KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103724822
Entry
103724822         CDS       T03372                                 
Symbol
Map2k3
Name
(RefSeq) mitogen-activated protein kinase kinase 3
  KO
K04432  mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi04010  MAPK signaling pathway
ngi04015  Rap1 signaling pathway
ngi04218  Cellular senescence
ngi04620  Toll-like receptor signaling pathway
ngi04664  Fc epsilon RI signaling pathway
ngi04668  TNF signaling pathway
ngi04714  Thermogenesis
ngi04750  Inflammatory mediator regulation of TRP channels
ngi04912  GnRH signaling pathway
ngi04935  Growth hormone synthesis, secretion and action
ngi04936  Alcoholic liver disease
ngi05014  Amyotrophic lateral sclerosis
ngi05022  Pathways of neurodegeneration - multiple diseases
ngi05132  Salmonella infection
ngi05135  Yersinia infection
ngi05145  Toxoplasmosis
ngi05161  Hepatitis B
ngi05169  Epstein-Barr virus infection
ngi05170  Human immunodeficiency virus 1 infection
ngi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ngi05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103724822 (Map2k3)
   04015 Rap1 signaling pathway
    103724822 (Map2k3)
   04668 TNF signaling pathway
    103724822 (Map2k3)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    103724822 (Map2k3)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    103724822 (Map2k3)
   04664 Fc epsilon RI signaling pathway
    103724822 (Map2k3)
  09152 Endocrine system
   04912 GnRH signaling pathway
    103724822 (Map2k3)
   04935 Growth hormone synthesis, secretion and action
    103724822 (Map2k3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103724822 (Map2k3)
  09159 Environmental adaptation
   04714 Thermogenesis
    103724822 (Map2k3)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103724822 (Map2k3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103724822 (Map2k3)
   05161 Hepatitis B
    103724822 (Map2k3)
   05169 Epstein-Barr virus infection
    103724822 (Map2k3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103724822 (Map2k3)
   05135 Yersinia infection
    103724822 (Map2k3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    103724822 (Map2k3)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    103724822 (Map2k3)
   05022 Pathways of neurodegeneration - multiple diseases
    103724822 (Map2k3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103724822 (Map2k3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    103724822 (Map2k3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ngi01001]
    103724822 (Map2k3)
Enzymes [BR:ngi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     103724822 (Map2k3)
Protein kinases [BR:ngi01001]
 Serine/threonine kinases: STE group
  STE7 family
   103724822 (Map2k3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Haspin_kinase Pkinase_fungal Seadorna_VP7 Choline_kinase APH RIO1 DUF4344
Other DBs
NCBI-GeneID: 103724822
NCBI-ProteinID: XP_008820167
UniProt: A0A8C6RLP5
LinkDB
Position
Un
AA seq 347 aa
MESPAASPPAGLPPTKGKSKRKKDLRISCVTKPPVSNPTPPRNLDSRTFITIGDRNFEVE
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADQFSPEFVD
FTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTDITAFVKEILGEDS
NT seq 1044 nt   +upstreamnt  +downstreamnt
atggagtcgcccgccgcgagccctcccgccggcttgcctccgaccaaaggaaaatccaaa
aggaaaaaggatttacggatatcctgtgtgaccaagccacctgtgtccaatcccacacca
ccccggaacctagactcccggactttcatcaccattggagaccgaaactttgaggtggaa
gctgatgacttggtgactatctcagagctgggccgtggagcctacggggtggtggagaaa
gtgagacatgctcagagcggcactatcatggctgtaaagcgcatccgggccactgtgaac
tcacaagagcagaagcgactgcttatggacctagacatcaacatgcgcacagttgactgt
ttctacactgtcaccttctatggtgccctcttcagagagggagatgtgtggatctgtatg
gagctcatggatacatccctggacaagttctaccggaaagtgctggataagaacatgaca
attccggaggacatcctgggagagattgctgtgtctatcgtgcgggccctggagcacctg
catagcaagctgtctgtaatccacagagatgtaaagccatccaatgtcctcatcaacaag
gagggccatgtaaagatgtgcgactttggcatcagtggctacctggtagactcagtggca
aagacaatggatgctggctgcaagccctacatggctcccgagaggatcaaccctgagctg
aatcagaagggctacaatgtcaagtctgatgtctggagcctcggcatcaccatgatcgag
atggccatcctgaggttcccttatgagtcctgggggaccccgttccagcagctgaagcag
gtagtggaggagccatctccccagctcccagctgaccagttctcccctgagtttgtggac
ttcactagccagtgcttaaggaagaaccctgcagaacgtatgagctacctggagctgatg
gaacaccctttcttcaccttgcacaaaactaagaagacagacatcactgcctttgtgaag
gagatccttggagaggattcatag

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