KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103733121
Entry
103733121         CDS       T03372                                 
Symbol
Pik3cd
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00562  Inositol phosphate metabolism
ngi01100  Metabolic pathways
ngi01521  EGFR tyrosine kinase inhibitor resistance
ngi01522  Endocrine resistance
ngi01524  Platinum drug resistance
ngi04012  ErbB signaling pathway
ngi04014  Ras signaling pathway
ngi04015  Rap1 signaling pathway
ngi04024  cAMP signaling pathway
ngi04062  Chemokine signaling pathway
ngi04066  HIF-1 signaling pathway
ngi04068  FoxO signaling pathway
ngi04070  Phosphatidylinositol signaling system
ngi04071  Sphingolipid signaling pathway
ngi04072  Phospholipase D signaling pathway
ngi04081  Hormone signaling
ngi04140  Autophagy - animal
ngi04150  mTOR signaling pathway
ngi04151  PI3K-Akt signaling pathway
ngi04152  AMPK signaling pathway
ngi04210  Apoptosis
ngi04211  Longevity regulating pathway
ngi04213  Longevity regulating pathway - multiple species
ngi04218  Cellular senescence
ngi04360  Axon guidance
ngi04370  VEGF signaling pathway
ngi04380  Osteoclast differentiation
ngi04510  Focal adhesion
ngi04550  Signaling pathways regulating pluripotency of stem cells
ngi04611  Platelet activation
ngi04613  Neutrophil extracellular trap formation
ngi04620  Toll-like receptor signaling pathway
ngi04625  C-type lectin receptor signaling pathway
ngi04630  JAK-STAT signaling pathway
ngi04650  Natural killer cell mediated cytotoxicity
ngi04660  T cell receptor signaling pathway
ngi04662  B cell receptor signaling pathway
ngi04664  Fc epsilon RI signaling pathway
ngi04666  Fc gamma R-mediated phagocytosis
ngi04668  TNF signaling pathway
ngi04670  Leukocyte transendothelial migration
ngi04722  Neurotrophin signaling pathway
ngi04725  Cholinergic synapse
ngi04750  Inflammatory mediator regulation of TRP channels
ngi04810  Regulation of actin cytoskeleton
ngi04910  Insulin signaling pathway
ngi04914  Progesterone-mediated oocyte maturation
ngi04915  Estrogen signaling pathway
ngi04917  Prolactin signaling pathway
ngi04919  Thyroid hormone signaling pathway
ngi04923  Regulation of lipolysis in adipocytes
ngi04926  Relaxin signaling pathway
ngi04929  GnRH secretion
ngi04930  Type II diabetes mellitus
ngi04931  Insulin resistance
ngi04932  Non-alcoholic fatty liver disease
ngi04933  AGE-RAGE signaling pathway in diabetic complications
ngi04935  Growth hormone synthesis, secretion and action
ngi04960  Aldosterone-regulated sodium reabsorption
ngi04973  Carbohydrate digestion and absorption
ngi05010  Alzheimer disease
ngi05017  Spinocerebellar ataxia
ngi05020  Prion disease
ngi05100  Bacterial invasion of epithelial cells
ngi05132  Salmonella infection
ngi05135  Yersinia infection
ngi05142  Chagas disease
ngi05146  Amoebiasis
ngi05160  Hepatitis C
ngi05161  Hepatitis B
ngi05162  Measles
ngi05163  Human cytomegalovirus infection
ngi05164  Influenza A
ngi05165  Human papillomavirus infection
ngi05166  Human T-cell leukemia virus 1 infection
ngi05167  Kaposi sarcoma-associated herpesvirus infection
ngi05168  Herpes simplex virus 1 infection
ngi05169  Epstein-Barr virus infection
ngi05170  Human immunodeficiency virus 1 infection
ngi05171  Coronavirus disease - COVID-19
ngi05200  Pathways in cancer
ngi05203  Viral carcinogenesis
ngi05205  Proteoglycans in cancer
ngi05206  MicroRNAs in cancer
ngi05207  Chemical carcinogenesis - receptor activation
ngi05208  Chemical carcinogenesis - reactive oxygen species
ngi05210  Colorectal cancer
ngi05211  Renal cell carcinoma
ngi05212  Pancreatic cancer
ngi05213  Endometrial cancer
ngi05214  Glioma
ngi05215  Prostate cancer
ngi05218  Melanoma
ngi05220  Chronic myeloid leukemia
ngi05221  Acute myeloid leukemia
ngi05222  Small cell lung cancer
ngi05223  Non-small cell lung cancer
ngi05224  Breast cancer
