Nannospalax galili (Upper Galilee mountains blind mole rat): 103744745
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Entry
103744745 CDS
T03372
Symbol
Ern1
Name
(RefSeq) endoplasmic reticulum to nucleus signaling 1
KO
K08852
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:
2.7.11.1
3.1.26.-]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi04140
Autophagy - animal
ngi04141
Protein processing in endoplasmic reticulum
ngi04210
Apoptosis
ngi04932
Non-alcoholic fatty liver disease
ngi05010
Alzheimer disease
ngi05012
Parkinson disease
ngi05014
Amyotrophic lateral sclerosis
ngi05016
Huntington disease
ngi05017
Spinocerebellar ataxia
ngi05022
Pathways of neurodegeneration - multiple diseases
ngi05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
103744745 (Ern1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
103744745 (Ern1)
09143 Cell growth and death
04210 Apoptosis
103744745 (Ern1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
103744745 (Ern1)
05012 Parkinson disease
103744745 (Ern1)
05014 Amyotrophic lateral sclerosis
103744745 (Ern1)
05016 Huntington disease
103744745 (Ern1)
05017 Spinocerebellar ataxia
103744745 (Ern1)
05022 Pathways of neurodegeneration - multiple diseases
103744745 (Ern1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
103744745 (Ern1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
103744745 (Ern1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ngi01001
]
103744745 (Ern1)
Enzymes [BR:
ngi01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
103744745 (Ern1)
Protein kinases [BR:
ngi01001
]
Serine/threonine kinases: Other
IRE family
103744745 (Ern1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
Ribonuc_2-5A
PK_Tyr_Ser-Thr
PQQ_2
PQQ
Pkinase_fungal
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
103744745
NCBI-ProteinID:
XP_008844801
UniProt:
A0A8C6RK32
LinkDB
All DBs
Position
Un
AA seq
977 aa
AA seq
DB search
MPAWRLPLLLALLLLLSGPGIFGSTSTITLPETLLFVSTLDGSLHAVSKRTGSIKWTLKE
DPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYM
GKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNAT
YFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLR
KVIHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPS
MVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFNPGLKGKSKLNYLRNY
WLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENTPTTV
SQDVEEKLTRAPAKPEAPVDSMLKDVATIILSTFLLVGWVAFIITYPLSVHQQRQLQHQQ
FQKELEKIQLLQQQQLPFHPHGDLTQDPEFLDTSGLFSESSGTSSPSPSPRASNHSLHSS
SSASRAGPSPFLEQDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKR
ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH
LGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGKIKAMISDFGLCKKLAV
GRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQ
RQANILLGACSLDCFCSDKHEDVIARELIEKMISMDPQQRPSAKRVLRHPFFWSLEKQLQ
FFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL
LRAMRNKKHHYRELPVEVQETLGSLPDDFVRYFTSRFPHLLSHTYRAMELCSQERLFQPY
YLHEPTEPQPPVTPDAL
NT seq
2934 nt
NT seq
+upstream
nt +downstream
nt
atgccggcctggcgactgccgctcctgctggcgctgctgctgctgctgtccggccctggg
