Nannospalax galili (Upper Galilee mountains blind mole rat): 103731296
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Entry
103731296 CDS
T03372
Symbol
Lrrk2
Name
(RefSeq) leucine rich repeat kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi05012
Parkinson disease
ngi05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
103731296 (Lrrk2)
05022 Pathways of neurodegeneration - multiple diseases
103731296 (Lrrk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ngi01001
]
103731296 (Lrrk2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ngi04131
]
103731296 (Lrrk2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
ngi04147
]
103731296 (Lrrk2)
Enzymes [BR:
ngi01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
103731296 (Lrrk2)
Protein kinases [BR:
ngi01001
]
Serine/threonine kinases: TKL group
LRRK family
103731296 (Lrrk2)
Membrane trafficking [BR:
ngi04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
103731296 (Lrrk2)
Exosome [BR:
ngi04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
103731296 (Lrrk2)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
LRR_4
COR-B
Ras
COR-A
ARMC6
WDR55
Beta-prop_RSE1_2nd
Beta-prop_WDR36-Utp21_1st
Arf
Ank_2
LRR_9
Beta-prop_EML_2
Beta-prop_EML
WD40_CDC20-Fz
Beta-prop_VPS8
T2SSE
nSTAND3
AAA_22
ARM_CUL7_CUL9
GTP_EFTU
MMR_HSR1
LRR_13
G-alpha
ABC_tran
LRR_NXF1-5
AAA_7
PduV-EutP
Kdo
Gtr1_RagA
AAA_16
Beta-prop_RIG_2nd
MobB
TniB
TrwB_AAD_bind
AAA_29
NB-ARC
FtsK_SpoIIIE
SRPRB
Septin
cobW
nSTAND_NTPase5
AAA_18
TsaE
Beta-prop_WDR5
NACHT
Motif
Other DBs
NCBI-GeneID:
103731296
NCBI-ProteinID:
XP_008827892
UniProt:
A0A8C6RW99
LinkDB
All DBs
Position
Un
AA seq
2527 aa
AA seq
DB search
MASGLGQGCEEDEEEEGLKKLIVRLNHVQESKQVSTLVQLLEDLLVFTYSDRASKLFEGK
NFHVPLLLVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLI
LKMLTVHHANVNLSTVGLKALDLLLNSGKITLLILDEECDIFLLIFDAMHTYSTNDEVQK
LGCKALHVLFERVSEEQLIEFVENKDYMVLLRALNSFREEEEIVLHVLHCLHSLAIPCNN
VEVLMSGNVRCYNIVVEAMKTFPSSEKIQHVSCCLLHRLTLGNFFNILVLNEVHDFVVKA
VRQYPENPSLQISGLSCLALLTETIFLNQDLEERNENQDHSDEEEEEKLFWLEACYRALT
QHRKNKHVQEAACWALNNLLMYQNGLHRKIGDEDGQLPVHREVMLSMLMHSSSKDVFQAS
ANALSILLEQNVNFRKILLSKGIYLNVLELMQKHGNSPEVAESGCRMLSHLFEGSSTTLD
TMAVVLPKIITVMKSHETSLPVQLEALRAIVHFVVTGLPEESKAEFQCKLNMVKKQCFRN
DIHKLVLAALNRFIGNPGVQKCGLKVMSSLVHLPEALEVLSLHGAVDTILHTLQMYPDDQ
EIQCLGLSLMGCLITKKNLCIGTGHLLAKILVSSLQRFKDVAAVQATGLQTVLAILELSV
PFAKLLVHHSFDLVIFLQMSSSVMEPKDEQFLNLCCKCFAKLAADDELKNVMLERACDQN
NSVMVECLLLLGADANHMKGATSLIYQVCEKENSSKLVELLLNGGCREQDVRKALTVSIR
RGDSQVVSLLLRRLALDLANNSICLGGFCMGKIEPSWLGPLFPDKSSNLRKQTNVGSVLA
RMVLRYQTKSAVEEGASAGDGSFAEDGLLHKLDEWTFLPDSSMDSVFGQSDDLDSEGSES
SFLMKRKSNSISVGEFYRDPVLQRCSPNTQRHSNSLGPIFDQEELLRRKRKILSSDDSLR
SSKLPSYSRHSGSSSSLTSERDCITSLDLSANELRDIDALSPRCCLSGHLEHLVKLELQQ
NVLTCFPQHLCETLKCLTHLDLHSNKFTSFPSYLLKMTCITNLDVSRNDIGPSVVLDPTV
KCPTLKQLNLSYNQLSLVPENLATAVENLEQLTLEGNKIAGICSSLSLKELKVLNVCKNH
ISSLPENFLEDCQKVESFSAKMNFLATMPVLPSSITSLKLSQNKFTCIPDVILILPHLRS
LDMSNNNIDCLPGPAHWKSLNLRELLFSNNQISILNLSEKPHLWSRVEKLHLSHNKLREI
