KEGG   Sciurus carolinensis (gray squirrel): 124970294
Entry
124970294         CDS       T08117                                 
Name
(RefSeq) mitogen-activated protein kinase 3
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
ncar  Sciurus carolinensis (gray squirrel)
Pathway
ncar01521  EGFR tyrosine kinase inhibitor resistance
ncar01522  Endocrine resistance
ncar01524  Platinum drug resistance
ncar04010  MAPK signaling pathway
ncar04012  ErbB signaling pathway
ncar04014  Ras signaling pathway
ncar04015  Rap1 signaling pathway
ncar04022  cGMP-PKG signaling pathway
ncar04024  cAMP signaling pathway
ncar04062  Chemokine signaling pathway
ncar04066  HIF-1 signaling pathway
ncar04068  FoxO signaling pathway
ncar04071  Sphingolipid signaling pathway
ncar04072  Phospholipase D signaling pathway
ncar04114  Oocyte meiosis
ncar04140  Autophagy - animal
ncar04148  Efferocytosis
ncar04150  mTOR signaling pathway
ncar04151  PI3K-Akt signaling pathway
ncar04210  Apoptosis
ncar04218  Cellular senescence
ncar04261  Adrenergic signaling in cardiomyocytes
ncar04270  Vascular smooth muscle contraction
ncar04350  TGF-beta signaling pathway
ncar04360  Axon guidance
ncar04370  VEGF signaling pathway
ncar04371  Apelin signaling pathway
ncar04380  Osteoclast differentiation
ncar04510  Focal adhesion
ncar04517  IgSF CAM signaling
ncar04520  Adherens junction
ncar04540  Gap junction
ncar04550  Signaling pathways regulating pluripotency of stem cells
ncar04611  Platelet activation
ncar04613  Neutrophil extracellular trap formation
ncar04620  Toll-like receptor signaling pathway
ncar04621  NOD-like receptor signaling pathway
ncar04625  C-type lectin receptor signaling pathway
ncar04650  Natural killer cell mediated cytotoxicity
ncar04657  IL-17 signaling pathway
ncar04658  Th1 and Th2 cell differentiation
ncar04659  Th17 cell differentiation
ncar04660  T cell receptor signaling pathway
ncar04662  B cell receptor signaling pathway
ncar04664  Fc epsilon RI signaling pathway
ncar04666  Fc gamma R-mediated phagocytosis
ncar04668  TNF signaling pathway
ncar04713  Circadian entrainment
ncar04720  Long-term potentiation
ncar04722  Neurotrophin signaling pathway
ncar04723  Retrograde endocannabinoid signaling
ncar04724  Glutamatergic synapse
ncar04725  Cholinergic synapse
ncar04726  Serotonergic synapse
ncar04730  Long-term depression
ncar04810  Regulation of actin cytoskeleton
ncar04910  Insulin signaling pathway
ncar04912  GnRH signaling pathway
ncar04914  Progesterone-mediated oocyte maturation
ncar04915  Estrogen signaling pathway
ncar04916  Melanogenesis
ncar04917  Prolactin signaling pathway
ncar04919  Thyroid hormone signaling pathway
ncar04921  Oxytocin signaling pathway
ncar04926  Relaxin signaling pathway
ncar04928  Parathyroid hormone synthesis, secretion and action
ncar04929  GnRH secretion
ncar04930  Type II diabetes mellitus
ncar04933  AGE-RAGE signaling pathway in diabetic complications
ncar04934  Cushing syndrome
ncar04935  Growth hormone synthesis, secretion and action
ncar04960  Aldosterone-regulated sodium reabsorption
ncar05010  Alzheimer disease
ncar05020  Prion disease
ncar05022  Pathways of neurodegeneration - multiple diseases
ncar05034  Alcoholism
ncar05132  Salmonella infection
ncar05133  Pertussis
ncar05135  Yersinia infection
ncar05140  Leishmaniasis
ncar05142  Chagas disease
ncar05145  Toxoplasmosis
ncar05152  Tuberculosis
ncar05160  Hepatitis C
ncar05161  Hepatitis B
ncar05163  Human cytomegalovirus infection
ncar05164  Influenza A
ncar05165  Human papillomavirus infection
ncar05166  Human T-cell leukemia virus 1 infection
ncar05167  Kaposi sarcoma-associated herpesvirus infection
ncar05170  Human immunodeficiency virus 1 infection
ncar05171  Coronavirus disease - COVID-19
ncar05200  Pathways in cancer
ncar05203  Viral carcinogenesis
ncar05205  Proteoglycans in cancer
ncar05206  MicroRNAs in cancer
ncar05207  Chemical carcinogenesis - receptor activation
ncar05208  Chemical carcinogenesis - reactive oxygen species
ncar05210  Colorectal cancer
ncar05211  Renal cell carcinoma
ncar05212  Pancreatic cancer
ncar05213  Endometrial cancer
ncar05214  Glioma
ncar05215  Prostate cancer
ncar05216  Thyroid cancer
ncar05218  Melanoma
ncar05219  Bladder cancer
ncar05220  Chronic myeloid leukemia
ncar05221  Acute myeloid leukemia
ncar05223  Non-small cell lung cancer
ncar05224  Breast cancer
ncar05225  Hepatocellular carcinoma
ncar05226  Gastric cancer
