KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103752052
Entry
103752052         CDS       T03372                                 
Symbol
Map2k4
Name
(RefSeq) mitogen-activated protein kinase kinase 4
  KO
K04430  mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi04010  MAPK signaling pathway
ngi04012  ErbB signaling pathway
ngi04620  Toll-like receptor signaling pathway
ngi04664  Fc epsilon RI signaling pathway
ngi04668  TNF signaling pathway
ngi04912  GnRH signaling pathway
ngi04926  Relaxin signaling pathway
ngi04935  Growth hormone synthesis, secretion and action
ngi04936  Alcoholic liver disease
ngi05132  Salmonella infection
ngi05135  Yersinia infection
ngi05142  Chagas disease
ngi05161  Hepatitis B
ngi05166  Human T-cell leukemia virus 1 infection
ngi05167  Kaposi sarcoma-associated herpesvirus infection
ngi05169  Epstein-Barr virus infection
ngi05208  Chemical carcinogenesis - reactive oxygen species
ngi05417  Lipid and atherosclerosis
ngi05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103752052 (Map2k4)
   04012 ErbB signaling pathway
    103752052 (Map2k4)
   04668 TNF signaling pathway
    103752052 (Map2k4)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    103752052 (Map2k4)
   04664 Fc epsilon RI signaling pathway
    103752052 (Map2k4)
  09152 Endocrine system
   04912 GnRH signaling pathway
    103752052 (Map2k4)
   04926 Relaxin signaling pathway
    103752052 (Map2k4)
   04935 Growth hormone synthesis, secretion and action
    103752052 (Map2k4)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    103752052 (Map2k4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103752052 (Map2k4)
   05161 Hepatitis B
    103752052 (Map2k4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103752052 (Map2k4)
   05169 Epstein-Barr virus infection
    103752052 (Map2k4)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103752052 (Map2k4)
   05135 Yersinia infection
    103752052 (Map2k4)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    103752052 (Map2k4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103752052 (Map2k4)
   05418 Fluid shear stress and atherosclerosis
    103752052 (Map2k4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    103752052 (Map2k4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ngi01001]
    103752052 (Map2k4)
Enzymes [BR:ngi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     103752052 (Map2k4)
Protein kinases [BR:ngi01001]
 Serine/threonine kinases: STE group
  STE7 family
   103752052 (Map2k4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like Pkinase_fungal Seadorna_VP7 ABC1 Haspin_kinase Choline_kinase APH
Other DBs
NCBI-GeneID: 103752052
NCBI-ProteinID: XP_008853917
LinkDB
Position
Un
AA seq 371 aa
MFLLKALRRLFPSLLPLDGSKLSRAVVASIPPLSSLDHLPCLCLLERLRTHSIESSGKLK
ISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMD
LDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKI
TLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRP
YMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQL
SNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQM
PATPSSPMYVD
NT seq 1116 nt   +upstreamnt  +downstreamnt
atgtttctcctgaaggcgctaaggaggctctttccttctctccttcctttggatggttcc
aagctttccagggctgtggtagcaagcatcccgcctttatcttcacttgatcaccttccc
tgtctttgcctcttagagagactgagaacacacagcattgagtcgtcaggaaaactgaag
atctcccctgaacaacactgggatttcactgcagaggacttgaaagaccttggagaaatt
ggacgaggagcttatggttctgtcaacaaaatggtccacaaaccaagtgggcaaataatg
gcagttaaaagaatacggtcaacagtggatgaaaaagaacaaaaacaacttcttatggat
ttggatgtagtaatgcggagtagcgattgcccgtatattgttcagttttatggtgcgctc
ttcagagagggtgactgttggatctgtatggaactcatgtctacctcgtttgataagttt
tacaaatatgtatatagtgtattagatgatgttattccagaagaaattttaggcaaaatc
actttagcaactgtgaaagcactaaaccacttaaaagaaaacttgaaaattattcacaga
gatatcaaaccttcaaatattcttctggacagaagtggaaatattaaactctgtgacttt
ggcatcagtggacagctggtggactccattgccaagacaagagatgctgggtgtaggcca
tacatggcacctgaaagaatagacccaagtgcatcccgacaaggctatgatgtccgctct
gatgtctggagtttggggatcacgctgtacgagttggccacaggccgatttccttatcca
aagtggaatagtgtatttgatcagctaacacaagtggtgaaaggagatcctccacagctg
agtaattcggaagaaagggaattctcccccagtttcatcaactttgtcaacttgtgcctt
acgaaggatgaatctaaaaggccaaagtataaagaacttctgaaacatccctttattttg
atgtatgaagaacgtaccgtcgaggtagcatgctatgtttgtaaaatcctggatcaaatg
ccagctactcccagctctcctatgtatgtcgactga

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