PPEIGFLENLTSLDVSHNSELRSFPNEMGKLSKIWDLPLDELHLSFDFKHVGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKSDLSMQGATVGIDVKDWPIQI
RGKKKKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIVNESLNFKIRDQPVVGQLIPDCYLELEKIILSERRTVPIEFPVIDQKRLLQLVKGN
QLQLDENELPQAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGCLR
HPKGIISRRDVEKFLSKKKRFPKNYMAQYFKLLEKFQIALPIGEECLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHTESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRTIMLNNDELEFEQTPEFLLGDGSFGSVYRATYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLILLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDIFTTGSRITEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPLAEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRHILIPKNIIVECMVATNL
NSKNGSLWLGCGHTDKGQLSFLDLNTEKCSYEEVVDSRILCLALVHLPAEKESWIVCGTQ
SGALLVINTRDETKRHNLEKMTDSVTCLYCNSFSKQSKQNNFLLVGTADGNLVIFEDKAV
KCKGAVPLKTLHIGDVSMPLMCLSESMNSAERNLTWGGCGTKVFSFSSDFTIQKLIETRT
SQLFSYAAFSDSSITAVAVDTALYVAKKNSPVVEVWDKKTEKLCELIDTVHFLKEVMVKT
NRESKHKLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRIINNFCDSVRVMVP
AQLGSLKNVMLVLGYKRKSTEGTEEQKEIQSCLSIWDINLPHEVQNLEKHIDVRTELADK
MRRTSVD
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcctgggtcaggggtgcgaggaggacgaggaggaggagggtctgaagaag
ctgatcgtcaggctgaaccacgtccaggagagcaagcaggtctcgacgctggtgcagctg
ctggaggacctgctggtgttcacctactccgaccgcgcctccaagttgttcgaaggtaaa
aatttccacgtgcccctgctgctcgtcctggactcctacatgagggtggccagcgtgcag
caggtgggttggtcacttctatgcaaattaatagaagtctgtccagggacaatgcaaagc
ttaatgggaccccaggatgttggaaatgattgggaagttcttggtgtccaccaactgatt
cttaaaatgctaactgttcatcatgccaatgtaaacctgtcaacagttggactgaaggcc
ctagatctcctcctaaattcaggcaaaatcactttgctgatcctggatgaagagtgtgat
atcttcttgttaatttttgatgccatgcacacgtattcaaccaatgatgaagttcagaaa
cttggatgcaaagctttacatgtgctgtttgagagagtttccgaggaacaactgattgag
tttgttgagaacaaagattatatggtattgctaagagcattgaacagtttcagggaggaa
gaggaaatcgtgttgcacgtgctgcactgcctacactccctggcaattccgtgcaacaac
gttgaagtcctcatgagtggcaatgtcaggtgttacaacattgtagtagaagccatgaaa
accttccctagcagtgaaaaaattcaacatgtgagctgctgcctgctccacaggctcaca
ttaggtaattttttcaacatcctggtgttaaatgaggtgcatgattttgtggtgaaagct
gtgcggcaatatccagagaacccgtcactacaaatatccgggctgagctgcctagcgctc
ctcactgagaccatttttttaaaccaagacttggaggaaaggaatgaaaatcaggatcac
agtgatgaagaggaagaggagaagctgttctggctggaagcgtgctacagagccctcacc
cagcatcgcaagaacaagcacgtgcaggaggctgcatgctgggcgctgaataatctcctt
atgtaccagaacggtttacacaggaagattggagacgaagatggccagctcccagtgcac
agggaagtgatgctgtctatgctgatgcactcctcgtccaaagacgtcttccaagcatcc
gccaatgcactatccatactcttggaacaaaatgttaatttcaggaaaatcctgctgtca
aaaggcatatacctgaatgtcttggagctgatgcagaaacacgggaattctcctgaggtg
gcggagagtggctgtagaatgctgagtcatttgtttgaaggaagtagcactaccctggac
acaatggcagtagtgctccccaaaataataacagtgatgaaaagccatgaaacctcactg
ccggtgcaactggaggcactgagggccattgtacactttgtggtgacaggactaccagaa
gaatcaaaggctgaattccaatgcaagctgaacatggttaaaaagcaatgtttcaggaat
gatattcacaaactggttctagccgctctgaacaggttcattggaaatcctggggttcag
aaatgtggattgaaagtgatgtcttctctagtacatcttcccgaagccttagaggtattg
tcgctgcatggtgccgttgataccatccttcacacactgcagatgtacccagatgaccaa
