KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103728077
Entry
103728077         CDS       T03372                                 
Symbol
Nfkb1
Name
(RefSeq) nuclear factor kappa B subunit 1
  KO
K02580  nuclear factor NF-kappa-B p105 subunit
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi01523  Antifolate resistance
ngi04010  MAPK signaling pathway
ngi04014  Ras signaling pathway
ngi04024  cAMP signaling pathway
ngi04062  Chemokine signaling pathway
ngi04064  NF-kappa B signaling pathway
ngi04066  HIF-1 signaling pathway
ngi04071  Sphingolipid signaling pathway
ngi04151  PI3K-Akt signaling pathway
ngi04210  Apoptosis
ngi04211  Longevity regulating pathway
ngi04218  Cellular senescence
ngi04380  Osteoclast differentiation
ngi04613  Neutrophil extracellular trap formation
ngi04620  Toll-like receptor signaling pathway
ngi04621  NOD-like receptor signaling pathway
ngi04622  RIG-I-like receptor signaling pathway
ngi04623  Cytosolic DNA-sensing pathway
ngi04625  C-type lectin receptor signaling pathway
ngi04657  IL-17 signaling pathway
ngi04658  Th1 and Th2 cell differentiation
ngi04659  Th17 cell differentiation
ngi04660  T cell receptor signaling pathway
ngi04662  B cell receptor signaling pathway
ngi04668  TNF signaling pathway
ngi04722  Neurotrophin signaling pathway
ngi04917  Prolactin signaling pathway
ngi04920  Adipocytokine signaling pathway
ngi04926  Relaxin signaling pathway
ngi04931  Insulin resistance
ngi04932  Non-alcoholic fatty liver disease
ngi04933  AGE-RAGE signaling pathway in diabetic complications
ngi04936  Alcoholic liver disease
ngi05010  Alzheimer disease
ngi05022  Pathways of neurodegeneration - multiple diseases
ngi05030  Cocaine addiction
ngi05132  Salmonella infection
ngi05133  Pertussis
ngi05134  Legionellosis
ngi05135  Yersinia infection
ngi05140  Leishmaniasis
ngi05142  Chagas disease
ngi05145  Toxoplasmosis
ngi05146  Amoebiasis
ngi05152  Tuberculosis
ngi05160  Hepatitis C
ngi05161  Hepatitis B
ngi05162  Measles
ngi05163  Human cytomegalovirus infection
ngi05164  Influenza A
ngi05165  Human papillomavirus infection
ngi05166  Human T-cell leukemia virus 1 infection
ngi05167  Kaposi sarcoma-associated herpesvirus infection
ngi05168  Herpes simplex virus 1 infection
ngi05169  Epstein-Barr virus infection
ngi05170  Human immunodeficiency virus 1 infection
ngi05171  Coronavirus disease - COVID-19
ngi05200  Pathways in cancer
ngi05202  Transcriptional misregulation in cancer
ngi05203  Viral carcinogenesis
ngi05206  MicroRNAs in cancer
ngi05207  Chemical carcinogenesis - receptor activation
ngi05208  Chemical carcinogenesis - reactive oxygen species
ngi05212  Pancreatic cancer
ngi05215  Prostate cancer
ngi05220  Chronic myeloid leukemia
ngi05221  Acute myeloid leukemia
ngi05222  Small cell lung cancer
ngi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ngi05321  Inflammatory bowel disease
ngi05415  Diabetic cardiomyopathy
ngi05417  Lipid and atherosclerosis
ngi05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103728077 (Nfkb1)
   04014 Ras signaling pathway
    103728077 (Nfkb1)
   04064 NF-kappa B signaling pathway
    103728077 (Nfkb1)
   04668 TNF signaling pathway
    103728077 (Nfkb1)
   04066 HIF-1 signaling pathway
    103728077 (Nfkb1)
   04071 Sphingolipid signaling pathway
    103728077 (Nfkb1)
   04024 cAMP signaling pathway
    103728077 (Nfkb1)
   04151 PI3K-Akt signaling pathway
    103728077 (Nfkb1)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    103728077 (Nfkb1)
   04218 Cellular senescence
    103728077 (Nfkb1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    103728077 (Nfkb1)
   04620 Toll-like receptor signaling pathway
    103728077 (Nfkb1)
   04621 NOD-like receptor signaling pathway
    103728077 (Nfkb1)
   04622 RIG-I-like receptor signaling pathway
    103728077 (Nfkb1)
   04623 Cytosolic DNA-sensing pathway
    103728077 (Nfkb1)
   04625 C-type lectin receptor signaling pathway
    103728077 (Nfkb1)
