Nannospalax galili (Upper Galilee mountains blind mole rat): 103736919
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Entry
103736919 CDS
T03372
Symbol
Gclc
Name
(RefSeq) glutamate-cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00270
Cysteine and methionine metabolism
ngi00480
Glutathione metabolism
ngi01100
Metabolic pathways
ngi01240
Biosynthesis of cofactors
ngi04216
Ferroptosis
Module
ngi_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
103736919 (Gclc)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
103736919 (Gclc)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
103736919 (Gclc)
Enzymes [BR:
ngi01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
103736919 (Gclc)
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Paralog
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
103736919
NCBI-ProteinID:
XP_008834763
UniProt:
A0A8C6WCI2
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Position
Un
AA seq
637 aa
AA seq
DB search
MGLLSQGSPLSWADTQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVQLVLSGEDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSVLEENQAICTITSFPRLGCAGFTLPEYKPNPEEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPEDEEAAKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNCYRISKSRYDSIDSYLSKCGEKYNDIDLTVDKEIYEQLLK
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGLFYFRKDICKGGNAVVDGCGKAQMSSELAAEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDKMNYS
LILKCNQIANELCECPELLGSGFRKAKYGGGKIDSSS
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggccgacacgcagcgccacgccgac
cacgtgcggcgccacggcatcctccagttcctgcacatctaccacgcggtcaaggaccgc
cacaaggacgtgctcaagtggggcgacgaggtggaatacatgttggtatcttttgatcat
gaaaataaaaaagtccagttggtcctgtctggagaagatgttctggaaacactgcaggag
aagggggaaaggacaaacccaaaccatccgaccctctggagaccagagtatgggagttac
atgattgaagggacgcctgggcagccctacggaggaaccatgtctgagttcaacacagtc
gaggacaacatgaggaaacgccggaaggaggctacttctgtattagaagaaaaccaggct
atttgcacaataacctcatttcccagactaggctgtgctggattcacactgcctgagtac
aaacccaacccagaggaaggaggtgcatctaagtccctcttctttccagacgaagcaata
aacaagcacccccgcttcagtaccctaacaaggaacatccgacatagaagaggggaaaag
gttgtcatcaatgtgccaatatttaaggacaagaacacaccatctccatttatagaaaca
tttcctgaagatgaggaggcagcaaaggcttctaagccagaccacatttacatggatgcc
atgggctttgggatgggcaattgctgccttcaggtaacattccaagcctgcagcatatct
gaggccagatacctttatgaccaattggccactatctgcccaattgtcatggctttgagt
gctgcatctcctttttaccgaggctacgtgtcagacattgactgtcgctggggagtgatt
tctgcatctgtagatgataggacacgggaggagagaggactggagcctctgaagaacaat
tgctataggattagtaaatctcggtatgattcaatagacagctacttatctaagtgtggt
gagaaatacaatgacatcgatttgaccgtagataaggaaatctacgagcagctcttgaag
gaaggcattgatcatcttctggcccagcatgttgctcacctctttattagagacccactg
accctttttgaagagaaaatacacctggatgatgccaatgagtctgaccattttgagaat
attcagtccacaaattggcaaacaatgagatttaaaccaccccctccaaactcagatatc
ggatggagagtagagttccgacccatggaggtgcagttaacagactttgagaactctgcc
tatgtggtgtttgtggtgcttctcaccagggtgatcctctcatacaaactggactttctc
attccactgtcaaaggttgatgaaaacatgaaagtggcacagaagcgggacgctgtcttg
caggggctgttttatttcaggaaggatatctgcaaaggtggcaacgctgtggtggatgga
tgtggtaaggcccagatgagctcagagctggccgcagaggagtacaccctcatgagcata
gacaccatcatcaacgggaaggaaggcgtgtttcctggactcattcccattctgaactct
tacctggagaacatggaagtagatgtggacaccagatgcagtatcctgaactacctaaag
ctgataaagaaaagagcgtctggagaactaatgacagttgctagatggatgcgagagttt
attgcaaaccatcctgactacaagcaagacagtgtaataactgacaaaatgaactatagt
cttattttgaaatgtaaccaaattgcaaatgaattatgtgaatgtccagagttactagga
tcaggatttagaaaagcaaagtatggtggaggaaaaattgactcttccagctag
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