gaaattcagtgtctgggcttaagtttaatgggatgcttaattacaaagaagaatttatgc
attggaacaggacacctcctggcaaaaattctggtttccagtttacagcgatttaaagat
gttgctgcagtacaggctacgggattgcagaccgtcttggcaatccttgagctctcagtg
ccgtttgctaagctgctggtgcatcattcatttgatttggtaatcttcctccagatgtct
tccagtgtcatggaaccaaaggatgagcagtttctcaacctgtgttgcaaatgctttgca
aaactggctgcggatgatgagttgaaaaatgtaatgctggagagagcgtgcgaccagaac
aacagcgtcatggttgaatgcttgcttctgttgggagctgatgccaatcacatgaagggg
gcgacttcattaatttatcaggtatgtgagaaagagaacagttcaaagttggtggaactg
ttgcttaacggtgggtgccgtgagcaggatgtgcggaaagcactgacagtaagcatccgg
agaggtgacagccaggtggtcagcttgcttttgaggcggctggccctcgacctggccaac
aacagcatttgccttggaggattttgcatgggaaaaatcgaaccttcctggcttggtcct
ctatttccagacaagtcatctaatttaagaaaacaaacaaacgtaggctctgtgctagcg
agaatggtactccgatatcagacgaaaagtgcagtggaggaaggagcctcagctggcgat
gggagctttgctgaagacggtctacttcataaattggatgaatggaccttccttcccgat
tcgtctatggacagcgtgtttggtcaaagcgatgatctggatagtgaaggaagtgaaagt
tcatttctcatgaaaaggaaatcaaattcaattagtgtaggagaattttacagagatcct
gtgttgcaacgctgctcaccaaatacacagagacattccaattcattgggtcccattttt
gatcaggaggaattactgaggcgaaaaagaaaaatactgtcttcagatgattcgctcagg
tcctccaagcttccatcctattcaaggcattcgggaagctcttcttccctgacttctgag
cgagactgtatcacatcgctagacctctcggccaacgagctgagggacatcgatgccctg
agcccgcggtgctgtctcagcggccacctggagcacctggtgaagctggagcttcagcag
aacgtcctcacctgtttcccgcagcacctgtgcgagactctgaagtgtttgacacatttg
gatttgcacagtaacaaattcacatcatttccctcttacttgttgaaaatgacttgtatc
accaatcttgatgtctcgcgaaacgacatcgggccctctgtagttttagatcccacggtg
aagtgcccgaccctgaaacagcttaacctgtcatacaaccagctgtctttggtcccagag
aacctcgccactgcggtggaaaacctggagcagctcacgttggaaggaaataaaatagct
gggatatgttcttccttgagcttgaaggaactgaaggttttaaatgtctgtaaaaaccac
atttcatcccttcctgagaactttcttgaggattgtcagaaagtggagagtttcagtgcc
aaaatgaattttcttgctactatgcctgtcttaccttcctccataacaagcctaaaatta
tctcagaataaatttacatgcattccagatgtaattttaattctaccacacctgcggtcg
ctggacatgagcaacaataacattgactgtctgccagggcctgcacactggaaatctctg
aacttaagggaactcctgtttagcaataatcagatcagcatcttgaacttgagtgaaaaa
ccgcacctgtggtctagggtagagaaactccatctttcccacaataaactgagagagatt
ccacctgagattggctttcttgaaaatctgacatctcttgatgttagtcacaactcggaa
ctgagatcttttcccaacgaaatggggaaattaagcaaaatatgggatcttcccttggat
gagttgcatctgagttttgacttcaagcatgtaggatgtaaagccaaagacatcataagg
tttcttcaacaacgtttgaaaaaggctgtgccctacaacaggatgaagcttatgattgtg
ggtaatactggaagtggtaaaaccacgttacttcagcagttaatgaaaatgaagaaatca
gatcttagcatgcagggggccacggttggcatcgatgtgaaagactggcctatccaaatc
agaggcaaaaagaagaaagacctcgttctaaacgtgtgggactttgcaggtcgtgaggag
ttctacagcacacatccccacttcatgacccagagagctctgtacctcgctgtctatgac
ctgagcaaagggcaggcagaagtggacgccatgaagccctggctcttcaatatcaaggcc
cgtgcttcttcttcccccgtgattctcgtgggtacacatctggatgtttctgatgagaag
cagcgcaaagcctgcataagtaaaatcaccaaggagctcttgaacaagcgaggattccct
gccatccgggattaccactttgtgaacgccactgaggagtctgatgctttggcaaaactt
cggaaaaccatcgtaaatgagagtcttaatttcaagattcgggatcagcctgttgtcggg
cagctaatcccagactgctacctcgaactggagaaaatcatcttatcagagcgaagaact
gtgccaattgaatttcctgtgattgaccagaaacgcctgttacagctagtgaagggaaac
cagctgcagctggatgaaaacgagcttccccaggcggttcacttcttaaacgagtcagga
