KEGG   Sciurus carolinensis (gray squirrel): 124971006
Entry
124971006         CDS       T08117                                 
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ncar  Sciurus carolinensis (gray squirrel)
Pathway
ncar01521  EGFR tyrosine kinase inhibitor resistance
ncar01522  Endocrine resistance
ncar04010  MAPK signaling pathway
ncar04012  ErbB signaling pathway
ncar04014  Ras signaling pathway
ncar04015  Rap1 signaling pathway
ncar04022  cGMP-PKG signaling pathway
ncar04024  cAMP signaling pathway
ncar04062  Chemokine signaling pathway
ncar04068  FoxO signaling pathway
ncar04071  Sphingolipid signaling pathway
ncar04072  Phospholipase D signaling pathway
ncar04140  Autophagy - animal
ncar04150  mTOR signaling pathway
ncar04151  PI3K-Akt signaling pathway
ncar04210  Apoptosis
ncar04218  Cellular senescence
ncar04270  Vascular smooth muscle contraction
ncar04360  Axon guidance
ncar04370  VEGF signaling pathway
ncar04371  Apelin signaling pathway
ncar04510  Focal adhesion
ncar04540  Gap junction
ncar04550  Signaling pathways regulating pluripotency of stem cells
ncar04613  Neutrophil extracellular trap formation
ncar04625  C-type lectin receptor signaling pathway
ncar04630  JAK-STAT signaling pathway
ncar04650  Natural killer cell mediated cytotoxicity
ncar04660  T cell receptor signaling pathway
ncar04662  B cell receptor signaling pathway
ncar04664  Fc epsilon RI signaling pathway
ncar04666  Fc gamma R-mediated phagocytosis
ncar04720  Long-term potentiation
ncar04722  Neurotrophin signaling pathway
ncar04726  Serotonergic synapse
ncar04730  Long-term depression
ncar04810  Regulation of actin cytoskeleton
ncar04910  Insulin signaling pathway
ncar04912  GnRH signaling pathway
ncar04914  Progesterone-mediated oocyte maturation
ncar04915  Estrogen signaling pathway
ncar04916  Melanogenesis
ncar04917  Prolactin signaling pathway
ncar04919  Thyroid hormone signaling pathway
ncar04921  Oxytocin signaling pathway
ncar04926  Relaxin signaling pathway
ncar04928  Parathyroid hormone synthesis, secretion and action
ncar04929  GnRH secretion
ncar04935  Growth hormone synthesis, secretion and action
ncar05010  Alzheimer disease
ncar05022  Pathways of neurodegeneration - multiple diseases
ncar05034  Alcoholism
ncar05132  Salmonella infection
ncar05152  Tuberculosis
ncar05160  Hepatitis C
ncar05161  Hepatitis B
ncar05163  Human cytomegalovirus infection
ncar05164  Influenza A
ncar05165  Human papillomavirus infection
ncar05167  Kaposi sarcoma-associated herpesvirus infection
ncar05170  Human immunodeficiency virus 1 infection
ncar05200  Pathways in cancer
ncar05205  Proteoglycans in cancer
ncar05206  MicroRNAs in cancer
ncar05207  Chemical carcinogenesis - receptor activation
ncar05208  Chemical carcinogenesis - reactive oxygen species
ncar05210  Colorectal cancer
ncar05211  Renal cell carcinoma
ncar05212  Pancreatic cancer
ncar05213  Endometrial cancer
ncar05214  Glioma
ncar05215  Prostate cancer
ncar05218  Melanoma
ncar05219  Bladder cancer
ncar05220  Chronic myeloid leukemia
ncar05221  Acute myeloid leukemia
ncar05223  Non-small cell lung cancer
ncar05224  Breast cancer
ncar05225  Hepatocellular carcinoma
ncar05226  Gastric cancer
ncar05230  Central carbon metabolism in cancer
ncar05231  Choline metabolism in cancer
ncar05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ncar00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    124971006
   04012 ErbB signaling pathway
    124971006
   04014 Ras signaling pathway
    124971006
   04015 Rap1 signaling pathway
    124971006