ncar05230  Central carbon metabolism in cancer
ncar05231  Choline metabolism in cancer
ncar05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ncar05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ncar00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    124970294
   04012 ErbB signaling pathway
    124970294
   04014 Ras signaling pathway
    124970294
   04015 Rap1 signaling pathway
    124970294
   04350 TGF-beta signaling pathway
    124970294
   04370 VEGF signaling pathway
    124970294
   04371 Apelin signaling pathway
    124970294
   04668 TNF signaling pathway
    124970294
   04066 HIF-1 signaling pathway
    124970294
   04068 FoxO signaling pathway
    124970294
   04072 Phospholipase D signaling pathway
    124970294
   04071 Sphingolipid signaling pathway
    124970294
   04024 cAMP signaling pathway
    124970294
   04022 cGMP-PKG signaling pathway
    124970294
   04151 PI3K-Akt signaling pathway
    124970294
   04150 mTOR signaling pathway
    124970294
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    124970294
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    124970294
   04148 Efferocytosis
    124970294
  09143 Cell growth and death
   04114 Oocyte meiosis
    124970294
   04210 Apoptosis
    124970294
   04218 Cellular senescence
    124970294
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    124970294
   04520 Adherens junction
    124970294
   04540 Gap junction
    124970294
   04550 Signaling pathways regulating pluripotency of stem cells
    124970294
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    124970294
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    124970294
   04613 Neutrophil extracellular trap formation
    124970294
   04620 Toll-like receptor signaling pathway
    124970294
   04621 NOD-like receptor signaling pathway
    124970294
   04625 C-type lectin receptor signaling pathway
    124970294
   04650 Natural killer cell mediated cytotoxicity
    124970294
   04660 T cell receptor signaling pathway
    124970294
   04658 Th1 and Th2 cell differentiation
    124970294
   04659 Th17 cell differentiation
    124970294
   04657 IL-17 signaling pathway
    124970294
   04662 B cell receptor signaling pathway
    124970294
   04664 Fc epsilon RI signaling pathway
    124970294
   04666 Fc gamma R-mediated phagocytosis
    124970294
   04062 Chemokine signaling pathway
    124970294
  09152 Endocrine system
   04910 Insulin signaling pathway
    124970294
   04929 GnRH secretion
    124970294
   04912 GnRH signaling pathway
    124970294
   04915 Estrogen signaling pathway
    124970294
   04914 Progesterone-mediated oocyte maturation
    124970294
   04917 Prolactin signaling pathway
    124970294
   04921 Oxytocin signaling pathway
    124970294
   04926 Relaxin signaling pathway
    124970294
   04935 Growth hormone synthesis, secretion and action
    124970294
   04919 Thyroid hormone signaling pathway
    124970294
   04928 Parathyroid hormone synthesis, secretion and action
    124970294
   04916 Melanogenesis
    124970294
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    124970294
   04270 Vascular smooth muscle contraction
    124970294
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    124970294
  09156 Nervous system
   04724 Glutamatergic synapse
    124970294
   04725 Cholinergic synapse
    124970294
   04726 Serotonergic synapse
    124970294
   04720 Long-term potentiation
    124970294
   04730 Long-term depression
    124970294
   04723 Retrograde endocannabinoid signaling
    124970294
   04722 Neurotrophin signaling pathway
    124970294
  09158 Development and regeneration
   04360 Axon guidance
    124970294
   04380 Osteoclast differentiation
    124970294
  09159 Environmental adaptation
   04713 Circadian entrainment
    124970294
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    124970294
   05206 MicroRNAs in cancer
    124970294
   05205 Proteoglycans in cancer
    124970294
   05207 Chemical carcinogenesis - receptor activation
    124970294
   05208 Chemical carcinogenesis - reactive oxygen species
    124970294
   05203 Viral carcinogenesis
    124970294
   05230 Central carbon metabolism in cancer
    124970294
   05231 Choline metabolism in cancer
    124970294
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    124970294
  09162 Cancer: specific types
   05210 Colorectal cancer
    124970294
   05212 Pancreatic cancer
