Nannospalax galili (Upper Galilee mountains blind mole rat): 103731125
Help
Entry
103731125 CDS
T03372
Symbol
Top2a
Name
(RefSeq) topoisomerase (DNA) II alpha
KO
K03164
DNA topoisomerase II [EC:
5.6.2.2
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi01524
Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09160 Human Diseases
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
103731125 (Top2a)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
ngi03032
]
103731125 (Top2a)
03036 Chromosome and associated proteins [BR:
ngi03036
]
103731125 (Top2a)
Enzymes [BR:
ngi01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
103731125 (Top2a)
DNA replication proteins [BR:
ngi03032
]
Eukaryotic type
DNA Topoisomerases
103731125 (Top2a)
Chromosome and associated proteins [BR:
ngi03036
]
Eukaryotic type
Chromosome condensation proteins
Other regulators of chromosome condensation
103731125 (Top2a)
Centrosome formation proteins
Centriole proteins
103731125 (Top2a)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DNA_topoisoIV
TOPRIM_C
DNA_gyraseB
DTHCT
HATPase_c
Toprim
Motif
Other DBs
NCBI-GeneID:
103731125
NCBI-ProteinID:
XP_008827664
UniProt:
A0A8C6QSG3
LinkDB
All DBs
Position
Un
AA seq
1526 aa
AA seq
DB search
MEVSPLQPVHENMQMNKKKNEDPKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQM
WVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNN
GKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVET
ASKEYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVR
RAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNPLKVVHEQVNPRWEVCL
TMSEKGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKAGVAVKAHQVKNHMW
IFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQV
QLNKKCSAVKHNKIKGIPKLDDANDAGSRNSAECTLILTEGDSAKTLAVSGLGVVGRDKY
GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTD
QDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSS
TPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQTDDR
KEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDG
LKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIISLAQNFVGSNNL
NLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLTRLLFPLKDDHTLKFLYDDNQRVEPEWY
IPIIPMVLINGAEGIGTGWSCKIPNFDIREVVNNIRRLMDGEEPLPMLPSYKNFKGTIEE
LASNQYVINGEVAILNSTTIEISELPIRVWTQTYKEQVLEPMLNGTEKTPPLITDYREYH
TDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRD
FFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDNEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELC
KQRNEKEQELDTLKRKSPSDLWKEDLAAFIEELESIEAKEKQDEQVGLPGKGGKAKGKKA
QASEVLPSPHGKRVIPQVTMEMKAGAEKKIKKKIKSENIEGTPNEDGLELEGLKQRLGKK
QKREPGTKKQTTLPFKPIKKGKKRNPWSDSESDMSSTESNFDVPPRETEPRRAAAKTKFT
MDLDSDEDFSDFDEKNEDEDFLPSDASPPKTKTPPKNTKKALKPQKSTMSVVDLETDDIK
DSVPPSPSPPVANFPVETEVLKLPSKKNVTVKKTATKSQSTTSTAGTKKKTAPKGTKSDS
ALYSGSLGKPEPAKTKIRRKRKPSTSDDSDSNFEKIISKAATSKKPKGESEAFHLDVDSA
VAPRAKSGRAKKPIKYLEESDEDDLF
NT seq
4581 nt
NT seq
+upstream
nt +downstream
nt
atggaggtgtcaccgctgcagcctgtacatgaaaatatgcaaatgaacaaaaagaaaaat
gaagacccaaagaaaagactgtctatcgaaagaatctaccagaaaaaaacacaattggaa
catattttgctccgtccagatacctacattggctctgtggaattagtaacccagcaaatg
tgggtttatgatgaagatgttggcattaactatagggaagtcacttttgttcctggtttg
tacaaaatctttgatgagatactagttaatgctgcagacaacaaacaaagggacccaaaa
atgtcttgtattagagtcacaattgacccagagaacaatttaattagtatatggaataat
ggaaaaggaattcctgttgttgaacacaaagttgagaaaatgtatgtcccagctctcata
tttggacagctcttaacttctagtaactatgatgatgatgaaaagaaagtaacaggtggt
cgaaatggctatggagccaaattgtgcaacatattcagtaccaaatttactgtggaaaca
gccagtaaagaatacaagaaaatgttcaaacagacatggatggataacatggggagagct
ggtgacatggaactcaagccctttagtggagaagattacacatgtatcaccttccagcct
gacctatctaagtttaaaatgcaaagcctggacaaagacatcgttgcactgatggttaga
agagcctatgacattgctgggtccactaaagatgtcaaagtctttctcaatggaaataag
ctgccagtaaaagggttccgtagttatgtggatatgtatttgaaggataagttggatgaa
actgggaacccactgaaagtagtccatgaacaagtaaacccaaggtgggaagtgtgctta
