| Entry |
|
| Symbol |
Plcb1
|
| Name |
(RefSeq) phospholipase C beta 1
|
| KO |
|
| Organism |
ngi Nannospalax galili (Upper Galilee mountains blind mole rat)
|
| Pathway |
| ngi04070 | Phosphatidylinositol signaling system |
| ngi04072 | Phospholipase D signaling pathway |
| ngi04261 | Adrenergic signaling in cardiomyocytes |
| ngi04270 | Vascular smooth muscle contraction |
| ngi04613 | Neutrophil extracellular trap formation |
| ngi04621 | NOD-like receptor signaling pathway |
| ngi04723 | Retrograde endocannabinoid signaling |
| ngi04750 | Inflammatory mediator regulation of TRP channels |
| ngi04919 | Thyroid hormone signaling pathway |
| ngi04925 | Aldosterone synthesis and secretion |
| ngi04927 | Cortisol synthesis and secretion |
| ngi04928 | Parathyroid hormone synthesis, secretion and action |
| ngi04933 | AGE-RAGE signaling pathway in diabetic complications |
| ngi04935 | Growth hormone synthesis, secretion and action |
| ngi04961 | Endocrine and other factor-regulated calcium reabsorption |
| ngi04973 | Carbohydrate digestion and absorption |
| ngi05022 | Pathways of neurodegeneration - multiple diseases |
| ngi05163 | Human cytomegalovirus infection |
|
| Module |
| ngi_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
| Brite |
KEGG Orthology (KO) [BR:ngi00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
103735195 (Plcb1)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
103735195 (Plcb1)
04310 Wnt signaling pathway
103735195 (Plcb1)
04371 Apelin signaling pathway
103735195 (Plcb1)
04020 Calcium signaling pathway
103735195 (Plcb1)
04070 Phosphatidylinositol signaling system
103735195 (Plcb1)
04072 Phospholipase D signaling pathway
103735195 (Plcb1)
04071 Sphingolipid signaling pathway
103735195 (Plcb1)
04022 cGMP-PKG signaling pathway
103735195 (Plcb1)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
103735195 (Plcb1)
04081 Hormone signaling
103735195 (Plcb1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
103735195 (Plcb1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
103735195 (Plcb1)
04613 Neutrophil extracellular trap formation
103735195 (Plcb1)
04621 NOD-like receptor signaling pathway
103735195 (Plcb1)
04062 Chemokine signaling pathway
103735195 (Plcb1)
09152 Endocrine system
04911 Insulin secretion
103735195 (Plcb1)
04922 Glucagon signaling pathway
103735195 (Plcb1)
04929 GnRH secretion
103735195 (Plcb1)
04912 GnRH signaling pathway
103735195 (Plcb1)
04915 Estrogen signaling pathway
103735195 (Plcb1)
04921 Oxytocin signaling pathway
103735195 (Plcb1)
04926 Relaxin signaling pathway
103735195 (Plcb1)
04935 Growth hormone synthesis, secretion and action
103735195 (Plcb1)
04918 Thyroid hormone synthesis
103735195 (Plcb1)
04919 Thyroid hormone signaling pathway
103735195 (Plcb1)
04928 Parathyroid hormone synthesis, secretion and action
103735195 (Plcb1)
04916 Melanogenesis
103735195 (Plcb1)
04924 Renin secretion
103735195 (Plcb1)
04925 Aldosterone synthesis and secretion
103735195 (Plcb1)
04927 Cortisol synthesis and secretion
103735195 (Plcb1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
103735195 (Plcb1)
04270 Vascular smooth muscle contraction
