| Entry |
|
| Symbol |
PLCB1
|
| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
|
| KO |
|
| Organism |
nle Nomascus leucogenys (northern white-cheeked gibbon)
|
| Pathway |
| nle04070 | Phosphatidylinositol signaling system |
| nle04072 | Phospholipase D signaling pathway |
| nle04261 | Adrenergic signaling in cardiomyocytes |
| nle04270 | Vascular smooth muscle contraction |
| nle04613 | Neutrophil extracellular trap formation |
| nle04621 | NOD-like receptor signaling pathway |
| nle04723 | Retrograde endocannabinoid signaling |
| nle04750 | Inflammatory mediator regulation of TRP channels |
| nle04919 | Thyroid hormone signaling pathway |
| nle04925 | Aldosterone synthesis and secretion |
| nle04927 | Cortisol synthesis and secretion |
| nle04928 | Parathyroid hormone synthesis, secretion and action |
| nle04933 | AGE-RAGE signaling pathway in diabetic complications |
| nle04935 | Growth hormone synthesis, secretion and action |
| nle04961 | Endocrine and other factor-regulated calcium reabsorption |
| nle04973 | Carbohydrate digestion and absorption |
| nle05022 | Pathways of neurodegeneration - multiple diseases |
| nle05163 | Human cytomegalovirus infection |
|
| Module |
| nle_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
| Brite |
KEGG Orthology (KO) [BR:nle00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
100597115 (PLCB1)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
100597115 (PLCB1)
04310 Wnt signaling pathway
100597115 (PLCB1)
04371 Apelin signaling pathway
100597115 (PLCB1)
04020 Calcium signaling pathway
100597115 (PLCB1)
04070 Phosphatidylinositol signaling system
100597115 (PLCB1)
04072 Phospholipase D signaling pathway
100597115 (PLCB1)
04071 Sphingolipid signaling pathway
100597115 (PLCB1)
04022 cGMP-PKG signaling pathway
100597115 (PLCB1)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
100597115 (PLCB1)
04081 Hormone signaling
100597115 (PLCB1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
100597115 (PLCB1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100597115 (PLCB1)
04613 Neutrophil extracellular trap formation
100597115 (PLCB1)
04621 NOD-like receptor signaling pathway
100597115 (PLCB1)
04062 Chemokine signaling pathway
100597115 (PLCB1)
09152 Endocrine system
04911 Insulin secretion
100597115 (PLCB1)
04922 Glucagon signaling pathway
100597115 (PLCB1)
04929 GnRH secretion
100597115 (PLCB1)
04912 GnRH signaling pathway
100597115 (PLCB1)
04915 Estrogen signaling pathway
100597115 (PLCB1)
04921 Oxytocin signaling pathway
100597115 (PLCB1)
04926 Relaxin signaling pathway
100597115 (PLCB1)
04935 Growth hormone synthesis, secretion and action
100597115 (PLCB1)
04918 Thyroid hormone synthesis
100597115 (PLCB1)
04919 Thyroid hormone signaling pathway
100597115 (PLCB1)
04928 Parathyroid hormone synthesis, secretion and action
100597115 (PLCB1)
04916 Melanogenesis
100597115 (PLCB1)
04924 Renin secretion
100597115 (PLCB1)
04925 Aldosterone synthesis and secretion
100597115 (PLCB1)
04927 Cortisol synthesis and secretion
100597115 (PLCB1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
100597115 (PLCB1)
04270 Vascular smooth muscle contraction
100597115 (PLCB1)
09154 Digestive system
04970 Salivary secretion
100597115 (PLCB1)
04971 Gastric acid secretion
100597115 (PLCB1)
04972 Pancreatic secretion
100597115 (PLCB1)
04973 Carbohydrate digestion and absorption
100597115 (PLCB1)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
100597115 (PLCB1)
09156 Nervous system
04724 Glutamatergic synapse
100597115 (PLCB1)
04725 Cholinergic synapse
100597115 (PLCB1)
04728 Dopaminergic synapse
100597115 (PLCB1)
04726 Serotonergic synapse
100597115 (PLCB1)
04720 Long-term potentiation
100597115 (PLCB1)
04730 Long-term depression
100597115 (PLCB1)
04723 Retrograde endocannabinoid signaling
100597115 (PLCB1)
09157 Sensory system
04742 Taste transduction
100597115 (PLCB1)
04750 Inflammatory mediator regulation of TRP channels
100597115 (PLCB1)
09159 Environmental adaptation
04713 Circadian entrainment
100597115 (PLCB1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100597115 (PLCB1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
100597115 (PLCB1)
09174 Infectious disease: parasitic
05146 Amoebiasis
100597115 (PLCB1)
05142 Chagas disease
100597115 (PLCB1)
05143 African trypanosomiasis
100597115 (PLCB1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100597115 (PLCB1)
05016 Huntington disease
100597115 (PLCB1)
05017 Spinocerebellar ataxia
100597115 (PLCB1)
