Sciurus carolinensis (gray squirrel): 124977081 Help Entry 124977081         CDS       T08117                                  Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism ncar  Sciurus carolinensis (gray squirrel) Pathway ncar01521   EGFR tyrosine kinase inhibitor resistance ncar04151   PI3K-Akt signaling pathway ncar04217   Necroptosis ncar04380   Osteoclast differentiation ncar04550   Signaling pathways regulating pluripotency of stem cells ncar04620   Toll-like receptor signaling pathway ncar04621   NOD-like receptor signaling pathway ncar04630   JAK-STAT signaling pathway ncar04658   Th1 and Th2 cell differentiation ncar04659   Th17 cell differentiation ncar05140   Leishmaniasis ncar05145   Toxoplasmosis ncar05152   Tuberculosis ncar05160   Hepatitis C ncar05161   Hepatitis B ncar05162   Measles ncar05163   Human cytomegalovirus infection ncar05164   Influenza A ncar05165   Human papillomavirus infection ncar05166   Human T-cell leukemia virus 1 infection ncar05167   Kaposi sarcoma-associated herpesvirus infection ncar05168   Herpes simplex virus 1 infection ncar05169   Epstein-Barr virus infection ncar05171   Coronavirus disease ncar05200   Pathways in cancer ncar05203   Viral carcinogenesis ncar05212   Pancreatic cancer ncar05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:ncar00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     124977081    04151 PI3K-Akt signaling pathway     124977081  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     124977081   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     124977081  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     124977081    04621 NOD-like receptor signaling pathway     124977081    04658 Th1 and Th2 cell differentiation     124977081    04659 Th17 cell differentiation     124977081   09158 Development and regeneration    04380 Osteoclast differentiation     124977081  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     124977081    05203 Viral carcinogenesis     124977081    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     124977081   09162 Cancer: specific types    05212 Pancreatic cancer     124977081   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     124977081    05161 Hepatitis B     124977081    05160 Hepatitis C     124977081    05171 Coronavirus disease     124977081    05164 Influenza A     124977081    05162 Measles     124977081    05168 Herpes simplex virus 1 infection     124977081    05163 Human cytomegalovirus infection     124977081    05167 Kaposi sarcoma-associated herpesvirus infection     124977081    05169 Epstein-Barr virus infection     124977081    05165 Human papillomavirus infection     124977081   09171 Infectious disease: bacterial    05152 Tuberculosis     124977081   09174 Infectious disease: parasitic    05145 Toxoplasmosis     124977081    05140 Leishmaniasis     124977081   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     124977081  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ncar01001]     124977081 Enzymes [BR:ncar01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      124977081 Protein kinases [BR:ncar01001]  Non-receptor tyrosine kinases   JAK family [OT]    124977081 SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  124977081 NCBI-ProteinID:  XP_047396276 LinkDB All DBs Position 1:156434986..156567473 Genome browser AA seq 1155 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKAEVNQVAPEPGVEVTFYLPDREPLRLGSGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMIKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WLHSNDSGNVLYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLENKHKKDEEKNKIQE EWNNFSYFPEITHIVIKESLVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHH YLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGNEEGMYVLRWSCTDFDNILMTVTC FEKSEVLGTHKQFKNFQIEVQKGRYSLHGSDRNFPSLEGLMSHLKKQILRTDNISFVLKR CCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGDHLGRGTRTHIYSGTL LDYKDDEGAAEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVE NIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLL AREGIDSEIGPFIKLSDPGIPVTVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTT LWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIM RDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSG SLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDF GLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSES SPMALFLKMIGPTQGQMTVTRLVNTLKEGKRLPCPPNCPDQVYQLMRKCWELQPSNRTTF QSLIEGFEALLKYEA NT seq 3468 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaacataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaaagcggaggtgaatcaggtggcccctgagccaggggtggaagtgaccttc tatcttccggacagggagcccctccggctgggcagtggagagtacacagcagaggagctg tgcatcagggctgcgcaggaatgctgtatctctcctctatgccacaacctctttgcctta tatgatgagaacaccaagctctggtatgctccgaaccgcaccatcaccgttgatgacaag atgtcactccgacttcactaccgcatgaggttctatttcacaaactggcatgggaccaat gacaatgagcagtctgtatggcgacattcaccaaagaagcagaaaaatggctatgagaag aaaaaggttccagatgcaacccctctccttgatgccagctcgctggagtacctgtttgct cagggacagtatgatttggtcaaatgcctggctcccattcgggaccccaagactgagcag gatgggcatgatattgagaatgagtgcctggggatggctgtcctggccatctcacactat gccatgataaagaagatgcagttgccagaacttcccaaggacatcagttacaagcgatat attccagaaacattgaataaatccatcagacagaggaaccttcttaccaggatgcggata aacaatgttttcaaggatttcctaaaggaatttaacaacaagacaatttgtgacagcagt gtgtccactcatgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat tatggggctgaaatatttgagacttctatgttattgatttcatcagaaaatgaaatgaat tggcttcattcgaatgacagtggaaatgttctctatgaagtgatggtaactggaaatctt ggaatccagtggcggcagaaaccaaatgttgttcctgttgaaaaggaaaaaaataaactg aagcggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaaaatccaggaa gaatggaacaatttttcttatttccctgaaatcactcacattgtaatcaaggagtcttta gtcagcatcaataagcaggacaacaaaaaaatggaactgaagctttcttcccatgaggag gccttgtcctttgtgtccctggttgatggctacttccgactcacagctgatgcccatcat tacctctgcaccgatgtggctcccccattgatagtccacaacatacagaatggctgtcac ggtccaatctgcacagaatatgccatcaataagctgcggcaagaagggaacgaggagggg atgtacgtgctgaggtggagctgcaccgactttgacaacatcctcatgactgtcacctgc tttgaaaagtctgaggtgctgggtacccataagcagttcaagaattttcagatcgaggta cagaagggccgctacagcctgcatggctcggaccgcaacttccccagcctggaaggcctc atgagccacctcaagaagcagatcctgcgcaccgacaacatcagctttgtgctgaagcgc tgctgccaacccaagcctcgagaaatctccaatctgttggtggccaccaagaaggcccag gagtggcagcctgtctaccccatgagccagctgagttttgatcggatcctcaagaaagat attgttcaaggtgatcaccttggcagaggcacaagaacacacatctactctgggaccctg ctggattacaaggacgatgaaggggctgctgaagagaagagaataaaagtgatactcaaa gtcttagaccccagccacagggacatttctctggccttctttgaagcagctagcatgatg agacaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgagacgtggaa aatatcatggtggaggagtttgtggaggggggacccctggatctcttcatgcaccggaaa agcgatgtcctcactacaccatggaagttcaaagttgccaaacagctggccagtgccctg agttacttggaagataaagacctggtccatggaaatgtgtgtaccaaaaatctccttctg gcccgtgagggcattgacagtgaaattggcccattcatcaagctcagtgaccctggaatc cctgtcactgtactatcaaggcaagagtgcatagaacgaatcccatggattgctcccgag tgtgttgaagactctaagaacctgagcgtggctgctgacaaatggagctttggaaccaca ctctgggaaatctgctacaatggcgagatccccctgaaagataagacgctgattgagaaa gagagattctatgaaagccggtgcagaccagtgacaccatcgtgcaaggagctggccgac ctcatgactcgctgcatgaactatgaccccaatcagagacccttcttccgagccatcatg agggacattaacaagcttgaagagcagaatccagacattgtttcagaaaaaaaaccagca actgaggtagatcccacacattttgaaaagcgcttcctaaagaggatccgcgacttggga gagggccactttgggaaagttgagctctgcaggtatgacccagagggggacaatacagga gagcaggtagctgtcaaatccctgaagcctgagagtggaggtaaccacatagctgatctg aagaaggaaatagaaatcttaaggaacctctatcatgagaacattgtgaagtacaaagga atctgcactgaagatggaggaaatggtattaagcttatcatggagtttctgccttctgga agccttaaggaatatcttccaaagaataagaacaaaattaaccttaaacagcagctaaaa tatgctgttcagatttgtaaggggatggactatttgggttctcggcaatatgttcaccgg gacttagcagcaagaaatgtccttgttgagagtgaacaccaagtgaaaattggagacttt ggtttaaccaaagcaattgaaacggataaggagtactacaccgtcaaggacgaccgggac agccctgtgttttggtacgcaccagaatgtttaattcagtgtaaattttatattgcctct gatgtctggtcttttggagtgaccctgcatgagctgcttacttactgtgattcagagtct agtcccatggctttgttcctgaaaatgataggcccaactcaaggccagatgaccgtaaca agacttgtgaacacgctgaaagaaggaaaacgtttgccatgtccgcctaactgtcctgat caggtttatcaacttatgagaaaatgctgggaattacagccatcgaatcggacaaccttt cagagccttatcgaaggatttgaagcacttttaaaatacgaagcatga

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