103735195 (Plcb1)
09154 Digestive system
04970 Salivary secretion
103735195 (Plcb1)
04971 Gastric acid secretion
103735195 (Plcb1)
04972 Pancreatic secretion
103735195 (Plcb1)
04973 Carbohydrate digestion and absorption
103735195 (Plcb1)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
103735195 (Plcb1)
09156 Nervous system
04724 Glutamatergic synapse
103735195 (Plcb1)
04725 Cholinergic synapse
103735195 (Plcb1)
04728 Dopaminergic synapse
103735195 (Plcb1)
04726 Serotonergic synapse
103735195 (Plcb1)
04720 Long-term potentiation
103735195 (Plcb1)
04730 Long-term depression
103735195 (Plcb1)
04723 Retrograde endocannabinoid signaling
103735195 (Plcb1)
09157 Sensory system
04742 Taste transduction
103735195 (Plcb1)
04750 Inflammatory mediator regulation of TRP channels
103735195 (Plcb1)
09159 Environmental adaptation
04713 Circadian entrainment
103735195 (Plcb1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103735195 (Plcb1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
103735195 (Plcb1)
09174 Infectious disease: parasitic
05146 Amoebiasis
103735195 (Plcb1)
05142 Chagas disease
103735195 (Plcb1)
05143 African trypanosomiasis
103735195 (Plcb1)
09164 Neurodegenerative disease
05010 Alzheimer disease
103735195 (Plcb1)
05016 Huntington disease
103735195 (Plcb1)
05017 Spinocerebellar ataxia
103735195 (Plcb1)
05022 Pathways of neurodegeneration - multiple diseases
103735195 (Plcb1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
103735195 (Plcb1)
05415 Diabetic cardiomyopathy
103735195 (Plcb1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
103735195 (Plcb1)
04934 Cushing syndrome
103735195 (Plcb1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:ngi04131]
103735195 (Plcb1)
Enzymes [BR:ngi01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
103735195 (Plcb1)
Membrane trafficking [BR:ngi04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
103735195 (Plcb1)
Endocytosis
Macropinocytosis
Phospholipase C
103735195 (Plcb1)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| LinkDB |
|
| Position |
Un
|
| AA seq |
1172 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDTIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNDSLARKGQISVDGFMRYLN
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMDPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTHSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSETPSEARTTPAENGVNHTTSLTPKPPSQAQHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTAKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAVLDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKETCEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLLEKHKEIRQQILDEKP
KGEGSSSFLSETCLEDPSVPPNFTPPNPQALK |
| NT seq |
3519 nt +upstreamnt +downstreamnt
atggccggggctcagcccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgtcacccca
attattttgaggactgatcctcagggatttttcttctactggacagatcaaaataaggag
acggagctgttggatctcagtcttgtcaaggatgccaggtgtgggaagcatgccaaggcc
cccaaggaccccaaattacgtgaacttctggatgtggggaacatcgggcacctggaacat
cgcatgataacagtggtatatgggcctgacctggtgaacatttctcatttgaatcttgtg
gctttccaagaggaagtggccaaggaatggacaaatgaggttttcagcttggcaacaaac
