Nannospalax galili (Upper Galilee mountains blind mole rat): 103738596
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Entry
103738596 CDS
T03372
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
KO
K00922
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:
2.7.1.153
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00562
Inositol phosphate metabolism
ngi01100
Metabolic pathways
ngi01521
EGFR tyrosine kinase inhibitor resistance
ngi01522
Endocrine resistance
ngi01524
Platinum drug resistance
ngi04012
ErbB signaling pathway
ngi04014
Ras signaling pathway
ngi04015
Rap1 signaling pathway
ngi04024
cAMP signaling pathway
ngi04062
Chemokine signaling pathway
ngi04066
HIF-1 signaling pathway
ngi04068
FoxO signaling pathway
ngi04070
Phosphatidylinositol signaling system
ngi04071
Sphingolipid signaling pathway
ngi04072
Phospholipase D signaling pathway
ngi04140
Autophagy - animal
ngi04150
mTOR signaling pathway
ngi04151
PI3K-Akt signaling pathway
ngi04152
AMPK signaling pathway
ngi04210
Apoptosis
ngi04211
Longevity regulating pathway
ngi04213
Longevity regulating pathway - multiple species
ngi04218
Cellular senescence
ngi04360
Axon guidance
ngi04370
VEGF signaling pathway
ngi04380
Osteoclast differentiation
ngi04510
Focal adhesion
ngi04550
Signaling pathways regulating pluripotency of stem cells
ngi04611
Platelet activation
ngi04613
Neutrophil extracellular trap formation
ngi04620
Toll-like receptor signaling pathway
ngi04625
C-type lectin receptor signaling pathway
ngi04630
JAK-STAT signaling pathway
ngi04650
Natural killer cell mediated cytotoxicity
ngi04660
T cell receptor signaling pathway
ngi04662
B cell receptor signaling pathway
ngi04664
Fc epsilon RI signaling pathway
ngi04666
Fc gamma R-mediated phagocytosis
ngi04668
TNF signaling pathway
ngi04670
Leukocyte transendothelial migration
ngi04722
Neurotrophin signaling pathway
ngi04725
Cholinergic synapse
ngi04750
Inflammatory mediator regulation of TRP channels
ngi04810
Regulation of actin cytoskeleton
ngi04910
Insulin signaling pathway
ngi04914
Progesterone-mediated oocyte maturation
ngi04915
Estrogen signaling pathway
ngi04917
Prolactin signaling pathway
ngi04919
Thyroid hormone signaling pathway
ngi04923
Regulation of lipolysis in adipocytes
ngi04926
Relaxin signaling pathway
ngi04929
GnRH secretion
ngi04930
Type II diabetes mellitus
ngi04931
Insulin resistance
ngi04932
Non-alcoholic fatty liver disease
ngi04933
AGE-RAGE signaling pathway in diabetic complications
ngi04935
Growth hormone synthesis, secretion and action
ngi04960
Aldosterone-regulated sodium reabsorption
ngi04973
Carbohydrate digestion and absorption
ngi05010
Alzheimer disease
ngi05017
Spinocerebellar ataxia
ngi05020
Prion disease
ngi05100
Bacterial invasion of epithelial cells
ngi05132
Salmonella infection
ngi05135
Yersinia infection
ngi05142
Chagas disease
ngi05146
Amoebiasis
ngi05160
Hepatitis C
ngi05161
Hepatitis B
ngi05162
Measles
ngi05163
Human cytomegalovirus infection
ngi05164
Influenza A
ngi05165
Human papillomavirus infection
ngi05166
Human T-cell leukemia virus 1 infection
ngi05167
Kaposi sarcoma-associated herpesvirus infection
ngi05168
Herpes simplex virus 1 infection
ngi05169
Epstein-Barr virus infection
ngi05170
Human immunodeficiency virus 1 infection
ngi05171
Coronavirus disease - COVID-19
ngi05200
Pathways in cancer
ngi05203
Viral carcinogenesis
ngi05205
Proteoglycans in cancer
ngi05206
MicroRNAs in cancer
ngi05207
Chemical carcinogenesis - receptor activation
ngi05208
Chemical carcinogenesis - reactive oxygen species
ngi05210
Colorectal cancer
ngi05211
Renal cell carcinoma