   04660 T cell receptor signaling pathway
    103728077 (Nfkb1)
   04658 Th1 and Th2 cell differentiation
    103728077 (Nfkb1)
   04659 Th17 cell differentiation
    103728077 (Nfkb1)
   04657 IL-17 signaling pathway
    103728077 (Nfkb1)
   04662 B cell receptor signaling pathway
    103728077 (Nfkb1)
   04062 Chemokine signaling pathway
    103728077 (Nfkb1)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    103728077 (Nfkb1)
   04917 Prolactin signaling pathway
    103728077 (Nfkb1)
   04926 Relaxin signaling pathway
    103728077 (Nfkb1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103728077 (Nfkb1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    103728077 (Nfkb1)
  09149 Aging
   04211 Longevity regulating pathway
    103728077 (Nfkb1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103728077 (Nfkb1)
   05202 Transcriptional misregulation in cancer
    103728077 (Nfkb1)
   05206 MicroRNAs in cancer
    103728077 (Nfkb1)
   05207 Chemical carcinogenesis - receptor activation
    103728077 (Nfkb1)
   05208 Chemical carcinogenesis - reactive oxygen species
    103728077 (Nfkb1)
   05203 Viral carcinogenesis
    103728077 (Nfkb1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103728077 (Nfkb1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    103728077 (Nfkb1)
   05221 Acute myeloid leukemia
    103728077 (Nfkb1)
   05220 Chronic myeloid leukemia
    103728077 (Nfkb1)
   05215 Prostate cancer
    103728077 (Nfkb1)
   05222 Small cell lung cancer
    103728077 (Nfkb1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103728077 (Nfkb1)
   05170 Human immunodeficiency virus 1 infection
    103728077 (Nfkb1)
   05161 Hepatitis B
    103728077 (Nfkb1)
   05160 Hepatitis C
    103728077 (Nfkb1)
   05171 Coronavirus disease - COVID-19
    103728077 (Nfkb1)
   05164 Influenza A
    103728077 (Nfkb1)
   05162 Measles
    103728077 (Nfkb1)
   05168 Herpes simplex virus 1 infection
    103728077 (Nfkb1)
   05163 Human cytomegalovirus infection
    103728077 (Nfkb1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103728077 (Nfkb1)
   05169 Epstein-Barr virus infection
    103728077 (Nfkb1)
   05165 Human papillomavirus infection
    103728077 (Nfkb1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103728077 (Nfkb1)
   05135 Yersinia infection
    103728077 (Nfkb1)
   05133 Pertussis
    103728077 (Nfkb1)
   05134 Legionellosis
    103728077 (Nfkb1)
   05152 Tuberculosis
    103728077 (Nfkb1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103728077 (Nfkb1)
   05145 Toxoplasmosis
    103728077 (Nfkb1)
   05140 Leishmaniasis
    103728077 (Nfkb1)
   05142 Chagas disease
    103728077 (Nfkb1)
  09163 Immune disease
   05321 Inflammatory bowel disease
    103728077 (Nfkb1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103728077 (Nfkb1)
   05022 Pathways of neurodegeneration - multiple diseases
    103728077 (Nfkb1)
  09165 Substance dependence
   05030 Cocaine addiction
    103728077 (Nfkb1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103728077 (Nfkb1)
   05418 Fluid shear stress and atherosclerosis
    103728077 (Nfkb1)
   05415 Diabetic cardiomyopathy
    103728077 (Nfkb1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    103728077 (Nfkb1)
   04932 Non-alcoholic fatty liver disease
    103728077 (Nfkb1)
   04931 Insulin resistance
    103728077 (Nfkb1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    103728077 (Nfkb1)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    103728077 (Nfkb1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:ngi03000]
    103728077 (Nfkb1)
Transcription factors [BR:ngi03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Rel/Ankyrin
    103728077 (Nfkb1)
SSDB
Motif
Pfam: RHD_DNA_bind RHD_dimer Ank Ank_2 Ank_4 Ank_3 Ank_5 Death
Other DBs
NCBI-GeneID: 103728077
NCBI-ProteinID: XP_017651883
LinkDB
Position
Un
AA seq 961 aa
MAEDDPYGGTGQLFHLSNLPHPIFNTELYPPEMPLSTADGPYLQILEQPKQRGFRFRYVC
EGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDG
ICTVAAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLAYLQAE
GGGDRQLTDREKEIIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYD
SKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFS
PTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQR
KRQKLMPNFSDSFGGGGGAGAGGGGMFGSGGGGGSAGSPGPGYGFPHYGFPAYSGITFHS
GATKSNAGMKHGTTNTDLKNDPKGYDKSDSRELPSLSGKESETAEQDKTSHTSRNNEAAP
TPLVGAREQDPEFQGNLFLEKALQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENG
DSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLR
VGADLSLLDRWGNSALHLAAKEGHDKILSVLLKHRKTAHLIDCPNGEGLNAIHIAVMSNN
LPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPL
HIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDESWEKAGEDEGVVPGTTPLDMAANWQ
VFDILNGKPYERVFTSEDILPQGDMKQLTEDTKLQLYKLLEIPDPDKNWATLAQKLGLGI
LNNAFRLSPAPSKTLMDNYEVSGGTIKELMEALRQMGYTEAIDVIQATFRTSENKASSPK
TAAHLLPLSSSTRQHIGNKAAGKICLIHKKKCVFLNQENLERILTIIRLDFKRDVTTRGP
P
NT seq 2886 nt   +upstreamnt  +downstreamnt
atggcagaagacgatccatatggagggactggacaactatttcatttgagcaatttgcct
catccaatatttaatacagaattatatccaccagaaatgccactgtcaacagcagatggc
ccataccttcaaatattagagcaaccaaaacagagaggatttcgtttccgttatgtatgt
gaaggcccatcccatggcggacttcctggtgcttctagtgaaaagaacaagaagtcctac
cctcaagtcaaaatctgcaactacgtgggaccagcaaaggttattgttcagttggtcaca
aatggaaaaaatatccatctgcatgcccacagtctggtgggaaaacactgtgaggatggg
atctgcactgtagccgctggacccaaggacatggtagttggctttgcaaacctaggaata
cttcatgtgacaaagaaaaaagtatttgaaacactggaagcacgaatgaccgaggcgtgt
atacggggctacaatcctgggcttctggtacattctgaccttgcatatctgcaagcagaa
ggtggaggagaccggcaactcacagatcgggaaaaggagatcatccgccaggcagctctg
cagcagacaaaagagatggacctgagtgtggtgcgcctcatgttcacagcctttcttcct
gacagcaccggcagcttcacaaggcgcctggagcctgtggtatcagacgccatctacgac
agcaaagctcccaatgcatccaacttgaaaattgtaagaatggacagaacagcgggatgt
gtaactggaggggaagaaatttatcttctctgtgacaaagttcaaaaagatgacatccag
attcgattttatgaagaggaggaaaatggtggagtttgggaaggatttggagatttttcc
cccacagatgttcatagacaatttgccatcgtctttaaaactccaaagtataaggatgtc
aacattacaaaaccagcttcggtgtttgtccaacttcggaggaaatctgatttggagact
agtgaaccaaaaccttttctctactatcctgaaatcaaagataaagaggaagtgcagcgc
aaacgacagaagctcatgcccaacttctccgacagtttcggtggtggtggcggagccgga
gctggaggcggaggcatgttcgggagtggtggtggaggagggagtgctggaagccccggc
ccaggatatggcttcccgcactatggatttcctgcttacagtgggatcacattccattct
ggagccactaaatccaatgctgggatgaagcatggaaccacaaacactgatttgaaaaat
gaccctaaaggttatgacaagagtgatagcagagagcttccgagtctctctgggaaggaa
agtgaaactgcagaacaagataagacatcccacacatccaggaacaatgaggctgctccg
acacccttggtgggagccagggaacaggatcctgaattccagggtaacctctttctcgag
aaggctttgcagctcgccaagcggcatgccaatgccctttttgactatgcagtgactgga
gacgtgaagatgttactggctgtgcagcgccatcttactgcagtgcaggatgagaatggg
gacagcgtcttgcacttagctatcatccaccttcatgctcagcttgtgagggatctgcta
gaagtcacatccggtctgatctctgatgacatcatcaacatgagaaatgatctatatcag
acacctttgcacttggcagtaattaccaagcaagaagatgtggtggaggacttgcttaga
gttggggccgacctgagccttctggaccgctggggtaactctgctttgcacctagctgcc
aaagaagggcatgataaaatcctcagtgtcttactcaagcacagaaagacagcacacctt
attgactgccccaacggagaaggtctaaatgccattcacatagccgtgatgagcaataac
ctgccgtgcctgctgctgcttgtggccgctggggcagatgtcaacgctcaggagcagaag
tctgggcgcacagcactgcacctggctgtggagcacgacaacatctccttggctggctgc
ctgcttctggagggtgatgcccacgtggacagtactacctatgatgggacgacgccccta
catatagcagctggaagagggtctactaggttggcagctcttctcaaagcagcaggagca
gatcccttggtagagaactttgagcctctctatgacctggatgagtcttgggaaaaggct
ggagaagatgagggagtcgtgccgggcaccacacccctagatatggctgccaactggcag
gtatttgacatattaaatgggaaaccatatgagcgagtgttcacatctgaagacatactg
ccacaaggagacatgaagcagctgactgaagatacaaaacttcagctctacaagttgcta
gaaattcctgatccagacaaaaactgggctactctggcacagaaattgggtctgggaata
cttaataatgccttccggctgagtcctgctccttctaaaactcttatggacaactacgag
gtgtctggaggaaccatcaaagagctgatggaggccctgcgacagatgggctacacagag
gccattgacgtgatccaggcaacattccgcacctcagaaaacaaggcctccagccccaaa
accgctgctcacttgctgcctctctcttcctccacaaggcagcacataggtaataaagca
gctggaaaaatatgcctgattcataagaaaaaatgtgtatttttgaatcaagagaatttg
gagaggattctgacaatcataaggctagatttcaagagagatgtgacaacccgtggccca
ccctga

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