ctgctggcccaaaacatgtccagggacgcgtttctggaaaaagcatacactaaacttaag
ctgcaggtcactccagaagggcgcattcctctcaaaaacatctatcgcttgttttcagca
gaccggaagagagttgaaaccgcattagaggcttgtagtcttccatcttcaaggaatgat
accatacctcaagaggatttcactccagatgtgtacagagttttcctgaacaatctttgt
ccccgacctgaaatcgataacatcttttctgaatttggtgccaaaagcaaaccatacctt
actgttgatcagatgatggattttatcaaccttaagcaacgagatccccggctaaatgaa
atactttatccacctttgaaacaagagcaagtccaagtgttgattgagaagtatgaacct
aatgacagccttgccagaaaagggcagatatcagtggatgggttcatgcgctacctgaac
ggagaagaaaatggcgtcgtttcacctgagaaactggatttgaatgaagacatgtctcag
ccgctgtctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctgggaactcctctgtagagatgtatcgccaagtgcttctgtcgggatgtcgctgtgtg
gaactggactgctggaaggggcggactgcagaggaagaacctgtcatcacccatggattc
accatgacaactgaaatatccttcaaggaagtgatagaagcaattgccgagtgtgcattc
aagacgtcacctttcccaattctcctctcctttgaaaaccatgtggattccccaaagcaa
caagccaagatggcagagtattgccgactcatcttcggcgatgcccttctcatggaccca
ctggaaaaatacccactggaatccggagtgcctcttccaagccctatggatttaatgtat
aagattttggtgaaaaataagaagaaatcacacaagtcgtcagaaggaagtggtaaaaag
aagctttcggagcaagcctccaatacacacagcgactcctccagcgtgttcgagccatca
tctccaggagccggggaagcagatacagagagtgatgatgacgacgacgatgatgactgt
aaaaaatcttcaatggatgagggtacggctgggagcgaggccatggccacggaagagatg
tccaatctggtgaactacattcaacctgtcaagtttgagtcctttgaaatttcaaaaaaa
agaaacaaaagctttgaaatgtcttccttcgtggaaaccaaagggcttgaacaacttacg
aagtctccagtggaatttgtagaatataataaaatgcaactcagtaggatatatcctaaa
ggaacgcgtgtggattcatccaactacatgcctcagctcttctggaatgctggctgtcag
atggtggcactcaatttccagacagtggacctggccatgcaaataaacatggggatgtac
gagtacaacgggaagagcggctacagactaaagccagagttcatgaggaggccggacaag
cattttgatccatttacagaaggcatcgtagatgggatagtggccaacactttgtccgtt
aagatcatttcagggcagtttctttctgataagaaagttgggacttatgtggaggtggat
atgtttggtttgcccgtggacacaaggaggaaagcatttaagaccaagacgtcccaaggg
aatgctgtaaatcctgtctgggaagaagaaccgattgtgttcaagaaggtagtgctgcct
tctctggcctgtttgaggatagcagcatacgaagagggaggcaaatttattggccaccgg
atcttgccagtacaagccattcggccaggctatcactacatctgtctgcggaatgagagg
aaccagcctctgatgctgccagctgtctttgtctacatagaggtgaaagactatgtacca
gacacgtatgcagatgtgatagaagctctgtcaaacccgatccgttatgtgaatctgatg
gagcagagagctaagcaactggccgccctgacactggaagatgaagaggaagtaaagaaa
gaggctgatcctggggaaacaccatcagagactccaagtgaagccaggactactccagca
gaaaatggagtgaatcacaccacatccttgacacccaagccaccttcccaggctcagcac
agtcaaccagctccaggttctgtgaaggcacctgccaaaacagaagaccttatccagagt
gtcttgacagaagtggaagcgcagactattgaagagctcaagcaacagaaatcgtttgtg
aaacttcaaaagaagcattacaaagaaatgaaagacctggttaagagacaccacaagaaa
accaccgacctgatcaaggagcacactgcgaagtacaacgagattcagaatgactacttg
agaagaagggcagccttggaaaagtctgccaaaaaggacagcaagaaaaaatctgaaccc
agcagccctgaccatggttcctccgccattgagcaagaccttgcagtgctggatgcagaa
atgacccagaagttaatcgacttaaaggacaaacagcagcaacagttgcttaatcttcgt
caagaacagtattacagtgagaagtaccagaagcgtgagcatattaaactgcttattcag
aagttgacagatgtggccgaagagtgtcagaacaatcaattaaagaagctcaaggaaacc
tgtgagaaagagaagaaagaactaaagaagaaaatggataaaaagaggcaggagaagata
acagaagctaagtccaaggacaaaagccagatggaagaggagaagacagagatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaaagg
caagaaaaacttttggagaaacacaaggagatccgccagcagatcctggatgagaagccc
aagggggaaggttcctcctcattcttgtcggaaacttgccttgaggatccctctgtcccc
cccaactttactccccccaaccctcaagctctcaagtga |