ngi05212
Pancreatic cancer
ngi05213
Endometrial cancer
ngi05214
Glioma
ngi05215
Prostate cancer
ngi05218
Melanoma
ngi05220
Chronic myeloid leukemia
ngi05221
Acute myeloid leukemia
ngi05222
Small cell lung cancer
ngi05223
Non-small cell lung cancer
ngi05224
Breast cancer
ngi05225
Hepatocellular carcinoma
ngi05226
Gastric cancer
ngi05230
Central carbon metabolism in cancer
ngi05231
Choline metabolism in cancer
ngi05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
ngi05415
Diabetic cardiomyopathy
ngi05417
Lipid and atherosclerosis
ngi05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
103738596 (Pik3ca)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
103738596 (Pik3ca)
04014 Ras signaling pathway
103738596 (Pik3ca)
04015 Rap1 signaling pathway
103738596 (Pik3ca)
04370 VEGF signaling pathway
103738596 (Pik3ca)
04630 JAK-STAT signaling pathway
103738596 (Pik3ca)
04668 TNF signaling pathway
103738596 (Pik3ca)
04066 HIF-1 signaling pathway
103738596 (Pik3ca)
04068 FoxO signaling pathway
103738596 (Pik3ca)
04070 Phosphatidylinositol signaling system
103738596 (Pik3ca)
04072 Phospholipase D signaling pathway
103738596 (Pik3ca)
04071 Sphingolipid signaling pathway
103738596 (Pik3ca)
04024 cAMP signaling pathway
103738596 (Pik3ca)
04151 PI3K-Akt signaling pathway
103738596 (Pik3ca)
04152 AMPK signaling pathway
103738596 (Pik3ca)
04150 mTOR signaling pathway
103738596 (Pik3ca)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
103738596 (Pik3ca)
09143 Cell growth and death
04210 Apoptosis
103738596 (Pik3ca)
04218 Cellular senescence
103738596 (Pik3ca)
09144 Cellular community - eukaryotes
04510 Focal adhesion
103738596 (Pik3ca)
04550 Signaling pathways regulating pluripotency of stem cells
103738596 (Pik3ca)
09142 Cell motility
04810 Regulation of actin cytoskeleton
103738596 (Pik3ca)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
103738596 (Pik3ca)
04613 Neutrophil extracellular trap formation
103738596 (Pik3ca)
04620 Toll-like receptor signaling pathway
103738596 (Pik3ca)
04625 C-type lectin receptor signaling pathway
103738596 (Pik3ca)
04650 Natural killer cell mediated cytotoxicity
103738596 (Pik3ca)
04660 T cell receptor signaling pathway
103738596 (Pik3ca)
04662 B cell receptor signaling pathway
103738596 (Pik3ca)
04664 Fc epsilon RI signaling pathway
103738596 (Pik3ca)
04666 Fc gamma R-mediated phagocytosis
103738596 (Pik3ca)
04670 Leukocyte transendothelial migration
103738596 (Pik3ca)
04062 Chemokine signaling pathway
103738596 (Pik3ca)
09152 Endocrine system
04910 Insulin signaling pathway
103738596 (Pik3ca)
04923 Regulation of lipolysis in adipocytes
103738596 (Pik3ca)
04929 GnRH secretion
103738596 (Pik3ca)
04915 Estrogen signaling pathway
103738596 (Pik3ca)
04914 Progesterone-mediated oocyte maturation
103738596 (Pik3ca)
04917 Prolactin signaling pathway
103738596 (Pik3ca)
04926 Relaxin signaling pathway
103738596 (Pik3ca)
04935 Growth hormone synthesis, secretion and action
103738596 (Pik3ca)
04919 Thyroid hormone signaling pathway
103738596 (Pik3ca)
09154 Digestive system
04973 Carbohydrate digestion and absorption
103738596 (Pik3ca)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
103738596 (Pik3ca)
09156 Nervous system
04725 Cholinergic synapse
103738596 (Pik3ca)
04722 Neurotrophin signaling pathway
103738596 (Pik3ca)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
103738596 (Pik3ca)
09158 Development and regeneration
04360 Axon guidance
103738596 (Pik3ca)
04380 Osteoclast differentiation
103738596 (Pik3ca)
09149 Aging
04211 Longevity regulating pathway
103738596 (Pik3ca)