   04370 VEGF signaling pathway
    124971006
   04371 Apelin signaling pathway
    124971006
   04630 JAK-STAT signaling pathway
    124971006
   04068 FoxO signaling pathway
    124971006
   04072 Phospholipase D signaling pathway
    124971006
   04071 Sphingolipid signaling pathway
    124971006
   04024 cAMP signaling pathway
    124971006
   04022 cGMP-PKG signaling pathway
    124971006
   04151 PI3K-Akt signaling pathway
    124971006
   04150 mTOR signaling pathway
    124971006
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    124971006
  09143 Cell growth and death
   04210 Apoptosis
    124971006
   04218 Cellular senescence
    124971006
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    124971006
   04540 Gap junction
    124971006
   04550 Signaling pathways regulating pluripotency of stem cells
    124971006
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    124971006
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    124971006
   04625 C-type lectin receptor signaling pathway
    124971006
   04650 Natural killer cell mediated cytotoxicity
    124971006
   04660 T cell receptor signaling pathway
    124971006
   04662 B cell receptor signaling pathway
    124971006
   04664 Fc epsilon RI signaling pathway
    124971006
   04666 Fc gamma R-mediated phagocytosis
    124971006
   04062 Chemokine signaling pathway
    124971006
  09152 Endocrine system
   04910 Insulin signaling pathway
    124971006
   04929 GnRH secretion
    124971006
   04912 GnRH signaling pathway
    124971006
   04915 Estrogen signaling pathway
    124971006
   04914 Progesterone-mediated oocyte maturation
    124971006
   04917 Prolactin signaling pathway
    124971006
   04921 Oxytocin signaling pathway
    124971006
   04926 Relaxin signaling pathway
    124971006
   04935 Growth hormone synthesis, secretion and action
    124971006
   04919 Thyroid hormone signaling pathway
    124971006
   04928 Parathyroid hormone synthesis, secretion and action
    124971006
   04916 Melanogenesis
    124971006
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    124971006
  09156 Nervous system
   04726 Serotonergic synapse
    124971006
   04720 Long-term potentiation
    124971006
   04730 Long-term depression
    124971006
   04722 Neurotrophin signaling pathway
    124971006
  09158 Development and regeneration
   04360 Axon guidance
    124971006
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    124971006
   05206 MicroRNAs in cancer
    124971006
   05205 Proteoglycans in cancer
    124971006
   05207 Chemical carcinogenesis - receptor activation
    124971006
   05208 Chemical carcinogenesis - reactive oxygen species
    124971006
   05230 Central carbon metabolism in cancer
    124971006
   05231 Choline metabolism in cancer
    124971006
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    124971006
  09162 Cancer: specific types
   05210 Colorectal cancer
    124971006
   05212 Pancreatic cancer
    124971006
   05225 Hepatocellular carcinoma
    124971006
   05226 Gastric cancer
    124971006
   05214 Glioma
    124971006
   05221 Acute myeloid leukemia
    124971006
   05220 Chronic myeloid leukemia
    124971006
   05218 Melanoma
    124971006
   05211 Renal cell carcinoma
    124971006
   05219 Bladder cancer
    124971006
   05215 Prostate cancer
    124971006
   05213 Endometrial cancer
    124971006
   05224 Breast cancer
    124971006
   05223 Non-small cell lung cancer
    124971006
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    124971006
   05161 Hepatitis B