acaatgagtgaaaaaggctttcagcagattagtttcgtcaatagcattgctacttccaag
ggtggcagacatgttgattatgtagctgatcagattgtgagtaaacttgttgatgtagtg
aagaagaagaacaaggctggtgttgcagtaaaagcacatcaggtgaaaaatcacatgtgg
atttttgtaaatgccttaattgaaaacccaacctttgactctcagacaaaagaaaacatg
actttacaagccaagagctttggatcgacatgtcaattaagtgaaaaattcatcaaagct
gcaattggctgtggtattgtagaaagtatactaaactgggtgaagtttaaggcccaagtc
cagctaaacaagaagtgttcagctgtaaaacataacaaaatcaagggaattcccaaactc
gatgatgccaatgatgcagggagccgaaactccgctgaatgtacacttatcctgactgag
ggagactcggccaaaactctggcagtttcaggccttggtgttgttggaagagacaaatac
ggtgttttcccacttagaggaaaaatactcaatgtccgagaagcttctcataaacagatc
atggaaaatgctgaaattaacaatatcatcaaaattgtgggtcttcagtataagaaaaac
tatgaagatgaagattcattgaagactcttcgttatgggaagataatgattatgacagat
caggaccaagatggttcccatatcaaaggcttgctgattaactttatccatcacaactgg
ccctctcttctgcgacatcgtttcctagaggaatttatcactcccattgtaaaggtgtct
aaaaacaagcaagaaatagcattctacagtcttcctgaatttgaagaatggaagagttct
actccaaatcacaaaaaatggaaagtcaaatattacaaaggtttgggcaccagcacttca
aaagaagctaaggaatattttgcagatatgaaaagacatcgtattcaattcaaatattct
gggcctgaagacgatgctgcaatcagcctagcctttagtaaaaaacagactgatgatcga
aaggaatggttaactaatttcatggaagacagaagacaacggaaattacttggccttcct
gaggattatttgtatgggcaaactactacttacctgacatataatgacttcataaacaag
gaacttatcctgttctcaaattctgataatgaaagatctatcccatctatggtagatggt
ttgaaaccaggtcagagaaaggttttatttacttgtttcaaacggaatgacaagcgagaa
gtgaaggttgcccagttagctgggtcagtggcagaaatgtcctcttatcaccatggtgag
atgtcactaatgatgaccattatcagtttggctcagaattttgtgggtagcaataatttg
aacctcttgcagcccattggccagtttggtaccaggctgcatggtggcaaggattctgct
agtcctcgatacatctttacaatgctcagccctttgactaggttgttatttccactgaaa
gacgatcacacattgaagtttttatatgatgataatcaacgtgttgagcctgaatggtac
attcctattatacccatggtgctgataaatggtgctgaaggaatcggaactgggtggtct
tgcaaaatccccaactttgacattcgtgaagttgtaaataatatcaggcgtttgatggat
ggagaagaacctttgccaatgcttccaagttacaagaacttcaagggtactattgaagag
ctagcttcaaatcaatatgtgattaatggtgaagtagctattctgaattccacaaccatt
gaaatctcagagcttcccatcagagtgtggacccagacatacaaagaacaggttctagaa
cccatgttgaatggcactgagaagacaccccctcttataacagactatagagaataccat
acagataccactgtgaagtttgttgtgaaaatgactgaagaaaaactggcagaggcagag
agagttggactacacaaagtcttcaaactccaaaccagtctcacctgcaactctatggtg
ctttttgaccatgtaggctgtttaaagaaatatgacacagtgttggatattctaagagac
ttctttgaactcaggcttaaatattatggattaagaaaagaatggcttctaggaatgctt
ggtgcggaatctgctaaactgaacaatcaggctcgttttatactagagaaaatagatggc
aaaataatcattgaaaataaacctaaaaaagaattaattaaagttctgattcagagagga
tatgattcagatcctgtgaaagcctggaaagaagctcagcaaaaggttccagatgaagaa
gaaaatgaagagagtgacaatgaaaagagcgactctgtgacggactctggaccgaccttc
aactaccttcttgatatgcctctttggtatctgacgaaggagaagaaagatgaactgtgc
aaacagaggaatgaaaaggaacaagagctggatacattaaagagaaagagtccatccgac
ttgtggaaggaggacttagctgctttcattgaagaactagagtctattgaagccaaggaa
aaacaagatgagcaagtgggacttcctggaaaggggggaaaagcaaagggaaagaaagca
caagcatctgaagttctgccttctcctcacggaaaaagggtcattccccaagtgaccatg
gagatgaaagcaggtgcagaaaagaaaattaaaaagaaaattaagagtgaaaatatcgag
ggaacacctaatgaggatggtctggaactagaaggcctcaaacagagattagggaagaaa
cagaaaagagaaccaggtacaaagaagcaaactacattgccatttaagcccatcaaaaaa
gggaaaaagagaaacccctggtctgattctgaatcggatatgagcagtactgaaagtaat
tttgatgtccctccacgagaaacagagccacgaagagctgcagcaaaaaccaaattcaca
atggatttggattcagatgaagatttctcagattttgatgaaaaaaatgaagatgaagac
tttttgccatctgatgctagtccacctaaaaccaaaactcccccaaaaaatactaaaaaa
gcactaaagccacagaaaagtactatgtcagtagttgacctggaaactgatgatattaag
gacagtgtaccgccttctccgagccctcctgttgccaacttcccagttgaaactgaagtt
ttaaaactaccttctaaaaagaatgtgacagtgaagaagacggcaacaaaaagtcagtct
accacctccactgctggtaccaaaaaaaaaactgcaccaaaagggaccaaatcagactca
gccttgtattctggcagcctaggaaagcctgagcctgccaaaaccaagatccgtcgcaaa
aggaagccatctacttctgatgactccgactctaattttgagaaaataatttctaaagct
gccacaagcaagaaacctaagggagagagtgaagccttccatctggacgtggattcagct
gtggctccccgggcaaaatctggacgagcaaagaaacctattaagtacctggaagagtca
gatgaagacgatcttttttaa
DBGET
integrated database retrieval system
