KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100600507
Entry
100600507         CDS       T03265                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle00562  Inositol phosphate metabolism
nle01100  Metabolic pathways
nle04015  Rap1 signaling pathway
nle04020  Calcium signaling pathway
nle04022  cGMP-PKG signaling pathway
nle04062  Chemokine signaling pathway
nle04070  Phosphatidylinositol signaling system
nle04071  Sphingolipid signaling pathway
nle04072  Phospholipase D signaling pathway
nle04081  Hormone signaling
nle04082  Neuroactive ligand signaling
nle04261  Adrenergic signaling in cardiomyocytes
nle04270  Vascular smooth muscle contraction
nle04310  Wnt signaling pathway
nle04371  Apelin signaling pathway
nle04540  Gap junction
nle04611  Platelet activation
nle04613  Neutrophil extracellular trap formation
nle04621  NOD-like receptor signaling pathway
nle04713  Circadian entrainment
nle04720  Long-term potentiation
nle04723  Retrograde endocannabinoid signaling
nle04724  Glutamatergic synapse
nle04725  Cholinergic synapse
nle04726  Serotonergic synapse
nle04728  Dopaminergic synapse
nle04730  Long-term depression
nle04742  Taste transduction
nle04750  Inflammatory mediator regulation of TRP channels
nle04911  Insulin secretion
nle04912  GnRH signaling pathway
nle04915  Estrogen signaling pathway
nle04916  Melanogenesis
nle04918  Thyroid hormone synthesis
nle04919  Thyroid hormone signaling pathway
nle04921  Oxytocin signaling pathway
nle04922  Glucagon signaling pathway
nle04924  Renin secretion
nle04925  Aldosterone synthesis and secretion
nle04926  Relaxin signaling pathway
nle04927  Cortisol synthesis and secretion
nle04928  Parathyroid hormone synthesis, secretion and action
nle04929  GnRH secretion
nle04933  AGE-RAGE signaling pathway in diabetic complications
nle04934  Cushing syndrome
nle04935  Growth hormone synthesis, secretion and action
nle04961  Endocrine and other factor-regulated calcium reabsorption
nle04970  Salivary secretion
nle04971  Gastric acid secretion
nle04972  Pancreatic secretion
nle04973  Carbohydrate digestion and absorption
nle05010  Alzheimer disease
nle05016  Huntington disease
nle05017  Spinocerebellar ataxia
nle05022  Pathways of neurodegeneration - multiple diseases
nle05142  Chagas disease
nle05143  African trypanosomiasis
nle05146  Amoebiasis
nle05163  Human cytomegalovirus infection
nle05200  Pathways in cancer
nle05415  Diabetic cardiomyopathy
nle05417  Lipid and atherosclerosis
Module
nle_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:nle00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100600507 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100600507 (PLCB4)
   04310 Wnt signaling pathway
    100600507 (PLCB4)
   04371 Apelin signaling pathway
    100600507 (PLCB4)
   04020 Calcium signaling pathway
    100600507 (PLCB4)
   04070 Phosphatidylinositol signaling system
    100600507 (PLCB4)
   04072 Phospholipase D signaling pathway
    100600507 (PLCB4)
   04071 Sphingolipid signaling pathway
    100600507 (PLCB4)
   04022 cGMP-PKG signaling pathway
    100600507 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    100600507 (PLCB4)
   04081 Hormone signaling
    100600507 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100600507 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100600507 (PLCB4)
   04613 Neutrophil extracellular trap formation
    100600507 (PLCB4)
   04621 NOD-like receptor signaling pathway
    100600507 (PLCB4)
   04062 Chemokine signaling pathway
    100600507 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    100600507 (PLCB4)
   04922 Glucagon signaling pathway
    100600507 (PLCB4)
   04929 GnRH secretion
    100600507 (PLCB4)
   04912 GnRH signaling pathway
    100600507 (PLCB4)
   04915 Estrogen signaling pathway
    100600507 (PLCB4)
   04921 Oxytocin signaling pathway
    100600507 (PLCB4)
   04926 Relaxin signaling pathway
    100600507 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    100600507 (PLCB4)
   04918 Thyroid hormone synthesis
    100600507 (PLCB4)
   04919 Thyroid hormone signaling pathway
    100600507 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    100600507 (PLCB4)
   04916 Melanogenesis
    100600507 (PLCB4)
   04924 Renin secretion
    100600507 (PLCB4)
   04925 Aldosterone synthesis and secretion
    100600507 (PLCB4)
   04927 Cortisol synthesis and secretion
    100600507 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100600507 (PLCB4)
   04270 Vascular smooth muscle contraction
    100600507 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    100600507 (PLCB4)
   04971 Gastric acid secretion
    100600507 (PLCB4)
