KEGG   Naegleria gruberi: NAEGRDRAFT_78714
Entry
NAEGRDRAFT_78714  CDS       T01241                                 
Name
(RefSeq) dihydroorotate dehydrogenase family protein
  KO
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Organism
ngr  Naegleria gruberi
Pathway
ngr00240  Pyrimidine metabolism
ngr00410  beta-Alanine metabolism
ngr00770  Pantothenate and CoA biosynthesis
ngr01100  Metabolic pathways
Module
ngr_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Brite
KEGG Orthology (KO) [BR:ngr00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    NAEGRDRAFT_78714
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    NAEGRDRAFT_78714
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    NAEGRDRAFT_78714
Enzymes [BR:ngr01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2  dihydropyrimidine dehydrogenase (NADP+)
     NAEGRDRAFT_78714
SSDB
Motif
Pfam: DHO_dh Fer4_20 Fer4_21 Pyr_redox_2 Fer4_7 Pyr_redox_3 Fer4_10 NAD_binding_8 Fer4_6 Fer4_9 Fer4_2 Dus FAD_oxidored Fer4 FAD_binding_2 Pyr_redox Fer4_4 DAO Thi4
Other DBs
NCBI-GeneID: 8861902
NCBI-ProteinID: XP_002680621
JGI: Naegr1_78714
UniProt: D2V5Y1
LinkDB
AA seq 1038 aa
MASSTNFLTLGLEDIENLNLNPKIQKYASVRPSKETEKLKQHYKRNIPINTKQLKYDFRD
NKHSTLTEKSAIVEASRCLKCADAPCQSSCPTSLDIKSFISCISTGNYYGAAKMIFSDNP
LGLSCGMVCPVSNLCAGSCNLAATEEGPININGLQAFATDVFRKMKLKQIRDPDATPLDK
LPESYKAKIALVGAGPASISCATFLARMGYQNVTIFEKGQYAGGLSTQEIPQNRLPYEAV
EFEVNLMKDLGVKVEYNKELGRDFTVESLKNDGYEAIFLGIGLPDPNKESIFDGLTPEQG
FYTSKDFLPAVMQSSKDGICGCKASNQKLPKLYGKVVILGIGDTALDVYGSSIRCGADKA
VLVFRRGFSEMRCVEEEFEPAMKEKCDVLPNCLPKQIIMKDGRISGIELYKTEVDSNGKL
VIDEDQFIRLKCDFVVSAFGCTLKSENIIKSLSPVAVNNYGRVPINNTTMETEVKGVFAG
GDLIGSGMTVEASNDGKTASWYIHRYIQEELHKADRLSDAPQLPKFFTEVDKVDISVEVC
GVKFENPYGLASAPPCTTADMIDRAFDAGWGFAVTKTFGLDKDLVTNVSPRIIRGSVTTN
RGPHQSAFMNIELISEKSATYWCTAITELKKKHPTKIVIASIMAAFKEEDWKFLATKAEQ
AGADMIELNLSCPHGMGEKGLGLACGMDPYLVLNICKWVRAVTKIPFFAKLTPNVTDVLQ
IATAARDGGADGVTATNTVSGLMTLKPDATAWPAVGANKRTTYGGVSGNAIRPIAMKAVS
KVAKNIPGYPILATGGCDSADVALQFIHAGASVVQICSSVQNQDFTVIEDYITGLKALMY
INAHPAFKGWTGQTPPVVEEKKVGLPRFGPYELKRRELDVKEIEEKGVLTGRHEDNMPAE
IEQVIKVPSINDVVAKAVPRIGSWGELDPKFDHHVIAVINDDKCINCGKCYLTCNDSGYQ
AISFDKDTHIPKVSDDDCTGCTLCYSVCPVLDCIEMVPRKTEYKSQRGIAPGEFSQEAVL
KFASLYDSNGSLVSDMHE
NT seq 3117 nt   +upstreamnt  +downstreamnt
atggcctcatcgactaatttcctaactcttggattggaagacattgaaaatttaaatctc
aacccaaagattcaaaagtatgcttcagtgagaccaagcaaggaaactgaaaagcttaag
caacactacaagagaaatattccaatcaataccaaacaattaaaatatgattttagagac
aacaagcactctacattgacagagaagagtgctatcgtggaagcaagcagatgtttaaag
tgtgctgacgctccatgtcaatcttcttgtccaacttcattggatattaagagttttatt
agttgtatttctactggaaattactatggtgctgccaagatgattttctctgacaatcca
ctaggtttgtcatgtggtatggtttgtcctgttagtaatttgtgtgcaggaagctgtaac
ttggctgctaccgaagaaggcccaattaatatcaatggtttgcaagcattcgcaactgat