atttttggaagtaccagcacaataacactgcctgaaaccttgttgtttgtttcaaccctg
gatggaagtttgcacgctgtcagcaagaggacaggctcaatcaagtggactttaaaagaa
gatccagtcctgcaggttccgacacacgtggaagagcctgccttcctcccagatcccaat
gatggtagtctgtacacacttgggggcaagaacaacgaaggtctgacgaaacttcccttt
accatcccagaattggtccaggcatccccatgccgaagttcagatggaatcctctacatg
ggtaaaaagcaggacatttggtatgtcattgacctcctgactggcgagaagcagcagact
ttgtcatcagcctttgcagatagtctctgcccctctacctccctgctgtatcttggccgg
acagagtacactatcaccatgtatgacacaaagacccgtgaactccgctggaatgccacc
tattttgactacgcagcctcactgcccgaggacgacgtggactacaaaatgtcccacttt
gtgtccaatggcgacggactggtggtaactgtggatagtgaatctggggacgtcctatgg
atccaaaactatgcctctcctgtggtagccttctacgtctggcagcgggagggactgagg
aaggtgatacatatcaatgttgccgtggagactctgcgctacttgaccttcatgtctggg
gaagtagggcgcatcaccaagtggaagtatccattccccaaagagacggaggccaagagc
aagctgacgcctaccctatatgttgggaagtactccaccagcctgtatgcctctccctca
atggtgcacgagggggtcgccgttgtgccccgaggcagcactcttcctttgctggaaggc
ccccagaccgatggcgtcaccattggggacaaaggggaatgtgtgatcacgcccagcaca
gacctcaagtttaaccctggactgaaagggaagagcaagctgaactacttgagaaattac
tggcttctcataggacaccatgaaaccccactgtctgcatctaccaagatgcttgagaga
tttcccaacaatctgcccaaacatcgggaaaatgtgattcctgctgattcagaaaaaaag
agctttgaggaagttatcaacctggttgaccagacttcagaaaacacaccaaccactgtg
tctcaggatgtagaggagaaactgactcgtgcccctgccaagcctgaggcccctgtggac
tccatgctcaaggatgtggccaccatcatcctaagcacgtttctgctggttggatgggta
gccttcatcatcacctaccccttgagcgtgcatcagcagcgccagctccagcaccagcag
ttccagaaggaactggagaaaatccagctcctgcagcagcagcagctgcccttccaccca
catggagacctgacccaagaccctgagttcctggatacgtctggcctcttctcagaaagc
tcaggcaccagcagccccagcccatcccccagagcttctaaccactcacttcactccagc
agctctgcttccagggctggcccaagccctttcctggagcaggatgacgaggatgaggaa
accagaatggtgattgttgggaaaatttcattctgtcccaaggatgtcctgggccatgga
gctgagggtacaattgtatacaagggcatgtttgacaaccgtgacgtggctgtgaagagg
atcctccccgagtgctttagctttgcagaccgtgaggtccagctgcttcgagaatccgac
gagcacccgaacgtgatccgctacttctgcacagagaaggaccggcagttccagtacatt
gccattgagctatgtgcagctaccctgcaggagtatgtagagcagaaggactttgcccac
cttggcctggagcccatcaccttgctgcagcagaccacctccggcctggcacacctgcac
tccctcaacattgttcacagagacctgaagccccacaacatcctcctctccatgcctaat
gcacatggcaagatcaaggctatgatctctgactttggcctctgcaagaagctggcagtg
ggcaggcacagtttcagccgccgctctggggtgcctggcactgaaggctggatagcccca
gagatgctgagtgaagactgcaaggagaaccctacctacacagtggacatcttctctgca
ggctgtgtcttctactatgtcatctctgagggtagccaccctttcggcaagtccctgcag
cgtcaggccaacatcctcctgggcgcctgcagccttgactgcttctgctctgacaaacac
gaagatgtcattgctcgtgagttgatagagaaaatgatttcgatggacccccaacagcga
ccatctgcaaagcgtgtgctaagacacccattcttctggagcctggaaaagcagctgcag
ttttttcaggacgtgagtgaccggatagaaaaggagtccttggatggcccaatagtgaag
cagttagagagaggtgggagagctgtggtgaagatggactggcgggagaacatcactgtc
cccctgcagacagatctgcgtaaattcagaacctacaaaggtggctccgtcagagatctc
ctccgagccatgagaaataagaagcaccactaccgagagctccctgtggaggttcaggag
acactgggttccctccctgatgactttgtgcgctacttcacttcgcgcttcccccacctc
ctctctcacacctaccgggccatggagctctgcagccaggagagactcttccagccctac
tacttgcatgagcccacggagccccagcccccagtgactccagatgccctctga
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