    124971006
   05160 Hepatitis C
    124971006
   05164 Influenza A
    124971006
   05163 Human cytomegalovirus infection
    124971006
   05167 Kaposi sarcoma-associated herpesvirus infection
    124971006
   05165 Human papillomavirus infection
    124971006
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    124971006
   05152 Tuberculosis
    124971006
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    124971006
   05022 Pathways of neurodegeneration - multiple diseases
    124971006
  09165 Substance dependence
   05034 Alcoholism
    124971006
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    124971006
   01522 Endocrine resistance
    124971006
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ncar01001]
    124971006
Enzymes [BR:ncar01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     124971006
Protein kinases [BR:ncar01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   124971006
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 124971006
NCBI-ProteinID: XP_047390621
LinkDB
Position
19:12813467..12898300
AA seq 668 aa
MEHIQGAWRTISNGFGLKDAVFEGSSCISPTIVEQFGYQRRASDDGKLTDPSRTSSTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGESGAPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPTSEGALSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLSASPRAWSRRFCLRGRDA
IRSHSESASPSALSSSPSNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DDNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacattcagggggcctggaggacgatcagcaatggctttggactcaaggacgcg
gtgttcgagggctccagctgcatctcccctaccatagtcgagcagttcggctaccagcgc
cgggcctcggacgatggcaaactcacggatccttccaggacgagcagcacaatccgtgtt
ttcttgccgaataagcaacgaacagtggtcaatgtgcggaatggcatgagcttgcacgac
tgcctcatgaaggcgctcaaggtccgaggcctgcagcccgagtgctgcgccgtgttccga
cttctccacgagcacaagggtaaaaaagcacgtttagattggaatactgacgccgcctct
ttgattggagaagagcttcaggtggacttcctggaccacgttcccctcaccacacacaat
tttgctcggaagacgttcctgaagcttgccttctgcgacatctgtcagaagttcctgtta
aatggatttcgatgtcagacttgtggctacaaatttcatgagcattgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttgttgtttcctaattccacc
gtgggtgagagcggggccccagcgctgccttctctgacgatgcgccggatgcgggagtct
gtgtcccggatgcctgtgagttcccagcacaggtactccacgccccacgccttcaccttc
aacacctccagccccacctccgaaggcgccctctcccagaggcagaggtccacgtccacg
cccaacgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataac
agcctgagtgcttctcccagggcgtggtccagacgattttgtttgaggggaagagacgcg
attcgaagccacagcgaatcagcctcgccctcagccctgtccagcagccccagcaacctg
agccccacaggctggtcacagcccaagaccccggtgccagcacagagggagcgggcgcca
ggatccgggacccaggagaagaacaaaattaggccccgtgggcagagagactcaagctac
tactgggaaatcgaggccagcgaagtcatgctgtccacccgcatcggctcgggctccttt
ggaactgtttataagggcaagtggcacggagacgttgcagtgaagatcctgaaggtcgtc
gaccccaccccggagcagttccaggccttcaggaacgaggtggctgtcttgcgcaaaacg
cgacacgtgaacatcctgctcttcatggggtacatgactaaggacaacctggccattgtg
acccaatggtgtgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttc
cagatgttccagctgatcgacattgcccggcagacggctcagggaatggactacttgcac
gccaagaacatcatccaccgagacatgaagtccaacaacatatttctccatgaaggctta
acggtgaaaattggagattttggtttggcgacagtgaagtcacgctggagtggctctcag
caggttgaacaacccaccggctccgtgctgtggatggcccccgaggtgatccgaatgcag
gatgacaaccccttcagcttccagtccgacgtctactcctacggcatcgtcctgtacgag
ctgatgacgggggagctgccctactcccacatcaacaaccgagaccagatcatcttcatg
gtgggccgaggctacgcctccccggacctcagcaagctgtacaagaactgccccaaagcc
atgaagaggctggtggccgactgcgtgaagaaggtgaaggaagagaggcctctgttcccc
cagatcctgtcttccattgagctgctccaacactccctgcccaagatcaaccggagcgcg
tctgagccatccctgcaccgggcggcccacaccgaggatatcaatgcttgcacgctgacc
acgtccccaaggctgcccgtcttctag

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