gtccttcttcattttcaagacccagcactgcagttgagtgatttgtattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtaaaagtggaaggctgtctgaga
catcccaagggcatcatttcccgtagagatgtggaaaagttcctttcaaagaaaaagaga
tttccaaagaactatatggctcagtacttcaaactcctagaaaaattccagatcgccttg
ccgataggagaagagtgtttgctggttccaagcagtttatctgaccacagacctgtgatt
gagctccctcattgtgagaactccgaaattatcattagattatatgaaatgccatacttt
ccaatgggattttggtccagattaattaatcgattacttgaaatttcacctttcatgctt
tctggaagagaaagagcacttcgcccaaacaggatgtactggcgccaagggatctacttg
aactggtctcccgaggcttactgtctagtaggatctgaggtcttggacaatcacacagag
agtttcttgaaaattacagttccatcctgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgattctctcatggaagagtggtttcctggactgctagagattgatatt
tgcggtgaaggagaaaccctgttaaagaaatgggctttatacagttttaacgatggtgaa
gaacatcaaaaaatcttgcttgatgacctgatgaagaaagcagaggaaggagatcttctg
gttaatccagatcaacccagactcaccattccaatatctcagattgctcctgacctgatt
ttggctgacctgcctagaaccatcatgctgaataatgatgagctggaatttgaacaaact
cctgagtttctcttaggtgatggcagttttggatcagtgtatcgagccacctatgaagga
gaagaagtagctgtgaagatttttaataagcatacgtcactcaggctgttacgacaagag
ctggtggtgctttgccacctccaccaccccagcttgatactgttgctggcggctgggatt
cgaccgcgaatgctggtgatggagttggcctccaagggctccttggatcgcctgcttcag
caagacaaagccagcctcaccagaaccctccagcacaggatcgccctgcatgtggctgat
ggcttgaggtacctccattcagccatgatcatataccgtgatctgaaaccacacaacgtg
ctgctcttcaccctgtatcccaacgctgccatcatcgccaagatcgcagactacggcatt
gcgcaatactgctgtagaatgggcataaagacctcagagggcaccccagggttccgggca
cctgaagttgccaggggaaatgtcatttataaccagcaggctgatgtttattcattcggc
ttgctactctatgacattttcacaactggaagtagaataacggagggcttgaagttccca
aatgagtttgacgaattggcaatccaaggaaaattgcctgatccagttaaagaatatggt
tgtgctccatggcctctggctgagaagttaattaaaaagtgtttgaaagaaaatcctcaa
gaaagacctacttctgcccaggtctttgacattttgaattcagctgaattaatttgtctg
atgagacatattttaatacctaagaacattattgttgaatgcatggttgctacaaatctg
aacagcaagaatggaagcctctggctgggctgtggacacaccgacaaggggcagctctct
ttccttgacttaaacaccgaaaaatgcagttatgaggaagtggtggatagtagaatatta
tgtttggctttggtgcatcttcctgctgaaaaagaaagttggattgtgtgcgggacacag
tcgggggctctcctggtcatcaacaccagagacgagacgaagaggcacaacctggaaaag
atgacggattctgttacctgtctgtattgcaattccttttccaagcagagcaagcaaaac
aattttcttttggtgggaactgctgatggcaatttagtgatttttgaagataaggcagtt
aagtgtaaaggtgctgtccccctgaagacgctacacataggtgatgtcagcatgcccctc
atgtgcttgagcgagtccatgaattcagctgaaagaaaccttacctggggaggatgcggc
accaaagtcttctccttttccagtgatttcaccattcagaaactcatcgagacaaggacc
agccagctgttttcttacgcagcgttcagcgattccagcatcacggctgtggcagtcgac
acggctctctatgttgccaagaaaaacagccccgtggtagaggtgtgggacaagaaaacg
gaaaaactctgtgaactcatagacactgtgcacttcttaaaggaggtaatggtaaaaaca
aacagagaatcaaagcacaagctgtcttactccgggagggtgaaggcactctgcctgcag
aagaacacagctctctggatagggactggcggaggccacatcttactcctggatctttcc
actcggcgcgtcatacgcatcattaacaacttctgtgattctgttagagtcatggtccca
gcacagttaggaagccttaaaaacgtcatgctggttttgggctataagcggaaaagtacg
gaaggaacagaagaacagaaagagatacaatcttgcttgtctatttgggacatcaatctt
ccacacgaagtgcaaaatttagagaagcacattgacgtgagaacagaattagctgataaa
atgagaagaacgtctgtcgactag
DBGET
integrated database retrieval system