gtctttagaaagatgaaattgaaacaaatcagagacccagatgctactcctctcgacaaa
ttaccagaatcatacaaggccaagattgctctcgttggtgcaggtcctgccagtatttca
tgtgctactttcttggctagaatgggttatcaaaatgttaccatctttgaaaagggacaa
tatgctggtggtttgagcactcaagaaattccacaaaatcgtctcccatacgaagctgtt
gagtttgaagtcaacttgatgaaggatttgggtgttaaagtcgaatataacaaggaatta
ggaagagatttcactgttgaatcactcaagaatgatggttatgaagccatctttttgggt
attggtcttccagatccaaataaggaatcaatctttgacggattgaccccagaacaaggt
ttctacacctctaaggatttccttccagcggtcatgcaatcatcaaaggatggtatctgt
ggttgtaaggcatcaaaccaaaagcttccaaagttatatggtaaggttgttattttgggt
attggtgatactgccctcgatgtttatggttctagtattagatgtggagctgataaggct
gttcttgttttccgtcgtggtttctctgaaatgagatgtgtcgaagaagaatttgaacca
gccatgaaggaaaagtgtgacgtacttccaaattgtttaccaaaacaaattatcatgaag
gatggcagaatttctggtatcgaattgtacaagactgaagttgactctaatggtaaactt
gtcattgatgaagatcagttcatcagactcaaatgtgactttgtcgtttctgcatttggt
tgcactttgaagagtgaaaatattatcaagtccctttcacctgttgctgttaataattat
ggtagagttcctatcaataatacaacaatggaaaccgaagtcaagggtgtttttgctggt
ggtgacttgattggtagtggtatgacagtagaggcaagcaatgatggtaaaactgcatct
tggtacattcatcgttatatccaagaagaattgcataaggctgatagactctctgatgct
cctcaacttccaaagttctttactgaagttgataaggttgatatttcagttgaagtatgt
ggtgtcaagtttgaaaatccatacggtcttgcttctgctccaccttgtactactgctgat
atgattgatcgtgcttttgatgctggttggggctttgctgtcactaagacttttggtttg
gataaggatttggttactaatgtttcaccaagaattattcgtggttcagtcactacaaac
agaggtcctcatcaatctgctttcatgaatattgaattgatttctgaaaagtctgctact
tattggtgtactgctattactgagttgaagaagaaacatccaactaagattgttattgcc
tctatcatggctgcttttaaggaagaagattggaagttccttgctactaaggccgaacaa
gctggtgctgacatgattgaattgaacttgtcttgtcctcacggtatgggtgaaaagggt
ttaggtttggcttgtggtatggatccatatcttgttttgaatatttgtaaatgggttaga
gctgttaccaagattccattctttgccaagctcactccaaacgttactgatgttttgcaa
attgctactgctgctagagatggtggtgctgatggtgttactgccacaaatactgtttct
ggtttaatgactcttaaacctgatgcgaccgcctggccagcagttggtgccaataagaga
actacctacggtggtgtcagtggtaatgcaattagaccaattgctatgaaggctgtttct
aaggttgctaagaacattcctggttatccaattcttgctactggtggttgtgacagtgct
gatgttgctttgcaattcattcatgctggtgcttcagttgtccaaatttgttcatctgtc
caaaatcaagattttactgttattgaagattacattactggattgaaggccttgatgtat
atcaatgctcatcctgcattcaagggttggactggtcaaactccaccagttgtagaagaa
aagaaagttggtttgccaagatttggtccatatgaattgaagagaagagaactcgatgtc
aaggaaattgaagaaaagggagttttgactggtagacatgaagataatatgccagctgaa
attgaacaagttatcaaggttccatccattaacgatgttgttgctaaggctgttccaaga
attggttcttggggtgaattggatccaaaattcgatcaccacgttattgctgtcattaat
gatgacaagtgtatcaattgtggtaaatgctacctgacttgtaatgacagtggttatcaa
gccatttctttcgataaggacactcacattccaaaggttagtgatgacgattgtactggt
tgtactttgtgttactctgtttgtccagttttggattgtattgaaatggttcctcgtaag
actgaatacaaatctcagagaggtattgctccaggtgaattctcacaagaagctgttttg
aagtttgccagtttgtatgattcaaatggttcccttgtttctgatatgcacgaataa

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