05022 Pathways of neurodegeneration - multiple diseases
100597115 (PLCB1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
100597115 (PLCB1)
05415 Diabetic cardiomyopathy
100597115 (PLCB1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
100597115 (PLCB1)
04934 Cushing syndrome
100597115 (PLCB1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:nle04131]
100597115 (PLCB1)
Enzymes [BR:nle01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
100597115 (PLCB1)
Membrane trafficking [BR:nle04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
100597115 (PLCB1)
Endocytosis
Macropinocytosis
Phospholipase C
100597115 (PLCB1)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| LinkDB |
|
| Position |
11:2505524..3293143
|
| AA seq |
1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLARKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEPPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSS
EELGGDIPGKEFDTPL |
| NT seq |
3651 nt +upstreamnt +downstreamnt
atggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactcaactattgttactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctactggatctcagccttgtcaaagatgccagatgtgggagacacgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacatcgggcgcctggagcag
cgcatgatcacagtggtgtatgggcctgaccttgtgaacatctcgcatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgtattcctctcaaaaacatatatcgcttgttttcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctcaacaacctttgc
cctcgacctgaaattgataacatcttttcagaatttggtgccaaaagcaaaccatatctt
accgttgatcagatgatggattttatcaaccttaagcagcgagatcctcggcttaatgaa
atactttatccacctctaaaacaagagcaagtccaagtattgattgagaagtatgaaccc
aacagcagtctcgccagaaaaggacaaatatcagtggatgggttcatgcgctatctgagc
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcag
cccctttctcactatttcattaattcctcgcacaacacctacctcacagctggccaactg
gctggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtg
gagctggactgctggaagggacggactgcagaagaggaacctgtcatcacccatggcttc
accatgacaactgaaatatctttcaaggaagtgatagaagcaattgcggagtgtgcattt
aagacttcaccttttccaattctcctttcgtttgagaaccatgtggattccccaaagcag
caagccaagatggcggaatactgccgactgatctttggggatgcccttctcatggagccc
ctggaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtat
aaaattttggtgaaaaataagaagaaatcacacaagtcatcagaaggaagcggcaaaaag
aagctctcagaacaagcttccaacacctacagtgactcctccagcgtgttcgagccctca
tccccaggagccggagaagctgatacggaaagtgacgatgacgatgatgatgatgactgt
aaaaaatcttcaatggatgaggggaccgctggaagtgaggctatggccacagaagaaatg
tctaacctggtgaactacattcagccagtcaagtttgagtcatttgaaatttcaaaaaaa
agaaataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacaactcacc
aagtctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
ggaacacgtgtggattcatccaactatatgcctcagctcttctggaacgcaggttgtcag
atggtggcacttaatttccagacaatggacctggctatgcaaataaatatggggatgtat
gaatacaacgggaagagtggctacagattgaagccagagttcatgaggaggcctgacaag
cattttgatccatttactgaaggcatcgtagatgggatagtggcaaacactttgtctgtt
aagattatttcaggtcagtttctttctgataagaaagttgggacttatgtggaagtggat
atgtttggtttgcctgtggatacaaggaggaaggcatttaagaccaaaacatcccaagga
aatgctgtgaatcctgtctgggaagaagaacctattgtgttcaaaaaggtggttcttcct
actctggcctgtttgagaatagcagtttatgaagaaggaggtaaattcattggccaccgt
atcttgccagtgcaagccattcggccaggctatcactatatctgtctaaggaatgaaagg
aaccagcctctgacgctgcctgctgtctttgtctacatagaagtgaaagactatgtgcca
gacacatatgcagatgtcattgaagctttatcaaacccaatccgatatgtgaacctgatg
gaacagagagctaagcaattggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggagaaacaccatcagagcctccaagtgaagcgagaacgactccagca
gaaaatggggtgaatcacactacaaccctgacacccaagccaccctcccaggctctccac
agccagccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gtcttaacagaagtggaagcacagaccatcgaagaactaaagcaacagaaatcgtttgtg
aaacttcaaaagaaacactacaaagaaatgaaagacctggttaagagacaccacaagaaa
accactgaccttatcaaagaacacactaccaagtataatgaaattcagaatgactacttg
agaaggagagcagctttggaaaagtccgccaaaaaggacagtaagaaaaaatcggaaccc
agcagccctgatcatggttcatcaacgattgagcaagacctcgctgccctggatgctgaa
atgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcgg
caagaacagtattatagtgaaaaataccagaagcgagaacacattaaactgcttattcaa
aagttgacggatgtcgcagaagagtgtcagaacaatcagttaaagaagctcaaagaaatc
tgtgagaaagaaaagaaagaattaaagaagaaaatggataaaaagaggcaagagaagata
acagaagctaaatccaaagacaaaagtcagatggaagaggagaagacagagatgatccgg
tcgtatatccaggaagtggtgcagtatatcaagaggctagaagaggcgcaaagtaaacgg
caagaaaaactcgtagagaaacacaaggaaatacgtcagcagatcctggatgaaaagccc
aagctgcaggtggagctggagcaagaataccaagacaaattcaaaagactgcccctcgag
attttggaattcgtgcaggaagccatgaaaggaaagatcagtgaagacagcaatcacggt
tctgcccctctctccctgtcctcagaccctggaaaagtgaaccacaagactccctccagt
gaggagctgggaggagacatcccaggaaaagaatttgatactcctctgtga |