04213 Longevity regulating pathway - multiple species
103738596 (Pik3ca)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103738596 (Pik3ca)
05206 MicroRNAs in cancer
103738596 (Pik3ca)
05205 Proteoglycans in cancer
103738596 (Pik3ca)
05207 Chemical carcinogenesis - receptor activation
103738596 (Pik3ca)
05208 Chemical carcinogenesis - reactive oxygen species
103738596 (Pik3ca)
05203 Viral carcinogenesis
103738596 (Pik3ca)
05230 Central carbon metabolism in cancer
103738596 (Pik3ca)
05231 Choline metabolism in cancer
103738596 (Pik3ca)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
103738596 (Pik3ca)
09162 Cancer: specific types
05210 Colorectal cancer
103738596 (Pik3ca)
05212 Pancreatic cancer
103738596 (Pik3ca)
05225 Hepatocellular carcinoma
103738596 (Pik3ca)
05226 Gastric cancer
103738596 (Pik3ca)
05214 Glioma
103738596 (Pik3ca)
05221 Acute myeloid leukemia
103738596 (Pik3ca)
05220 Chronic myeloid leukemia
103738596 (Pik3ca)
05218 Melanoma
103738596 (Pik3ca)
05211 Renal cell carcinoma
103738596 (Pik3ca)
05215 Prostate cancer
103738596 (Pik3ca)
05213 Endometrial cancer
103738596 (Pik3ca)
05224 Breast cancer
103738596 (Pik3ca)
05222 Small cell lung cancer
103738596 (Pik3ca)
05223 Non-small cell lung cancer
103738596 (Pik3ca)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
103738596 (Pik3ca)
05170 Human immunodeficiency virus 1 infection
103738596 (Pik3ca)
05161 Hepatitis B
103738596 (Pik3ca)
05160 Hepatitis C
103738596 (Pik3ca)
05171 Coronavirus disease - COVID-19
103738596 (Pik3ca)
05164 Influenza A
103738596 (Pik3ca)
05162 Measles
103738596 (Pik3ca)
05168 Herpes simplex virus 1 infection
103738596 (Pik3ca)
05163 Human cytomegalovirus infection
103738596 (Pik3ca)
05167 Kaposi sarcoma-associated herpesvirus infection
103738596 (Pik3ca)
05169 Epstein-Barr virus infection
103738596 (Pik3ca)
05165 Human papillomavirus infection
103738596 (Pik3ca)
09171 Infectious disease: bacterial
05132 Salmonella infection
103738596 (Pik3ca)
05135 Yersinia infection
103738596 (Pik3ca)
05100 Bacterial invasion of epithelial cells
103738596 (Pik3ca)
09174 Infectious disease: parasitic
05146 Amoebiasis
103738596 (Pik3ca)
05142 Chagas disease
103738596 (Pik3ca)
09164 Neurodegenerative disease
05010 Alzheimer disease
103738596 (Pik3ca)
05017 Spinocerebellar ataxia
103738596 (Pik3ca)
05020 Prion disease
103738596 (Pik3ca)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
103738596 (Pik3ca)
05418 Fluid shear stress and atherosclerosis
103738596 (Pik3ca)
05415 Diabetic cardiomyopathy
103738596 (Pik3ca)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
103738596 (Pik3ca)
04932 Non-alcoholic fatty liver disease
103738596 (Pik3ca)
04931 Insulin resistance
103738596 (Pik3ca)
04933 AGE-RAGE signaling pathway in diabetic complications
103738596 (Pik3ca)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103738596 (Pik3ca)
01524 Platinum drug resistance
103738596 (Pik3ca)
01522 Endocrine resistance
103738596 (Pik3ca)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ngi04131
]
103738596 (Pik3ca)
Enzymes [BR:
ngi01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
103738596 (Pik3ca)
Membrane trafficking [BR:
ngi04131
]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
103738596 (Pik3ca)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI3Ka
PI3_PI4_kinase
PI3K_C2
PI3K_rbd
PI3K_p85B
DUF2321
ABC1
Ribosomal_S15
Motif
Other DBs
NCBI-GeneID:
103738596
NCBI-ProteinID:
XP_008836896
UniProt:
A0A8C6QUS2
LinkDB
All DBs
Position
Un
AA seq
1068 aa
AA seq