ngi05225  Hepatocellular carcinoma
ngi05226  Gastric cancer
ngi05230  Central carbon metabolism in cancer
ngi05231  Choline metabolism in cancer
ngi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ngi05415  Diabetic cardiomyopathy
ngi05417  Lipid and atherosclerosis
ngi05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103733121 (Pik3cd)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103733121 (Pik3cd)
   04014 Ras signaling pathway
    103733121 (Pik3cd)
   04015 Rap1 signaling pathway
    103733121 (Pik3cd)
   04370 VEGF signaling pathway
    103733121 (Pik3cd)
   04630 JAK-STAT signaling pathway
    103733121 (Pik3cd)
   04668 TNF signaling pathway
    103733121 (Pik3cd)
   04066 HIF-1 signaling pathway
    103733121 (Pik3cd)
   04068 FoxO signaling pathway
    103733121 (Pik3cd)
   04070 Phosphatidylinositol signaling system
    103733121 (Pik3cd)
   04072 Phospholipase D signaling pathway
    103733121 (Pik3cd)
   04071 Sphingolipid signaling pathway
    103733121 (Pik3cd)
   04024 cAMP signaling pathway
    103733121 (Pik3cd)
   04151 PI3K-Akt signaling pathway
    103733121 (Pik3cd)
   04152 AMPK signaling pathway
    103733121 (Pik3cd)
   04150 mTOR signaling pathway
    103733121 (Pik3cd)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    103733121 (Pik3cd)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103733121 (Pik3cd)
  09143 Cell growth and death
   04210 Apoptosis
    103733121 (Pik3cd)
   04218 Cellular senescence
    103733121 (Pik3cd)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103733121 (Pik3cd)
   04550 Signaling pathways regulating pluripotency of stem cells
    103733121 (Pik3cd)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103733121 (Pik3cd)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103733121 (Pik3cd)
   04613 Neutrophil extracellular trap formation
    103733121 (Pik3cd)
   04620 Toll-like receptor signaling pathway
    103733121 (Pik3cd)
   04625 C-type lectin receptor signaling pathway
    103733121 (Pik3cd)
   04650 Natural killer cell mediated cytotoxicity
    103733121 (Pik3cd)
   04660 T cell receptor signaling pathway
    103733121 (Pik3cd)
   04662 B cell receptor signaling pathway
    103733121 (Pik3cd)
   04664 Fc epsilon RI signaling pathway
    103733121 (Pik3cd)
   04666 Fc gamma R-mediated phagocytosis
    103733121 (Pik3cd)
   04670 Leukocyte transendothelial migration
    103733121 (Pik3cd)
   04062 Chemokine signaling pathway
    103733121 (Pik3cd)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103733121 (Pik3cd)
   04923 Regulation of lipolysis in adipocytes
    103733121 (Pik3cd)
   04929 GnRH secretion
    103733121 (Pik3cd)
   04915 Estrogen signaling pathway
    103733121 (Pik3cd)
   04914 Progesterone-mediated oocyte maturation
    103733121 (Pik3cd)
   04917 Prolactin signaling pathway
    103733121 (Pik3cd)
   04926 Relaxin signaling pathway
    103733121 (Pik3cd)
   04935 Growth hormone synthesis, secretion and action
    103733121 (Pik3cd)
   04919 Thyroid hormone signaling pathway
    103733121 (Pik3cd)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    103733121 (Pik3cd)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    103733121 (Pik3cd)
  09156 Nervous system
   04725 Cholinergic synapse
    103733121 (Pik3cd)
   04722 Neurotrophin signaling pathway
    103733121 (Pik3cd)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103733121 (Pik3cd)
  09158 Development and regeneration
   04360 Axon guidance
    103733121 (Pik3cd)
   04380 Osteoclast differentiation
    103733121 (Pik3cd)
  09149 Aging
   04211 Longevity regulating pathway
    103733121 (Pik3cd)
   04213 Longevity regulating pathway - multiple species
    103733121 (Pik3cd)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103733121 (Pik3cd)
   05206 MicroRNAs in cancer
    103733121 (Pik3cd)
