KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103740979
Entry
103740979         CDS       T03372                                 
Symbol
Jak2
Name
(RefSeq) Janus kinase 2
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi01521  EGFR tyrosine kinase inhibitor resistance
ngi04062  Chemokine signaling pathway
ngi04081  Hormone signaling
ngi04148  Efferocytosis
ngi04151  PI3K-Akt signaling pathway
ngi04217  Necroptosis
ngi04550  Signaling pathways regulating pluripotency of stem cells
ngi04630  JAK-STAT signaling pathway
ngi04658  Th1 and Th2 cell differentiation
ngi04659  Th17 cell differentiation
ngi04725  Cholinergic synapse
ngi04917  Prolactin signaling pathway
ngi04920  Adipocytokine signaling pathway
ngi04933  AGE-RAGE signaling pathway in diabetic complications
ngi04935  Growth hormone synthesis, secretion and action
ngi05140  Leishmaniasis
ngi05145  Toxoplasmosis
ngi05152  Tuberculosis
ngi05161  Hepatitis B
ngi05164  Influenza A
ngi05167  Kaposi sarcoma-associated herpesvirus infection
ngi05168  Herpes simplex virus 1 infection
ngi05200  Pathways in cancer
ngi05207  Chemical carcinogenesis - receptor activation
ngi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ngi05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    103740979 (Jak2)
   04151 PI3K-Akt signaling pathway
    103740979 (Jak2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    103740979 (Jak2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    103740979 (Jak2)
  09143 Cell growth and death
   04217 Necroptosis
    103740979 (Jak2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    103740979 (Jak2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    103740979 (Jak2)
   04659 Th17 cell differentiation
    103740979 (Jak2)
   04062 Chemokine signaling pathway
    103740979 (Jak2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    103740979 (Jak2)
   04917 Prolactin signaling pathway
    103740979 (Jak2)
   04935 Growth hormone synthesis, secretion and action
    103740979 (Jak2)
  09156 Nervous system
   04725 Cholinergic synapse
    103740979 (Jak2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103740979 (Jak2)
   05207 Chemical carcinogenesis - receptor activation
    103740979 (Jak2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103740979 (Jak2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    103740979 (Jak2)
   05164 Influenza A
    103740979 (Jak2)
   05168 Herpes simplex virus 1 infection
    103740979 (Jak2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103740979 (Jak2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    103740979 (Jak2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    103740979 (Jak2)
   05140 Leishmaniasis
    103740979 (Jak2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103740979 (Jak2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103740979 (Jak2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103740979 (Jak2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ngi01001]
    103740979 (Jak2)
Enzymes [BR:ngi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     103740979 (Jak2)
Protein kinases [BR:ngi01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   103740979 (Jak2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M
Other DBs
NCBI-GeneID: 103740979
NCBI-ProteinID: XP_008839879
UniProt: A0A8C6Q9Y1
LinkDB
Position
Un
AA seq 1132 aa
MGMACLTMTEMEATSTPPVHQNGDIPGNASSVKQVDPVLQVYLYHSLGKAEGVYLKFPTG
EYVAEEICVAASKACGITPVYHNMFALMSEAERIWYPPNHVFHIDESTSHNILYRIRFYF
PHWYCSGSNRTYRYGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKEKDQTPLAIYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEQFEVKESARGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVSIKQANQECSNESRIVTIHKQDGKILEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFDKYFLTFAVERDNIIEYKHCLITKNENREYNLSGTKRNFSSLKDLLNC
YRMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVHISPTLQRHNNVNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWA
MHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPEGCPDEIYIIMTECWNNNVNQRPSFRDLALRVDQIRDSMAA
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcttgccttacaatgacagaaatggaagcaacttccacacctcctgtacat
cagaatggagatattcctggaaatgctagttctgtgaagcaagtagatccagtccttcag
gtatatctgtaccactcccttggaaaagctgaaggagtttatctgaagtttccaactgga
gagtatgttgcagaagaaatttgtgttgctgcttctaaagcttgtggtattacacctgtg
tatcataatatgtttgctttaatgagtgaagcagaaagaatctggtatccacccaaccat
gtcttccacatagatgagtcaaccagccataatatactctacagaataagattttacttt
cctcactggtattgcagtggcagcaacagaacctatcgatacggaatatctcgtggggct
gaagcacctcttcttgatgactttgtcatgtcttacctctttgctcagtggcggcatgat
tttgtgcatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg
atggcggtgttagatatgatgcgaatagctaaagagaaggatcagacacccctggctatc
tacaattccatcagctataagacattcttaccaaaatgcgttcgagcaaagatccaagac
taccatattttgacccggaagcgaataaggtaccgatttcgcagatttattcagcagttc
agtcaatgcaaagccactgccaggaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcaatttgaagtaaaagaatctgcaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgatttt
cctgatattattgatgtcagtattaagcaagcaaaccaggaatgctcaaatgaaagtaga
attgtaactatccataagcaagatgggaaaattttggaaattgaacttagctcattaaga
gaagctttgtcatttgtatcattaattgatggatattatagactaactgcagatgcacac
cattacctctgtaaagaagtagcaccaccagcagtgcttgagaatatacagagcaactgt
catggcccaatttcaatggattttgcaattagtaaactgaagaaagcgggtaatcagact
ggattatatgtacttcgatgtagtcctaaggactttgataaatattttctgacctttgct
gttgagcgagataatatcattgaatataagcattgtttgattacaaagaatgagaacaga
gagtacaacctcagtgggactaagaggaacttcagcagtcttaaagaccttctgaactgc
taccggatggaaactgttcgctcagacaatataattttccagtttactaaatgctgtccc
ccaaagccaaaagataagtcaaaccttctagtcttcagaacaaatggtgtttctgatgtt
cacatctcaccaacgttacagaggcataataatgtgaaccaaatggtgttccacaaaatc
agaaatgaagatttgatatttaatgaaagccttggccaaggtacttttaccaaaattttt
aaaggtataagaagagaagtaggagattatggtcagctgcatgaaacagaagttcttttg
aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg
atgagtcagctttctcacaagcatttggttttgaattacggagtatgtgtctgtggagag
gagaatattctggttcaagagtttgttaaatttggatcactagatacgtatctgaaaaaa
aataaaaattccataaacatattatggaaactcggagtggctaaacagttggcatgggca
atgcattttctagaagagaaatcccttattcacggaaatgtatgtgccaaaaatattcta
cttatcagagaagaagataggaaaacaggaaatcctcctttcatcaaacttagtgaccct
ggcatcagcattacagttttaccaaaggacattcttcaggagagaataccttgggtacca
cctgaatgtattgaaaatcccaaaaatctaaatctggcaacagacaaatggagttttggt
accactctgtgggaaatttgcagtggaggagataagcctctaagtgctctggattctcaa
agaaagctacagttttatgaagataagcatcagcttcctgcaccaaagtggacagaatta
gcaaaccttataaataattgcatggattatgaaccagatttcaggccttctttcagagcc
atcatacgagatcttaacagtttgtttactccggattatgaactattaacagaaaatgac
atgctaccaaacatgagaataggtgccctaggattttctggtgcttttgaagacagagac
cctacacagtttgaggagagacatttgaaatttctacagcaactcggcaagggtaacttt
gggagtgtggagatgtgccgctatgaccccctacaagacaacactggagaggtggtggct
gttaaaaagctacagcacagcacggaagagcacctcagggattttgaaagggaaattgaa
atcctgaaatccttgcagcatgacaacattgtaaagtacaagggagtatgctacagtgct
ggtcggcgtaacctaagattaattatggaatatttgccatatggaagtttacgggactat
ctccaaaaacataaagaacggatcgatcacaaaaaacttctgcagtacacatctcagata
tgcaagggtatggagtatcttggtacaaaaaggtatatccacagagacctagcaacaaga
aatatattggtggaaaatgagaaccgagttaaaattggagattttggattaaccaaagtc
ttgccacaagacaaagaatactacaaagtaaaagaaccaggtgaaagccccatattctgg
tatgctccagaatcactgaccgagagcaagttttctgtggcctcagatgtttggagtttt
ggtgtggttctgtatgaacttttcacatatattgagaagagtaaaagtccaccagtggaa
tttatgcgaatgattggcaatgacaagcaaggacagatgattgtgttccatctgatagag
ctcctgaagaataatgggagattgccaaggcctgaagggtgcccagatgagatatatatt
atcatgacagaatgctggaacaacaatgtaaatcagcgtccctccttcagggacctggca
cttcgagtggatcaaatacgggacagtatggctgcgtga

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