   04972 Pancreatic secretion
    100600507 (PLCB4)
   04973 Carbohydrate digestion and absorption
    100600507 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100600507 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    100600507 (PLCB4)
   04725 Cholinergic synapse
    100600507 (PLCB4)
   04728 Dopaminergic synapse
    100600507 (PLCB4)
   04726 Serotonergic synapse
    100600507 (PLCB4)
   04720 Long-term potentiation
    100600507 (PLCB4)
   04730 Long-term depression
    100600507 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    100600507 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    100600507 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    100600507 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100600507 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100600507 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100600507 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100600507 (PLCB4)
   05142 Chagas disease
    100600507 (PLCB4)
   05143 African trypanosomiasis
    100600507 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100600507 (PLCB4)
   05016 Huntington disease
    100600507 (PLCB4)
   05017 Spinocerebellar ataxia
    100600507 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    100600507 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100600507 (PLCB4)
   05415 Diabetic cardiomyopathy
    100600507 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100600507 (PLCB4)
   04934 Cushing syndrome
    100600507 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nle04131]
    100600507 (PLCB4)
Enzymes [BR:nle01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100600507 (PLCB4)
Membrane trafficking [BR:nle04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100600507 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100600507 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 100600507
NCBI-ProteinID: XP_003252648
Ensembl: ENSNLEG00000014256
UniProt: A0A2I3GKX5
LinkDB
Position
11:3445093..3855559
AA seq 1187 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRTLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV
NT seq 3564 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagttttcgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaagggcggatagtttgtgtc
tgcagtggcacagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaac
gtcagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattaccagaacatttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cccacggcattttcttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aatgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttatctcactggcagacagtttggtgggaag
tcttcggtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcaggactttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagcggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaatctgcctccccagcaaacatcttagaggacgataatgaagaggag
atcgaaagtgctgaccaagaggaggaagctcaccctgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcttcagat
gaccttgaacatgaaaacaacaaaaagggcctggtcactgtagaagatgagcaggcatgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtccacaatg
atcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatatt
cattataacatgtcttcttttaatgaatcagtcggccttggctacttgaagacacatgca
attgaatttgtcaattacaacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaacatttgac
cccttctctgaaactcctgttgatggcgttattgcagccacttgctcagtgcaggttata
tcaggtcaattcttatcagataagaaaattggcacctatgtagaagtagatatgtatggg
ttgcccactgacaccatacgtaaggaattccgaactcgcatggttatgaataacggactc
aatccagtttacaatgaggagtcattcgtatttcggaaggtgatcctgccggacctggct
gtcttgagaatagctgtgtatgatgataacaacaagctgattggccagaggatcctcccg
cttgatggcctccaggcaggatatcgacacatttcccttcgaaacgaaggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctctcaattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagccgatgtgcccagtgac
acttccaaaaatgacaagaaaggaaaggccaacaccgccaaagcaaatgtgacccctcag
agtagctctgaactcagaccaacaaccacggctgccctggcctctggtgtggaagccaag
aaaggtattgaacttatccctcaagtaaggatagaagacttaaagcagatgaaggcttac
ttgaagcatttaaagaaacagcagaaggagctaaattctttaaagaagaaacatgcaaag
gaacacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggcacagtat
gacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaatcaaaattcagacgctgacatcagat
cacaaatctaaggtcaaagagattgtagcacagcacacgaaggaatggtcagaaatgatc
aatacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgag
ctgctgaaaaagctactcatcaatgcccacgagcagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaagaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaaaagactcgcaatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatctagaattcctagag
aaacagaatgagcaggcgaaggagatgcagcagatggtgaaattggaagccgagatggac
cgcagaccagcaacagtagtatga

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