    124970294
   05225 Hepatocellular carcinoma
    124970294
   05226 Gastric cancer
    124970294
   05214 Glioma
    124970294
   05216 Thyroid cancer
    124970294
   05221 Acute myeloid leukemia
    124970294
   05220 Chronic myeloid leukemia
    124970294
   05218 Melanoma
    124970294
   05211 Renal cell carcinoma
    124970294
   05219 Bladder cancer
    124970294
   05215 Prostate cancer
    124970294
   05213 Endometrial cancer
    124970294
   05224 Breast cancer
    124970294
   05223 Non-small cell lung cancer
    124970294
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    124970294
   05170 Human immunodeficiency virus 1 infection
    124970294
   05161 Hepatitis B
    124970294
   05160 Hepatitis C
    124970294
   05171 Coronavirus disease - COVID-19
    124970294
   05164 Influenza A
    124970294
   05163 Human cytomegalovirus infection
    124970294
   05167 Kaposi sarcoma-associated herpesvirus infection
    124970294
   05165 Human papillomavirus infection
    124970294
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    124970294
   05135 Yersinia infection
    124970294
   05133 Pertussis
    124970294
   05152 Tuberculosis
    124970294
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    124970294
   05140 Leishmaniasis
    124970294
   05142 Chagas disease
    124970294
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    124970294
   05020 Prion disease
    124970294
   05022 Pathways of neurodegeneration - multiple diseases
    124970294
  09165 Substance dependence
   05034 Alcoholism
    124970294
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    124970294
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    124970294
   04933 AGE-RAGE signaling pathway in diabetic complications
    124970294
   04934 Cushing syndrome
    124970294
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    124970294
   01524 Platinum drug resistance
    124970294
   01522 Endocrine resistance
    124970294
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ncar01001]
    124970294
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:ncar03036]
    124970294
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ncar04147]
    124970294
Enzymes [BR:ncar01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     124970294
Protein kinases [BR:ncar01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   124970294
Chromosome and associated proteins [BR:ncar03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     124970294
Exosome [BR:ncar04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   124970294
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Haspin_kinase FTA2 Kdo
Other DBs
NCBI-GeneID: 124970294
NCBI-ProteinID: XP_047389497
LinkDB
Position
18:complement(20089364..20095701)
AA seq 380 aa
MAAAAAAQGGGGGEPRGADGVGPGVPGEVEIVKGQPFDVGPRYTQLQYIGEGAYGMVSSA
YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVY
IVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD
LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML
SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS
DSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKER
LKELIFQETARFQPGAPEAP
NT seq 1143 nt   +upstreamnt  +downstreamnt
atggcggcggcggcggcggctcaggggggcgggggcggggagccccggggagccgatggg
gtcggcccgggggtcccgggggaagtggagatagtgaaggggcagccgttcgacgtgggc
ccgcgctacacgcagctgcagtacatcggcgagggcgcgtacggcatggtcagctcggct
tatgaccacgtgcgcaagactcgagtggccatcaagaagatcagccccttcgagcatcag
acctactgccagcgtacactacgagagatccagatattgctgcgtttccgccatgagaat
gtcataggcatccgagacattcttcgggcacctacactggaagccatgagggatgtctac
attgtgcaggacctgatggagacagacctgtacaagttgctcaaaagccagcagctgagc
aacgaccatatctgctacttcctctaccagatcctgaggggcctcaagtatattcactcg
gccaatgtgctccaccgggatctaaagccctccaacctgcttatcaacaccacctgcgac
cttaagatctgcgatttcggcctggccaggatcgctgatcctgaacatgaccacactggc
tttctgacagagtacgtggctacacgctggtaccgggctccagagatcatgcttaactcc
aagggctacaccaagtccatcgacatctggtctgtgggctgcattctggctgagatgctc
tccaaccggcccatctttcctggcaagcactacctggaccagctcaaccacattctgggt
atcctgggctccccttctcaagaggacctgaattgtattatcaacatgaaggcccgaaac
tacctacagtctctgccctccaagaccaaggtggcctgggccaagctctttcccaagtcg
gactcaaaagctcttgacctgctggaccggatgttaaccttcaaccccaataaacggatc
acagtggaggaagcactggctcacccctacctggaacagtactatgaccccacagatgag
ccggtggccgaggaacccttcactttcgacatggagctggatgatctacccaaggagagg
ctgaaagagctcatcttccaggagacagcccgcttccagccaggggcaccagaggcccca
taa

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