DB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREAMLVTIKHELFQEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILSVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPTD
SFTMPSYSRRISTATPYMNGETPTKSLWVINSVLRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIHIPDLPRAARLCVSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq
3207 nt
NT seq
+upstream
nt +downstream
nt
atgcctccgcgaccgtcatcaggagaactgtggggcatccacttgatgcccccacgaatc
ctagtggagtgtttactcccaaacggaatgatagtgactttggagtgcctccgtgaggct
atgctagtcaccatcaagcacgaactgtttcaggaagccaggaaataccctctccaccag
cttctgcaggatgagtcttcttacattttcgtaagtgttacccaggaagcagaaagggaa
gaattttttgatgaaacaagacgcctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaatcggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagatccggaagtccaagacttccga
cggaacattctgagtgtgtgcaaagaagccgtggacctgcgggatctgaactcccctcac
agcagagcaatgtatgtctaccctcccaatgtggagtcttccccagagctgccaaagcac
atttacaacaagttagataaaggacaaatcatagtagtgatttgggtcatagtctctcca
aataacgacaagcagaaatacactctgaagatcaaccatgactgtgtgccagagcaagtc
atcgctgaagcaatcaggaagaaaacccgcagtatgctgctgtcctcggagcagctgaag
ctctgcgtcctggagtaccagggcaagtacatcttgaaggtgtgtggctgcgatgagtac
ttcttggagaagtaccctctgagccagtataagtacataagaagctgtataatgctggga
aggatgcccaacttgatgctgatggccaaggaaagcctttattcccagctgccaaccgac
agcttcaccatgccatcctactctaggcgcatctccacagccacgccctacatgaatgga
gagacacctaccaagtccctctgggttataaatagcgtgctcagaatcaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagagcccttatgtgacaatgtgaacactcaaagagtaccttgttcaaat
cctaggtggaacgagtggctgaattacgacatacacattcccgaccttcctcgggctgct
cgactttgtgtttctatttgctctgttaaaggccggaagggcgcgaaggaggagcactgc
ccactggcctgggggaacataaacttgtttgattacacagacaccctggtatccgggaaa
atggctttgaacctctggccggtgccacatggtctggaagatctgctgaaccctattggt
gtcacagggtcaaatccaaataaggaaactccatgcttagagttggagtttgactggttc
agcagtgtggtgaagtttccagatatgtcggtgattgaagagcacgccaattggtctgtg
tctcgagaagctggattcagttactcccacgcaggactgagtaatagactagctagagac
aacgagctcagagaaaatgacaaagagcagctccgggcactctgtacccgagaccctctg
tcggaaatcactgagcaggagaaggacttcctgtggagccacagacactattgtgtaact
attcctgaaatcctacccaaactgcttctgtctgttaagtggaattccagagatgaagtg
gcccagatgtactgcttagtgaaagactggcctccaatcaaaccagagcaggccatggag
cttctagactgtaattatccagatcctatggttcggagttttgccgttcggtgcttggaa
aaatacttaacagacgacaagctttctcagtacctaatccagcttgtacaggtcctaaaa
tatgaacagtatttggataacctcctcgtgagatttttgctcaagaaagcattgacaaat
caaaggatcggccactttttcttttggcatttaaagtctgaaatgcacaacaagacagtc
agtcagaggttcggcctgctgctggagtcttactgccgtgcctgtgggatgtatctgaag
cacttgaacagacaggtggaggccatggagaagctcatcaacctgacagacatcctgaag
caggagaagaaggatgagacgcagaaggtgcagatgaagtttttagttgaacagatgagg
cagccagatttcatggatgccttgcagggctttctgtcccctctaaaccctgctcaccaa
ctagggaacctcaggcttgaagagtgtcggatcatgtcctctgcaaaaagaccactgtgg
ctgaactgggagaacccagacatcatgtcggagctgctgttccagaacaatgagatcatc
ttcaaaaatggcgatgatctgcggcaagacatgctgactcttcagatcatccgcatcatg
gagaacatctggcagaaccagggcctcgaccttcgaatgcttccttatggctgtctgtcg
attggggactgtgtggggctcattgaggtggtgaggaattctcataccatcatgcagatc
cagtgcaaaggaggcctgaagggggctctgcagttcaacagccacacgctgcatcagtgg
ctcaaggacaagaacaagggcgagatatacgatgcagccattgacctgttcacacgctca
tgcgctgggtactgcgtggccacattcatcctggggataggagatcgacataacagcaac
atcatggtgaaagacgatgggcagctgtttcatatagattttgggcactttctggatcac
aagaagaagaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttt
ttaatagtgattagtaaaggagcccaagaatacacaaagaccagagagtttgagaggttt
caggagatgtgttacaaggcttacctagctatccggcagcatgccaatctcttcatcaac
ctgttctccatgatgctcggctccgggatgcccgaactgcagtcctttgatgacattgcg
tatattcggaagactctcgccttggataaaactgagcaagaggctttggaatacttcaca
aaacaaatgaatgatgcacatcatggcggctggacgacaaaaatggattggatcttccac
actatcaagcagcacgctttgaactga
DBGET
integrated database retrieval system