   05205 Proteoglycans in cancer
    103733121 (Pik3cd)
   05207 Chemical carcinogenesis - receptor activation
    103733121 (Pik3cd)
   05208 Chemical carcinogenesis - reactive oxygen species
    103733121 (Pik3cd)
   05203 Viral carcinogenesis
    103733121 (Pik3cd)
   05230 Central carbon metabolism in cancer
    103733121 (Pik3cd)
   05231 Choline metabolism in cancer
    103733121 (Pik3cd)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103733121 (Pik3cd)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103733121 (Pik3cd)
   05212 Pancreatic cancer
    103733121 (Pik3cd)
   05225 Hepatocellular carcinoma
    103733121 (Pik3cd)
   05226 Gastric cancer
    103733121 (Pik3cd)
   05214 Glioma
    103733121 (Pik3cd)
   05221 Acute myeloid leukemia
    103733121 (Pik3cd)
   05220 Chronic myeloid leukemia
    103733121 (Pik3cd)
   05218 Melanoma
    103733121 (Pik3cd)
   05211 Renal cell carcinoma
    103733121 (Pik3cd)
   05215 Prostate cancer
    103733121 (Pik3cd)
   05213 Endometrial cancer
    103733121 (Pik3cd)
   05224 Breast cancer
    103733121 (Pik3cd)
   05222 Small cell lung cancer
    103733121 (Pik3cd)
   05223 Non-small cell lung cancer
    103733121 (Pik3cd)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103733121 (Pik3cd)
   05170 Human immunodeficiency virus 1 infection
    103733121 (Pik3cd)
   05161 Hepatitis B
    103733121 (Pik3cd)
   05160 Hepatitis C
    103733121 (Pik3cd)
   05171 Coronavirus disease - COVID-19
    103733121 (Pik3cd)
   05164 Influenza A
    103733121 (Pik3cd)
   05162 Measles
    103733121 (Pik3cd)
   05168 Herpes simplex virus 1 infection
    103733121 (Pik3cd)
   05163 Human cytomegalovirus infection
    103733121 (Pik3cd)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103733121 (Pik3cd)
   05169 Epstein-Barr virus infection
    103733121 (Pik3cd)
   05165 Human papillomavirus infection
    103733121 (Pik3cd)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103733121 (Pik3cd)
   05135 Yersinia infection
    103733121 (Pik3cd)
   05100 Bacterial invasion of epithelial cells
    103733121 (Pik3cd)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103733121 (Pik3cd)
   05142 Chagas disease
    103733121 (Pik3cd)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103733121 (Pik3cd)
   05017 Spinocerebellar ataxia
    103733121 (Pik3cd)
   05020 Prion disease
    103733121 (Pik3cd)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103733121 (Pik3cd)
   05418 Fluid shear stress and atherosclerosis
    103733121 (Pik3cd)
   05415 Diabetic cardiomyopathy
    103733121 (Pik3cd)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103733121 (Pik3cd)
   04932 Non-alcoholic fatty liver disease
    103733121 (Pik3cd)
   04931 Insulin resistance
    103733121 (Pik3cd)
   04933 AGE-RAGE signaling pathway in diabetic complications
    103733121 (Pik3cd)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103733121 (Pik3cd)
   01524 Platinum drug resistance
    103733121 (Pik3cd)
   01522 Endocrine resistance
    103733121 (Pik3cd)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ngi04131]
    103733121 (Pik3cd)
Enzymes [BR:ngi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     103733121 (Pik3cd)
Membrane trafficking [BR:ngi04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    103733121 (Pik3cd)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 103733121
NCBI-ProteinID: XP_008830114
UniProt: A0A8C6W628
LinkDB
Position
Un
AA seq 1045 aa
MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPFFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAALRQQLGWEAWLQYSFPLQLEPSARSWGP
GTLRVPNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVERPEDYA
LQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
TKPPPIPAKKPSSVSLWSLEQPFCIELIEGSKVNADERMKLVVQAGLFHGNEMLCKTVSS
SEVSVCSEPVWKQRLEFDISICDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERRLYMWPSVPDEKGELLNPAGTVRSNPNTESAAALVICLPEVAP
HPVYFPALEKILELGRHGERGRITEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLGALELLDFNFPDCHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPHTKEMMHMCMR
QETYMEALSHLQSPLDPSTLLEEVCSVEQCTFMDSKMKPLWIMYSSEEAGSAGSVGIIFK
NGDDLRQDMLTLQMIQLMDILWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQL
NKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNI
MIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTSNSEKFERFRGY
CERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKF
NEALRESWKTKVNWLAHNVSKDNRQ
NT seq 3138 nt   +upstreamnt  +downstreamnt
atgccccctggggtggactgccccatggagttctggaccaaagaggagagccagagcgtg
gccgtcgacttcttgctgcccacaggggtctacctgaacttcccagtgtcccgcaatgcc
aacctcagcaccatcaagcaggtgttgtggcatcgcgcacagtatgagccgttcttccac
atgctcagcgacccggaggcctatgtgttcacctgtgtcaaccagacagctgagcagcag
gagctggaggatgagcagcggcgactgtgtgatgtccagcccttcctgcctgtgctgcgc
cttgtggcccgagagggtgaccgtgtgaagaagctcatcaactcacagatcagcctcctc
atcggcaaaggcctccatgagtttgactccctgcgagacccagaagtgaatgacttccga
accaagatgcgccagttttgtgaggaggccgctgctctccgccagcagctaggctgggag
gcctggctacagtatagcttccccctgcagctggagccctcagcaaggagctgggggcct
ggaacgctgcgtgtccccaaccgagccctgctggtcaatgtgaagttcgagggcagtgag
gagagcttcactttccaggtgtctactaaggacatgcccctggcactgatggcctgtgcc
ctccggaagaaggccacagtgttccggcagcccctggtggagcggcccgaggactatgcg
ctgcaggtgaatgggaggcatgagtacctctatggcagctacccgctctgccagttccag
tatatctgcagttgcttgcacagcggactgaccccccatctgaccatggtccactcctcc
tccatccttgctatgagggatgaacagagcaaccctgccccccaagtccagaaaccacgc
accaaacctcctcccattcctgccaagaagccttcctctgtgtccctgtggtccctggag
cagccattctgcatagagctgatcgagggcagcaaagtgaacgccgatgagcggatgaag
ctggtggtacaggctgggctcttccatggcaacgagatgctgtgcaagacggtgtctagc
tcggaggtgagtgtgtgttcagagcccgtgtggaagcagcggctggagtttgacatcagc
atctgtgacctaccgcgcatggcccggctctgcttcgccctatacgctgtggtcgagaaa
gccaagaaggctcgctccaccaagaagaaatccaagaaagcggactgccccatcgcctgg
gccaacctcatgctattcgactacaaagaccagctcaagactggggagcgccgtctctac
atgtggccctctgtcccagatgagaaaggagagctgctgaaccctgcgggtacagtgcgc
agtaaccccaacacagagagtgctgctgccttggtcatctgcctgcccgaggtggccccc
catcctgtgtacttccctgccctggagaagatcctggagctggggcgtcatggagaacgt
gggcgcatcacagaggaggagcagctgcagctgcgggaaatcctggagcggcgggggtct
ggggagctgtatgaacatgagaaagacctggtgtggaagatgcggcatgaagtccaggag
cacttcccggaggcactggcccgcctgctgctggtcaccaagtggaacaagcacgaggat
gtggcccagatgctgtatttgctgtgctcctggcccgagctgcctgtgctgggtgccctg
gagctgctggacttcaacttcccggactgccacgtgggctccttcgccatcaagtcccta
cggaaactgacggacgacgagcttttccagtacctgctgcagctggtgcaggtgctcaag
tacgagtcctacctggactgtgagctgaccaaattcttgctggaccgtgccttggccaac
cgcaagatcggccacttcctcttctggcaccttcgctccgagatgcacgtaccatcagtg
gccctgcgttttggcctcatcatggaggcctactgcagaggtagcactcaccacatgaag
gtgctgatgaaacagggggaagcactgagcaagctgaaggcattgaatgactttgtgaag
gtgagctcccagaagaccaccaagccccacaccaaggagatgatgcacatgtgtatgcgc
caggagacctacatggaggccctgtctcacctgcagtccccactggaccccagtaccctg
ctggaggaagtctgcagtgtggagcagtgcactttcatggactccaagatgaagccactg
tggatcatgtacagcagcgaggaggcgggcagtgctggcagcgtgggcatcatctttaag
aacggggatgacctccgccaggacatgctgactctgcagatgatccagctcatggacatc
ctgtggaagcaggagggcctggacctgaggatgaccccctatggctgcctccctactgga
gaccgcacaggcctcattgaggtggtcctccactctgacaccatcgccaacatccaactg
aacaagagcaacatggcagccacagccgccttcaacaaggatgccctgcttaactggctc
aagtctaagaaccctggggaggccctggaccgggccatcgaggaattcaccctgtcctgt
gctggctactgcgtagccacgtatgtgctggggatcggcgaccggcatagcgacaacatc
atgatccgagagagtgggcagctgttccatattgattttggccactttctggggaacttc
aagaccaagtttggaatcaaccgtgagcgagtcccattcatcctcacctatgactttgtg
cacgtcattcagcaggggaagactagtaacagtgagaagttcgaaaggttccggggctac
tgtgaacgagcctacaccattctgcggcgccacgggctgctcttcctccacctctttgcc
ctgatgcgtgcggcaggcctgcctgagctcagctgctccaaagacatccaatatctcaag
gactctctagcgctggggaagacagaggaagaagcactaaagcacttccgggtgaagttc
aatgaagctctgcgggagagctggaagaccaaagtgaactggttggcacacaacgtgtcc
aaagataacaggcagtag

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