KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103725694
Entry
103725694         CDS       T03372                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00562  Inositol phosphate metabolism
ngi01100  Metabolic pathways
ngi01521  EGFR tyrosine kinase inhibitor resistance
ngi04012  ErbB signaling pathway
ngi04014  Ras signaling pathway
ngi04020  Calcium signaling pathway
ngi04062  Chemokine signaling pathway
ngi04064  NF-kappa B signaling pathway
ngi04066  HIF-1 signaling pathway
ngi04070  Phosphatidylinositol signaling system
ngi04072  Phospholipase D signaling pathway
ngi04360  Axon guidance
ngi04370  VEGF signaling pathway
ngi04380  Osteoclast differentiation
ngi04611  Platelet activation
ngi04613  Neutrophil extracellular trap formation
ngi04625  C-type lectin receptor signaling pathway
ngi04650  Natural killer cell mediated cytotoxicity
ngi04662  B cell receptor signaling pathway
ngi04664  Fc epsilon RI signaling pathway
ngi04666  Fc gamma R-mediated phagocytosis
ngi04670  Leukocyte transendothelial migration
ngi04722  Neurotrophin signaling pathway
ngi04750  Inflammatory mediator regulation of TRP channels
ngi04919  Thyroid hormone signaling pathway
ngi04933  AGE-RAGE signaling pathway in diabetic complications
ngi04935  Growth hormone synthesis, secretion and action
ngi05167  Kaposi sarcoma-associated herpesvirus infection
ngi05169  Epstein-Barr virus infection
ngi05170  Human immunodeficiency virus 1 infection
ngi05171  Coronavirus disease - COVID-19
ngi05200  Pathways in cancer
ngi05205  Proteoglycans in cancer
ngi05206  MicroRNAs in cancer
ngi05214  Glioma
ngi05223  Non-small cell lung cancer
ngi05225  Hepatocellular carcinoma
Module
ngi_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103725694
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103725694
   04014 Ras signaling pathway
    103725694
   04370 VEGF signaling pathway
    103725694
   04064 NF-kappa B signaling pathway
    103725694
   04066 HIF-1 signaling pathway
    103725694
   04020 Calcium signaling pathway
    103725694
   04070 Phosphatidylinositol signaling system
    103725694
   04072 Phospholipase D signaling pathway
    103725694
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103725694
   04613 Neutrophil extracellular trap formation
    103725694
   04625 C-type lectin receptor signaling pathway
    103725694
   04650 Natural killer cell mediated cytotoxicity
    103725694
   04662 B cell receptor signaling pathway
    103725694
   04664 Fc epsilon RI signaling pathway
    103725694
   04666 Fc gamma R-mediated phagocytosis
    103725694
   04670 Leukocyte transendothelial migration
    103725694
   04062 Chemokine signaling pathway
    103725694
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    103725694
   04919 Thyroid hormone signaling pathway
    103725694
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103725694
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103725694
  09158 Development and regeneration
   04360 Axon guidance
    103725694
   04380 Osteoclast differentiation
    103725694
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103725694
   05206 MicroRNAs in cancer
    103725694
   05205 Proteoglycans in cancer
    103725694
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    103725694
   05214 Glioma
    103725694
   05223 Non-small cell lung cancer
    103725694
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103725694
   05171 Coronavirus disease - COVID-19
    103725694
   05167 Kaposi sarcoma-associated herpesvirus infection
    103725694
   05169 Epstein-Barr virus infection
    103725694
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103725694
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103725694
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ngi04131]
    103725694
Enzymes [BR:ngi01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103725694
Membrane trafficking [BR:ngi04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103725694
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103725694
