatggttttaagtttttgacagaccaatcctatattgatgttctacct
gagttccgagattcgtaccccattaagtatgtccacgcctttgaaagcaaccattttatt
tactttttgacggtccagcgggaaactctagatgctcagacttttcacacaagaataatc
aggttctgttccgtagactctggtttgcattcgtacatggaaatgcctctggagtgtatt
ctcacagaaaagagaagaaagagatccacaagggaggaagtgtttaatattctccaagct
gcgtacgtcagtaagcctgggacccagctcgctaagcaaataggtgccaacctgaatgat
gatattctctacggggtgtttgcacaaagcaaaccagattctgtcgaaccaatgaatcgc
tctgctgtctgtgcgttccctgtcaaatatgtcaatgagttcttcaacaagatcgtcaac
aaaaacaatgtgagatgtctccagcatttttatggccccaaccacgaccactgcttcaat
aggacacttttgagaaattcatcaggctgcgaagtgcgcagtgatgaataccgaacggag
tttaccacagctttgcagcgcgttgacttattcatgggccagttcaaccaagtcctctta
acatctatatccacctttattaaaggagacctcaccatcgctaatcttggaacatcagag
ggtcgattcatgcaggttgtggtttctcgatcaggatcattaaccccacacgtgaatttt
ctcctggattcccaccctgtgtctccagaagcaattgtggagcacccgctaaaccaaaat
ggctatacactcgttgtcactgggaagaagatcaccaaaatcccgctgaatggcttgggc
tgtgaacatttccagtcctgcagtcagtgcctctccgccccttcctttgtgcagtgtggc
tggtgccatgataaatgtgtgcgattggaggaatgccctggtggaacatggactcaggag
acctgtctgcctacaatctacaaggttttcccaactagtgccccccttgaaggagggaca
acgctgaccatatgtggctgggactttggattcaagaggaataataaatttgacttgaag
aaaaccaaagttctccttggaaatgagagctgcaccttgaccttaagtgagagcacaata
aacatgttgaaatgcacagttggtcctgcaatgaatgaacatttcaatatgtccatagtt
atttcaaacagtcgagggaccgtacattatagtacattttcctatgtggatcctataata
aaaagtatttctccaagttatggtcctaaaactggtggcactttacttacattaactgga
aagcacctaaacagtggaaattctagacacatttcaattggtggaaaaacatgtacttta
aaaagtgtttcagatagtattctcgagtgttataccccagcccaaagcactccaactgag
tttcctattaaattgaaaattgacttagccaaccgagagatgaacagcttcatttaccgg
gaagaccccattgtctatgaaatacatcccaccaaatcttttgttagtggtgggagcaca
ataacaggtgttggaaaaaacctgaattcagttagtatcctgaggatggtaataaatgtt
cacgaagcaggaaggaactttacagtggcatgtcagcatcgctctaattcggagataatc
tgctgtacaactccttcactacaacagctgaacctacaactccccctgaaaaccaaagcc
tttttcatgttagatgggatccattccaaatactttgatctcatttatgtacataatcct
gtgtttaagccttttgaaaagccagtgatgatctcaataggcagtaaaaatgtactggaa
attaagggaaacgatattgaccctgaagcagttaaaggtgaagtgttaaaagttggaaat
aagagctgtgagaatatacagtcacattctgaagccgttttatgtacggtccccaatgac
ctgctgaaattgaacagcgaactaaatatagagtggaagcatgcaatttcttcaaccgtc
cttggaaaagtgatagttcaaccagatcagaatttcacaggactgattgttggtgttgtc
tcaatatcaataatactcttattattacttgggcttttcctgtggctgaaaaggagaaag
caaattaaagatctgggcagtgaattagttcgctatgatgcaagagtacacactcctcat
ttggataggcttgtaagtgcccgaagtgtaagcccaactacagaaatggtttcaaatgaa
tctgtagactaccgagctacttttccagaagaccagtttcctaactcatctcagaatggg
tcttgcagacaagtgcagtatcctctgacagacctatcccccatcctaactagtggggac
tctgatatatccagtccattactgcaaaatactgtccacattgacctcagtgctctaaat
ccagagctggtccaggcagttcagcatgtagtgattgggccaagcagcctgattgtgcat
ttcaatgaagtcataggaagaggacatttcgggtgtgtatatcatgggactttgttggac
aacgatgataagaaaattcactgtgctgtgaaatccttgaatagaatcactgacatagga
gaagtttcccaatttctgaccgagggaatcatcatgaaagattttagtcatcccaatgtt
ctctcgctcttgggaatctgccttcgaagtgaggggtctccactggtggtcctaccatac
atgaaacatggggatcttcgaaatttcattagaaatgagactcacaaccccactgtgaaa
gatcttattggctttggtcttcaagtagccaaaggcatgaaatatcttgcaagcaaaaag
tttgtccacagagacttggctgcaagaaactgtatgctggatgaaagatttacagtcaaa
gttgctgattttggccttgccagagacgtgtatgataaggaatactatagcgtacacaac
aaaacaggtgcaaaactgccggtgaagtggatggctttagagagcctgcaaactcagaaa
tttaccaccaagtcagatgtgtggtcctttggcgtgctcctctgggaactgatgacaaga
ggagcaccaccttatcctgatgtcaacacctttgatataacagtatatttgttgcaaggc
agaaggctcctacaacctgaatactgcccagatcccttgtatgaagtgatgctgaaatgc
tggcaccctaaagctgaactgcgcccatccttttctgaactggtctccaggatatcagcg
atattctctactttcattggggagcactatgtccatgtgaacgctacatacgtgaatgtc
aaatgtgtcgctccatatccttctctgttgtcatcacaagataatgttgatggcgagggg
gatacatga

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