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y EF-hand_PLCG2 SH2 PH PH_12 C2 EF-hand_like
Other DBs
NCBI-GeneID: 103725694
NCBI-ProteinID: XP_017651059
LinkDB
Position
Un
AA seq 920 aa
MKYRAIVVSKRMTPFGKDQNSVSSEIMPAERIIEDNPLGSLCRGILDLNTYNVVKAAQGK
NQKPFIFILEPKKQGDPPMEFATDRVEELFEWFQSIREITWKMDTKENNMRYWEKNQSIA
IELSGLVVYCKPTSKTKDHLENPDFREIRSFVEMKANSIVRQKLGDLLWYNHKGLTRVYP
KGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRSDK
YDPMSPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVTTP
SRSQHALTLPCADHHAKVGLWSEESAAGVWIHSEMDIMEIKEICPGRSCKDFERAKAVHH
QEDCCFTILYGTQFVLNTLSLATDSKEDAVKWLSGLKILHQEAMSASTPTMIESWLRKQI
YSVDQTRRNRSCCCCGNTENQKIHLFRETLETFSKEPLAEAPQKEQLTQEICAHKDDLSF
EQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLQDFQRFLLHEQQELWA
QDLSKVRERMTKFIDDTMRETSEPFLFVDEFLTYLFSXENSIWDEKYNVVDMQDMNNPLY
LTRDQLRSESSIEAYIRCLRAGCHCIELGCLDGPDGKPIIYHGWTRTTKIKFDDVVQAIR
DHAFVSSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDLLLTKPTEASADQLPSPCQLREK
IIIKKWTRHYCAIADAKLSFSDDIEQNVEEELVQDTPPTELHFGKKWFHKKVERRTSAEK
LLQEYCAEMGAKDGTFLVQESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYYLTDNT
MFNSIYALIQHYRETHLHCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDMLMWIPR
DGAFLIRKREGTDSYVITFR
NT seq 2763 nt   +upstreamnt  +downstreamnt
atgaagtaccgagctattgttgtaagcaagagaatgacgccctttggaaaggaccagaac
agtgtcagttccgagatcatgccggccgaaagaattattgaagacaacccccttgggtct
ctctgcagaggtattttggacctcaatacctacaatgtcgtgaaggccgctcaggggaaa
aaccagaaaccattcatcttcatcctggagcccaagaagcagggggaccctcccatggag
ttcgccacagaccgtgtggaggagctgttcgaatggtttcagagcatccgggagatcacg
tggaagatggatacaaaggagaacaacatgaggtactgggaaaagaaccagtccatcgcc
attgagctctccggcctggttgtctactgcaagccaaccagcaaaaccaaggaccatttg
gaaaaccccgacttccgagaaatccgctccttcgtagagatgaaggccaacagcattgtc
agacagaagctgggagatctcctgtggtacaatcacaagggcctgacccgagtctaccca
aagggacagagagttgactcttcaaactatgaccccttccggctatggctctgtggctcc
cagatggtagcgctcaatttccagactgcagacaagtacatgcaaatgaaccatgcgttg
ttttcgctcaatgggcggacgggctacgtcctgcagcccgagagcatgcggtctgacaag
tacgacccgatgtccccagagtcgcaaaggaagatcttgatgactctcaccgtcaaggtt
cttggcgcacgccacctccccaaacttgggcggagtattgcctgtccctttgtagaggtg
gaaatctgtggagccgaatatgacaacaacaagtttaagacaacggttgtgacaactcct
tcaagatcccaacatgcgctgaccctgccatgtgccgaccaccatgccaaggtggggctg
tggtctgaggaaagtgctgcaggtgtttggattcactctgagatggacatcatggagata
aaggaaatctgcccagggaggagctgtaaggacttcgagcgtgccaaggccgtccatcac
caagaggactgctgcttcaccatcctctatggcacccagttcgtcctcaacacgctcagt
ctggcaaccgactcgaaggaggacgcagtgaagtggttgtctggcttgaagatcctccac
caggaagccatgagcgcatctactcccaccatgatcgagagttggctgagaaagcagatt
tattcagtggatcaaaccagaagaaacaggtcctgctgctgctgtggcaacacggaaaat
cagaaaatccaccttttccgagagaccctagagacattttcaaaagaacctttggccgaa
gcaccccagaaagagcagctgacacaagaaatctgtgcacacaaagacgacctcagtttt
gaacagttccatctcttctataaaaaacttatgtttgagcagcaaaaatcgatactcgac
gaattcaagaaggactcctctgtgttcatcctggggaacacagaccggccagatgcatct
gctgtctacctgcaggacttccagaggtttctcttacatgaacagcaggagctttgggct
caggatttaagcaaagtccgggagcggatgaccaagtttattgacgatacgatgagggaa
acctcagagcccttcttgtttgtggatgagttcctcacatacctgttctcatgagaaaac
agcatctgggatgagaaatacaacgtggtggacatgcaggacatgaacaaccccttgtac
ctcaccagggaccagctgcgcagcgagtcgtccatagaggcgtacatccgctgcctgcgt
gccggctgccattgcattgaattgggctgcttggatgggcctgatggaaaacccatcatc
taccacggctggacgcggaccaccaagatcaagtttgatgatgttgtgcaagccatccgg
gaccatgcctttgtttcctccagcttccctgtgatcctgtccatcgaggagcactgcagc
gtcgagcagcagcgccacatggctaaggtgttcaaggaggtgttgggagatctgctgctg
acaaagcccacggaggccagtgccgaccagctgccctcaccctgccagctgcgagagaag
atcatcatcaagaaatggactcgccactactgtgccattgctgacgccaagctgtccttt
agcgatgacattgaacagaatgtggaggaggagctggttcaggatactccccctacagag
ctgcattttgggaagaagtggttccataagaaggtggagaggaggaccagcgctgaaaaa
ctcctgcaggagtactgtgccgagatgggggccaaggacggcaccttcctggtgcaggag
agcgagaccttccccaacgactacaccttgtctttctggcggtcaggccgtgtgcagcac
tgcaggatccgctccaccatggaaggcggaaccatgaagtactacctgacagacaacacc
atgttcaacagcatctacgccctcattcagcactaccgggaaacacacctgcattgtgcg
gagttcgagcttcggcttaccgacccagtgcccaaccccaacccgcatgagtctaagcca
tggtactacgacaggctgagccggggggaggcagaggacatgctgatgtggatccccaga
gatggagccttcctcatccggaagcgggaggggactgactcctacgtcatcaccttcagg
tag

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